On Friday, January 4, 2019 at 1:57:46 PM UTC-6,
helper wrote:
> Suggests insulin resistance.
>
> ...
Nonsense. < 24 units per day of insulin for
an individual (me) who has ZERO endogenous
insulin production (per a C-Peptide test)
indicates absolutely ZERO insulin resistance.
Further details provided in two parts:
- - - - - - - - - - - -
Part One - 'Normal' daily insulin for Islit
A commonly quoted normal daily insulin amount
for those with Islit: "Patients with type 1
diabetes typically require an insulin dosage
of 0.5 to 1.0 unit per kg per day".
For me, at my current weight (BMI = 27.6),
they say my dosage should be 39 to 78 units
per day. My dosage is < 24 units per day.
I've never dosed more than 50 units per day.
Islit individuals experimenting with very
low carb dieting will dose much lower daily
amounts as long as their very low carb diet
efforts continue, and that's typically not
a long-term project by the overwhelming
majority of Islit individuals.
End Part One
- - - - - - - - - - - -
- - - - - - - - - - - -
Part Two - Normal Endogenous Insulin
Production in non-Islit individuals
Study the following:
~ ~ ~
Preface
Clarifying superior new terms for BMI:
BMI < 18.5 = slimmest
BMI 18.5 to 24. 9 = slim
BMI 25 to 29.9 = ideal
BMI 30 to 34.9 = heavy
BMI 35 to 39.9 = heavier
BMI 40 and above = heaviest
Longest life = ideal, BMI ~27.
[used in clarifying inserts in brackets,
and used in other clarifying inserts not
having to do with BMI, not part of orig-
inal article in the following]:
End Preface
~ ~ ~
- - -
How much insulin is produced daily by
the pancreas in a healthy human being?
https://www.quora.com/How-much-insulin-is-produced-daily-by-the-pancreas-in-a-healthy-human-being
- - -
A lean [slimmest? the lean term may be referring
to BMI < 18.5, but since that term wasn't defined,
one can only guess what BMI level that is referring
to] healthy individual might secrete about 35 units
of insulin per day, yet will have about 10 times
this amount stored within his [her] pancreas.
By contrast, a [heavy] insulin-resistant person
might need to produce [in non-Islit individuals,
many of which have Cellosis or PreCellosis] >100
units daily to maintain normal blood glucose lev-
els.
Here is a graph that shows the insulin secretion
over the 24 hours in a healthy individual:
https://qph.fs.quoracdn.net/main-qimg-8b96d68064fbe9fda75026594a89fa18
Insulin is a hormone that regulates the [glucose]
levels in the blood [released endogenously in those
who don't use exogenous insulin; everyone with Islit
& a minority with non-Islit High Glucose Conditions
(HGCs) use exogenous insulin].
The major role of insulin is to stimulate cells of
the body to absorb glucose inside the cell, thus
reducing blood glucose levels [and in those who
don't have Islit, regulatory counter hormones are
endogenously released to prevent hypoglycemia, ...
... though those with non-Islit HGCs, if using
hypoglycemia-causing meds, are also vulnerable
to hypoglycemia, said vulnerability amplified
by exercise].
Insulin is produced by β–cells of pancreas [Islit
individuals have near-totally to totally lost all
endogenous insulin production]. It is a hormone
which is released into portal vein.
Pancreas of a healthy human being contain 200
units of insulin. The average daily secretion of
insulin ranges from 30 to 50 units [obviously not
in those who have no endogenous insulin or in
those who secrete more due to having insulin
resistance, as indicated above].
There are several factors that affect the amount
of insulin released by the body:
Factors responsible for increased insulin secre-
tion [in non-Islit individuals] are:
o Intake of food rich in sugar (carbohydrates) ...
o Intake of food rich in fats like cheese, butter,
deep fried food
o [Heavy] individuals, who are mildly [or
significantly] insulin resistant
o Taking up a large meal
o Taking up a high calorie meal.
Factors responsible for decreased insulin secretion
[in non-Islit individuals] are:
o Fasting for a longer duration
o Period of stress
o Reduced blood glucose level
Dr. Varun Gupta
- - - end excerpts - - -
End Part Two
- - - - - - - - - - - -
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
Pro-Humanist FREELOVER, I got Insulinitis
(Islit) at age 5 in March, 1961 -- I used
a Dexcom G4 Continuous Glucose Monitor
(since October, 2013) -and- was using an
Omnipod Insulin Pump (since January, 2014).
However, due to losing my job & health
insurance on April 11, I've switched back
to using insulin injections on May 29
(regular insulin and NPH insulin, up ...
... to 10 injections daily, 2 with NPH,
the rest with regular) and to using the
relatively inexpensive Freestyle Libre
CGM (over $4,000 less per year than the
Dexcom G6 CGM).
C.ure I.nsulinitis A.ssociation
https://prohuman.net/glucoseanomaliesresearch.htm
- - -
The old confusing way which all-too-often
involves folks using the diabetes / diabetic
words without a clarifier:
Logic and reasoning behind ceasing using
diabetes & diabetic & reactive hypoglycemia
words and phrases, replacing all that with
vastly superior names, ending diabetes &
diabetic & reactive hypoglycemia confusion,
misleading, & misunderstanding:
Diabetes Bubble / Diabetes Bubble Burst
https://prohuman.net/diabetesbubblediabetesbubbleburst.htm
High Glucose Conditions, HGCs, unprevent-
ability / nonreversibility of all-but-one
of the specific types of High Glucose
Conditions (thus far, research is ongoing
to change that):
o 11 specific types of rapid-onset Insulin-
itis, unpreventable & nonreversible (thus
far), predominate type, Insulitis Insul-
initis (sometimes called type 1 diabetes,
often confusingly called diabetes with
no clarifier).
o 1 specific type of slow-onset Insulinitis,
Latent Autoimmune Insulinitis, also un-
preventable & nonreversible (thus far)
(sometimes called latent autoimmune dia-
betes in adults, often confusingly called
diabetes with no clarifier).
o 20 specific types of Cellosis, unpreven-
table & nonreversible (thus far) (all
types sometimes called type 2 diabetes,
often confusingly called diabetes with
no clarifier);
only 1 specific type of ANY HGC is pre-
ventable (in many, with lifestyle alter-
ations) & reversible (possible if action
is taken up to 10 years after diagnosis),
Preventable Cellosis.
Due to the long period of time in which
Cellosis typically takes to develop, the
prestage in which intervention has a
chance to reduce the risk of getting
Cellosis is called PreCellosis (the old
confusing name is prediabetes).
o 1 specific type of High Glucose Condi-
tion only occurring in the late stage
of impregnation in women, a type that's
transient but that increases risk of ...
... later getting Cellosis, that condi-
tion called Gestational Cellosis (some-
times called gestational diabetes, some-
times confusingly called diabetes with
no clarifier).
o 11 specific types of Diminosis (new name
created in 2010 for a condition that is
sometimes called maturity onset diabetes
of the young, often confusingly called
diabetes with no clarifier), unpreven-
table & nonreversible (thus far).
o 12 specific types of Neonatal Diminosis
(new name created in 2010 for a condition]
that is sometimed called neonatal diabetes,
often confusingly called diabetes with no
clarifier), 8 types are permanent, but ...
... 4 types are transient, unpreventable
& nonreversible in the permanent specific
types (thus far).
o 24 specific types of Ohiglucons (new
name created in 2010 for other diabetes
mellitus, but often confusingly called
diabetes with no clarifier), unpreven-
table & nonreversible (thus far).
A mostly Non-Glucose Anomaly, Insipidus,
it's also unpreventable & nonreversible
(thus far):
o 6 specific types of Insipidus (new name
created in 2010 for diabetes insipidus,
sometimes confusingly called diabetes
with no clarifier), 4 specific types
don't include high glucose & are unpre-
ventable & nonreversible (thus far), ...
... 2 specific rare types do include
high glucose & are unpreventable &
nonreversible (thus far).
A Low Glucose Condition, Hut:
o The 21 specific types of Hut (new name
created in 2010 for Hypoglycemia Un-
caused by Treatments for High Glucose,
often confusingly called reactive hypo-
glycemia, confusing in that it does
not occur as a reaction to treatment ...
... for High Glucose; one form is
sometimes called hyperinsulinism),
some specific types are preventable
& reversible, some aren't (thus far).
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~