Today's seminar in Charlotte really got me going again on a joint paper
with two set theorists. Two weeks from now we will be ready to see whether
it is time to "cash in our chips" and not try for more theorems in addition
to the sweeping ones we already have.
This is way past my usual bedtime, so I'm skipping over one set of questions for now.
On Thursday, June 8, 2023 at 10:25:48 PM UTC-4, John Harshman wrote:
> On 6/8/23 7:04 PM,
peter2...@gmail.com wrote:
> > On Thursday, June 8, 2023 at 8:25:47 PM UTC-4,
peter2...@gmail.com wrote:
> >> I've been occupied on other threads these last three days, but now I return
> >> here to post on another misconception, much more widespread than
> >> the one I talk about in the OP: it is the one that claims that ID theory is not testable.
> >>
> >> This may be true of some published examples, but it is demonstrably false where five
> >> competing hypotheses of the origin of life [OOL] *on* *earth* are concerned.
> >> I have posted many times about them before, but I think few people
> >> are aware of the last three as being unavoidably in competition with each other
> >> as well as with the other two.
> >
> > The following, then, are mutually incompatible hypotheses for the origin of life (OOL) on earth:
> >
> >> (1) [by far the most popular] It took place on earth from beginning to end.
> >> (2) Undirected panspermia (e.g. that of Arrhenius, refined by Hoyle and Wickramasinghe):
> >> life originating on other planets and brought to earth by comets or meteorites.
> >> (3) The Xordaxian directed panspermia (DP) hypothesis.
> >> (4) The Golian DP hypothesis.
> >> (5) The Throomian DP hypothesis.
> >
> > The last three are incompatible with each other because they give very different
> > starting points for the design that produced the microorganisms that were sent to earth.
> >
> >> These are all purely naturalistic. The first two assume no intelligent design at all,
> >> while (3) to (5) assume increasing degrees of design by naturally evolved beings on about
> >> our own level of intelligence, on exoplanets at a time when our solar system was less than
> >> a gigayear old (ca. 3.5 gigayears ago, to pick a nice round number).
> >>
> >> The hypothesized physical differences between them makes their roles incompatible.
> >> They involve some knowledge of biochemistry, and to keep this post reasonably short,
> >> I will postpone a description of the Golians and the Throomians to my next post.
> >
> > This is that "next post," and I'll begin with a partial, incomplete description: the species
> > described in (3) and (4) both used protein enzymes to do the bulk of the work of their cells, just like in our cells.
> > On the other hand Throomians (5) lacked protein enzmyes. The work that went on in
> > their cells was done by RNA enzymes, known as ribozymes.
> >
> > We have many huge ribozymes known as ribosomes in almost all our cells [red blood cells may be an exception].
> > They are part of the mechanism for producing new protein molecules from amino acids -- but this
> > is getting a little ahead of ourselves. What's most relevant here is that we have only a handful
> > of other kinds of ribozymes occurring naturally in our bodies, whereas they were the *only* enzymes
> > the Throomians had in their bodies.
> >
> > This gives (5) a huge relative advantage over (3) and (4) in their competition with alternative (1).
> > I have often compared the origin of life as we know it, according to alternative (1) as a 100-floor skyscraper
> > with the simplest free-living prokaryotes (bacteria) on the top floor.
> >
> > On the other hand, the analogues of bacteria on the planet Throom
> > had genomes of RNA and DNA and ribozymes (including ribosomes) for
> > producing structural proteins (much simpler than protein enzymes).
> > This puts them somewhere between the 50th and 70th floors depending
> > on how advanced their overall genomes were. Earth OOL,
> > believed in by almost everyone here to conform to alternative (1),
> > had to go through a similar stage according to the conventional wisdom.
> >
> > The science of OOL has an enormous obstacle to overcome here: the "protein
> > takeover," replacing almost all ribozymes with protein enzymes that do the same work.
> > So we are still far from the 100th floor, with no idea of how the "protein takeover"
> > could have occurred in the mere 500 million years or less allotted for it on earth.
<snip alluded to above>
> > The Throomian hypothesis circumvents all this: it makes the Throomians responsible
> > for producing this protein takeover step by step in their labs. It was a huge
> > undertaking, probably spanning the equivalent of centuries or millennia in
> > the pace at which they lived their lives. But it was child's play compared to
> > what alternative (1) demands: no intelligent intervention whatsoever.
> Why would they do this? If the idea was to seed a planet with life
> capable of evolving intelligence, why mess with success?
The simplest reason in some ways harks back to my choice for the term "Throomian."
It was inspired by the Thrymans of Poul Anderson's "We Claim These Stars."
They used ammonia instead of water as their universal solvent, and
IIRC they had a metabolism like that of archae known as methanogens.
They may have ascertained that on "rocky" or "terrestrial" planets, water solubility
and photosynthesis would be the best key to a successful biosphere.
IIRC proteins are less vulnerable to water than RNA, and hardy enzymes
may be needed to survive a multi-myriad-year long voyage.
Even if we assume that the Throomians evolved on an earth-like planet,
there are a number of possible reasons, and earth's own alleged
abiogenesis should be a good guide to finding some of them: WHY did
protein enzymes so nearly completely supplant ribozymes, unless
they had some qualities that make them far superior?
What do you suppose those might be? Greater fidelity, more resistant
to degradation, much smaller size to do the same work?
That last one could even stimulate your science fiction loving imagination.
Think of Theodore Sturgeon's short story "Microcosmic God,"
but with an upbeat compromise solution for all concerned.
Amnesty, and a nice pension in exchange for the contents
of his lab, with the more primitive ones sent to a far distant planetary system
where the Throomians had no hope of going. Using only primitive
organisms would give them enough eons before evolution produced
technologically advanced protein-based organisms capable of
becoming a threat to any (vastly!) distant descendants of theirs.
I gave you a science fiction plot to stimulate your interest,
but more prosaic events could have resulted in the same
ultimate outcome. Also different motivations might have
come into play, from Crick and Orgel's altruistic motives
to the terraforming ideas of Mark Isaak.
> evolution with ribozymes instead of protein enzymes produced the
> Barsoomians, after all.
Where on earth did you dig up this wild anachronism? Edgar Rice Burroughs,
creator of Barsoom, died in 1950. Ribozymes...well, read the following:
"In 1967, Carl Woese, Francis Crick, and Leslie Orgel were the first to suggest that RNA could act as a catalyst. This idea was based upon the discovery that RNA can form complex secondary structures.[7] These ribozymes were found in the intron of an RNA transcript, which removed itself from the transcript, as well as in the RNA component of the RNase P complex, which is involved in the maturation of pre-tRNAs. In 1989, Thomas R. Cech and Sidney Altman shared the Nobel Prize in chemistry for their "discovery of catalytic properties of RNA".[8] The term ribozyme was first introduced by Kelly Kruger et al. in a paper published in Cell in 1982.[1]
https://en.wikipedia.org/wiki/Ribozyme
Nor will ribosomes save you. They were only discovered in the mid-1950's, and it took
a while longer to learn about their indispensable role in the workings of the cell took .
<snip for focus>
> > QUOTE OF THE DAY
> >
> > An honest man, armed with all the knowledge available
> > to us now, could only state that in some sense, the
> > origin of life seems at the moment to be almost a miracle,
> > so many are the conditions which would have had to have
> > been satisfied to get it going.
> > --Nobel Laureate Francis Crick, _Life Itself_,
> > Simon and Schuster, 1981, p. 88
This was this book that introduced me to directed panspermia.
I wonder whether anyone else in talk.origins has ever read it
from cover to cover. I, for one, am still impressed
by the the simple yet effective way Crick introduced and developed the theory.
Peter Nyikos
Professor, Dept. of Mathematics -- standard disclaimer--
U. of South Carolina in Columbia
http://people.math.sc.edu/nyikos