Re: Supplements for Neuropathy
Andrew B. Chung, MD/PhD
> What supplements provide relief from polyneuropathy? Would the
> following be the most important? Already doing paleo-type diet,
> moderate exercise and multi-vitamins.
>
> Benfotiamine
> Vitamin B6 (P-5-P)
> R-Lipoic Acid
> NAC
> Acetyl-L-Carnitine
In our collective clinical experience, no supplement(s) can overcome
the deleterious effect that PIACs from VAT (black fat) has on the
fragile efferent fibers of sensory neurons thereby causing the
peripheral neuropathy.
Be hungry... be healthy... be hungrier... be healthier...
Prayerfully in the awesome name of LORD Jesus Christ,
Andrew <><
--
http://groups.google.com/group/sci.med.cardiology/msg/cd9918679e6b3d6f?
jay
Good advice. I try to fast on Sundays.
The formation of peripheral myelin protein 22 aggregates is hindered
by the enhancement of autophagy and expression of cytoplasmic
chaperones.
The accumulation of misfolded proteins is associated with various
neurodegenerative conditions. Peripheral myelin protein 22 (PMP22) is
a hereditary neuropathy-linked, short-lived molecule that forms
aggresomes when the proteasome is inhibited or the protein is mutated.
We previously showed that the removal of pre-existing PMP22 aggregates
is assisted by autophagy. Here we examined whether the accumulation of
such aggregates could be suppressed by experimental induction of
autophagy and/or chaperones. Enhancement of autophagy during
proteasome inhibition hinders protein aggregate formation and
correlates with a reduction in accumulated proteasome substrates.
Conversely, simultaneous inhibition of autophagy and the proteasome
augments the formation of aggregates. An increase of heat shock
protein levels by geldanamycin treatment or heat shock preconditioning
similarly hampers aggresome formation. The beneficial effects of
autophagy and chaperones in preventing the accumulation of misfolded
PMP22 are additive and provide a potential avenue for therapeutic
approaches in hereditary neuropathies linked to PMP22 mutations. PMID:
17174099
Andrew B. Chung, MD/PhD
Fasting can result in hyperketonemia, which suppresses hunger.
It is only when we are hungrier, that our bodies "burn" away the VAT
(black fat):
http://groups.google.com/group/sci.med.cardiology/msg/3558812d72ab4e17?
Prayerfully in the awesome name of LORD Jesus Christ,
Andrew <><
--
http://groups.google.com/group/sci.med.cardiology/msg/ede50caf5f7c3989?
timo...@my-deja.com
1999. There may be more positive evidence since then. High pyridoxine
supplementation usually in excess of 600 mg./day has resulted in
neuropathy in a small number of people. They were taking it for carpal
tunnel syndrome. They were also taking it w/o other B vitamins and the
condition was reversible. Personally I have taken 1000 mg/d for
extended periods w/o side effects. It's probably best to steer clear
of supplementation IMHO.
Exp Clin Endocrinol Diabetes. 1999;107(7):421-30.Links
Alpha-lipoic acid in the treatment of diabetic polyneuropathy in
Germany: current evidence from clinical trials.Ziegler D, Reljanovic
M, Mehnert H, Gries FA.
Diabetes-Forschungsinstitut an der Heinrich-Heine-Universität,
Düsseldorf, Germany. dan.z...@dfi.uni-duesseldorf.de
Diabetic neuropathy represents a major health problem, as it is
responsible for substantial morbidity, increased mortality, and
impaired quality of life. Near-normoglycaemia is now generally
accepted as the primary approach to prevention of diabetic neuropathy,
but is not achievable in a considerable number of patients. In the
past two decades several medical treatments that exert their effects
despite hyperglycaemia have been derived from the experimental
pathogenetic concepts of diabetic neuropathy. Such compounds have been
designed to improve or slow the progression of the neuropathic process
and are being evaluated in clinical trials, but with the exception of
alpha-lipoic acid (thioctic acid) which is available in Germany, none
of these drugs is currently available in clinical practice. Here we
review the current evidence from the clinical trials that assessed the
therapeutic efficacy and safety of thioctic acid in diabetic
polyneuropathy. Thus far, 15 clinical trials have been completed using
different study designs, durations of treatment, doses, sample sizes,
and patient populations. Within this variety of clinical trials, those
with beneficial effects of thioctic acid on either neuropathic
symptoms and deficits due to polyneuropathy or reduced heart rate
variability resulting from cardiac autonomic neuropathy used doses of
at least 600 mg per day. The following conclusions can be drawn from
the recent controlled clinical trials. 1.) Short-term treatment for 3
weeks using 600 mg of thioctic acid i.v. per day appears to reduce the
chief symptoms of diabetic polyneuropathy. A 3-week pilot study of
1800 mg per day given orally indicates that the therapeutic effect may
be independent of the route of administration, but this needs to be
confirmed in a larger sample size. 2.) The effect on symptoms is
accompanied by an improvement of neuropathic deficits. 3.) Oral
treatment for 4-7 months tends to reduce neuropathic deficits and
improves cardiac autonomic neuropathy. 4.) Preliminary data over 2
years indicate possible long-term improvement in motor and sensory
nerve conduction in the lower limbs. 5.) Clinical and postmarketing
surveillance studies have revealed a highly favourable safety profile
of the drug. Based on these findings, a pivotal long-term multicenter
trial of oral treatment with thioctic acid (NATHAN I Study) is being
conducted in North America and Europe aimed at slowing the progression
of diabetic polyneuropathy using a clinically meaningful and reliable
primary outcome measure that combines clinical and neurophysiological
assessment.
PMID: 10595592 [PubMed - indexed for MEDLINE]
Andrew B. Chung, MD/PhD
>
> Here is the result of small clinical trials in humans in Germany as of
> 1999. There may be more positive evidence since then. High pyridoxine
> supplementation usually in excess of 600 mg./day has resulted in
> neuropathy in a small number of people. They were taking it for carpal
> tunnel syndrome. They were also taking it w/o other B vitamins and the
> condition was reversible. Personally I have taken 1000 mg/d for
> extended periods w/o side effects. It's probably best to steer clear
> of supplementation IMHO.
A GI tract including its bacterial flora that is processing an optimal
amount of food each day is one that is capable, with GOD's blessing,
of extracting and supplying the required nutrients (macro, micro, and
trace) in a precisely regulated fashion to meet the specific highly
variable requirements of the body.
By GOD's design, there is one optimal amount for every adult as
denoted by the Hebrew word "omer" (Exodus 16:16).
Have been eating HIS optimal amount since 1997 so that I can
personally testify that GOD is absolutely right in HIS design.
Laus Deo ! ! !
Be hungry... be healthy... be hungrier... be euglycemic...
Prayerfully in the awesome name of LORD Jesus Christ,
Andrew <><
--
http://groups.google.com/group/sci.med.cardiology/msg/3558812d72ab4e17?
Marshall Price
> jay wrote:
>> What supplements provide relief from polyneuropathy? Would the
>> following be the most important? Already doing paleo-type diet,
>> moderate exercise and multi-vitamins.
>>
>> Benfotiamine
>> Vitamin B6 (P-5-P)
>> R-Lipoic Acid
>> NAC
>> Acetyl-L-Carnitine
>
> In our collective clinical experience, no supplement(s) can overcome
> the deleterious effect that PIACs from VAT (black fat) has on the
> fragile efferent fibers of sensory neurons thereby causing the
> peripheral neuropathy.
What are PIACs?
--
Marshall Price of Miami
Known to Yahoo as d021317c
Andrew B. Chung, MD/PhD
> Andrew, in the Holy Spirit, boldly wrote:
> > jay wrote:
> >> What supplements provide relief from polyneuropathy? Would the
> >> following be the most important? Already doing paleo-type diet,
> >> moderate exercise and multi-vitamins.
> >>
> >> Benfotiamine
> >> Vitamin B6 (P-5-P)
> >> R-Lipoic Acid
> >> NAC
> >> Acetyl-L-Carnitine
> >
> > In our collective clinical experience, no supplement(s) can overcome
> > the deleterious effect that PIACs from VAT (black fat) has on the
> > fragile efferent fibers of sensory neurons thereby causing the
> > peripheral neuropathy.
>
> What are PIACs?
Pro-Inflammatory AdipoCytokines
Be hungry... be healthy... be hungrier... be euglycemic...
Prayerfully in the awesome name of LORD Jesus Christ,
Andrew <><
--
http://groups.google.com/group/sci.med.cardiology/msg/3558812d72ab4e17?
Marshall Price
Those links don't mention "VAT" or "black."
Also, are you aware of the fact that when "lord" is written in upper
case, that signals that it is being used as a substitute for the
tetragrammaton? "LORD Jesus Christ" is entirely different from "Lord
Jesus Christ," and it seems to imply that the author opposes the
doctrine of the trinity.
"KING," on the other hand, means nothing, except that the author
enjoys flouting typographical conventions.
Marshall Price
> Here is the result of small clinical trials in humans in Germany as of
> 1999. There may be more positive evidence since then. High pyridoxine
> supplementation usually in excess of 600 mg./day has resulted in
> neuropathy in a small number of people. They were taking it for carpal
> tunnel syndrome. They were also taking it w/o other B vitamins and the
> condition was reversible. Personally I have taken 1000 mg/d for
> extended periods w/o side effects. It's probably best to steer clear
> of supplementation IMHO.
Taking large amounts of B6 without extra B2 is a no-no.
Marshall Price
> denoted by the Hebrew word "omer" (Exodus 16:16).
Why not save us the trouble of looking it up?
Andrew B. Chung, MD/PhD
http://groups.google.com/group/sci.med.cardiology/msg/f20e435e3ec529db?
Be hungry... be healthy... be hungrier... be euglycemic...
Prayerfully in the awesome name of LORD Jesus Christ,
Andrew <><
--
http://groups.google.com/group/sci.med.cardiology/msg/3558812d72ab4e17?
Andrew B. Chung, MD/PhD
> Andrew, in the Holy Spirit, wrote in part:
>
> > By GOD's design, there is one optimal amount for every adult as
> > denoted by the Hebrew word "omer" (Exodus 16:16).
>
> Why not save us the trouble of looking it up?
"Each one is to gather as much as he needs. Take an omer for each
person you have in your tent." -- LORD Almighty GOD (Exodus 16:16)
16 + 16 = 32
Reminding us that the one optimal amount is 32 ounces.
Truth
Chung has been told many times that scholars agree that an omer is a
biblical measure of volume equivalent to approximately 2 liters or
quarts. Yet he is fixated on the fact that the verse mentioning an
omer as being the right amount of food for the Israelites wandering in
the desert is Exodus 16:16. He therefore twists this to be numerology
"proof" that an omer is 2 pounds or 32 ounces.
Chung initially fixated on the 2 pounds per person per day diet when
he saw some IMAX film about Everest climbers and mistakenly came away
with the idea that those climbers ate only 2 pounds of food per day.
As his mental illness progressed and he became more fixated on quasi-
Christianity, this 2 pounds a day morphed from being inspired by the
IMAX Everest film into being inspired by Chung's lone ranger,
idiosyncratic and mistaken interpretation of the biblical measure of
volume, an omer.
Chung is a disgraced ex-cardiologist who lost his first post-
cardiology fellowship job in Ocala, Florida in about 3 months and has
not worked since. He is a pathological, regressed narcissist and a
known Usenet k00k and a pathological liar.
Respond to his posts for amusement value only. Nothing that he says is
evidence-based.
Marshall Price
>> Andrew, in the Holy Spirit, wrote in part:
>>
>>> By GOD's design, there is one optimal amount for every adult as
>>> denoted by the Hebrew word "omer" (Exodus 16:16).
>> Why not save us the trouble of looking it up?
>
> "Each one is to gather as much as he needs. Take an omer for each
> person you have in your tent." -- LORD Almighty GOD (Exodus 16:16)
>
> 16 + 16 = 32
>
> Reminding us that the one optimal amount is 32 ounces.
Huh?
You take the numbers from the chapter and verse? But those aren't in
the original. Then you add them together? Why? Why "ounces"?
"Optimal amount" of what? Manna? Per day?
An omer is a tenth of an ephah, which is about a bushel, which is
about 32 quarts, so an omer (as a measure of grain) is about 3.2 quarts.
That's "an optimal amount" for a day?
Why take something God said to the Israelites gathering manna in the
desert (if I recall correctly) as his "design" for "every adult"? And
where are you getting manna, anyway?
Marshall Price
Well, what do you know! I wonder whether it's occurred to him that
two pounds of butter is different from two pounds of watermelon.
Roman soldiers used to march all day on a handful of dry wheat, but
they never read the Bible, so what did they know? ;-)
Andrew B. Chung, MD/PhD
>
> Huh ?
May reading the following help you understand:
Life in these industrialized countries is essentially life in blessed feed lots.
Thus, it remains smarter to simply eat less, down to the right amount:
Be hungry... be healthy... be hungrier... be healthier:
http://TheWellnessFoundation.com/BeHealthier
Prayerfully in the infinite power and might of the Holy Spirit,
Andrew <><
--
Andrew B. Chung, MD/PhD
Lawful steward of http://EmoryCardiology.com
A latter-day disciple of the KING of kings and LORD of lords.
http://HeartMDPhD.com/HolySpirit/DiscipleNow
Andrew B. Chung, MD/PhD
> Andrew, in the Holy Spirit, boldly wrote:
> > neighbor Marshall Price wrote:
> >> Andrew, in the Holy Spirit, wrote in part:
> >>
> >>> By GOD's design, there is one optimal amount for every adult as
> >>> denoted by the Hebrew word "omer" (Exodus 16:16).
>
> >> Why not save us the trouble of looking it up?
> >
> > "Each one is to gather as much as he needs. Take an omer for each
> > person you have in your tent." -- LORD Almighty GOD (Exodus 16:16)
> >
> > 16 + 16 = 32
> >
> > Reminding us that the one optimal amount is 32 ounces.
>
> Huh?
http://groups.google.com/group/sci.med.cardiology/msg/cf518e37250dcbe6?
Be hungry... be healthy... be hungrier... be healthier...
Uncle Frederik
>>> 16 + 16 = 32
>>>
>>> Reminding us that the one optimal amount is 32 ounces.
We have received new footage in which we see that when Chung was born
he popped out first and then a small scale popped out later. The scale
measured 32 ounces only.
This reminds us that 32 ounces is indeed the predetermined amount by
God, as chung has been claiming.
>> Huh?
>
> http://groups.google.com/group/sci.med.cardiology/...
> Be hungry... be healthy... be hungrier... be healthier...
Wrong!
Be thirsty.. be healthy .. be thirstier ... be healthier...