On 6/1/2021 9:07 PM, Glenn wrote:
> On Tuesday, June 1, 2021 at 5:46:03 PM UTC-7, Ron O wrote:
>> On 6/1/2021 4:45 PM, Glenn wrote:
>>> On Tuesday, June 1, 2021 at 4:21:04 AM UTC-7, Ron O wrote:
>>>> On 6/1/2021 1:58 AM, Glenn wrote:
>>>>> On Thursday, May 27, 2021 at 3:11:05 PM UTC-7, Glenn wrote:
>>>>>> "Membrane repair would have been necessary with the first cell."
>>>>>>
>>>>>> Read the rest at
>>>>>>
https://evolutionnews.org/2021/05/zip-it-how-cells-repair-leaking-membranes/
>>>>>>
>>>>>> Must a reproducing lifeform be contained within a membrane?
>>>>>> Is it conceivable that the environment of early Earth was not hostile to what we understand living things are made up of, and needed no protective membrane?
>>>>>>
>>>>>> This appears to be the first original and relevant "chicken or egg" problem.
>>>>>
>>>>> It seems I neglected to provide this;
>>>>>
>>>>> "The first forms of cellular life required self-assembled membranes that were likely to have been produced from amphiphilic compounds on the prebiotic Earth."
>>>>>
>>>>>
https://www.researchgate.net/publication/10893692_The_First_Cell_Membranes
>>>>>
>>>>> Would these scientists have been aware of the thousands of machiney thingies and other very complex structures that comprise cell membranes?
>>>
>>> First of all, I congratulate you for not beginning a post with an insult, leading question or assuming the conclusion,
>>> so I'm compelled to respond to your whole post.
>> You run because you never can deal with reality. I inform you about
>> your junk, but you run. That is what you do because you don't want to
>> understand what you put up.
>
> I'll let you get by with that typical starting rant. Don't let it go to your head.
You have to run from reality because you know that it is true. Just
look at the vast majority of your responses.
It seems that you do not know what the ID perps are in denial of for
this denial argument. You don't seem to understand it in this response
QUOTE:
Origin-of-life theorists often assume that membranes would spontaneously
form naturally around protocells by the properties of lipid
self-organization. That, however, is only the beginning of their
challenges. Membranes need channels for active transport to control what
goes in and out. They also need repair mechanisms if they break. If by
inconceivable chance miracles those properties also emerged along with
the lucky contents for life inside the membrane, they would never be
inherited if they were not preserved in the genetic code. But even that
is not enough. Along with code, machinery must be present to translate
the code into other machines that know what to do when a membrane
breaks. Unwatched membranes are vulnerable to leaks, and they don’t
care. Without foresight and oversight, protocells would be like bubbles
that pop in due time. Too bad for those hard-won living ingredients inside.
END QUOTE:
What does Glenn not get about what they are in denial of? They are
claiming that Membranes require a lot of things to function, and that
there is no path to develop those characteristics. It is a standard
god-of-the-gaps argument. We don't know how membranes evolved so god
did it.
QUOTE:
Membrane repair is a key emergency operation for a cell. Just like
countries with different military branches for external threats and
police agencies for internal threats, cells come well equipped to handle
breaches to their security. Saying these systems “have evolved” explains
nothing. Something had the foresight to know these systems would be
necessary for life and health. Something has the oversight to ensure
their successful operation. The irreducible complexity touched on with
this brief look at membrane repair provides additional and powerful
evidence for intelligent design.
END QUOTE:
They are claiming that membranes as we know them could not have evolved
on their own. Irreducible complexity is invoked even though there has
never been any system determined to be Behe's type of irreducibly
complex. What was the "scientific" test that both Minnich and Behe put
up to test IC? If the flagellum could evolve IC would be falsified for
flagellum being IC. They are claiming that membrane repair processes
could not evolve on their own and that lifeforms require these
processes. This is just the standard god of the gaps stupidity. They
claim that we don't know something, and then claim that their designer
fills the gap. They obviously have no idea of how this gap was filled
by their designer, and like Dean they don't want to know that. What was
the designer doing to evolve membranes over 3 billion years ago? No one
claims that the first membranes were as complex as they are today.
>>>
>>>> This should answer your question. Their paper is paywalled, but you can
>>>> read the abstract.
>>>>
>>>> QUOTE:
>>>> Organic compounds are synthesized in the interstellar medium and can be
>>>> delivered to planetary surfaces such as the early Earth, where they mix
>>>> with endogenous species. Some of these compounds are amphiphilic, having
>>>> polar and nonpolar groups on the same molecule. Amphiphilic compounds
>>>> spontaneously self-assemble into more complex structures such as
>>>> bimolecular layers, which in turn form closed membranous vesicles. The
>>>> first forms of cellular life required self-assembled membranes that were
>>>> likely to have been produced from amphiphilic compounds on the prebiotic
>>>> Earth. Laboratory simulations show that such vesicles readily
>>>> encapsulate functional macromolecules, including nucleic acids and
>>>> polymerases. The goal of future investigations will be to fabricate
>>>> artificial cells as models of the origin of life.
>>>> END QUOTE:
>>>
>>> Surely you don't believe this shows an awareness "of the thousands of machiney thingies and other very complex structures that comprise cell membranes", or why they claim that a membrane was *required*.
>> Surely, you understand that they didn't need to have any such awareness
>> because they were talking about the first such membranes, not what we
>> have after over 3 billion years of evolutionary improvement.
>
> Surely they needed to have some awareness, because they claim that the first cell required a membrane.
> Surely they didn't assume such a membrane was one that had no function, and sealed such RNA inside.
Surely they were talking about a time when those things did not exist.
Why keep denying reality?
>>
>> A membrane is required because that is what the ancestor of all extant
>> life had to have. Really, it is that simple. All extant cellular
>> lifeforms have lipid membranes. At sometime the ancestor of cellular
>> life would have had to develop one. They may have used something else
>> at first, but eventually the ancestor of cellular life on earth would
>> have settled on lipids.
>
> Your reasoning skills are very disappointing, and is irresponsive. It isn't that simple, nor is the claim that a membrane was required challenged. Neither is your claim that today all life have membranes.
> What you think may have happened is irrelevant.
Your running from reality in this way is more than disappointing and
irresponsive to what you can't deal with. Reality is just what it is.
I claim all cellular life, and this is a fact. Do you put up any
counter examples? No? Why not? It may be because there are none.
>>>>
>>>> They are obviously talking about what the first membranes were like and
>>>> not what membranes are like after over 3 billion years of evolution.
>>>> They admit that they don't even know what the first membranes were made
>>>> of ("likely" amphiphilic and lipids are only one type of amphiphilic
>>>> molecule), and speculate that amphiphilic molecules like lipids (didn't
>>>> have to be lipids) could have made up the first membranes.
>>>
>>> I agree. But to what extent do they identify what they must have been "like". You seem to want to deflect away from that. That they can simulate "such" vesicles can "encapsulate functional macromolecules" isn't saying much, and says NOTHING about why such membranes were *required*, let alone that they were even aware of the reasons.
>>> Did they discuss any of this?
>> So why did you expect them to be talking about extant membranes that
>> have evolved for over 3 billion years? They are required because the
>> ancestor had to have one because the descendent cells have one.
>
> That's silly, and contradictory. Just above you said 'They may have used something else at first".
> I didn't say I expected them to be talking about how membranes have evolved. You're deflecting, at best.
> Probably though you're just talking to yourself.
> I expect you to answer whether and why they did or didn't extrapolate on the reasons for why they claim a membrane was REQUIRED. If you want to insist that the reason they had was simply because all cells today have membranes, then you and they have a lot to account for, and "encapsulating" doesn't cut it. You KNOW there are many functions of a "membrane" that involve and REQUIRE many complex protein "machines" and structures that allows a cell to exist and reproduce. You continue to evade and ignore this.
Look at your claim that all life does not have membranes above. Virus
may be alive and might be considered lifeforms, but a lot of them rely
on protein shells and not lipid membranes. Your own counter to all
cellular life tells you that you are just wrong about this. Life
obviously could have done something different, and virus did. What
about all the papers about proteinaceous shells, and origin of life
researchers making spheres of proteins.
The fact is that membranes did not have to be initially used to keep
things inside. Just as I claim if membranes were as closed and secure
as the ID perps want them to be before we have all the systems to get
things in and out the early self replicators would be better off on the
outside of the vessicle. How are they going to get the components to
make more of themselves if early membranes are really good barriers?
>
>> There
>> may have been other self replicators that attached themselves to balls
>> of clay or silts with fine particulate mineral crystals, but the
>> ancestor of extant life must have developed a membrane at some time.
>
> Irresponsive and irrelevant.
No, just projection of what you are doing. Membranes are not needed to
keep units together. The first groups of self replicators likely didn't
use membranes. It is totally relevant to your claims about what the
researchers should have considered.
>
>> Membranes are obviously nice ways to keep any group of self replicators
>> together in order to help each other out, but you can do the same thing
>> by sticking them to some organic tar or some other mineral that doesn't
>> have to be carbon based, but was likely carbon based because the
>> molecules that were the first self replicators were likely carbon based.
>
> Put yourself in one without an oxygen tank and see how long you replicate.
Did the first lifeforms need oxygen? Denial of reality just to maintain
notions that just don't matter is what you are doing. Membranes were
not required for life to start. All extant cellular life is descended
from a lifeform that did develop lipid membranes. That is not the same
as claiming that membranes were required for abiogenesis.
>>>>
>>>> All you need to know about this IDiot denial is that they state that the
>>>> vesicles will self form. That is what is known. No one knows what the
>>>> first ones were made of.
>>>
>>> What "IDiot denial"??? And why is that all I need to know about "it"?
>>> "Self forming" a simple membrane isn't relevant, nor denied. The issue is why the first cells *required* these "vesicles", and *why*.
>
>> What were the ID perps that you got the membrane denial argument from in
>> denial of? How can you miss that the ID perps were just feeding you a
>> switch scam denial argument. They were claiming that the early membrane
>> needed a sophisticated repair system, but they obviously don't know
>> that.
>
> They don't, and you EVOidiots don't, and abiogenesis is a complete mystery that science has made no progress on.
> But to argue against the assumption that any living thing could not survive in an enclosed bubble is insane.
> Where is the "denial" in a claim that a membrane needed to be "sophisticated"?
> You're actually lying here, since "they" actually included a quote that fits the description of "sophisticated".
> Are the authors of the "paper in the EMBO Journal by Yan Zhen et al., “Sealing holes in cellular membranes,”
> IDiot perps pulling switch scams?
Why lie about abiogenesis to deny what the ID perps were doing? You
call it no progress, but what does real science have in terms of
abiogenesis, and what do IDiots have in terms of IDiocy? Abiogenesis
research has something, and IDiocy never developed any equivalent
science. Why has the bait and switch been going down for over 19 years?
Why don't you ever put up the ID science equivalent to what you claim
abiogenesis research lacks? Why is IDiocy not as good as your own level
of not good enough?
Read their argument. What do you think that they are doing when they
point out that today's membranes require sophisticated repair mechanisms?
>
>> They were claiming that no such sophiticated repair system could
>> have existed when the first membranes were forming. It was just one of
>> their standard types of denial stupidity. They don't know the answer,
>> but are just satisfied that the answer isn't known.
>
> There's another lie. They do not claim that "such a repair system could have existed when forming' in any shape or form. ID suggests that natural processes could not have made that happen.
> There is no denial there. You call it denial because you believe it. But you don't know, and you said above.
> And your opinion about what they are satisfied with is worthless, and irrelevant.
Read what they wrote. What about their claims that such sophisticated
mechanisms would have to be in place for membranes to remain intact in
the early lifeforms mean? Why ask the question of how early membranes
dealt with these issues after making claims about how sophisticated such
repair processes have to be today? This is just another case where you
did not understand what you were putting up. Why did the ID perps go to
the trouble of describing how membranes are repaired today. Why did
they take that description and apply it to the first membranes that
would have existed? Why doesn't the argument work and is worthless
denial? What is their alternative? Why don't they have one? The
ancestor of all extant cellular life likely had a lipid membrane because
all the descendant lineages have one, so what happened back then? When
all you have is denial, and you have nothing better than what you claim
isn't good enough. The denial argument fails.
>>
>> The first self replicators that might have used a lipid bilayer may not
>> have even used it as a vesicle forming membrane, but could have just
>> anchored in it so that they would stay together on the same patch of
>> lipid bilayer.
>
> You don't know that is even possible, but "used" ignores the fact that such a lipid bilayer must have had complex machines and structures to function and allow the "first self replicators" to survive.
> Here you're trying to imply that the first cells might not have needed membranes. And it's wild speculation.
No, neither do you know that they didn't. It is just a fact, that it
could have been used in that way. Demonstrate otherwise. What were the
first self replicators? When did these self replicators start using
shells or membranes? We don't know. What do you have to explain things?
>
>> It might spontaneously form a vesicle, but the early
>> self replicators were likely better off if they ended up outside the
>> vesicle so that they would have access to the parts they needed to self
>> replicate.
>
> You don't know that is even possible, let alone "likely", one of your favorite words.
> There are reasons for the claim that the first cell required a membrane. You even admit that above.
> This wild speculation of yours is your obsession talking, not science.
Before there were membranes the self replcators would have been exposed
to the open environment in some way. How would they adapt to being
walled off from what they needed to self replicate? What is your
alternative? Being on the outside of the vesicle is as good away as any
to be exposed to what you need. Not only that, but by the ID perp's own
reasoning these vesicles would be unstable so sometimes they would be
inside and sometimes they would be outside. All they would require is
to be stuck in the membrane at some attachment point between the
membrane and the self replicator.
>
>> Eventually they might have developed the means to stay
>> inside the vesicle and open it up once in a while to let the components
>> to make more of themselves into the vesicle, or the membrane could have
>> been unstable enough to let things in.
>
> If all we had to do was say "might" to get a buck, we'd all be rich. Such speculation can't be refuted, since it is baseless. Think about that when you're plucking chickens at work.
If you had anything more than "might" you could put it forward. Why is
switch scam denial and second rate god-of-the-gaps stupidity your only
option? Why doesn't this god-of-the-gaps stupidity rank among the Top
Six? Maybe they include it with #4 irreducible complexity, though it is
only their claim that it is irreducibly complex. Behe has never claimed
that about membranes.
>>>>
>>>> Glenn, they are using lipid nanoparticles to deliver the mRNA for the
>>>> Covid vaccines.
>>>
>>> What does that prove or show? Are you seriously comparing that to the first living cell?
>
>> That lipids spontaneously form around nucleic acids. Like the paper
>> claimed. Duh. It might be that the first membranes weren't formed
>> until nucleic acids started to be used for self replication. We don't
>> know what the first self replicating molecules were. The RNA world
>> would likely have been at least second generation self replicators after
>> self replicators had existed and evolved to make nucleotides.
>
> I wouldn't take your word for that for all the money in China.
> Just be aware, the covid vaccine is designed and the mRNA inside is not alive and doesn't reproduce.
Except that is what the authors claim, and not me. Sort of sad that you
don't understand that when I quoted them.
Why is this all that you can do to deny that you were wrong about why I
put up the quote? Denial to support your denial is stupid.
>
> And again, and again, and again, I don't deny anything, Ron. From all we know, the first cell must have had a membrane, for similar reasons as cells do today. And they are enormously complex, and requires very complex instructions to build and maintain them. You're in denial by trying to make it appear that some pre-first cell "replicator" worked away mutating and building all the instructions needed to build a membrane, then hopped in later, and wala, the first cell was born. That avoids the question and the issue.
Reread what you post and keep running from in denial. Membranes aren't
just used to keep things in today. They are used to keep things in
specific regions on specific sides of the membrane in order to function.
What do you not get about what membranes are used for today. Really,
what do you make of the mitochondrial membrane being 80% protein. These
proteins are part of the membrane. It isn't keeping them inside, some
are stuck more on one side of the membrane or the other. I am just
using what we already know what membranes do.
What is the IDiot alternative? If it doesn't include the evolution of
membranes, what do you think happened and what the first membranes were
doing? What is the basis for your speculation? My speculation is based
on what membranes are already known to do and are used for.
>
>>>
>>> I'm not talking about extant cells here. That would have been obvious to you. So should the fact that in the post to which you replied, the above is just below what is at the start of your long reply to:
>> Just think for a momment, and you should be able to get it if you have
>> learned anything at all.
>
> I'll not tolerate more of this crap from you. Call it running if you wish, as it seems to make you happy.
> For me to throw that back at you and say the same about you would be useless, as useless as you saying it.
So you aren't going to think for just a momment, and you'd rather wallow
in your ignorant denial forever.
>
>> When membranes first were used the first self
>> replicators already existed in a situation where they were not enclosed
>> in a membrane.
>
> Fantasy. Replication is what defines life. You're in denial of the subject at hand, the claim that the first cell required a membrane. If you object to that, you should have, and could have, said so long ago in this silly long ass series of long ass posts. But you didn't and are now only much later on trying to pull this bullcrap. Denial in all it's ugly glory.
> How often do you change your earplugs?
Does anyone claim that the first self replicators required to be
enclosed in a membrane? Projection about your using earplugs if only
due to your mental incompetense is noted. There may be some origin of
life speculations like that, but I don't know of any. What do you make
of all the research going into using clays and mineral crystals say
about your denial above that the first self replicators didn't need
membranes and adapted to their use?
>
> Just post a reference if you want me to "learn" that. Othewise, zip it.
Post your reference.
Here is mine.
https://en.wikipedia.org/wiki/Abiogenesis
What is the order of evolution of life from non life?
QUOTE:
While the details of this process are still unknown, the prevailing
scientific hypothesis is that the transition from non-living to living
entities was not a single event, but an evolutionary process of
increasing complexity that involved molecular self-replication,
self-assembly, autocatalysis, and the emergence of cell
membranes.[9][10][11]
END QUOTE:
Did you learn anything or are you going to remain willfully ignorant
forever?
>
>> They wold have had to adapt to it. As I said before, at
>> first they would likely be better off stuck on the outside of the
>> vesicle partially embedded in the lipids so that they could conduct the
>> lifestyle that they were used to. You just answered your own denial
>> about intact membranes and sophisticated repair. The first membranes
>> were likely unstable and opened and closed routinely, otherwise the self
>> replicators would not have been able to continue to replicate as they
>> had before they got involved with lipid membranes.
>
> More fantasy, irrelevant, irresponsive and contradictory.
Just more for you to deny in your own fashion. Why is denial your only
out. Got an alternative as good? Why is your alternative worse than
what you call "fantasy"? My speculation is based on what we know
membranes can do. What is your alternative based on?
>>>
>>> "Would these scientists have been aware of the thousands of machiney thingies and other very complex structures that comprise cell membranes?"
>> They obviously didn't have to be aware of any such thing, because they
>> were not needed when the first membranes formed. Why would the
>> researchers need to think that they were needed when they didn't exist
>> at that time.
>
> So you expect me to "learn" by accepting those claims??? You truly are mentally ill.
> So membranes didn't exist, and life floated around getting everything together so that it could make a membrane and jump in it. And you attribute that to the authors of the papers I posted? And you think I'm the idiot pulling switch scams?? Good lord almighty.
Just because you are mentally ill doesn't meant that you can't learn
anything. It is just more difficult for you to do. Try to understand
what the ID perp's argument was. They were in denial of membrane
evolution. What did they do to support that denial?
>>>
>>> So again, why did you ignore the above?
>> So again, have you learned anything, or are you going to resort to
>> willful ignorance and run from reality?
>
> I don't run from anything, never have, nuthead. But yes, I learned a litle about how you can spin a tale.
> Pity you have learned nothing. You could if you could face yourself.
What are you doing in all the snip and run posts that you keep putting
up? Why haven't you addressed the Top Six in the last 3 years?
Lying about what you do is just lame.
>>>>>
>>>>> I'll just blow a soap bubble and see if I can recreate one in the lab, but I can't quite yet envision the chick in the egg clucking. Damn, where'd I put that lab coat? Honey! Get me a beer, will you?
>>>>>
>>> I have told you that you are unresponsive to what you reply to. It appears even this sarcasm didn't push you to actually respond to what is actually said.
>>>
>> You are lucky that I didn't bother to respond to everything because it
>> is obviously something that needed no response. Just think of how
>> stupid you made yourself out to be.
>>
> As I already knew, responding to you is a waste of time. And you end with insult.
> So anyway, I made the attempt. It likely won't ever happen again.
As you already knew, you should have just snipped and ran, and likely
lied about it like you usually do.
>
> Continue with your ranting, Ron. Just remember if you can (though I doubt you can) that I won't bother trying to reason with you in the future, and don't be surprised that at the first sign of insult or silliness on your part you'll get snipped without reading the rest, and you can go merrily upward and onward with your silly accusations and reposting of reposts of reposts, with maybe the occasional addition of a url to another of your reposted repost posts.
>
>
Now you should have some idea of why you snip and run. What did you
learn about this god-of-the-gaps argument? Do you think that it is part
of the Top Six because they called it IC? You likely wouldn't have put
it up if you knew that this was supposed to be an IC IDiot bunch of
nonsense. It is just one more bit of IDiot evidence to run from. What
did the designer do over 3 billion years ago when he put a membrane
around the first self replicators? What was the plan and why did it
take him so long to evolve the eukaryotic membrane repair processes
talked about in this denial article? When did the designer evolve
eukaryotes? When did the designer make the cytoskeleton of eukaryotes
necessary? One of the membrane repair mechanisms is needed due to the
tension place on the membrane by the cytoskeleton, but cellular
lifeforms didn't always have one. It evolved to its present form when
some eukaryotes gave up their cell walls, but needed some structure, and
they wanted to maintain the ability to engulf things that they wanted
inside (phagocytosis).
Ron Okimoto