Flobert wrote:
>
> Study looks at why diabetes makes heart disease worse
>
> July 12, 2012
> By Julia Evangelou Strait
>
> Researchers at Washington University School of Medicine in St. Louis
> have received a $4.7 million grant from the National Heart, Lung, and
> Blood Institute to investigate heart disease in patients with diabetes.
>
> �Diabetes is an incredibly common problem,� says Jean E. Schaffer, MD,
> the Virginia Minnich Distinguished Professor of Medicine. �It affects a
> huge swath of the population. Importantly, people with diabetes don�t
> just have a metabolic disorder. They develop complications in many
> organs. And one of the most deadly complications is heart disease. We�re
> particularly interested in why people with diabetes suffer from
> unusually severe forms of heart disease.�
>
> For reasons not fully understood, people with diabetes are more likely
> to develop blockages in arteries. After a heart attack, the course of
> the subsequent heart disease is more aggressive than in people without
> diabetes. And even independent of blocked arteries, there is evidence
> that their hearts do not function like those of individuals without
> diabetes.
>
> According to the Centers for Disease Control and Prevention, almost 26
> million Americans are living with type 2 diabetes and another 79 million
> with undiagnosed diabetes or pre-diabetes, a condition that increases
> their risk of developing the full-blown variety. With such statistics,
> it is becoming increasingly important to explore the reasons behind the
> aggressive progress of cardiovascular disease in patients whose bodies
> do not properly regulate blood sugar.
>
> Schaffer and her colleagues suspect a likely culprit is abnormal lipid
> metabolism. Lipids are a class of molecules that include fats, such as
> fatty acids and triglycerides. Past studies have shown that patients
> with diabetes store higher levels of these lipids in their heart muscle,
> likely impairing cardiac function. These lipids appear to lead to
> inflammation and can also damage important parts of heart cells, such as
> proteins and DNA, leading to heart muscle dysfunction.
>
> �The problem is that we haven�t been able to make strong links between
> what we measure in a fasting blood sample, like triglycerides and free
> fatty acids, and the degree of heart muscle dysfunction,� Schaffer says.
> �In this type of heart muscle disorder, these common blood tests are not
> a good predictor of who is at highest risk for heart disease.�
>
> The goal of the new research program is to identify better measures of
> heart disease in patients with diabetes. The program has four major parts:
>
> Establish a clinically useful method to measure key lipids related
> to diabetes complications in blood samples.
> Identify markers of abnormal lipid metabolism in existing blood
> samples from clinical trial participants, including those in the
> Framingham Heart Study. Such large, well-designed clinical trials often
> have collected both blood samples and non-invasive imaging studies of
> cardiovascular function such as echocardiograms. Comparing the two may
> show correlations between markers of abnormal lipid metabolism and heart
> function.
> Design laboratory experiments, including studies in mouse models of
> diabetes and heart disease, to help understand how the abnormal lipids
> may contribute to heart muscle dysfunction.
> Perform a clinical trial for patients with type 2 diabetes to
> examine whether a drug that lowers blood lipids improves heart function.
>
> In addition to its own research program, Washington University will
> serve as the coordinating center among the five institutions chosen to
> receive funding from the National Institutes of Health (NIH) to study
> the abnormal metabolism of cardiovascular and lung diseases. The four
> partnering institutions are Cleveland Clinic, Emory University, National
> Jewish Health and Weill Cornell Medical College.
>
> �We will be working with the NIH and our partner institutions to help
> researchers interact and inform new approaches and new ideas in other
> studies,� Schaffer says.
>
> Schaffer emphasizes the multidisciplinary and collaborative nature of
> the research program and credits the School of Medicine�s BioMed 21
> initiative for providing the resources to facilitate this type of
> translational project.
>
> The research is supported by a grant (P20 HL113444) from the National
> Heart, Lung, and Blood Institute at the National Institutes of Health (NIH).
> Washington University School of Medicine�s 2,100 employed and volunteer
> faculty physicians also are the medical staff of Barnes-Jewish and St.
> Louis Children�s hospitals. The School of Medicine is one of the leading
> medical research, teaching and patient care institutions in the nation,
> currently ranked sixth in the nation by U.S. News & World Report.
> Through its affiliations with Barnes-Jewish and St. Louis Children�s
> hospitals, the School of Medicine is linked to BJC HealthCare.
Much smarter to simply
http://WDJW.net/Guard (Proverbs 4:23) the heart
by holding to the right amount, which is 32 oz of daily food thereby
stopping the overeating without harmful undernourishment in order to
lose the terrible
http://WDJW.net/VAT which is the root cause of the
type-2 diabetes so as to possibly achieve reversal/cure.
Yes, right amount (
http://WDJW.net/2PD-OMER Approach ) control as
Chris Malcolm, MU, **and** Rod Eastman are doing is much more
sophisticated and smarter:
http://groups.google.com/group/alt.support.diet.low-carb/msg/8d2ef74488074acf?
and
http://groups.google.com/group/sci.med.cardiology/msg/522ce5c058224656?
**and**
http://groups.google.com/group/sci.med.cardiology/msg/da03131060efa3b5?
http://groups.google.com/group/sci.med.cardiology/msg/055f2e7cf3c590ee?
Don't be an Ayoob:
https://groups.google.com/group/sci.med.cardiology/msg/91c1431a6b413912?
Be hungrier, which really is wonderfully healthier especially for
diabetics and other heart disease patients:
https://groups.google.com/group/sci.med.cardiology/msg/0e719da5c2d970ca?
... because we mindfully choose to openly care with our heart,
Andrew <><
--
Andrew B. Chung, MD/PhD
EmoryIMVC.org Cardiologist
and Author of the 2PD-OMER Approach:
http://groups.google.com/group/sci.med.cardiology/msg/9ad0c19df5ffc2f7?