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Anti-ROS -->Hydrogen From your Gut Flora --Durk/Sandy Pearson --> LCFOS --> Don't SMELL or BE Dum Dum chewing Gum Gum - Ben Franklin on Fartology -->Chessypoofs
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randall
May 31, 2012, 4:29:18 PM5/31/12
to
hi
This Durk/Sandy Hydrogen is sorta part III to the last two:
And in the last one.. old people smell vaccenic acid i promised A ben
Franklin FART thing..
It's in this ONE thanks to Durk.. but this is better as BB told us Ben
F was a vegetarian and
with good gut flora we know we BF was so FREAKing GREAT..
Those FARTs of his must of been or BEN sweet!
Thurs, May 31 2012 12:37 pm
Subject: Albert Ellis and Skin ++ More Insights -- More on--->>> More
or LESS Exercise <<<<-- Sexxxercise in the Balance --
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/bf5c164bf39e99df
Thurs, May 31 2012 1:04 pm
Subject: OLD People SMELL (?)-- Vaccenic Acid ? -- Microbes -->
Hydrogen (Durk Pearson) --BB Was Right! or (?) --Anthony Robbins --
Gravity & TIME -- E= Mc2 Smelly Fishy Or Timely? Time will TELL
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/d943bfdd0a1ed951
----------------------------------i need some music..
WAR what is it good for?
"War" by Edwin Starr (Original Video - 1969)
http://www.youtube.com/watch?v=01-2pNCZiNk
<time: 3:26>
Originally written under the Motown label, and first perform by The
Temptations, "War" was later re-released as a single with Edwin Starr
as vocals. This version is considered a more emotional version and has
become the most popular pro-test song ever.
<snip>
I didn't know that... love motown as it's bERRY GOOD ... Diana Ross is
light years ahead of bouncy.
It's beyonce me!
Then again my DAD would have said, Billie Holiday or many GREATs from
that era.
Hey! this tube thing screws up a few times... the youtube..that is..
Not ME!
http://en.wikipedia.org/wiki/Edwin_Starr
Wow
Edwin is better looking then our preezy... smaller ears, longer hair..
Alas we lost EDWIN in 2003 at the age of 61 to a heart attack... what
is that good for?
Nothing!
http://en.wikipedia.org/wiki/Myocardial_infarction
He needed:
http://en.wikipedia.org/wiki/Hyperhomocysteinemia
[...] Hyperhomocysteinemia or hyperhomocysteinaemia is a medical
condition characterized by an abnormally large level of homocysteine
in the blood.
As a consequence of the biochemical reactions in which homocysteine is
involved, deficiencies of the vitamins pyridoxine (B6), folic acid
(B9), or B12 can lead to high homocysteine levels.[1] Supplementation
with pyridoxine, folic acid, B12, or trimethylglycine (betaine)
reduces the concentration of homocysteine in the bloodstream.[2]
Hyperhomocysteinemia is a disease which increases risk of other artery
or vein diseases.
<snip>
How does one get around the GRIMM reaPer?
It's an EAR crease and calcium and smoking and eating crappy diet and
GENETIC's et al?
http://en.wikipedia.org/wiki/Myocardial_infarction#Risk_factors
But droPPing DEAD is better then being a vegetable for twenty years
and a burden on your loved juans.
I know, i know... only eat veggies and fruits and then you don't drop
DEAD, said BB? LOL
BB is for vegetarian and being like Albert Ellis sorta i'm guessing.
OTOH war keeps us FREE:
http://www.youtube.com/watch?v=bX7V6FAoTLc
And killing bin laden with a double tap and sleeping with the fishes
might
get this preezy enough votes for a second term? LOL
That anD wagging WAR on his opponent... chicago politics via rahm the
lamb emmanuel like?
War.. what is it good for?
Keeping mooooooooooooooooooooochele in the wIDE body to fly the
friendly sky's? LOL
OK
This next thing is Durk And SANDY (Shaw) Pearson selling something
called LCFOS to feed YOUR Gut bugs so they make HYDROGEN and
it knocks out the ROS in your Body.
Good idea?
A super charged anti-ROS deal inside of your very own gut flora...to
BOOT... LoL
So is it a GOOD idea?
YES, as " LCFOS fructans preferentially supported the growth of
bifidobacteria"
And even if in a RAT it's still a good THING, as most of these gene's
are conserved or
perverted by your current DIET.. LOL
So buck it up or boot it up... and go back to EDEN and tend to your
own garden
of enterotypicow bacteria.
Bifodo microbiota ARE good as they live in mOM's vagina and THEN when
you pass the birth canal they enter your Gi tract.
http://en.wikipedia.org/wiki/Bifidobacteria
Got it yet BB?
Will eating fruits like BB is now posting, do the same thing?
What is this LCFOS?
They are: Long-chain fructooligosaccharides
NO wiki page for it, but long chain these:
http://en.wikipedia.org/wiki/Fructooligosaccharide
[...] Food sources
FOS is extracted from fruits and vegetables such as bananas, onions,
chicory root, garlic, asparagus, barley, wheat, jícama, and leeks.
Some grains and cereals, such as wheat, also contain FOS.[3] The
Jerusalem artichoke and its relative yacón have been found to have the
highest concentrations of FOS of cultured plants
http://en.wikipedia.org/wiki/Jerusalem_artichoke
[...] aka --> sunchoke or sunroot--> edible tuber
[...] Jerusalem artichokes have 650 mg potassium per 1 cup (150g)
serving. They are also high in iron, and contain 10-12% of the US RDA
of fiber, niacin, thiamine, phosphorus and copper.[8]
Jerusalem artichokes can be used as animal feed, and, while they must
be washed before being fed to most animals, pigs forage and safely eat
them directly from the ground. The stalks and leaves can be harvested
and used for silage, though cutting the tops greatly reduces the
harvest of the roots.
<snip>
http://www.life-enhancement.com/article_template.asp?ID=2642
Hydrogen Therapy
The Emergence of A New Field of Medicine and How You Can Benefit From
It Right Now (with a little help from your friends ... READ ON)
By Durk Pearson & Sandy Shaw
Hydrogen therapy for the prevention and treatment of a variety of
diseases—particularly those associated with ROS (reactive oxygen
species) and inflammation—has become a hot research subject. Many
reports in peer-reviewed scientific and medical journals, including in
vitro and animal studies, plus some clinical trials in humans, have
already been published. Diseases that may be beneficially affected by
hydrogen therapy include, to name a few, atherosclerosis, ischemia-
reperfusion injury (as occurs in heart attacks and strokes), diabetes,
stress-induced cognitive impairments, Parkinson’s disease (as shown in
animal models), and various aspects of the metabolic syndrome (e.g.,
insulin sensitivity, glucose tolerance, and endothelial function)
As reported in an excellent review1 on the “recent progress toward
hydrogen medicine,” the author describes various methods being used in
published animal and human studies to administer hydrogen: inhalation
of hydrogen gas, oral ingestion by drinking hydrogen water, hydrogen
baths (because hydrogen easily penetrates the skin and distributes
throughout the body via blood flow),1 injection of hydrogen saline,
direct absorption of hydrogen (as in hydrogen containing eye drops),
and INCREASED PRODUCTION OF HYDROGEN BY GUT BACTERIA. Note: One reason
for the use of hydrogen water and hydrogen saline is that it is
possible to reliably control the dose administered to experimental
animals, which is important in determining results such as dose-
response relationships. In the case of gut bacteria-provided hydrogen,
it is less easy to determine the hydrogen “dose,” although one way to
at least partially overcome this problem is to measure the hydrogen
gas excreted by the lungs.
Hydrogen Is a Selective Antioxidant, Scavenging Dangerous Radicals But
Not Radicals Important as Physiological Signaling Molecules
Hydrogen and carbon dioxide, as well as (in some people) methane, are
gases released by colonic bacteria in the fermentation by the bacteria
of carbohydrates that reach the lower digestive tract. Hydrogen has
been known to have antioxidant properties for a long time, but its
recognition as having some advantages over conventional antioxidants
and its potential use as a therapeutic agent have only recently been
explored.2,2c
One of the most interesting findings concerning hydrogen as an
antioxidant is the discovery that it is a novel antioxidant because it
scavenges the toxic hydroxyl radical (the strongest of the oxidant
species)2c and the potent oxidant peroxynitrite (formed by the
reaction of superoxide and nitric oxide), but is far less effective in
scavenging physiological radicals such as superoxide and nitric oxide,
important (at low concentrations) as signaling molecules.2 Moreover,
hydrogen is able to diffuse extremely rapidly into tissue and
“effectively reaches the nucleus and mitochondria,”1 suggesting
“preventive effects on lifestyle-related diseases, cancer, and the
aging process.”1 Hydrogen also passes through the blood-brain barrier,
although most antioxidant compounds cannot do this.1
Safety of Hydrogen
Hydrogen (H2) is reported to have no cytotoxicity even at high
concentrations.1 “The safety of H2 for humans is demonstrated by its
application in Hydreliox, an exotic, breathing gas mixture of 49% H2,
50% helium and 1% O2, which is used to prevent decompression sickness
and nitrogen narcosis during very deep technical diving.”1
From time immemorial human beings have absorbed quantities of lactic
microbes by consuming in the uncooked condition substances such as
soured milk, kephir, sauerkraut, or salted cucumbers which have
undergone lactic fermentation. By these means they have unknowingly
lessened the evil consequences of intestinal putrefaction.
— Elie Metchnikoff, The Prolongation of Life
(the English translation, Putnam, 1908), pg. 171
Every unhealthy change in the quality of beer coincides with a
development of microscopic germs which are alien to the pure ferment
of beer.
— L. Pasteur, Studies on Fermentation: The Diseases of Beer
MacMillan & Co. 1879 (English translation) (pg. 19)
Hydrogen Is a Free Gift From Your Gut Bacteria ... No Prescription
Required
LCFOS Is a Food (Prebiotic) for Gut Bacteria That Produce Hydrogen
There are many papers on the effects of various types of non-
digestible carbohydrates (foods, called prebiotics, for gut bacteria)
that reach the lower digestive tract and are there converted to
(mostly) hydrogen by gut bacteria in the process of their extracting
energy from them. NOTE: There is considerable variation in the
individual response to prebiotics. For example, the microbiota of
people with “high” BMI (overweight or obese) have been found to
generate less hydrogen because they are able to digest carbohydrates
more efficiently than those with a lean BMI, leaving less to reach the
colonic bacteria. Long-chain fructooligosaccharides (LCFOS),
however, cannot be digested by humans, even obese ones.
LCFOS as a Food for Hydrogen-Producing Gut Bacteria
A recent paper2b studied the release of hydrogen gas and short chain
fatty acids by various fermentable dietary fibers by fecal bacteria.
The authors proposed, and we agree with their suggestion, that “a
slow, extended fermentation profile would be desirable to provide low
initial gas and short chain fatty acid over a longer period of
time.”2b If gas were released at a high volume very rapidly, it might
cause abdominal bloating and discomfort and flatus frequency. The
authors also suggest that “... the availability of SCFA [short chain
fatty acids produced by the gut bacteria] throughout the entire length
of colon is sought after because 50% to 60% of large intestinal cancer
occurs in the distal colon and the evidence indicates that, in
majority of the cases, chronic inflammation of this site promotes the
development of this type of cancer. Butyrate [a short chain fatty
acid] is particularly important in this context as it has anti-
inflammatory action apart from being the main energy source for
colonocytes.”2b LCFOS was reported to have (and the graph showed) slow
and moderate but incomplete fermentation. We thought that the overall
increase in gas production by gut bacteria fermentation of LCFOS and
its timing looked particularly good for the supplement we were
developing for our own use.
In the paper,2b the authors also explain that “[t]he distal colon is
typically the site of protein fermentation, which leads to the
production of such compounds as ammonia, phenol, p-cresol, and indoles
resulting in a risk of mucosal insult. Enhancement of carbohydrate
substrate availability to the distal colon microbiota may accordingly
improve gut health by production of beneficial SCFA [short-chain fatty
acids] and promotion of saccharolytic bacteria.”2bb In another paper,
2c the authors found that higher degree of polymerization of LCFOS
fructans preferentially supported the growth of bifidobacteria in
rats; the bifidobacteria group includes many gut bacteria found to be
beneficial in humans, though this particular group does not produce
hydrogen.
Another paper2d compares the effects of short chain versus long chain
LCFOS. LCFOS and fructooligosaccharides are fructans (fructose
oligosaccharides), which are fructose polymers used by plants to store
carbohydrates. As noted in the paper2d “[i]ngestion of fructans is
limited by various abdominal symptoms such as osmotic diarrhea, pain,
bloating, and flatulence due to colonic fermentation and production of
bacterial end-products,” including hydrogen gas. These side effects
occur more frequently with the shorter-chain inulin fructans and with
higher doses.2d “A dose of 5 g/d seems to be well tolerated,”2d
whereas higher amounts may induce one or more of the aforementioned
annoying side effects, primarily flatulence. A further way to limit
the likelihood of having uncomfortable bloating from gas is to take a
small quantity of simethicone to break up gas bubbles. See more on
that below.
The longer chain fructans also had a longer transit time as compared
to the shorter chain ones,2d which is likely to be advantageous in
terms of reaching the lower digestive tract for fermentation by gut
microbes.
Inulin Reduces Stink of Flatus Gas
One nice aspect of inulin is that, while it increases the gas output
of your digestive tract, it reduces the “smelly” aspects of that gas.
In one study of growing pigs,2 a 5% inulin extract (derived from
chicory) was given as a dietary supplement and was found to
significantly decrease the fecal excretion of skatole (the foul stench
in farts that results from the microbial degradation of tryptophan) as
compared to pigs fed the corn and soybean meal diet alone with no
inulin supplementation. (Skatole, mg/kg, in the control group was
18.93 as compared to 9.07 in the inulin-supplemented animals). This
study, published in the Journal of Animal Science, was funded, we
suspect, by hog farmers hoping to destink their operations and reduce
complaints by neighbors. Though we don’t suppose you get complaints
from neighbors about your stinky farts, you’ll have one less thing to
worry about if you take a dietary supplement that increases gas
production by gut bacteria without the stench.
Benjamin Franklin on the Invention of Non-offensive Farts
Benjamin Franklin had plenty to say about farts, as in his published
article, “To the Royal Academy of Farting” (c. 1781). There he
proposed that the invention of ways to promote pleasant smelling wind
would be of great benefit to mankind. He perceived serious social
risks of “permitting this Air to escape and mix with the Atmosphere,
[as it] is usually offensive to the Company, from the fetid Smell that
accompanies it.” In fact, he noted, “all well-bred People therefore,
to avoid giving such Offence, forcibly restrain the Efforts of Nature
to discharge that Wind.” In fact, he warns ominously, this unnatural
retention of gas as “[t]hat retain’d contrary to Nature, such as
habitual Cholics, Ruptures, Tympanies, &c. often destructive of the
Constitution, & sometimes of Life itself. Were it not for the odiously
offensive Smell accompanying such Escapes, polite People would
probably be under no more Restraint in discharging such Wind in
Company, than they are in spitting, or in blowing their Noses.”
Thus, Franklin proposed that there should be a prize made available
“[t]o discover some Drug wholesome & not disagreeable, to be mix’d
with our common Food, or Sauces, that shall render the natural
Discharges of Wind from our Bodies, not only inoffensive, but
agreeable as Perfumes.” “For the Encouragement of this Enquiry, (from
the immortal Honour to be reasonably expected by the Inventor) let it
be considered of how small Importance to Mankind, or to how small a
Part of Mankind have been useful those Discoveries in Science that
have heretofore made Philosophers famous ... What Comfort can the
Vortices of Descartes give to a Man who has Whirlwinds in his Bowels!”
“And surely such a Liberty of Expressing one’s Scent-iments, and
pleasing one another, is of infinitely more importance to human
Happiness than that Liberty of the Press, or of abusing one another,
which the English are so ready to fight & die for.”To read the entire
essay by Franklin, if you must, see URL: http://www.TeachingAmericanHistory.org/library/
index.asp?documentprint=470
Using a GRAS Food Ingredient to Break Up Gas Bubbles to Reduce the
Chances of Discomfort
We considered the use of a very wide variety of carbohydrates that are
able to pass incompletely digested or undigested into the lower
intestinal tract as fuel for fermentation by hydrogen producing
colonic microbiota. Many carbohydrates that pass into the lower
digestive tract would not be suitable for such use; for example, some
dietary carbohydrates such as cellulose, and methyl cellulose are not
digested in the upper digestive tract, but also pass through the lower
digestive tract essentially unmetabolized. Human colonic microbiota
cannot ferment them. Other carbohydrates such as lactulose or short
and even medium-chain fructooligosaccharides are so rapidly fermented
to release gases (mostly hydrogen, but some people’s microbiota also
produce methane) that they can result in pain, bloating, and even
explosive expulsion of foamy diarrhea, an embarrassing incident that
may require a rush to the toilet and a change of pants, known
colloquially as a “plotch.” (Sometimes science is not pretty.)
Durk found out many things by experimenting on his favorite guinea pig—
himself—with many different types of carbohydrates in the development
of a tolerable food for hydrogen producing resident colonic microbes.
Some of these experiments were remarkably unpleasant, messy, and even
painful. The final result was to identify a specific LCFOS as the type
of carbohydrate that would reach the lower digestive tract, there to
be fermented by intestinal microbes to produce hydrogen gas at the
right places at the right rate.
There was still sometimes a problem, depending on other foods
consumed, with the hydrogen being trapped as bubbles in the feces,
which prevented venting the excess hydrogen without risk of a plotch.
The addition of a GRAS (Generally Recognized As Safe) food grade
physiologically inert silicone defoaming agent caused the bubbles to
break and vent without unpleasant incident. With this addition, we can
consume a carefully selected LCFOS at doses discovered by experiment
to increase gas production without discomfort or (needless to say)
plotches.
As we mentioned above, the amount of gas released differs among
individuals in response to the ingestion of nondigestible
carbohydrates (prebiotics) that are the fuel gut microbiota convert to
hydrogen and short chain fatty acids. Though we have chosen a specific
prebiotic (LCFOS) for our own use to help avoid that problem, there is
still a possibility that some people may release enough gas to cause
bloating and discomfort. To help prevent this, we suggest the use of
simethicone, an FDA approved GRAS, Generally Recognized as Safe,
dietary ingredient used daily by many millions of people to relieve
the discomfort of gas. It is synthetic but quite safe and really
works.
Dietary Ingestion of Inulin May Increase Satiety in Response to Food
Intake
A paper3b examined the effects of either inulin or oligofructose on
gastrointestinal peptides that have been shown to play a role in food
intake or satiety. The authors had previously found that the addition
of inulin-type fructans at the dose of 10% (w/w) in the diet for
several weeks decreased triglyceride (fat) accumulation in the liver
and epididymal mass, both in normal and obese Zucker fa/fa rats. “Most
of the effects of inulin-type fructans on lipid metabolism correlated
with a decrease in food-derived energy intake, mainly due to a lower
calorific value of the fructans-containing diet.” The authors wanted
to find out what mechanisms were responsible for the satiating effect
of inulin-type fructans.
Gastrointestinal peptides that have been identified as being important
modulators of appetite through peripheral (vagus nerve) effects and/or
by acting directly on the arcuate nucleus of the brain include GLP-1
(glucagon-like peptide-1), oxyntomodulin and PYY. Hence, the authors
looked at the effects of inulin-type fructans of different degrees of
polymerization on GLP-1 and PYY in male Wistar rats—oligofructose,
oligofructose-enriched inulin, and LCFOS. Portal concentration of both
peptides was almost doubled after oligofructose treatment. Moreover,
they cite a human study in which human volunteers taking about 20 g
oligofructose/d for 7 d increased serum GLP-1 (see 3c).
Selected Studies on the Use of Hydrogen in the Prevention or Treatment
of Disease
There are many reports of hydrogen therapy in the literature, with
more being published at a rapid pace. We mention here a few examples.
Water Containing Dissolved Hydrogen Prevented the Decline in the
Proliferation of Progenitor Neural Cells and Impairment of Cognitive
Function in Stressed Mice
“Here we show that when chronic physical stress was applied to mice,
continuous consumption of hydrogen water reduced oxidative stress in
the brain, and prevented the decline in the proliferation of
progenitor neural cells and the impairment of cognitive function.”4 In
this study, hydrogen water (3.5 ml at 0.8 μM) was placed into the
stomach of each rat by a catheter. Thus, the hydrogen water may have
prevented the impairment of neurogenesis that is reported to occur in
stressed animals.
Inhalation of Hydrogen Gas Reduces Infarct Size in the Rat Model of
Reperfusion Injury in Heart Attacks
While the reintroduction of blood flow during a heart attack by, for
example, drugs that break up blood clots, can improve the survival of
experimental animals or humans, it also leads to heart damage as a
result of reperfusion. The reperfusion damage has been attributed
largely to hydroxyl radicals.5 It has been noted that “[s]tudies in
animal models of acute myocardial infarction show that reperfusion
injury accounts for up to 50% of the final size of a myocardial
infarct.”5 In one study,5 hydrogen gas administered to isolated,
perfused rat hearts, enhanced the recovery of left ventricular
function following anoxia-reoxygenation. In another part of the study,
rats were subjected to coronary artery occlusion for 30 minutes
followed by reperfusion for 24 hours. Hydrogen gas was administered at
the onset of ischemia (reduced blood flow) and continued for 60
minutes after reperfusion.
Even though blood flow was impaired in the ischemia myocardium,
hydrogen gas levels were increased by the administration of the gas.
“The peak level of hydrogen in the ischemic myocardium was reached at
approximately two-thirds of the value observed in the non-ischemic
myocardium.”5 “In the absence of H2 gas inhalation, infarct size
following ischemia-reperfusion was 41.6 ± 2.5% of the area at risk; by
comparison, inhalation of 0.5–2% H2 gas significantly reduced infarct
size, with 2% H2 gas providing the most prominent effects (21.2 ± 1.6%
area at risk).”5
In another study,6 hydrogen-rich saline protected rat myocardium
against ischemia/reperfusion injury. In this study, the hydrogen was
administered as an intraperitoneal injection before reperfusion in
animals that underwent 30 min. occlusion of the left anterior
descending coronary artery followed by 24-hour reperfusion.
Cultured Chondrocytes From Hog Cartilage or From Rat Meniscus
Fibrecartilage Protected From Oxidative Stress and Peroxynitrite
Derived From Nitric Oxide
We Hypothesize That Hydrogen May Reduce Pain, Too
Interestingly, peroxynitrite, a potent oxidant derived from the
chemical reaction of superoxide radicals with nitric oxide, has been
linked to PAIN; hence, reducing peroxynitrite may be an effective way
to decrease pain associated with oxidative stress/inflammation-induced
arthritis.6a,6b In fact, another paper6c discussed different types of
pain and the role played by superoxide and peroxynitrite but proposes
targeting peroxynitrite over that of superoxide because of the
physiological signaling of superoxide. “It may be PN [peroxynitrite]
is a more attractive target, in that unlike SO [superoxide] it has no
currently known beneficial role.”6c Since hydrogen preferentially
scavenges hydroxyl radicals and peroxynitrite over that of superoxide
and hydrogen peroxide, it may be beneficial in pain relief, though we
have not yet seen a published paper where this hypothesis is tested
experimentally. A review paper6d on reactive oxygen and nitrogen
species in pain agrees with other researchers “targeting PN
[peroxynitrite] may be a better therapeutic strategy [for treating
pain] than targeting SO [superoxide]. This is because, unlike PN,
which has no currently known beneficial role, SO may play a
significant role in learning and memory.”
Researchers7 treated cultured chondrocytes with SNAP (S-nitroso-N-
acetylpenicillamine), a donor of nitric oxide, in the presence or
absence of H2. “It is known that the matrix proteins of cartilage
(including aggrecan and type II collagen) and matrix
metalloproteinases (such as MMP3 and MMP13) are down- and up-regulated
by ONOO- [peroxynitrite], respectively. H2 restoratively increased the
gene expressions of aggrecan and type II collagen in the presence of
H2. Conversely, the gene expressions of MMP3 and MMP13 were
restoratively downregulated with H2. Thus, H2 acted to restore
transcriptional alterations induced by ONOO.”7 The researchers
concluded that “... novel pharmacological strategies aimed at
selective removal of ONOO- may represent a powerful method for
preventive and therapeutic use of H2 for joint diseases.”7
Consumption of Hydrogen Water Prevents Atherosclerosis in
Apolipoprotein E Knockout Mice
Mice and rats are typically resistant to developing atherosclerosis.
Hence, a common model for rodent atherosclerosis is to study animals
knocked out for the Apo E gene, which makes them susceptible to
atherosclerosis by reducing their ability to remove cholesterol from
cells. In a study of Apo E knockout mice,7b treatment with hydrogen
dissolved in water prevented the rapid atherosclerosis that usually
occurs in these genetically disabled animals. Atherosclerotic lesions
were found in the aortae of 6-month old Apo E knockout mice, whereas
in Apo E knockout mice that had drunk hydrogen water, the volume of
atherosclerotic lesion was significantly reduced.
The authors say that “[w]hen the preventive effect of atherosclerotic
lesions in this study is compared with the previous data that Apo E-/-
[Apo E knockout] mice was used, the efficacy of hydrogen water seems
to be greater than folic acid, vitamin E, iron, and alpha-lipoacid [we
assume they meant alpha lipoic acid]. “7b (references were given here
and have been deleted). The reference to iron is an oddity, with the
title of the paper cited suggesting that iron overload diminishes
atherosclerosis in Apo E-deficient mice. The effect of iron overload
in normal animals (without Apo E knocked out) would be expected to be
the exact opposite, that is, to increase atherosclerosis.
Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-
Accelerated Mice
The senescence-accelerated prone mouse 8 (SAMP8) is a frequently used
model for the study of and treatment of age-related changes. In this
recent study,8 researchers investigated the effects of drinking
hydrogen water for 30 days on the spatial memory decline and age-
related brain alterations in this animal model as compared to SAMR1
mice, senescence-accelerated resistant mouse 1. The results revealed
increased brain serotonin levels and elevated serum antioxidant
activity. Additionally, during 18 weeks of hydrogen water drinking,
the researchers observed decreased neurodegeneration in the
hippocampus, while marked loss of neurons in the hippocampus was noted
in the control, aged mice receiving regular water.
Results included, for example, that the SAMP8 mice treated with
hydrogen water had significantly faster escape latencies on days 5, 6,
and 7 in the Morris water maze test (where they had to find a hidden
platform in a pool of opaquely dyed water to escape drowning) as
compared to the SAMP8 mice given regular drinking water without
hydrogen gas dissolved in it. Then, on day 8, with the platform
removed (oh no), the mice were observed for how much time they spent
looking for the platform in its former location as a measure of memory
retention. Though there was no statistically significant difference in
time spent in the target zone between the SAMP8 mice receiving
hydrogen water and those receiving regular water, the number of passes
across the platform’s prior location was significantly higher in the
hydrogen water treated SAMP8 mice as compared to the regular water
receiving SAMP8 mice. This, the authors suggest, indicated that “HW
[hydrogen water] prevented the loss of some cognitive abilities in the
SAMP8 mice.”8
Hydrogen Saline Provides Neuroprotection Against Oxidative Stress in a
Cerebral Ischemia-Reperfusion Model in Rats
Here,9 the authors investigated the possible protective effects of
hydrogen saline against damage by hydroxyl radicals and peroxynitrite
in a middle cerebral artery occlusion rat model of stroke. Hydrogen
saline was found in the preliminary studies to significantly reduce
the infarct ratio (dead/injured cells) when applied at 0 or 3 hours
AFTER reperfusion, but there was only a slight reduction when injected
at 6 hours after reperfusion. Hence, the remaining experiments in this
study were performed with hydrogen saline administered 3 hours AFTER
reperfusion. “Neurological scores were dramatically reduced in the
MCAO [middle carotid artery occlusion] group (p<0.05 vs. sham) and
hydrogen saline treatment at 3 h after reperfusion significantly
improved the neurological function (p<0.01 vs. MCAO group) even though
some neurological dysfunction was still observed (p<0.05 vs. sham
group).” In other words, there was improvement in the hydrogen saline
group, but their neurological scores did not recover to that of the
control group not receiving MCAO treatment.
In addition, inflammation (as assessed by measures of the inflammatory
cytokines Il-1beta and TNF-alpha (tumor necrosis factor-alpha) was
decreased by hydrogen saline treatment. Oxidative stress can lead to
inflammation following ischemic stroke; hence, the decrease in levels
of IL-1beta and TNF-alpha indicated increased protection against
oxidative stress.
The authors further note that the therapeutic effects of hydrogen
saline were more profound than those they found in studies using
hydrogen inhalation. Also, they found the effects of intravenous
administration of hydrogen inferior to those of intraperitoneal
treatment, which they propose “may be explained by rapid elimination
of hydrogen through pulmonary gas exchange.”9
Hydrogen-Rich Saline Protects Against Intestinal Ischemia-Reperfusion
Injury in Rats
In another study of hydrogen in an animal (rat) model of ischemia-
reperfusion injury,9b the superior mesenteric artery of the small
intestine was clamped and ischemia maintained for 45 minutes and then
reperfusion initiated by the removal of the clamp. Assessed by
microscopic examination, protection by hydrogen was observed. In
addition, there were significant reductions in measures of
inflammation (the cytokines TNF-alpha, IL-1beta, and IL-6), lipid
peroxidation (MDA, malondialdehyde), and protein carbonyl and
myeloperoxidase activity, while no significant changes were observed
in the animals treated with nitrogen-rich saline.
Inhalation of Hydrogen Gas Suppressed Liver Damage in Mice Exposed to
Ischemia/Reperfusion Injury
Another study of an animal(mouse) model of ischemia-reperfusion
injury9c (reported by a different group of scientists from those
performing the studies cited in 9b) showed protective effects in mice
with complete occlusion for 90 minutes of the portal triad to the left
lobe and the left middle lobe of the liver, followed by reperfusion
for 180 minutes. Hydrogen inhalation suppressed liver cell death and
reduced levels of serum alanine aminotransferase and malondialdehyde.
In contrast, helium gas provided no protection.
Subjects at Risk of Metabolic Syndrome Show Improvements Following
Treatment with Hydrogen Rich Water
Metabolic syndrome is a cluster of symptoms that, when severe enough,
are categorized as diabetes 2. Risk factors for the metabolic syndrome
include obesity, insulin resistance, hypertension, and dyslipidemia. A
recent study10 examined the effects of treatment with hydrogen rich
water on antioxidant status of 20 subjects for 8 weeks who were at
risk of developing full-blown metabolic syndrome in an open label (not
blinded) pilot study.
Though there was no significant change in fasting glucose levels
during the 8 week study, there was a 39% increase (p<0.05) in
antioxidant enzyme superoxide dismutase (SOD) and a 43% decrease
(p<0.05) in thiobarbituric acid reactive substances (TBARS, a measure
of lipid peroxide formation) in urine. Subjects also had an 8%
increase in HDL-cholesterol and a 13% decrease in total cholesterol/
HDL-cholesterol from baseline to week 4. The authors conclude: “The
[hydrogen rich water generated via a magnesium stick] represents a
potentially novel therapeutic and preventive strategy for metabolic
syndrome.”10
In another study,10b 30 patients with type 2 diabetes controlled by
diet and exercise therapy and 6 patients with impaired glucose
tolerance were treated with hydrogen-rich water in a randomized,
double-blind, placebo-controlled, crossover study. The patients
received either 900 mL/d of hydrogen-rich pure water or 900 mL/d of
placebo pure water for 8 weeks with a 12-week washout period between
treatments. Intake of the hydrogen-rich water was associated with
significant decreases in modified low density lipoprotein (LDL)
cholesterol, small dense LDL, and urinary 8-isoprostanes (a measure of
free radical oxidative damage) by 15.5% (p<.01), 5.7 %(p<.05), and
6.6% (p<.05), respectively. In 4 of the 6 patients with impaired
glucose tolerance, the hydrogen-rich water normalized their oral
glucose tolerance test.
As the authors explained, the modification of LDL by acetylation,
carbamylation, glycation, glycoxidation, or oxidation lead to
increased uptake of LDL by macrophages in the process of becoming
atherogenic foam cells. Hydrogen-rich water was able to reduce the
modification of LDL to gain a net electronegative charge, decreased
small, dense LDL, and decreased urinary 8-isoprostanes, all of which
would be expected to have anti-atherogenic effects. The researchers
conclude that “a sufficient supply of this water may prevent or delay
development and progression of T2DM [type 2 diabetes mellitus] and
insulin resistance by providing protection against oxidative stress.
However, because of the small sample of patients in this study, the
results should be interpreted with caution.”10b
Hydrogen in Drinking Water Protects Mice Against Dopaminergic Cell
Loss by a Parkinson’s Disease Toxin
A frequently used model of Parkinson’s disease is to treat rodents
with MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a toxin that
induces a Parkinson’s disease-like condition by damaging or killing
dopaminergic neurons in the nigrostriatal area of the brain. Using
this procedure, a study10c reported that a low concentration of
hydrogen in drinking water of experimental mice reduced oxidative
stress induced by MPTP and significantly decreased cellular 8-
oxoguanine, a marker of DNA damage, and 4-hydroxynonenal, a marker of
lipid peroxidation, as compared to controls (receiving regular water).
Interestingly, the researchers reported that “[t]he effects of H2
water were dose-dependent, with a maximal effect at a much lower
concentration (0.08 ppm) than saturated concentration of H2 (1.5
ppm).”10c
There is also a very recent review article on the effects of hydrogen
in animal models of Parkinson’s disease.10d
Molecular Hydrogen Protects Rats Against Neurotoxin-induced
Degeneration in a Rat Model of Parkinson’s
In a different study10e using the neurotoxin 6-hydroxydopamine-induced
nigrostriatal degeneration in rats as a model for Parkinson’s disease,
researchers found hydrogen in water (~50% saturated) prevented both
the development and progression of nigrostriatal degeneration as
compared to rat’s drinking water containing no dissolved hydrogen gas.
In this study, they found protective effects of both pre- and post-
treatment of the neurotoxin-exposed rats to prevent dopaminergic cell
loss.
Breath Hydrogen Correlated with Satiety in Healthy Humans Consuming
Indigestible Carbohydrates in the Evening Meal
In another study,11 researchers examined the effect of including
indigestible carbohydrates in the evening meal of healthy human
subjects on glucose tolerance, inflammatory markers, and satiety in
the next day’s breakfast. Breath hydrogen was measured as an indicator
of fermentation of indigestible carbohydrates by colonic bacteria.
The evening meal was either enriched with barley kernel based bread,
which contains high levels of low GI (glycemic index) indigestible
carbohydrates in the form of HAB (high amylose barley kernels), HBB
(high beta-glucan barley kernels) or OB (ordinary barley kernels) or
with whole wheat bread flour. There was also a whole wheat bread that
consisted of whole wheat + dietary fiber + RS (resistant starch). The
results included finding that an evening meal of barley-kernel bread
significantly improved glucose tolerance at the following standardized
breakfast as compared to the whole wheat bread. In fact, the barley
kernel bread (OB) reduced the IAUC (incremental area under the curve)
for glucose during 0-120 minutes by 28% as compared to the whole wheat
bread evening meal. Interestingly, the whole wheat bread + dietary
fiber + resistant starch, which had a predicted glycemic index of 85
reduced the blood glucose after the standardized breakfast (0–120
minutes) by about 26% as compared to the whole wheat bread without the
fiber and resistant starch. The authors suggest that maybe low GI
isn’t per se necessary for the glucose tolerance advantage the next
day. We’re not so sure—a predicted GI of 85 doesn’t constitute a
measured GI.
One limitation of the study was that the subjects ate the test meals
at home, so that except for filling out a written form, compliance
could not be determined.
The researchers also reported finding that the evening meal with
barley-kernel bread resulted in lower concentrations of IL-6 and
higher concentrations of adiponectin, suggesting antiinflammatory
properties of the barley-kernel bread. At breakfast, the hydrogen
excretion (as measured in exhaled breath) correlated positively to
reported satiety. The evening meal with the HAB (high beta-glucan
barley kernels) resulted in a higher satiety score after the
standardized breakfast as compared with all the other evening meals.
Are the Benefits of Decreased Carbohydrate Digestion by Alpha-
Glucosidase Inhibitors Related to Increased Hydrogen Gas in the GI
Tract
An interesting hypothesis paper11b asks whether the benefits (such as
improved glucose tolerance and insulin sensitivity) that has been
reported in studies of type 2 diabetics given alpha-glucosidase
inhibitors (which reduce the ability of the upper digestive tract to
digest dissacharides such as sucrose) might be due to increased
hydrogen gas produced by gut microbes from the undigested
dissacharides that reach the lower digestive tract.
This is something we have also wondered. The authors of this paper did
an experiment to test their hypothesis. They examined whether the
administration of alpha-glucosidase inhibitors increases the level of
hydrogen production in the gastrointestinal tracts of 11 healthy
volunteers. The volunteers received acarbose (a drug used in the
treatment of diabetes that inhibits alpha-amylase and alpha-
glucosidase) at a dosage of 300 mg/day (100 mg, three times a day) for
4 days under free feeding conditions. On day 4, they measured the
levels of exhaled hydrogen and methane gases using a Breath Gas
Analyzer Model TGA-2000 (TERAMECS, Kyoto, Japan) and found that
acarbose treatment significantly increased the exhaled hydrogen at
every time point examined as compared to the hydrogen exhaled prior to
treatment. It was reported to have modest effects on methane
production. (Two of the 11 volunteers had no changes in their hydrogen
exhalation in response to acarbose.)
The authors propose that the amount of hydrogen gas produced as a
result of acarbose treatment was sufficient (judging from other
studies of hydrogen treatment) to reduce systemic oxidative stress.
Dietary Turmeric Increased Breath Hydrogen in Human Study
One way that may help to increase the hydrogen produced by your gut
microbiota is to eat foods rich in turmeric (such as curries) or to
take supplemental turmeric powder in capsules. (We didn’t include it
in our inulin formulation, which is designed to be taken as a powder
mixed with water or other liquid, because of the effect on flavor.) In
a human study,12 scientists tested the hypothesis that turmeric might
increase bowel motility by activating hydrogen-producing bacterial
flora in the colon. They had eight healthy subjects consume a curry
and rice dish either with or without turmeric. They then measured
breath hydrogen every 15 minutes for 6 hours by gas chromatography
with a semiconductor detector. They found that “[c]urry with turmeric
significantly increased the area under the curve of breath hydrogen
and shortened small-bowel transit time, compared with curry not
containing turmeric.”
The graph showing breath hydrogen vs. time after ingestion of the meal
showed that up to about 3 hours after eating, the turmeric containing
meal increased breath hydrogen significantly as compared to the meal
without turmeric. The curry without turmeric showed a slight increase
in breath hydrogen at about one hour after the meal but this increase
was not significant. “... breath hydrogen curves in both curry with
turmeric and turmeric knockout curry indicated two peaks. The initial
peak time, late peak time, and peak-to-peak time tended to be
shortened by turmeric, but this was not statistically significant.”12
The researchers didn’t restrict the ingestion of food by study
subjects that contained nondigestible carbohydrates before the
experiment except asking them to fast (drinking water was OK) for the
12 hours before the ingestion of the test meals.
To explain what caused the initial rise in breath hydrogen following a
meal (the postprandial state), the authors hypothesize that the so-
called gastro-ileal reflex causes the entry to non-absorbable
substrates into the colon. They further suggest that there could be
non-absorbable carbohydrates left in the ileum from the previous meal.
However, as they describe it, “the detailed mechanism of the initial
rise of breath hydrogen has not been established.” In their study, the
subjects eating the curry with turmeric ingested 0.5 g turmeric
containing 5.48 mg curcumin, 1.62 mg demethoxycurcumin, and 1.15 mg
bismethoxycurcumin, as well as other bioactive molecules present in
turmeric, such as zingiberene, curcumenole, curcmol, eugenol,
tetrahydroxycurcumin, triethylcurcumin, turmerin, turmerones, and
turmeronols. The researchers didn’t identify which of these components
was responsible for stimulating the increase in breath hydrogen.
One question we had was whether this study was really blind with
respect to the subjects eating the meals. Could they tell when a curry
contained no turmeric (which might effect both taste and color) and
might this knowledge have an effect on the outcome of the experiment?
Determining Normal Flatus Production: More Complicated Than You Think
Just to add a little note of frivolity here, we point out that there
have been studies (though not many) on the normal production of flatus
in humans. In one such study,13 scientists report that on a fiber free
diet (a liquid diet that contained no complex polysaccharides),
hydrogen was almost absent from the flatus—there was less than 1–3 ml/
24 hours of hydrogen in the flatus (one subject produced 21 ml) as
compared to their normal diet, less than 3% of the amount produced on
their normal diets. We suspect that the production of hydrogen in the
gut by resident bacteria may contribute significantly to how dietary
fiber provides important health benefits, such as reducing the risk of
colon cancer and cardiovascular disease.
The procedure used by the scientists in the study described in
reference #13 shows you what you have to go through just to determine
what might seem to some a silly physiological measurement. There were
ten healthy volunteers, five men and five women, aged 19–25 years
(betcha they were starving students doing it for a few bucks). Flatus
gas was collected by means of a flexible gas impermeable rubber tube
held in place with surgical tape or the subject’s underwear that was
attached at the other end to a plastic T-connector that was attached
to a laminated gas bag impermeable to gas diffusion. The patency of
the gas collection device was determined by having two volunteers
wearing the device and having the lower parts of their bodies
submerged in warm water for an hour during which time observers
checked for leaks (bubbling) and that gas was collected in the bags.
Gas was collected separately for overnight, for the fiber-free liquid
diet, as well as for a 24-hour period following test meals consisting
of 200 g of baked beans in tomato sauce. Detailed instructions (which
we will not go into here) were given to subjects as to how to proceed
when they needed to defecate. The authors note that the liquid diet
was sipped through a straw, resulting in some air swallowing, another
complication of the determination.
And so, in this way, the scientists got measurements for the
production of flatus by healthy young people. Of course, it could all
be done again (not with the same subjects of course) for getting
measurements of flatus produced by subjects consuming LCFOS-containing
diets. Another simpler way to determine how much hydrogen is generated
by colon bacteria is to measure breath hydrogen, as the hydrogen
generated in the colon is eventually mostly excreted from the body in
the lungs. You would still need to account for hydrogen taken up by
gut bacteria for their own use. As the authors note, slower passage of
gas through the colon allows more time for bacterial use of
fermentation gases.
Protection by Hydrogen Against Radiation
As the damage caused by radiation is largely a result of hydroxyl
radicals and hydrogen is a potent scavenger of hydroxyl radicals, it
is unsurprising that studies have reported protection by hydrogen
against radiation injury, though scavenging hydroxyl radicals is not
necessarily the only mechanism of its protective effects. One study14
explained that “[t]he gastrointestinal tract is one of the most
susceptible organs to radiation. As low as 1 Gy of radiation induces a
dramatic increase in apoptosis [programmed cell death] in mouse small
intestinal crypt within 3–6 h after exposure, predominantly in the
stem cell region.” In their study, the researchers tested the
protective effects of hydrogen-rich saline against gamma radiation to
cultured lymphocytes and the gastrointestinal tract in mice. In the
mice, for example, plasma SOD (superoxide dismutase) and GSH
(glutathione) concentrations were significantly higher at 12 hours
after irradiation in the hydrogen treated group as compared to the
controls. The plasma malondialdehyde (a lipid peroxidation product)
and intestinal 8-OHdG (a breakdown product of damaged DNA)
concentrations at 12 hours of irradiation in the hydrogen treated
group was significantly lower than that of the control group.
In another radiation study15 by the same group published in a
different journal that same year, hydrogen-rich water was tested for
its possible protection of the heart from damage by ionizing radiation
in mice. The authors hypothesized that the hydrogen-rich water would
protect against the hydroxyl radicals produced during irradiation.
They found decreased myocardium degeneration, decreased myocardium
malondialdehyde, decreased 8-hydroxydeoxyguanosine (8-OHdG) levels,
and increased levels of endogenous antioxidants in the hearts of
irradiated, hydrogen-water-treated mice as compared to irradiated but
untreated mice.
Thus, hydrogen might be a useful prophylactic under conditions where
you may be exposed to radiation. However, it is probably NOT a good
idea to use hydrogen at the same time you are receiving irradiation
therapy for cancer because of the risk that treatment effects (the
desired toxicity of the radiation to cancer cells) would be reduced.
Possible Protection by Hydrogen Against Mitochondrial Diseases
Involving Increased Oxidative Stress
One of the problems with the use of antioxidants in lifespan studies
is that most antioxidants are not able to enter the mitochondria,
where much of the generation of ROS (reactive oxygen species) takes
place. In fact, proponents of the mitochondrial theory of aging
propose that antioxidants have not generally been very effective in
lifespan studies precisely because they are unable to target ROS in
mitochondria and that mitochondria-targeted antioxidants are,
therefore, needed. Hydrogen may be a good way to overcome that problem
as it easily enters mitochondria.
A paper published early this year16 proposed the use of hydrogen “to
efficiently reduce oxidative stress with potential for the improvement
of mitochondrial diseases.” The author included very preliminary
evidence of possible improvements in small numbers of patients with
mitochondrial disorders treated with hydrogen. As the author noted,
the mechanism(s) for hydrogen’s beneficial effects are still unclear.
Improved Survival by Mice in a Model of Septic Shock
The authors of a recent paper17 report on the results of a study of
mice in a model of multiple organ dysfunction syndrome (MODS),
progressive deterioration of multiple organs as occurs, for example,
in patients with severe sepsis, septic shock, shock, multiple trauma,
severe burns, or pancreatitis. MODS is said to be the leading cause of
death in critically ill patients.17
The mice were subjected to treatment with zymosan, a substance derived
from the cell wall of the yeast Saccharomyces cerevisiae, that can
lead to life-threatening systemic inflammation. The authors had
already published a study18 in which hydrogen inhalation in septic
mice (sepsis induced by cecal ligation and puncture) had been shown to
significantly improve the survival rate and decrease organ damage. In
their study of zymosan-induced generalized inflammation,17 the
inhalation of 2% hydrogen for 60 minutes starting at 1 and 6 hours
after zymosan injection significantly improved the 14-day survival
rate of the injected mice from 10% (no hydrogen treatment) to 70%
(hydrogen inhalation). Moreover, the zymosan-injected hydrogen treated
mice had significant attenuation of damage markers and decreased
levels of oxidative products, increased activities of antioxidant
enzymes (such as superoxide dismutase), and reduced levels of early
and late proinflammatory cytokines (tumor necrosis factor alpha and
HMGB1) in serum and in tissue.17
CAUTIONARY NOTE ON THE CONSUMPTION OF HIGH FIBER DIETS
Fermentable Dietary Carbohydrates May Be Detrimental to Patients with
Irritable Bowel Syndrome
Patients with irritable bowel syndrome (IBS) appear to be sensitive to
increased “osmotic effects and gas production related to their rapid
fermentation by bacteria in the small and proximal large intestine.”19
In fact, IBS patients may improve on a diet with low quantities of
fermentable carbohydrates such as fructooligosaccharides. In a recent
study,19 researchers studied 15 healthy volunteers and 15 patients
with IBS for their response to either a low FODMAPs (Fermentable
Oligo- Di- and Mono-saccharides and Polyols) or high-FODMAPs diet. The
amount of hydrogen produced by subjects (the area under the curve) was
significantly higher during the high-FODMAPs diet as compared to the
low-FODMAP diet for both the healthy volunteers and the patients with
IBS. On the other hand, IBS patients produced more hydrogen gas than
healthy controls during both low-FODMAP and high-FODMAP diets. The
only noticeable change in the healthy subjects was increased flatus,
whereas the IBS subjects had significantly higher levels of typical
IBS symptoms (abdominal pain, bloating, and flatus). The IBS group,
but not the healthy controls, also had upper gastrointestinal symptoms
and lethargy during the high fructooligosaccharides diet.
Reduction of short-chain poorly absorbed carbohydrates in the diet
reduces symptoms of irritable bowel syndrome. Increased hydrogen
produced in IBS from short chain fructooligosaccharides influenced the
amount of hydrogen and methane produced and induced gastrointestinal
and systemic symptoms experienced by patients with IBS; normals only
experienced increased flatus. Hence, it may be inadvisable for IBS
patients to consume diets enriched in fermentable carbohydrates.
How Can YOU Benefit from Hydrogen Protection?
A 2% (by volume) mixture of hydrogen in air is not flammable or
explosive, but the equipment to reliably and accurately provide this
breathing mixture is expensive and must be maintained by skilled
technicians. We suspect that at some time in the future, hospitals
will make this available for use by patients suffering from a wide
variety of diseases involving free radical damage. Do NOT try this at
home (unless you really are a rocket scientist). Remember the
Hindenburg!
Water with hydrogen gas dissolved at saturation concentrations or less
is safe, but must either be made immediately before use or kept in a
tightly sealed glass or metal container. Hydrogen will quickly escape
through ordinary plastic bottles. A further disadvantage of hydrogen
water is that the duration of the hydrogen boost is short because the
ingested dissolved hydrogen will quickly escape through your lungs.
Nevertheless, animal experiments have shown substantial benefits from
this route of hydrogen administration.
Continuous colonic bacterial fermentation generation of hydrogen is
simple, safe, and provides sustained elevated tissue and blood levels
of dissolved hydrogen gas. We have chosen this method for our own use.
(Durk really is a rocket scientist and considered the 2% hydrogen in
air approach, but decided that the LCFOS method was a lot safer,
vastly less expensive, and just about as effective as hydrogen
inhalation.)
We have carefully studied the scientific literature as to the amount
of hydrogen produced, its time course of production, and the potential
for discomfort from producing too much hydrogen too fast too far up in
the gut. Of the many available fermentable fibers, we have chosen
LCFOS, which we have combined with a small amount of foam breaking
simethicone. We have found that without the latter, uncomfortable
abdominal distention is more likely. Worse yet, without the foam
breaker, one’s flatus can sometimes exit as a nasty brown fecal foam.
You really don’t want to go there ...
References
<snip>
Was this GREAT or what?
I want sweet smelling FARTs ... i wonder what people would think if we
became like those Canadians?
Farting Terrence and Philip
http://en.wikipedia.org/wiki/Terrance_and_Phillip#Terrance_and_Phillip
And
Chessypoofs puffs:
http://en.wikipedia.org/wiki/File:Cheesypoofs.png
randall...
This Durk/Sandy Hydrogen is sorta part III to the last two:
And in the last one.. old people smell vaccenic acid i promised A ben
Franklin FART thing..
It's in this ONE thanks to Durk.. but this is better as BB told us Ben
F was a vegetarian and
with good gut flora we know we BF was so FREAKing GREAT..
Those FARTs of his must of been or BEN sweet!
Thurs, May 31 2012 12:37 pm
Subject: Albert Ellis and Skin ++ More Insights -- More on--->>> More
or LESS Exercise <<<<-- Sexxxercise in the Balance --
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/bf5c164bf39e99df
Thurs, May 31 2012 1:04 pm
Subject: OLD People SMELL (?)-- Vaccenic Acid ? -- Microbes -->
Hydrogen (Durk Pearson) --BB Was Right! or (?) --Anthony Robbins --
Gravity & TIME -- E= Mc2 Smelly Fishy Or Timely? Time will TELL
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/d943bfdd0a1ed951
----------------------------------i need some music..
WAR what is it good for?
"War" by Edwin Starr (Original Video - 1969)
http://www.youtube.com/watch?v=01-2pNCZiNk
<time: 3:26>
Originally written under the Motown label, and first perform by The
Temptations, "War" was later re-released as a single with Edwin Starr
as vocals. This version is considered a more emotional version and has
become the most popular pro-test song ever.
<snip>
I didn't know that... love motown as it's bERRY GOOD ... Diana Ross is
light years ahead of bouncy.
It's beyonce me!
Then again my DAD would have said, Billie Holiday or many GREATs from
that era.
Hey! this tube thing screws up a few times... the youtube..that is..
Not ME!
http://en.wikipedia.org/wiki/Edwin_Starr
Wow
Edwin is better looking then our preezy... smaller ears, longer hair..
Alas we lost EDWIN in 2003 at the age of 61 to a heart attack... what
is that good for?
Nothing!
http://en.wikipedia.org/wiki/Myocardial_infarction
He needed:
http://en.wikipedia.org/wiki/Hyperhomocysteinemia
[...] Hyperhomocysteinemia or hyperhomocysteinaemia is a medical
condition characterized by an abnormally large level of homocysteine
in the blood.
As a consequence of the biochemical reactions in which homocysteine is
involved, deficiencies of the vitamins pyridoxine (B6), folic acid
(B9), or B12 can lead to high homocysteine levels.[1] Supplementation
with pyridoxine, folic acid, B12, or trimethylglycine (betaine)
reduces the concentration of homocysteine in the bloodstream.[2]
Hyperhomocysteinemia is a disease which increases risk of other artery
or vein diseases.
<snip>
How does one get around the GRIMM reaPer?
It's an EAR crease and calcium and smoking and eating crappy diet and
GENETIC's et al?
http://en.wikipedia.org/wiki/Myocardial_infarction#Risk_factors
But droPPing DEAD is better then being a vegetable for twenty years
and a burden on your loved juans.
I know, i know... only eat veggies and fruits and then you don't drop
DEAD, said BB? LOL
BB is for vegetarian and being like Albert Ellis sorta i'm guessing.
OTOH war keeps us FREE:
http://www.youtube.com/watch?v=bX7V6FAoTLc
And killing bin laden with a double tap and sleeping with the fishes
might
get this preezy enough votes for a second term? LOL
That anD wagging WAR on his opponent... chicago politics via rahm the
lamb emmanuel like?
War.. what is it good for?
Keeping mooooooooooooooooooooochele in the wIDE body to fly the
friendly sky's? LOL
OK
This next thing is Durk And SANDY (Shaw) Pearson selling something
called LCFOS to feed YOUR Gut bugs so they make HYDROGEN and
it knocks out the ROS in your Body.
Good idea?
A super charged anti-ROS deal inside of your very own gut flora...to
BOOT... LoL
So is it a GOOD idea?
YES, as " LCFOS fructans preferentially supported the growth of
bifidobacteria"
And even if in a RAT it's still a good THING, as most of these gene's
are conserved or
perverted by your current DIET.. LOL
So buck it up or boot it up... and go back to EDEN and tend to your
own garden
of enterotypicow bacteria.
Bifodo microbiota ARE good as they live in mOM's vagina and THEN when
you pass the birth canal they enter your Gi tract.
http://en.wikipedia.org/wiki/Bifidobacteria
Got it yet BB?
Will eating fruits like BB is now posting, do the same thing?
What is this LCFOS?
They are: Long-chain fructooligosaccharides
NO wiki page for it, but long chain these:
http://en.wikipedia.org/wiki/Fructooligosaccharide
[...] Food sources
FOS is extracted from fruits and vegetables such as bananas, onions,
chicory root, garlic, asparagus, barley, wheat, jícama, and leeks.
Some grains and cereals, such as wheat, also contain FOS.[3] The
Jerusalem artichoke and its relative yacón have been found to have the
highest concentrations of FOS of cultured plants
http://en.wikipedia.org/wiki/Jerusalem_artichoke
[...] aka --> sunchoke or sunroot--> edible tuber
[...] Jerusalem artichokes have 650 mg potassium per 1 cup (150g)
serving. They are also high in iron, and contain 10-12% of the US RDA
of fiber, niacin, thiamine, phosphorus and copper.[8]
Jerusalem artichokes can be used as animal feed, and, while they must
be washed before being fed to most animals, pigs forage and safely eat
them directly from the ground. The stalks and leaves can be harvested
and used for silage, though cutting the tops greatly reduces the
harvest of the roots.
<snip>
http://www.life-enhancement.com/article_template.asp?ID=2642
Hydrogen Therapy
The Emergence of A New Field of Medicine and How You Can Benefit From
It Right Now (with a little help from your friends ... READ ON)
By Durk Pearson & Sandy Shaw
Hydrogen therapy for the prevention and treatment of a variety of
diseases—particularly those associated with ROS (reactive oxygen
species) and inflammation—has become a hot research subject. Many
reports in peer-reviewed scientific and medical journals, including in
vitro and animal studies, plus some clinical trials in humans, have
already been published. Diseases that may be beneficially affected by
hydrogen therapy include, to name a few, atherosclerosis, ischemia-
reperfusion injury (as occurs in heart attacks and strokes), diabetes,
stress-induced cognitive impairments, Parkinson’s disease (as shown in
animal models), and various aspects of the metabolic syndrome (e.g.,
insulin sensitivity, glucose tolerance, and endothelial function)
As reported in an excellent review1 on the “recent progress toward
hydrogen medicine,” the author describes various methods being used in
published animal and human studies to administer hydrogen: inhalation
of hydrogen gas, oral ingestion by drinking hydrogen water, hydrogen
baths (because hydrogen easily penetrates the skin and distributes
throughout the body via blood flow),1 injection of hydrogen saline,
direct absorption of hydrogen (as in hydrogen containing eye drops),
and INCREASED PRODUCTION OF HYDROGEN BY GUT BACTERIA. Note: One reason
for the use of hydrogen water and hydrogen saline is that it is
possible to reliably control the dose administered to experimental
animals, which is important in determining results such as dose-
response relationships. In the case of gut bacteria-provided hydrogen,
it is less easy to determine the hydrogen “dose,” although one way to
at least partially overcome this problem is to measure the hydrogen
gas excreted by the lungs.
Hydrogen Is a Selective Antioxidant, Scavenging Dangerous Radicals But
Not Radicals Important as Physiological Signaling Molecules
Hydrogen and carbon dioxide, as well as (in some people) methane, are
gases released by colonic bacteria in the fermentation by the bacteria
of carbohydrates that reach the lower digestive tract. Hydrogen has
been known to have antioxidant properties for a long time, but its
recognition as having some advantages over conventional antioxidants
and its potential use as a therapeutic agent have only recently been
explored.2,2c
One of the most interesting findings concerning hydrogen as an
antioxidant is the discovery that it is a novel antioxidant because it
scavenges the toxic hydroxyl radical (the strongest of the oxidant
species)2c and the potent oxidant peroxynitrite (formed by the
reaction of superoxide and nitric oxide), but is far less effective in
scavenging physiological radicals such as superoxide and nitric oxide,
important (at low concentrations) as signaling molecules.2 Moreover,
hydrogen is able to diffuse extremely rapidly into tissue and
“effectively reaches the nucleus and mitochondria,”1 suggesting
“preventive effects on lifestyle-related diseases, cancer, and the
aging process.”1 Hydrogen also passes through the blood-brain barrier,
although most antioxidant compounds cannot do this.1
Safety of Hydrogen
Hydrogen (H2) is reported to have no cytotoxicity even at high
concentrations.1 “The safety of H2 for humans is demonstrated by its
application in Hydreliox, an exotic, breathing gas mixture of 49% H2,
50% helium and 1% O2, which is used to prevent decompression sickness
and nitrogen narcosis during very deep technical diving.”1
From time immemorial human beings have absorbed quantities of lactic
microbes by consuming in the uncooked condition substances such as
soured milk, kephir, sauerkraut, or salted cucumbers which have
undergone lactic fermentation. By these means they have unknowingly
lessened the evil consequences of intestinal putrefaction.
— Elie Metchnikoff, The Prolongation of Life
(the English translation, Putnam, 1908), pg. 171
Every unhealthy change in the quality of beer coincides with a
development of microscopic germs which are alien to the pure ferment
of beer.
— L. Pasteur, Studies on Fermentation: The Diseases of Beer
MacMillan & Co. 1879 (English translation) (pg. 19)
Hydrogen Is a Free Gift From Your Gut Bacteria ... No Prescription
Required
LCFOS Is a Food (Prebiotic) for Gut Bacteria That Produce Hydrogen
There are many papers on the effects of various types of non-
digestible carbohydrates (foods, called prebiotics, for gut bacteria)
that reach the lower digestive tract and are there converted to
(mostly) hydrogen by gut bacteria in the process of their extracting
energy from them. NOTE: There is considerable variation in the
individual response to prebiotics. For example, the microbiota of
people with “high” BMI (overweight or obese) have been found to
generate less hydrogen because they are able to digest carbohydrates
more efficiently than those with a lean BMI, leaving less to reach the
colonic bacteria. Long-chain fructooligosaccharides (LCFOS),
however, cannot be digested by humans, even obese ones.
LCFOS as a Food for Hydrogen-Producing Gut Bacteria
A recent paper2b studied the release of hydrogen gas and short chain
fatty acids by various fermentable dietary fibers by fecal bacteria.
The authors proposed, and we agree with their suggestion, that “a
slow, extended fermentation profile would be desirable to provide low
initial gas and short chain fatty acid over a longer period of
time.”2b If gas were released at a high volume very rapidly, it might
cause abdominal bloating and discomfort and flatus frequency. The
authors also suggest that “... the availability of SCFA [short chain
fatty acids produced by the gut bacteria] throughout the entire length
of colon is sought after because 50% to 60% of large intestinal cancer
occurs in the distal colon and the evidence indicates that, in
majority of the cases, chronic inflammation of this site promotes the
development of this type of cancer. Butyrate [a short chain fatty
acid] is particularly important in this context as it has anti-
inflammatory action apart from being the main energy source for
colonocytes.”2b LCFOS was reported to have (and the graph showed) slow
and moderate but incomplete fermentation. We thought that the overall
increase in gas production by gut bacteria fermentation of LCFOS and
its timing looked particularly good for the supplement we were
developing for our own use.
In the paper,2b the authors also explain that “[t]he distal colon is
typically the site of protein fermentation, which leads to the
production of such compounds as ammonia, phenol, p-cresol, and indoles
resulting in a risk of mucosal insult. Enhancement of carbohydrate
substrate availability to the distal colon microbiota may accordingly
improve gut health by production of beneficial SCFA [short-chain fatty
acids] and promotion of saccharolytic bacteria.”2bb In another paper,
2c the authors found that higher degree of polymerization of LCFOS
fructans preferentially supported the growth of bifidobacteria in
rats; the bifidobacteria group includes many gut bacteria found to be
beneficial in humans, though this particular group does not produce
hydrogen.
Another paper2d compares the effects of short chain versus long chain
LCFOS. LCFOS and fructooligosaccharides are fructans (fructose
oligosaccharides), which are fructose polymers used by plants to store
carbohydrates. As noted in the paper2d “[i]ngestion of fructans is
limited by various abdominal symptoms such as osmotic diarrhea, pain,
bloating, and flatulence due to colonic fermentation and production of
bacterial end-products,” including hydrogen gas. These side effects
occur more frequently with the shorter-chain inulin fructans and with
higher doses.2d “A dose of 5 g/d seems to be well tolerated,”2d
whereas higher amounts may induce one or more of the aforementioned
annoying side effects, primarily flatulence. A further way to limit
the likelihood of having uncomfortable bloating from gas is to take a
small quantity of simethicone to break up gas bubbles. See more on
that below.
The longer chain fructans also had a longer transit time as compared
to the shorter chain ones,2d which is likely to be advantageous in
terms of reaching the lower digestive tract for fermentation by gut
microbes.
Inulin Reduces Stink of Flatus Gas
One nice aspect of inulin is that, while it increases the gas output
of your digestive tract, it reduces the “smelly” aspects of that gas.
In one study of growing pigs,2 a 5% inulin extract (derived from
chicory) was given as a dietary supplement and was found to
significantly decrease the fecal excretion of skatole (the foul stench
in farts that results from the microbial degradation of tryptophan) as
compared to pigs fed the corn and soybean meal diet alone with no
inulin supplementation. (Skatole, mg/kg, in the control group was
18.93 as compared to 9.07 in the inulin-supplemented animals). This
study, published in the Journal of Animal Science, was funded, we
suspect, by hog farmers hoping to destink their operations and reduce
complaints by neighbors. Though we don’t suppose you get complaints
from neighbors about your stinky farts, you’ll have one less thing to
worry about if you take a dietary supplement that increases gas
production by gut bacteria without the stench.
Benjamin Franklin on the Invention of Non-offensive Farts
Benjamin Franklin had plenty to say about farts, as in his published
article, “To the Royal Academy of Farting” (c. 1781). There he
proposed that the invention of ways to promote pleasant smelling wind
would be of great benefit to mankind. He perceived serious social
risks of “permitting this Air to escape and mix with the Atmosphere,
[as it] is usually offensive to the Company, from the fetid Smell that
accompanies it.” In fact, he noted, “all well-bred People therefore,
to avoid giving such Offence, forcibly restrain the Efforts of Nature
to discharge that Wind.” In fact, he warns ominously, this unnatural
retention of gas as “[t]hat retain’d contrary to Nature, such as
habitual Cholics, Ruptures, Tympanies, &c. often destructive of the
Constitution, & sometimes of Life itself. Were it not for the odiously
offensive Smell accompanying such Escapes, polite People would
probably be under no more Restraint in discharging such Wind in
Company, than they are in spitting, or in blowing their Noses.”
Thus, Franklin proposed that there should be a prize made available
“[t]o discover some Drug wholesome & not disagreeable, to be mix’d
with our common Food, or Sauces, that shall render the natural
Discharges of Wind from our Bodies, not only inoffensive, but
agreeable as Perfumes.” “For the Encouragement of this Enquiry, (from
the immortal Honour to be reasonably expected by the Inventor) let it
be considered of how small Importance to Mankind, or to how small a
Part of Mankind have been useful those Discoveries in Science that
have heretofore made Philosophers famous ... What Comfort can the
Vortices of Descartes give to a Man who has Whirlwinds in his Bowels!”
“And surely such a Liberty of Expressing one’s Scent-iments, and
pleasing one another, is of infinitely more importance to human
Happiness than that Liberty of the Press, or of abusing one another,
which the English are so ready to fight & die for.”To read the entire
essay by Franklin, if you must, see URL: http://www.TeachingAmericanHistory.org/library/
index.asp?documentprint=470
Using a GRAS Food Ingredient to Break Up Gas Bubbles to Reduce the
Chances of Discomfort
We considered the use of a very wide variety of carbohydrates that are
able to pass incompletely digested or undigested into the lower
intestinal tract as fuel for fermentation by hydrogen producing
colonic microbiota. Many carbohydrates that pass into the lower
digestive tract would not be suitable for such use; for example, some
dietary carbohydrates such as cellulose, and methyl cellulose are not
digested in the upper digestive tract, but also pass through the lower
digestive tract essentially unmetabolized. Human colonic microbiota
cannot ferment them. Other carbohydrates such as lactulose or short
and even medium-chain fructooligosaccharides are so rapidly fermented
to release gases (mostly hydrogen, but some people’s microbiota also
produce methane) that they can result in pain, bloating, and even
explosive expulsion of foamy diarrhea, an embarrassing incident that
may require a rush to the toilet and a change of pants, known
colloquially as a “plotch.” (Sometimes science is not pretty.)
Durk found out many things by experimenting on his favorite guinea pig—
himself—with many different types of carbohydrates in the development
of a tolerable food for hydrogen producing resident colonic microbes.
Some of these experiments were remarkably unpleasant, messy, and even
painful. The final result was to identify a specific LCFOS as the type
of carbohydrate that would reach the lower digestive tract, there to
be fermented by intestinal microbes to produce hydrogen gas at the
right places at the right rate.
There was still sometimes a problem, depending on other foods
consumed, with the hydrogen being trapped as bubbles in the feces,
which prevented venting the excess hydrogen without risk of a plotch.
The addition of a GRAS (Generally Recognized As Safe) food grade
physiologically inert silicone defoaming agent caused the bubbles to
break and vent without unpleasant incident. With this addition, we can
consume a carefully selected LCFOS at doses discovered by experiment
to increase gas production without discomfort or (needless to say)
plotches.
As we mentioned above, the amount of gas released differs among
individuals in response to the ingestion of nondigestible
carbohydrates (prebiotics) that are the fuel gut microbiota convert to
hydrogen and short chain fatty acids. Though we have chosen a specific
prebiotic (LCFOS) for our own use to help avoid that problem, there is
still a possibility that some people may release enough gas to cause
bloating and discomfort. To help prevent this, we suggest the use of
simethicone, an FDA approved GRAS, Generally Recognized as Safe,
dietary ingredient used daily by many millions of people to relieve
the discomfort of gas. It is synthetic but quite safe and really
works.
Dietary Ingestion of Inulin May Increase Satiety in Response to Food
Intake
A paper3b examined the effects of either inulin or oligofructose on
gastrointestinal peptides that have been shown to play a role in food
intake or satiety. The authors had previously found that the addition
of inulin-type fructans at the dose of 10% (w/w) in the diet for
several weeks decreased triglyceride (fat) accumulation in the liver
and epididymal mass, both in normal and obese Zucker fa/fa rats. “Most
of the effects of inulin-type fructans on lipid metabolism correlated
with a decrease in food-derived energy intake, mainly due to a lower
calorific value of the fructans-containing diet.” The authors wanted
to find out what mechanisms were responsible for the satiating effect
of inulin-type fructans.
Gastrointestinal peptides that have been identified as being important
modulators of appetite through peripheral (vagus nerve) effects and/or
by acting directly on the arcuate nucleus of the brain include GLP-1
(glucagon-like peptide-1), oxyntomodulin and PYY. Hence, the authors
looked at the effects of inulin-type fructans of different degrees of
polymerization on GLP-1 and PYY in male Wistar rats—oligofructose,
oligofructose-enriched inulin, and LCFOS. Portal concentration of both
peptides was almost doubled after oligofructose treatment. Moreover,
they cite a human study in which human volunteers taking about 20 g
oligofructose/d for 7 d increased serum GLP-1 (see 3c).
Selected Studies on the Use of Hydrogen in the Prevention or Treatment
of Disease
There are many reports of hydrogen therapy in the literature, with
more being published at a rapid pace. We mention here a few examples.
Water Containing Dissolved Hydrogen Prevented the Decline in the
Proliferation of Progenitor Neural Cells and Impairment of Cognitive
Function in Stressed Mice
“Here we show that when chronic physical stress was applied to mice,
continuous consumption of hydrogen water reduced oxidative stress in
the brain, and prevented the decline in the proliferation of
progenitor neural cells and the impairment of cognitive function.”4 In
this study, hydrogen water (3.5 ml at 0.8 μM) was placed into the
stomach of each rat by a catheter. Thus, the hydrogen water may have
prevented the impairment of neurogenesis that is reported to occur in
stressed animals.
Inhalation of Hydrogen Gas Reduces Infarct Size in the Rat Model of
Reperfusion Injury in Heart Attacks
While the reintroduction of blood flow during a heart attack by, for
example, drugs that break up blood clots, can improve the survival of
experimental animals or humans, it also leads to heart damage as a
result of reperfusion. The reperfusion damage has been attributed
largely to hydroxyl radicals.5 It has been noted that “[s]tudies in
animal models of acute myocardial infarction show that reperfusion
injury accounts for up to 50% of the final size of a myocardial
infarct.”5 In one study,5 hydrogen gas administered to isolated,
perfused rat hearts, enhanced the recovery of left ventricular
function following anoxia-reoxygenation. In another part of the study,
rats were subjected to coronary artery occlusion for 30 minutes
followed by reperfusion for 24 hours. Hydrogen gas was administered at
the onset of ischemia (reduced blood flow) and continued for 60
minutes after reperfusion.
Even though blood flow was impaired in the ischemia myocardium,
hydrogen gas levels were increased by the administration of the gas.
“The peak level of hydrogen in the ischemic myocardium was reached at
approximately two-thirds of the value observed in the non-ischemic
myocardium.”5 “In the absence of H2 gas inhalation, infarct size
following ischemia-reperfusion was 41.6 ± 2.5% of the area at risk; by
comparison, inhalation of 0.5–2% H2 gas significantly reduced infarct
size, with 2% H2 gas providing the most prominent effects (21.2 ± 1.6%
area at risk).”5
In another study,6 hydrogen-rich saline protected rat myocardium
against ischemia/reperfusion injury. In this study, the hydrogen was
administered as an intraperitoneal injection before reperfusion in
animals that underwent 30 min. occlusion of the left anterior
descending coronary artery followed by 24-hour reperfusion.
Cultured Chondrocytes From Hog Cartilage or From Rat Meniscus
Fibrecartilage Protected From Oxidative Stress and Peroxynitrite
Derived From Nitric Oxide
We Hypothesize That Hydrogen May Reduce Pain, Too
Interestingly, peroxynitrite, a potent oxidant derived from the
chemical reaction of superoxide radicals with nitric oxide, has been
linked to PAIN; hence, reducing peroxynitrite may be an effective way
to decrease pain associated with oxidative stress/inflammation-induced
arthritis.6a,6b In fact, another paper6c discussed different types of
pain and the role played by superoxide and peroxynitrite but proposes
targeting peroxynitrite over that of superoxide because of the
physiological signaling of superoxide. “It may be PN [peroxynitrite]
is a more attractive target, in that unlike SO [superoxide] it has no
currently known beneficial role.”6c Since hydrogen preferentially
scavenges hydroxyl radicals and peroxynitrite over that of superoxide
and hydrogen peroxide, it may be beneficial in pain relief, though we
have not yet seen a published paper where this hypothesis is tested
experimentally. A review paper6d on reactive oxygen and nitrogen
species in pain agrees with other researchers “targeting PN
[peroxynitrite] may be a better therapeutic strategy [for treating
pain] than targeting SO [superoxide]. This is because, unlike PN,
which has no currently known beneficial role, SO may play a
significant role in learning and memory.”
Researchers7 treated cultured chondrocytes with SNAP (S-nitroso-N-
acetylpenicillamine), a donor of nitric oxide, in the presence or
absence of H2. “It is known that the matrix proteins of cartilage
(including aggrecan and type II collagen) and matrix
metalloproteinases (such as MMP3 and MMP13) are down- and up-regulated
by ONOO- [peroxynitrite], respectively. H2 restoratively increased the
gene expressions of aggrecan and type II collagen in the presence of
H2. Conversely, the gene expressions of MMP3 and MMP13 were
restoratively downregulated with H2. Thus, H2 acted to restore
transcriptional alterations induced by ONOO.”7 The researchers
concluded that “... novel pharmacological strategies aimed at
selective removal of ONOO- may represent a powerful method for
preventive and therapeutic use of H2 for joint diseases.”7
Consumption of Hydrogen Water Prevents Atherosclerosis in
Apolipoprotein E Knockout Mice
Mice and rats are typically resistant to developing atherosclerosis.
Hence, a common model for rodent atherosclerosis is to study animals
knocked out for the Apo E gene, which makes them susceptible to
atherosclerosis by reducing their ability to remove cholesterol from
cells. In a study of Apo E knockout mice,7b treatment with hydrogen
dissolved in water prevented the rapid atherosclerosis that usually
occurs in these genetically disabled animals. Atherosclerotic lesions
were found in the aortae of 6-month old Apo E knockout mice, whereas
in Apo E knockout mice that had drunk hydrogen water, the volume of
atherosclerotic lesion was significantly reduced.
The authors say that “[w]hen the preventive effect of atherosclerotic
lesions in this study is compared with the previous data that Apo E-/-
[Apo E knockout] mice was used, the efficacy of hydrogen water seems
to be greater than folic acid, vitamin E, iron, and alpha-lipoacid [we
assume they meant alpha lipoic acid]. “7b (references were given here
and have been deleted). The reference to iron is an oddity, with the
title of the paper cited suggesting that iron overload diminishes
atherosclerosis in Apo E-deficient mice. The effect of iron overload
in normal animals (without Apo E knocked out) would be expected to be
the exact opposite, that is, to increase atherosclerosis.
Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-
Accelerated Mice
The senescence-accelerated prone mouse 8 (SAMP8) is a frequently used
model for the study of and treatment of age-related changes. In this
recent study,8 researchers investigated the effects of drinking
hydrogen water for 30 days on the spatial memory decline and age-
related brain alterations in this animal model as compared to SAMR1
mice, senescence-accelerated resistant mouse 1. The results revealed
increased brain serotonin levels and elevated serum antioxidant
activity. Additionally, during 18 weeks of hydrogen water drinking,
the researchers observed decreased neurodegeneration in the
hippocampus, while marked loss of neurons in the hippocampus was noted
in the control, aged mice receiving regular water.
Results included, for example, that the SAMP8 mice treated with
hydrogen water had significantly faster escape latencies on days 5, 6,
and 7 in the Morris water maze test (where they had to find a hidden
platform in a pool of opaquely dyed water to escape drowning) as
compared to the SAMP8 mice given regular drinking water without
hydrogen gas dissolved in it. Then, on day 8, with the platform
removed (oh no), the mice were observed for how much time they spent
looking for the platform in its former location as a measure of memory
retention. Though there was no statistically significant difference in
time spent in the target zone between the SAMP8 mice receiving
hydrogen water and those receiving regular water, the number of passes
across the platform’s prior location was significantly higher in the
hydrogen water treated SAMP8 mice as compared to the regular water
receiving SAMP8 mice. This, the authors suggest, indicated that “HW
[hydrogen water] prevented the loss of some cognitive abilities in the
SAMP8 mice.”8
Hydrogen Saline Provides Neuroprotection Against Oxidative Stress in a
Cerebral Ischemia-Reperfusion Model in Rats
Here,9 the authors investigated the possible protective effects of
hydrogen saline against damage by hydroxyl radicals and peroxynitrite
in a middle cerebral artery occlusion rat model of stroke. Hydrogen
saline was found in the preliminary studies to significantly reduce
the infarct ratio (dead/injured cells) when applied at 0 or 3 hours
AFTER reperfusion, but there was only a slight reduction when injected
at 6 hours after reperfusion. Hence, the remaining experiments in this
study were performed with hydrogen saline administered 3 hours AFTER
reperfusion. “Neurological scores were dramatically reduced in the
MCAO [middle carotid artery occlusion] group (p<0.05 vs. sham) and
hydrogen saline treatment at 3 h after reperfusion significantly
improved the neurological function (p<0.01 vs. MCAO group) even though
some neurological dysfunction was still observed (p<0.05 vs. sham
group).” In other words, there was improvement in the hydrogen saline
group, but their neurological scores did not recover to that of the
control group not receiving MCAO treatment.
In addition, inflammation (as assessed by measures of the inflammatory
cytokines Il-1beta and TNF-alpha (tumor necrosis factor-alpha) was
decreased by hydrogen saline treatment. Oxidative stress can lead to
inflammation following ischemic stroke; hence, the decrease in levels
of IL-1beta and TNF-alpha indicated increased protection against
oxidative stress.
The authors further note that the therapeutic effects of hydrogen
saline were more profound than those they found in studies using
hydrogen inhalation. Also, they found the effects of intravenous
administration of hydrogen inferior to those of intraperitoneal
treatment, which they propose “may be explained by rapid elimination
of hydrogen through pulmonary gas exchange.”9
Hydrogen-Rich Saline Protects Against Intestinal Ischemia-Reperfusion
Injury in Rats
In another study of hydrogen in an animal (rat) model of ischemia-
reperfusion injury,9b the superior mesenteric artery of the small
intestine was clamped and ischemia maintained for 45 minutes and then
reperfusion initiated by the removal of the clamp. Assessed by
microscopic examination, protection by hydrogen was observed. In
addition, there were significant reductions in measures of
inflammation (the cytokines TNF-alpha, IL-1beta, and IL-6), lipid
peroxidation (MDA, malondialdehyde), and protein carbonyl and
myeloperoxidase activity, while no significant changes were observed
in the animals treated with nitrogen-rich saline.
Inhalation of Hydrogen Gas Suppressed Liver Damage in Mice Exposed to
Ischemia/Reperfusion Injury
Another study of an animal(mouse) model of ischemia-reperfusion
injury9c (reported by a different group of scientists from those
performing the studies cited in 9b) showed protective effects in mice
with complete occlusion for 90 minutes of the portal triad to the left
lobe and the left middle lobe of the liver, followed by reperfusion
for 180 minutes. Hydrogen inhalation suppressed liver cell death and
reduced levels of serum alanine aminotransferase and malondialdehyde.
In contrast, helium gas provided no protection.
Subjects at Risk of Metabolic Syndrome Show Improvements Following
Treatment with Hydrogen Rich Water
Metabolic syndrome is a cluster of symptoms that, when severe enough,
are categorized as diabetes 2. Risk factors for the metabolic syndrome
include obesity, insulin resistance, hypertension, and dyslipidemia. A
recent study10 examined the effects of treatment with hydrogen rich
water on antioxidant status of 20 subjects for 8 weeks who were at
risk of developing full-blown metabolic syndrome in an open label (not
blinded) pilot study.
Though there was no significant change in fasting glucose levels
during the 8 week study, there was a 39% increase (p<0.05) in
antioxidant enzyme superoxide dismutase (SOD) and a 43% decrease
(p<0.05) in thiobarbituric acid reactive substances (TBARS, a measure
of lipid peroxide formation) in urine. Subjects also had an 8%
increase in HDL-cholesterol and a 13% decrease in total cholesterol/
HDL-cholesterol from baseline to week 4. The authors conclude: “The
[hydrogen rich water generated via a magnesium stick] represents a
potentially novel therapeutic and preventive strategy for metabolic
syndrome.”10
In another study,10b 30 patients with type 2 diabetes controlled by
diet and exercise therapy and 6 patients with impaired glucose
tolerance were treated with hydrogen-rich water in a randomized,
double-blind, placebo-controlled, crossover study. The patients
received either 900 mL/d of hydrogen-rich pure water or 900 mL/d of
placebo pure water for 8 weeks with a 12-week washout period between
treatments. Intake of the hydrogen-rich water was associated with
significant decreases in modified low density lipoprotein (LDL)
cholesterol, small dense LDL, and urinary 8-isoprostanes (a measure of
free radical oxidative damage) by 15.5% (p<.01), 5.7 %(p<.05), and
6.6% (p<.05), respectively. In 4 of the 6 patients with impaired
glucose tolerance, the hydrogen-rich water normalized their oral
glucose tolerance test.
As the authors explained, the modification of LDL by acetylation,
carbamylation, glycation, glycoxidation, or oxidation lead to
increased uptake of LDL by macrophages in the process of becoming
atherogenic foam cells. Hydrogen-rich water was able to reduce the
modification of LDL to gain a net electronegative charge, decreased
small, dense LDL, and decreased urinary 8-isoprostanes, all of which
would be expected to have anti-atherogenic effects. The researchers
conclude that “a sufficient supply of this water may prevent or delay
development and progression of T2DM [type 2 diabetes mellitus] and
insulin resistance by providing protection against oxidative stress.
However, because of the small sample of patients in this study, the
results should be interpreted with caution.”10b
Hydrogen in Drinking Water Protects Mice Against Dopaminergic Cell
Loss by a Parkinson’s Disease Toxin
A frequently used model of Parkinson’s disease is to treat rodents
with MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a toxin that
induces a Parkinson’s disease-like condition by damaging or killing
dopaminergic neurons in the nigrostriatal area of the brain. Using
this procedure, a study10c reported that a low concentration of
hydrogen in drinking water of experimental mice reduced oxidative
stress induced by MPTP and significantly decreased cellular 8-
oxoguanine, a marker of DNA damage, and 4-hydroxynonenal, a marker of
lipid peroxidation, as compared to controls (receiving regular water).
Interestingly, the researchers reported that “[t]he effects of H2
water were dose-dependent, with a maximal effect at a much lower
concentration (0.08 ppm) than saturated concentration of H2 (1.5
ppm).”10c
There is also a very recent review article on the effects of hydrogen
in animal models of Parkinson’s disease.10d
Molecular Hydrogen Protects Rats Against Neurotoxin-induced
Degeneration in a Rat Model of Parkinson’s
In a different study10e using the neurotoxin 6-hydroxydopamine-induced
nigrostriatal degeneration in rats as a model for Parkinson’s disease,
researchers found hydrogen in water (~50% saturated) prevented both
the development and progression of nigrostriatal degeneration as
compared to rat’s drinking water containing no dissolved hydrogen gas.
In this study, they found protective effects of both pre- and post-
treatment of the neurotoxin-exposed rats to prevent dopaminergic cell
loss.
Breath Hydrogen Correlated with Satiety in Healthy Humans Consuming
Indigestible Carbohydrates in the Evening Meal
In another study,11 researchers examined the effect of including
indigestible carbohydrates in the evening meal of healthy human
subjects on glucose tolerance, inflammatory markers, and satiety in
the next day’s breakfast. Breath hydrogen was measured as an indicator
of fermentation of indigestible carbohydrates by colonic bacteria.
The evening meal was either enriched with barley kernel based bread,
which contains high levels of low GI (glycemic index) indigestible
carbohydrates in the form of HAB (high amylose barley kernels), HBB
(high beta-glucan barley kernels) or OB (ordinary barley kernels) or
with whole wheat bread flour. There was also a whole wheat bread that
consisted of whole wheat + dietary fiber + RS (resistant starch). The
results included finding that an evening meal of barley-kernel bread
significantly improved glucose tolerance at the following standardized
breakfast as compared to the whole wheat bread. In fact, the barley
kernel bread (OB) reduced the IAUC (incremental area under the curve)
for glucose during 0-120 minutes by 28% as compared to the whole wheat
bread evening meal. Interestingly, the whole wheat bread + dietary
fiber + resistant starch, which had a predicted glycemic index of 85
reduced the blood glucose after the standardized breakfast (0–120
minutes) by about 26% as compared to the whole wheat bread without the
fiber and resistant starch. The authors suggest that maybe low GI
isn’t per se necessary for the glucose tolerance advantage the next
day. We’re not so sure—a predicted GI of 85 doesn’t constitute a
measured GI.
One limitation of the study was that the subjects ate the test meals
at home, so that except for filling out a written form, compliance
could not be determined.
The researchers also reported finding that the evening meal with
barley-kernel bread resulted in lower concentrations of IL-6 and
higher concentrations of adiponectin, suggesting antiinflammatory
properties of the barley-kernel bread. At breakfast, the hydrogen
excretion (as measured in exhaled breath) correlated positively to
reported satiety. The evening meal with the HAB (high beta-glucan
barley kernels) resulted in a higher satiety score after the
standardized breakfast as compared with all the other evening meals.
Are the Benefits of Decreased Carbohydrate Digestion by Alpha-
Glucosidase Inhibitors Related to Increased Hydrogen Gas in the GI
Tract
An interesting hypothesis paper11b asks whether the benefits (such as
improved glucose tolerance and insulin sensitivity) that has been
reported in studies of type 2 diabetics given alpha-glucosidase
inhibitors (which reduce the ability of the upper digestive tract to
digest dissacharides such as sucrose) might be due to increased
hydrogen gas produced by gut microbes from the undigested
dissacharides that reach the lower digestive tract.
This is something we have also wondered. The authors of this paper did
an experiment to test their hypothesis. They examined whether the
administration of alpha-glucosidase inhibitors increases the level of
hydrogen production in the gastrointestinal tracts of 11 healthy
volunteers. The volunteers received acarbose (a drug used in the
treatment of diabetes that inhibits alpha-amylase and alpha-
glucosidase) at a dosage of 300 mg/day (100 mg, three times a day) for
4 days under free feeding conditions. On day 4, they measured the
levels of exhaled hydrogen and methane gases using a Breath Gas
Analyzer Model TGA-2000 (TERAMECS, Kyoto, Japan) and found that
acarbose treatment significantly increased the exhaled hydrogen at
every time point examined as compared to the hydrogen exhaled prior to
treatment. It was reported to have modest effects on methane
production. (Two of the 11 volunteers had no changes in their hydrogen
exhalation in response to acarbose.)
The authors propose that the amount of hydrogen gas produced as a
result of acarbose treatment was sufficient (judging from other
studies of hydrogen treatment) to reduce systemic oxidative stress.
Dietary Turmeric Increased Breath Hydrogen in Human Study
One way that may help to increase the hydrogen produced by your gut
microbiota is to eat foods rich in turmeric (such as curries) or to
take supplemental turmeric powder in capsules. (We didn’t include it
in our inulin formulation, which is designed to be taken as a powder
mixed with water or other liquid, because of the effect on flavor.) In
a human study,12 scientists tested the hypothesis that turmeric might
increase bowel motility by activating hydrogen-producing bacterial
flora in the colon. They had eight healthy subjects consume a curry
and rice dish either with or without turmeric. They then measured
breath hydrogen every 15 minutes for 6 hours by gas chromatography
with a semiconductor detector. They found that “[c]urry with turmeric
significantly increased the area under the curve of breath hydrogen
and shortened small-bowel transit time, compared with curry not
containing turmeric.”
The graph showing breath hydrogen vs. time after ingestion of the meal
showed that up to about 3 hours after eating, the turmeric containing
meal increased breath hydrogen significantly as compared to the meal
without turmeric. The curry without turmeric showed a slight increase
in breath hydrogen at about one hour after the meal but this increase
was not significant. “... breath hydrogen curves in both curry with
turmeric and turmeric knockout curry indicated two peaks. The initial
peak time, late peak time, and peak-to-peak time tended to be
shortened by turmeric, but this was not statistically significant.”12
The researchers didn’t restrict the ingestion of food by study
subjects that contained nondigestible carbohydrates before the
experiment except asking them to fast (drinking water was OK) for the
12 hours before the ingestion of the test meals.
To explain what caused the initial rise in breath hydrogen following a
meal (the postprandial state), the authors hypothesize that the so-
called gastro-ileal reflex causes the entry to non-absorbable
substrates into the colon. They further suggest that there could be
non-absorbable carbohydrates left in the ileum from the previous meal.
However, as they describe it, “the detailed mechanism of the initial
rise of breath hydrogen has not been established.” In their study, the
subjects eating the curry with turmeric ingested 0.5 g turmeric
containing 5.48 mg curcumin, 1.62 mg demethoxycurcumin, and 1.15 mg
bismethoxycurcumin, as well as other bioactive molecules present in
turmeric, such as zingiberene, curcumenole, curcmol, eugenol,
tetrahydroxycurcumin, triethylcurcumin, turmerin, turmerones, and
turmeronols. The researchers didn’t identify which of these components
was responsible for stimulating the increase in breath hydrogen.
One question we had was whether this study was really blind with
respect to the subjects eating the meals. Could they tell when a curry
contained no turmeric (which might effect both taste and color) and
might this knowledge have an effect on the outcome of the experiment?
Determining Normal Flatus Production: More Complicated Than You Think
Just to add a little note of frivolity here, we point out that there
have been studies (though not many) on the normal production of flatus
in humans. In one such study,13 scientists report that on a fiber free
diet (a liquid diet that contained no complex polysaccharides),
hydrogen was almost absent from the flatus—there was less than 1–3 ml/
24 hours of hydrogen in the flatus (one subject produced 21 ml) as
compared to their normal diet, less than 3% of the amount produced on
their normal diets. We suspect that the production of hydrogen in the
gut by resident bacteria may contribute significantly to how dietary
fiber provides important health benefits, such as reducing the risk of
colon cancer and cardiovascular disease.
The procedure used by the scientists in the study described in
reference #13 shows you what you have to go through just to determine
what might seem to some a silly physiological measurement. There were
ten healthy volunteers, five men and five women, aged 19–25 years
(betcha they were starving students doing it for a few bucks). Flatus
gas was collected by means of a flexible gas impermeable rubber tube
held in place with surgical tape or the subject’s underwear that was
attached at the other end to a plastic T-connector that was attached
to a laminated gas bag impermeable to gas diffusion. The patency of
the gas collection device was determined by having two volunteers
wearing the device and having the lower parts of their bodies
submerged in warm water for an hour during which time observers
checked for leaks (bubbling) and that gas was collected in the bags.
Gas was collected separately for overnight, for the fiber-free liquid
diet, as well as for a 24-hour period following test meals consisting
of 200 g of baked beans in tomato sauce. Detailed instructions (which
we will not go into here) were given to subjects as to how to proceed
when they needed to defecate. The authors note that the liquid diet
was sipped through a straw, resulting in some air swallowing, another
complication of the determination.
And so, in this way, the scientists got measurements for the
production of flatus by healthy young people. Of course, it could all
be done again (not with the same subjects of course) for getting
measurements of flatus produced by subjects consuming LCFOS-containing
diets. Another simpler way to determine how much hydrogen is generated
by colon bacteria is to measure breath hydrogen, as the hydrogen
generated in the colon is eventually mostly excreted from the body in
the lungs. You would still need to account for hydrogen taken up by
gut bacteria for their own use. As the authors note, slower passage of
gas through the colon allows more time for bacterial use of
fermentation gases.
Protection by Hydrogen Against Radiation
As the damage caused by radiation is largely a result of hydroxyl
radicals and hydrogen is a potent scavenger of hydroxyl radicals, it
is unsurprising that studies have reported protection by hydrogen
against radiation injury, though scavenging hydroxyl radicals is not
necessarily the only mechanism of its protective effects. One study14
explained that “[t]he gastrointestinal tract is one of the most
susceptible organs to radiation. As low as 1 Gy of radiation induces a
dramatic increase in apoptosis [programmed cell death] in mouse small
intestinal crypt within 3–6 h after exposure, predominantly in the
stem cell region.” In their study, the researchers tested the
protective effects of hydrogen-rich saline against gamma radiation to
cultured lymphocytes and the gastrointestinal tract in mice. In the
mice, for example, plasma SOD (superoxide dismutase) and GSH
(glutathione) concentrations were significantly higher at 12 hours
after irradiation in the hydrogen treated group as compared to the
controls. The plasma malondialdehyde (a lipid peroxidation product)
and intestinal 8-OHdG (a breakdown product of damaged DNA)
concentrations at 12 hours of irradiation in the hydrogen treated
group was significantly lower than that of the control group.
In another radiation study15 by the same group published in a
different journal that same year, hydrogen-rich water was tested for
its possible protection of the heart from damage by ionizing radiation
in mice. The authors hypothesized that the hydrogen-rich water would
protect against the hydroxyl radicals produced during irradiation.
They found decreased myocardium degeneration, decreased myocardium
malondialdehyde, decreased 8-hydroxydeoxyguanosine (8-OHdG) levels,
and increased levels of endogenous antioxidants in the hearts of
irradiated, hydrogen-water-treated mice as compared to irradiated but
untreated mice.
Thus, hydrogen might be a useful prophylactic under conditions where
you may be exposed to radiation. However, it is probably NOT a good
idea to use hydrogen at the same time you are receiving irradiation
therapy for cancer because of the risk that treatment effects (the
desired toxicity of the radiation to cancer cells) would be reduced.
Possible Protection by Hydrogen Against Mitochondrial Diseases
Involving Increased Oxidative Stress
One of the problems with the use of antioxidants in lifespan studies
is that most antioxidants are not able to enter the mitochondria,
where much of the generation of ROS (reactive oxygen species) takes
place. In fact, proponents of the mitochondrial theory of aging
propose that antioxidants have not generally been very effective in
lifespan studies precisely because they are unable to target ROS in
mitochondria and that mitochondria-targeted antioxidants are,
therefore, needed. Hydrogen may be a good way to overcome that problem
as it easily enters mitochondria.
A paper published early this year16 proposed the use of hydrogen “to
efficiently reduce oxidative stress with potential for the improvement
of mitochondrial diseases.” The author included very preliminary
evidence of possible improvements in small numbers of patients with
mitochondrial disorders treated with hydrogen. As the author noted,
the mechanism(s) for hydrogen’s beneficial effects are still unclear.
Improved Survival by Mice in a Model of Septic Shock
The authors of a recent paper17 report on the results of a study of
mice in a model of multiple organ dysfunction syndrome (MODS),
progressive deterioration of multiple organs as occurs, for example,
in patients with severe sepsis, septic shock, shock, multiple trauma,
severe burns, or pancreatitis. MODS is said to be the leading cause of
death in critically ill patients.17
The mice were subjected to treatment with zymosan, a substance derived
from the cell wall of the yeast Saccharomyces cerevisiae, that can
lead to life-threatening systemic inflammation. The authors had
already published a study18 in which hydrogen inhalation in septic
mice (sepsis induced by cecal ligation and puncture) had been shown to
significantly improve the survival rate and decrease organ damage. In
their study of zymosan-induced generalized inflammation,17 the
inhalation of 2% hydrogen for 60 minutes starting at 1 and 6 hours
after zymosan injection significantly improved the 14-day survival
rate of the injected mice from 10% (no hydrogen treatment) to 70%
(hydrogen inhalation). Moreover, the zymosan-injected hydrogen treated
mice had significant attenuation of damage markers and decreased
levels of oxidative products, increased activities of antioxidant
enzymes (such as superoxide dismutase), and reduced levels of early
and late proinflammatory cytokines (tumor necrosis factor alpha and
HMGB1) in serum and in tissue.17
CAUTIONARY NOTE ON THE CONSUMPTION OF HIGH FIBER DIETS
Fermentable Dietary Carbohydrates May Be Detrimental to Patients with
Irritable Bowel Syndrome
Patients with irritable bowel syndrome (IBS) appear to be sensitive to
increased “osmotic effects and gas production related to their rapid
fermentation by bacteria in the small and proximal large intestine.”19
In fact, IBS patients may improve on a diet with low quantities of
fermentable carbohydrates such as fructooligosaccharides. In a recent
study,19 researchers studied 15 healthy volunteers and 15 patients
with IBS for their response to either a low FODMAPs (Fermentable
Oligo- Di- and Mono-saccharides and Polyols) or high-FODMAPs diet. The
amount of hydrogen produced by subjects (the area under the curve) was
significantly higher during the high-FODMAPs diet as compared to the
low-FODMAP diet for both the healthy volunteers and the patients with
IBS. On the other hand, IBS patients produced more hydrogen gas than
healthy controls during both low-FODMAP and high-FODMAP diets. The
only noticeable change in the healthy subjects was increased flatus,
whereas the IBS subjects had significantly higher levels of typical
IBS symptoms (abdominal pain, bloating, and flatus). The IBS group,
but not the healthy controls, also had upper gastrointestinal symptoms
and lethargy during the high fructooligosaccharides diet.
Reduction of short-chain poorly absorbed carbohydrates in the diet
reduces symptoms of irritable bowel syndrome. Increased hydrogen
produced in IBS from short chain fructooligosaccharides influenced the
amount of hydrogen and methane produced and induced gastrointestinal
and systemic symptoms experienced by patients with IBS; normals only
experienced increased flatus. Hence, it may be inadvisable for IBS
patients to consume diets enriched in fermentable carbohydrates.
How Can YOU Benefit from Hydrogen Protection?
A 2% (by volume) mixture of hydrogen in air is not flammable or
explosive, but the equipment to reliably and accurately provide this
breathing mixture is expensive and must be maintained by skilled
technicians. We suspect that at some time in the future, hospitals
will make this available for use by patients suffering from a wide
variety of diseases involving free radical damage. Do NOT try this at
home (unless you really are a rocket scientist). Remember the
Hindenburg!
Water with hydrogen gas dissolved at saturation concentrations or less
is safe, but must either be made immediately before use or kept in a
tightly sealed glass or metal container. Hydrogen will quickly escape
through ordinary plastic bottles. A further disadvantage of hydrogen
water is that the duration of the hydrogen boost is short because the
ingested dissolved hydrogen will quickly escape through your lungs.
Nevertheless, animal experiments have shown substantial benefits from
this route of hydrogen administration.
Continuous colonic bacterial fermentation generation of hydrogen is
simple, safe, and provides sustained elevated tissue and blood levels
of dissolved hydrogen gas. We have chosen this method for our own use.
(Durk really is a rocket scientist and considered the 2% hydrogen in
air approach, but decided that the LCFOS method was a lot safer,
vastly less expensive, and just about as effective as hydrogen
inhalation.)
We have carefully studied the scientific literature as to the amount
of hydrogen produced, its time course of production, and the potential
for discomfort from producing too much hydrogen too fast too far up in
the gut. Of the many available fermentable fibers, we have chosen
LCFOS, which we have combined with a small amount of foam breaking
simethicone. We have found that without the latter, uncomfortable
abdominal distention is more likely. Worse yet, without the foam
breaker, one’s flatus can sometimes exit as a nasty brown fecal foam.
You really don’t want to go there ...
References
<snip>
Was this GREAT or what?
I want sweet smelling FARTs ... i wonder what people would think if we
became like those Canadians?
Farting Terrence and Philip
http://en.wikipedia.org/wiki/Terrance_and_Phillip#Terrance_and_Phillip
And
Chessypoofs puffs:
http://en.wikipedia.org/wiki/File:Cheesypoofs.png
randall...
JRStern
May 31, 2012, 7:14:16 PM5/31/12
to
On Thu, 31 May 2012 13:29:18 -0700 (PDT), randall <ranh...@aol.com>
wrote:
>Hydrogen Is a Selective Antioxidant, Scavenging Dangerous Radicals But
>Not Radicals Important as Physiological Signaling Molecules
...
So I guess it's true:
Beans, beans,
The musical fruit!
The more you eat
The more you toot!
The more you toot
The better you feel,
So have some beans
With every meal!
wrote:
>Hydrogen Is a Selective Antioxidant, Scavenging Dangerous Radicals But
>Not Radicals Important as Physiological Signaling Molecules
So I guess it's true:
Beans, beans,
The musical fruit!
The more you eat
The more you toot!
The more you toot
The better you feel,
So have some beans
With every meal!
randall
Jun 1, 2012, 1:47:31 PM6/1/12
to
On May 31, 4:14 pm, JRStern <JRSt...@foobar.invalid> wrote:
> On Thu, 31 May 2012 13:29:18 -0700 (PDT), randall <ranhu...@aol.com>
OK we KNOW Ben FRANKLIN had scrufy... aka --> psoriasis and ate beans
and like'd to FART.
How?
http://www.amazon.com/Fart-Proudly-Writings-Benjamin-Franklin/dp/089804801X
Fart Proudly: Writings of Benjamin Franklin You Never Read in School
[Paperback]
Read more reviews here:
http://books.google.com/books/about/Fart_Proudly.html?id=Z8I3bAlV25kC
I posted it: LOL
And you commented on it:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_frm/thread/d3d22c673aa3fc19/6a3c4c2caea2cab2?lnk=gst&q=randall+benjamin+franklin#6a3c4c2caea2cab2
(randall note: thanks to http://www.psoriasis-cure-now.org/ )
And BB posted this: May 28, 2012
Which brought BIG BEN FRANKLY back in to the veggy consciousness
GROOVE.
Either green eco freak-OH or obama carelessness to support commie
dumboism? LOL
http://en.wikipedia.org/wiki/Eco-socialism
Or a trip to experience freedom via CAPITALISM and hydrogen FUSION..
Not green, yet--> BRIGHT YELLOW from the SUN... on a blue orb with 7
billion
fusion machines.
BB posted this:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_frm/thread/bbd4297769db252a#
[...] Pythagoras, Socrates, Plato, Aristotle, Leonardo Da Vinci,
Isaac
Newton, Voltaire, Henry David Thoreau, George Bernard Shaw,____
Benjamin
Franklin ____, Thomas Edison, Dr. Albert Schweitzer, Mohandas
Karamchand
Gandhi. A more exhaustive list is here:
http://en.wikipedia.org/wiki/List_of_vegetarians
I ruthlessly stole this shorter one from Anthony Robbins.
<snip>
BB's link:
http://en.wikipedia.org/wiki/Famous_Vegetarians
[...] Benjamin Franklin (former)[101][nb 48]
Note: 101
http://books.google.co.uk/books?id=XsBJnpCwWLYC&pg=PA413#v=onepage&q&f=false
But most of these folks didn't live during a time of WANT? Or did
they?
Note : 48
[...] ^ Benjamin Franklin was a vegetarian only for a short period of
his life[516]
Note: 516 (below)
---------------
And I posted this (above link) regarding A--> Founding Father of the
United States.<----
Benjamin Franklin:
Sat, Jul 3 2010 6:43 pm
Subject: HaPPy 4th of JULY --from PSORiatic - BENJAMIN FRANKLIN -
Epigenetics - HDAC Inhibitors -TSA -
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/6b9909b46a0a5e2e
[...] http://www.psoriasis-cure-now.org/benfranklin-psoriasiswritings.php
[...] The Scurf appears to be compos’d of extreamly thin Scales one
upon another, which are white, and when rubb’d off dry, are light as
Bran. When the Skin is clear’d in the Bath, it looks red, and seems a
little elevated above the sound Skin that is around the Place; but it
is not sore: And in a few Hours after, it becomes dry, and feels
stiffned even in warm Water. The fine Lamina seem to be formed one
under another, and not to make an united thick Substance by adhering
together. In rubbing them off they separate, like Talc, each having a
Polish that shines.
His Head is now almost clear of the Disorder, as are also his Legs and
Thighs, and it seems diminish’d on his Arms. But it holds it s ground
on the Small of his Back and his Side.
There were in the Heighth of it some small Spots on his Hands and
Face, but they have quite disappear’d.
... He wishes to be inform’d Whether this troublesome Disease may not
be of Service to him in other Respects?
Whether it be safe to cure it?
If so, what are the medicines to be used?
And what ought to be his Regimen?
<snip>
Total hits for Ben in the p ng:
19 hits for ben Franklin: p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=+ben+franklin&start=0&
37 hits for : benjamin franklin - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=+benjamin+franklin&start=0&
8 hits: benjamin franklin scurfy - all groups:
https://groups.google.com/groups/search?qt_s=1&q=+benjamin+franklin+scurfy
yes...BEANs are magical... but how magical, is beyond my ken... till
NOW..
anti-ros?
who knew besides Ben Franklin and Durk/Sandy Pearson?
http://en.wikipedia.org/wiki/Beans,_Beans,_the_Musical_Fruit
[..] Lyrics
Various versions of the song exist.[3] These are some examples of the
lyrics:
Beans, beans, the musical fruit
The more you eat, the more you toot
The more you toot, the better you feel
So we have beans at every meal!1
or
Beans, beans, they're good for your heart
The more you eat, the more you fart
The more you fart, the happier/better you feel
So let's eat beans with every meal1
or
Beans, beans, they're good for your heart
The more you eat, the more you fart
The more you fart, the more you eat
The more you sit on the toilet seat
or
Beans, beans, they give you gas
They make you fart, and burn your ass
The more you eat, the more it hurts
So slow down your eating to stop the squirts
Beans, beans, the magical fruit the more you eat the more you toot
1This line can also be replaced with: "So eat them beans at every
meal"
<snip>
BEANS being somehow salient?
13 results for randall jumping bean's- p ng:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=randall+jumping+bean%27s&start=0&
Beans- 358 hits - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=bean%27s&start=0&
by date:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=bean%27s&start=0&scoring=d&
Bean's and Hydrogen! being salient:
854 hits -bean hydrogen- pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=bean%20hydrogen
11 of 854 have ROS:
http://www.ncbi.nlm.nih.gov/pubmed?term=bean%20hydrogen%20ros
But in the happy 4th of july post it says Ben ate mutton?
Yikes.. he's no 100% vegetarian!
I'm so let DOWN... i was really hoping.
But Ben was a LATE ONSET due to mutton.... I'm now thinking. (<w><G>)
yep and posted twice on the p ng:
2 results for benjamin franklin mutton
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=benjamin+franklin+mutton&start=0&
But really the same thing?
This says he ate salt beef and Fowl.
http://www.psoriasis-cure-now.org/benfranklin-psoriasiswritings.php
So tony robbins is scamming the vegetables?
Does tony expect this to go un-noticed in order to convert your
Gi tract to produce methane or hydrogen?
Is Tony that diabolical or is it angelic, perhaps?
^^^^^^^^^^^^^^^^^^^^^^^^^^^^LATE psor onset?
Ben Franklin and his scrufy like disease:
(Due to gut flora changes over 60 + years..?)
The nascent expanding microbiota your oughta has NOW
been recognized by Durk and Sandy as:
Things to COME!
Fusion inside of YOU via enterotype medicine!
"http://www.life-enhancement.com/article_template.asp?ID=2642
Hydrogen Therapy
The Emergence of A New Field of Medicine and How You Can Benefit From
It Right Now (with a little help from your friends ... READ ON) "
<snip>
5 hits: enterotypes (and growing albeit slowly to me. LOL)
http://www.ncbi.nlm.nih.gov/pubmed?term=enterotypes
And all goes back to using your microbiota to
balance Th1/Th2 immune inclinations:
http://en.wikipedia.org/wiki/T_helper_cell#Th1.2FTh2_Model_for_helper_T_cells
Imagine curing or simply treating all immune conditions (Th1 skew) and
cancer (Th2 skew) via your gut flora?
Simple as poPPing a pimple!
Th2 creates excess TREGs and causes cancer:
http://en.wikipedia.org/wiki/Regulatory_T_cells
And excessive Th1 cells generate TNF and IFN which attacks
the body and becomes autoimmune due to SFB and Th17.
http://en.wikipedia.org/wiki/T_helper_17_cell
Th17 --Induction by SFB in the small intestine
http://en.wikipedia.org/wiki/Segmented_filamentous_bacteria
Thank you Littman and Ivanov
http://www.ncbi.nlm.nih.gov/pubmed/20147894
Segmented filamentous bacteria take the stage.
pmid: 20147894
Dan, you guys deserve a Nobel prize for medicine
and peace? What the heck, it led to figuring out
how to prevent the Th2 skew in my mind using
Gut flora. (or imMucin type vaccines <w>)
But it's not this one is it?
Or is it another word for psoriasis?
http://www.ncbi.nlm.nih.gov/pubmed/17200412
J Exp Med. 2007 Jan 22;204(1):57-63. Epub 2007 Jan 2.
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like
disease.
Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, Hamann
A, Wagner H, Huehn J, Sparwasser T.
Source
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene,
Technische Universität München, 81675 Munich, Germany.
Abstract
The scurfy mutant mouse strain suffers from a fatal
lymphoproliferative disease leading to early death within 3-4 wk of
age. A frame-shift mutation of the forkhead box transcription factor
Foxp3 has been identified as the molecular cause of this multiorgan
autoimmune disease. Foxp3 is a central control element in the
development and function of regulatory T cells (T reg cells), which
are necessary for the maintenance of self-tolerance. However, it is
unclear whether dysfunction or a lack of T reg cells is etiologically
involved in scurfy pathogenesis and its human correlate, the IPEX
syndrome. We describe the generation of bacterial artificial
chromosome-transgenic mice termed "depletion of regulatory T
cell" (DEREG) mice expressing a diphtheria toxin (DT) receptor-
enhanced green fluorescent protein fusion protein under the control of
the foxp3 gene locus, allowing selective and efficient depletion of
Foxp3+ T reg cells by DT injection. Ablation of Foxp3+ T reg cells in
newborn DEREG mice led to the development of scurfy-like symptoms with
splenomegaly, lymphadenopathy, insulitis, and severe skin
inflammation. Thus, these data provide experimental evidence that the
absence of Foxp3+ T reg cells is indeed sufficient to induce a scurfy-
like phenotype. Furthermore, DEREG mice will allow a more precise
definition of the function of Foxp3+ T reg cells in immune reactions
in vivo.
PMID: 17200412
Free PMC Article
87 hits - Sparwasser T[Author] - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=Sparwasser%20T%5BAuthor%5D
Since 41 of 87 have foxp3 in them we know Sparwasser has insight in to
T regulatory cells (TREGs).
http://www.ncbi.nlm.nih.gov/pubmed?term=Sparwasser%20T%5BAuthor%5D%20foxp3
Did T reg cells go dormant in Ben Franklins Gut as he was a LATE
psoriasis onset?
Indicting a break in gut flora homeostasis of Bacteroides versus
Prevotella?
http://www.ncbi.nlm.nih.gov/pubmed/21885731
Linking long-term dietary patterns with gut microbial enterotypes.
Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, Bewtra
M, Knights D, Walters WA, Knight R, Sinha R, Gilroy E, Gupta K,
Baldassano R, Nessel L, Li H, Bushman FD, Lewis JD.
Science. 2011 Oct 7;334(6052):105-8. Epub 2011 Sep 1.
PMID: 21885731
OTOH FRANKLIN certainly had a nice LONG life, for his time period and
his skin wasn't much of a distraction:
http://en.wikipedia.org/wiki/Benjamin_Franklin
Note: 516
http://www.ivu.org/history/northam18/franklin.html
[...] In Part One of his autobiography Benjamin Franklin writes:
" When about 16 Years of Age, I happen'd to meet with a Book written
by one Tryon, recommending a Vegetable Diet. I determined to go into
it. My Brother being yet unmarried, did not keep House, but boarded
himself & his Apprentices in another family. My refusing to eat Flesh
occasioned an Inconveniency, and I was frequently chid for my
singularity. I made my self acquainted with Tryon's Manner of
preparing some of his Dishes, such as Boiling Potatoes, or Rice,
making Hasty Pudding, & a few others, and then propos'd to my Brother,
that if he would give me Weekly half the Money he paid for my Board, I
would board my self. He instantly agreed to it, and I presently found
that I could save half what he paid me. This was an additional Fund
for buying Books: But I had another Advantage in it. My Brother and
the rest going from the Printing House to their Meals, I remain'd
there alone, and dispatching presently my light Repast, (which often
was no more than a Bisket or a Slice of Bread, a Handful of Raisins or
a Tart from the Pastry Cook's, and a Glass of Water) had the rest of
the Time till their Return, for Study, in which I made the greater
Progress from that greater Clearness of Head & quicker Apprehension
which usually attend Temperance in Eating & Drinking. And now it was
that being on some Occasion made asham'd of my Ignorance in Figures,
which I had twice fail'd in learning when at School, I took Cocker's
Book of Arithmetick, & went thro' the whole of my self with great
Ease.--I also read Seller's & Sturmy's Books of Navigation, & became
acquainted with the little Geometry they contain, but never proceeded
far in that Science. -- And I read about this Time Locke On Human
Understanding and the Art of Thinking by Messrs du Port Royal."
Some 17 pages later Franklin discuss why he gave up vegetarianism:
" I believe I have omitted mentioning that in my first Voyage from
Boston, being becalm'd off Block Island, our People set about catching
Cod & hawl'd up a great many. Hitherto I had stuck to my Resolution of
not eating animal Food; and on this Occasion, I consider'd with my
Master Tryon, the taking every Fish as a kind of unprovoked Murder,
since none of them had or ever could do us any Injury that might
justify the Slaughter.--All this seem'd very reasonable.--But I had
formerly been a great Lover of Fish, & when this came hot out of the
Frying Pan, it smelt admirably well. I balanc'd some time between
Principle & inclination: till I recollected, that when the Fish were
opened, I saw smaller Fish taken out of their Stomachs:--Then, thought
I, if you eat one another, I don't see why we mayn't eat you. So I
din'd upon Cod very heartily and continu'd to eat with other People,
returning only now & then occasionally to a vegetable Diet. So
convenient a thing it is to be a reasonable Creature, since it enables
one to find or make a Reason for every thing one has a mind to do.--"
--Franklin Writings, Library of America (1987)
Of course we could add that the same argument couldn't be applied to
eating cows, pigs, and chickens. Also, when Franklin lived, there
weren't refrigerators or supermarkets and the large variety of
vegetarian food contained therein, including off season fruits and
vegetables imported from various parts of the world...
- contributed by David Hurwitz
<snip>
Of course it's always been ABOUT lowering the induction FLORA in my
case
by increasing lactic acid loving bacterium in the colon and L.
Plantarum
in the small intestines via fermented cabbage (sauerkraut + kimchi) .
Which i've said lowers pH in the colon to a slightly acidic pH.
As i've ONLY said that 40 times i'm surprised cruiser didn't go to
town:
40 results for randall slightly acidic ph - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=randall+slightly+acidic+ph&start=0&
Oh WELL
Time WILL TELL...
randall... creation of a hydrogen fusion reactor inside of You is
kewl! FART it uP!
> On Thu, 31 May 2012 13:29:18 -0700 (PDT), randall <ranhu...@aol.com>
> wrote:
>
> >Hydrogen Is a Selective Antioxidant, Scavenging Dangerous Radicals But
> >Not Radicals Important as Physiological Signaling Molecules
>
> ...
>
> So I guess it's true:
>
> Beans, beans,
> The musical fruit!
> The more you eat
> The more you toot!
> The more you toot
> The better you feel,
> So have some beans
> With every meal!
JRx,
>
> >Hydrogen Is a Selective Antioxidant, Scavenging Dangerous Radicals But
> >Not Radicals Important as Physiological Signaling Molecules
>
> ...
>
> So I guess it's true:
>
> Beans, beans,
> The musical fruit!
> The more you eat
> The more you toot!
> The more you toot
> The better you feel,
> So have some beans
> With every meal!
OK we KNOW Ben FRANKLIN had scrufy... aka --> psoriasis and ate beans
and like'd to FART.
How?
http://www.amazon.com/Fart-Proudly-Writings-Benjamin-Franklin/dp/089804801X
Fart Proudly: Writings of Benjamin Franklin You Never Read in School
[Paperback]
Read more reviews here:
http://books.google.com/books/about/Fart_Proudly.html?id=Z8I3bAlV25kC
I posted it: LOL
And you commented on it:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_frm/thread/d3d22c673aa3fc19/6a3c4c2caea2cab2?lnk=gst&q=randall+benjamin+franklin#6a3c4c2caea2cab2
(randall note: thanks to http://www.psoriasis-cure-now.org/ )
And BB posted this: May 28, 2012
Which brought BIG BEN FRANKLY back in to the veggy consciousness
GROOVE.
Either green eco freak-OH or obama carelessness to support commie
dumboism? LOL
http://en.wikipedia.org/wiki/Eco-socialism
Or a trip to experience freedom via CAPITALISM and hydrogen FUSION..
Not green, yet--> BRIGHT YELLOW from the SUN... on a blue orb with 7
billion
fusion machines.
BB posted this:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_frm/thread/bbd4297769db252a#
[...] Pythagoras, Socrates, Plato, Aristotle, Leonardo Da Vinci,
Isaac
Newton, Voltaire, Henry David Thoreau, George Bernard Shaw,____
Benjamin
Franklin ____, Thomas Edison, Dr. Albert Schweitzer, Mohandas
Karamchand
Gandhi. A more exhaustive list is here:
http://en.wikipedia.org/wiki/List_of_vegetarians
I ruthlessly stole this shorter one from Anthony Robbins.
<snip>
BB's link:
http://en.wikipedia.org/wiki/Famous_Vegetarians
[...] Benjamin Franklin (former)[101][nb 48]
Note: 101
http://books.google.co.uk/books?id=XsBJnpCwWLYC&pg=PA413#v=onepage&q&f=false
But most of these folks didn't live during a time of WANT? Or did
they?
Note : 48
[...] ^ Benjamin Franklin was a vegetarian only for a short period of
his life[516]
Note: 516 (below)
---------------
And I posted this (above link) regarding A--> Founding Father of the
United States.<----
Benjamin Franklin:
Sat, Jul 3 2010 6:43 pm
Subject: HaPPy 4th of JULY --from PSORiatic - BENJAMIN FRANKLIN -
Epigenetics - HDAC Inhibitors -TSA -
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/6b9909b46a0a5e2e
[...] http://www.psoriasis-cure-now.org/benfranklin-psoriasiswritings.php
[...] The Scurf appears to be compos’d of extreamly thin Scales one
upon another, which are white, and when rubb’d off dry, are light as
Bran. When the Skin is clear’d in the Bath, it looks red, and seems a
little elevated above the sound Skin that is around the Place; but it
is not sore: And in a few Hours after, it becomes dry, and feels
stiffned even in warm Water. The fine Lamina seem to be formed one
under another, and not to make an united thick Substance by adhering
together. In rubbing them off they separate, like Talc, each having a
Polish that shines.
His Head is now almost clear of the Disorder, as are also his Legs and
Thighs, and it seems diminish’d on his Arms. But it holds it s ground
on the Small of his Back and his Side.
There were in the Heighth of it some small Spots on his Hands and
Face, but they have quite disappear’d.
... He wishes to be inform’d Whether this troublesome Disease may not
be of Service to him in other Respects?
Whether it be safe to cure it?
If so, what are the medicines to be used?
And what ought to be his Regimen?
<snip>
Total hits for Ben in the p ng:
19 hits for ben Franklin: p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=+ben+franklin&start=0&
37 hits for : benjamin franklin - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=+benjamin+franklin&start=0&
8 hits: benjamin franklin scurfy - all groups:
https://groups.google.com/groups/search?qt_s=1&q=+benjamin+franklin+scurfy
yes...BEANs are magical... but how magical, is beyond my ken... till
NOW..
anti-ros?
who knew besides Ben Franklin and Durk/Sandy Pearson?
http://en.wikipedia.org/wiki/Beans,_Beans,_the_Musical_Fruit
[..] Lyrics
Various versions of the song exist.[3] These are some examples of the
lyrics:
Beans, beans, the musical fruit
The more you eat, the more you toot
The more you toot, the better you feel
So we have beans at every meal!1
or
Beans, beans, they're good for your heart
The more you eat, the more you fart
The more you fart, the happier/better you feel
So let's eat beans with every meal1
or
Beans, beans, they're good for your heart
The more you eat, the more you fart
The more you fart, the more you eat
The more you sit on the toilet seat
or
Beans, beans, they give you gas
They make you fart, and burn your ass
The more you eat, the more it hurts
So slow down your eating to stop the squirts
Beans, beans, the magical fruit the more you eat the more you toot
1This line can also be replaced with: "So eat them beans at every
meal"
<snip>
BEANS being somehow salient?
13 results for randall jumping bean's- p ng:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=randall+jumping+bean%27s&start=0&
Beans- 358 hits - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=bean%27s&start=0&
by date:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=bean%27s&start=0&scoring=d&
Bean's and Hydrogen! being salient:
854 hits -bean hydrogen- pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=bean%20hydrogen
11 of 854 have ROS:
http://www.ncbi.nlm.nih.gov/pubmed?term=bean%20hydrogen%20ros
But in the happy 4th of july post it says Ben ate mutton?
Yikes.. he's no 100% vegetarian!
I'm so let DOWN... i was really hoping.
But Ben was a LATE ONSET due to mutton.... I'm now thinking. (<w><G>)
yep and posted twice on the p ng:
2 results for benjamin franklin mutton
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=benjamin+franklin+mutton&start=0&
But really the same thing?
This says he ate salt beef and Fowl.
http://www.psoriasis-cure-now.org/benfranklin-psoriasiswritings.php
So tony robbins is scamming the vegetables?
Does tony expect this to go un-noticed in order to convert your
Gi tract to produce methane or hydrogen?
Is Tony that diabolical or is it angelic, perhaps?
^^^^^^^^^^^^^^^^^^^^^^^^^^^^LATE psor onset?
Ben Franklin and his scrufy like disease:
(Due to gut flora changes over 60 + years..?)
The nascent expanding microbiota your oughta has NOW
been recognized by Durk and Sandy as:
Things to COME!
Fusion inside of YOU via enterotype medicine!
"http://www.life-enhancement.com/article_template.asp?ID=2642
Hydrogen Therapy
The Emergence of A New Field of Medicine and How You Can Benefit From
It Right Now (with a little help from your friends ... READ ON) "
5 hits: enterotypes (and growing albeit slowly to me. LOL)
http://www.ncbi.nlm.nih.gov/pubmed?term=enterotypes
And all goes back to using your microbiota to
balance Th1/Th2 immune inclinations:
http://en.wikipedia.org/wiki/T_helper_cell#Th1.2FTh2_Model_for_helper_T_cells
Imagine curing or simply treating all immune conditions (Th1 skew) and
cancer (Th2 skew) via your gut flora?
Simple as poPPing a pimple!
Th2 creates excess TREGs and causes cancer:
http://en.wikipedia.org/wiki/Regulatory_T_cells
And excessive Th1 cells generate TNF and IFN which attacks
the body and becomes autoimmune due to SFB and Th17.
http://en.wikipedia.org/wiki/T_helper_17_cell
Th17 --Induction by SFB in the small intestine
http://en.wikipedia.org/wiki/Segmented_filamentous_bacteria
Thank you Littman and Ivanov
http://www.ncbi.nlm.nih.gov/pubmed/20147894
Segmented filamentous bacteria take the stage.
pmid: 20147894
Dan, you guys deserve a Nobel prize for medicine
and peace? What the heck, it led to figuring out
how to prevent the Th2 skew in my mind using
Gut flora. (or imMucin type vaccines <w>)
But it's not this one is it?
Or is it another word for psoriasis?
http://www.ncbi.nlm.nih.gov/pubmed/17200412
J Exp Med. 2007 Jan 22;204(1):57-63. Epub 2007 Jan 2.
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like
disease.
Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, Hamann
A, Wagner H, Huehn J, Sparwasser T.
Source
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene,
Technische Universität München, 81675 Munich, Germany.
Abstract
The scurfy mutant mouse strain suffers from a fatal
lymphoproliferative disease leading to early death within 3-4 wk of
age. A frame-shift mutation of the forkhead box transcription factor
Foxp3 has been identified as the molecular cause of this multiorgan
autoimmune disease. Foxp3 is a central control element in the
development and function of regulatory T cells (T reg cells), which
are necessary for the maintenance of self-tolerance. However, it is
unclear whether dysfunction or a lack of T reg cells is etiologically
involved in scurfy pathogenesis and its human correlate, the IPEX
syndrome. We describe the generation of bacterial artificial
chromosome-transgenic mice termed "depletion of regulatory T
cell" (DEREG) mice expressing a diphtheria toxin (DT) receptor-
enhanced green fluorescent protein fusion protein under the control of
the foxp3 gene locus, allowing selective and efficient depletion of
Foxp3+ T reg cells by DT injection. Ablation of Foxp3+ T reg cells in
newborn DEREG mice led to the development of scurfy-like symptoms with
splenomegaly, lymphadenopathy, insulitis, and severe skin
inflammation. Thus, these data provide experimental evidence that the
absence of Foxp3+ T reg cells is indeed sufficient to induce a scurfy-
like phenotype. Furthermore, DEREG mice will allow a more precise
definition of the function of Foxp3+ T reg cells in immune reactions
in vivo.
PMID: 17200412
Free PMC Article
87 hits - Sparwasser T[Author] - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=Sparwasser%20T%5BAuthor%5D
Since 41 of 87 have foxp3 in them we know Sparwasser has insight in to
T regulatory cells (TREGs).
http://www.ncbi.nlm.nih.gov/pubmed?term=Sparwasser%20T%5BAuthor%5D%20foxp3
Did T reg cells go dormant in Ben Franklins Gut as he was a LATE
psoriasis onset?
Indicting a break in gut flora homeostasis of Bacteroides versus
Prevotella?
http://www.ncbi.nlm.nih.gov/pubmed/21885731
Linking long-term dietary patterns with gut microbial enterotypes.
Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, Bewtra
M, Knights D, Walters WA, Knight R, Sinha R, Gilroy E, Gupta K,
Baldassano R, Nessel L, Li H, Bushman FD, Lewis JD.
Science. 2011 Oct 7;334(6052):105-8. Epub 2011 Sep 1.
PMID: 21885731
OTOH FRANKLIN certainly had a nice LONG life, for his time period and
his skin wasn't much of a distraction:
http://en.wikipedia.org/wiki/Benjamin_Franklin
Note: 516
http://www.ivu.org/history/northam18/franklin.html
[...] In Part One of his autobiography Benjamin Franklin writes:
" When about 16 Years of Age, I happen'd to meet with a Book written
by one Tryon, recommending a Vegetable Diet. I determined to go into
it. My Brother being yet unmarried, did not keep House, but boarded
himself & his Apprentices in another family. My refusing to eat Flesh
occasioned an Inconveniency, and I was frequently chid for my
singularity. I made my self acquainted with Tryon's Manner of
preparing some of his Dishes, such as Boiling Potatoes, or Rice,
making Hasty Pudding, & a few others, and then propos'd to my Brother,
that if he would give me Weekly half the Money he paid for my Board, I
would board my self. He instantly agreed to it, and I presently found
that I could save half what he paid me. This was an additional Fund
for buying Books: But I had another Advantage in it. My Brother and
the rest going from the Printing House to their Meals, I remain'd
there alone, and dispatching presently my light Repast, (which often
was no more than a Bisket or a Slice of Bread, a Handful of Raisins or
a Tart from the Pastry Cook's, and a Glass of Water) had the rest of
the Time till their Return, for Study, in which I made the greater
Progress from that greater Clearness of Head & quicker Apprehension
which usually attend Temperance in Eating & Drinking. And now it was
that being on some Occasion made asham'd of my Ignorance in Figures,
which I had twice fail'd in learning when at School, I took Cocker's
Book of Arithmetick, & went thro' the whole of my self with great
Ease.--I also read Seller's & Sturmy's Books of Navigation, & became
acquainted with the little Geometry they contain, but never proceeded
far in that Science. -- And I read about this Time Locke On Human
Understanding and the Art of Thinking by Messrs du Port Royal."
Some 17 pages later Franklin discuss why he gave up vegetarianism:
" I believe I have omitted mentioning that in my first Voyage from
Boston, being becalm'd off Block Island, our People set about catching
Cod & hawl'd up a great many. Hitherto I had stuck to my Resolution of
not eating animal Food; and on this Occasion, I consider'd with my
Master Tryon, the taking every Fish as a kind of unprovoked Murder,
since none of them had or ever could do us any Injury that might
justify the Slaughter.--All this seem'd very reasonable.--But I had
formerly been a great Lover of Fish, & when this came hot out of the
Frying Pan, it smelt admirably well. I balanc'd some time between
Principle & inclination: till I recollected, that when the Fish were
opened, I saw smaller Fish taken out of their Stomachs:--Then, thought
I, if you eat one another, I don't see why we mayn't eat you. So I
din'd upon Cod very heartily and continu'd to eat with other People,
returning only now & then occasionally to a vegetable Diet. So
convenient a thing it is to be a reasonable Creature, since it enables
one to find or make a Reason for every thing one has a mind to do.--"
--Franklin Writings, Library of America (1987)
Of course we could add that the same argument couldn't be applied to
eating cows, pigs, and chickens. Also, when Franklin lived, there
weren't refrigerators or supermarkets and the large variety of
vegetarian food contained therein, including off season fruits and
vegetables imported from various parts of the world...
- contributed by David Hurwitz
<snip>
Of course it's always been ABOUT lowering the induction FLORA in my
case
by increasing lactic acid loving bacterium in the colon and L.
Plantarum
in the small intestines via fermented cabbage (sauerkraut + kimchi) .
Which i've said lowers pH in the colon to a slightly acidic pH.
As i've ONLY said that 40 times i'm surprised cruiser didn't go to
town:
40 results for randall slightly acidic ph - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=randall+slightly+acidic+ph&start=0&
Oh WELL
Time WILL TELL...
randall... creation of a hydrogen fusion reactor inside of You is
kewl! FART it uP!
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