Persistent COVID-19 infection of heart and brain seen in autopsies

HeartDoc Andrew

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Dec 29, 2023, 1:45:17 AM12/29/23

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Abstract from Stein, S.R., Ramelli, S.C., Grazioli, A. et al.
SARS-CoV-2 infection and persistence in the human body and brain at
autopsy. Nature 612, 758–763 (2022):

Coronavirus disease 2019 (COVID-19) is known to cause multi-organ
dysfunction1,2,3 during acute infection with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), with some patients experiencing
prolonged symptoms, termed post-acute sequelae of SARS-CoV-2
(refs.?4,5). However, the burden of infection outside the respiratory
tract and time to viral clearance are not well characterized,
particularly in the brain3,6,7,8,9,10,11,12,13,14. Here we carried out
complete autopsies on 44 patients who died with COVID-19, with
extensive sampling of the central nervous system in 11 of these
patients, to map and quantify the distribution, replication and
cell-type specificity of SARS-CoV-2 across the human body, including
the brain, from acute infection to more than seven months following
symptom onset. We show that SARS-CoV-2 is widely distributed,
predominantly among patients who died with severe COVID-19, and that
virus replication is present in multiple respiratory and
non-respiratory tissues, including the brain, early in infection.
Further, we detected persistent SARS-CoV-2 RNA in multiple anatomic
sites, including throughout the brain, as late as 230 days following
symptom onset in one case. Despite extensive distribution of
SARS-CoV-2 RNA throughout the body, we observed little evidence of
inflammation or direct viral cytopathology outside the respiratory
tract. Our data indicate that in some patients SARS-CoV-2 can cause
systemic infection and persist in the body for months.

Nature Journal link:
https://Nature.com/articles/s41586-022-05542-y

HeartDoc Andrew

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Dec 30, 2023, 1:51:32 AM12/30/23

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Google link to the original post in sci.med.cardiology:
https://groups.google.com/g/sci.med.cardiology/c/YfsYdH3CXro/m/nNRnC7ncAwAJ

HeartDoc Andrew

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Jan 31, 2024, 3:17:34 PMJan 31

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Again, here's the Google link to the OP in sci.med.cardiology:
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HeartDoc Andrew

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Feb 2, 2024, 12:01:04 AMFeb 2

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02/01/24 Again, here's the OP in sci.med.cardiology ...

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HeartDoc Andrew

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Feb 2, 2024, 6:48:32 AMFeb 2

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02/02/24 Again, here's the OP in sci.med.cardiology ...

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HeartDoc Andrew

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02/03/24 Again, here's the OP in sci.med.cardiology ...

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HeartDoc Andrew

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Feb 5, 2024, 3:29:19 AMFeb 5

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02/05/24 Again, here's the OP in sci.med.cardiology ...

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HeartDoc Andrew

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Feb 5, 2024, 1:41:23 PMFeb 5

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02/05/24 AgainX2, here's the OP in sci.med.cardiology ...

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HeartDoc Andrew

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02/05/24 AgainX4, here's the OP in sci.med.cardiology ...

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Feb 9, 2024, 2:45:05 PMFeb 9

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HeartDoc Andrew

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HeartDoc Andrew

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HeartDoc Andrew

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HeartDoc Andrew

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Feb 21, 2024, 10:33:56 PMFeb 21

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HeartDoc Andrew

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Feb 22, 2024, 4:02:51 AMFeb 22

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