Hi Sam
Hopefully I can explain our setup. Our shows are built by our sound designer usually starting about 9-12 months before rehearsals. This gives them plenty of time to get things roughed in. Most of the time in their studio. Our sound designer likes the way Nuendo operates. A lot of flexibility and power in a DAW. Plugins, processing, sheer track count. Our last show came in at about 1200 audio tracks. He likes not downmix things because it makes it a lot easier to adjust mixes and make edits and other things in the house during rehearsals. The Nuendo project with audio is brought to the house playback system a few months ahead for initial work and final mixing in the house. We bus it down to about 40 + channels which route to various speaker feeds, etc. 1 output is designated SMPTE and get's fed to a SMPTE DA Shaper, and on to departments. They like to keep SMPTE on Nuendo in case of changes. they can cut it, slide it, etc. works well. During rehearsals the sound designer manages the Nuendo mix from his programming station, but the FOH operator has screen to Nuendo access as well for locating, playback etc in Nuendo during rehearsals. Qlab is the control computer interface to Play Nuendo and cues using a Qwidget button box and the Ipad Qlab app. Qlab is managed and programmed but the FOH operators. We do a lot of manual sound fx from Qlab (punches, hits, other fx as needed) and Qlab is great at that. Qlab would not excel well at the massive track count and easy DSP power that Nuendo has, but is great for misc fx and also as our master "Play" computer and network triggers.
We also do a lot of ambient fx during music / smpte breaks in the show. Rain, thunder, wind, crickets, etc and Qlab handles that extremely well. Those cues get triggered by incoming timecode from Nuendo. Usually a trigger for a qlab sound fx happens near the end of a Music / Smpte block like we like to call it, and the FX will run thru those "dry"times. Fade out cues happen when the next Qlab "Play Nuendo" command goes. Most times the fade out triggers with timecode later in the next music cue or it may happen in the "Play" group command. The group cues plays Nuendo, and fades out the fx, triggers misc lighting cues and other things as needed.
We could use Nuendo with Midi program changes or Note or CC, but it was easier to read an incoming timecode stream and for the FOH operators to make adjustments to the cue timing in Qlab versus having a midi track in Nuendo, and asking the sound designer for a change, when he may be extremely busy during rehearsals working with the directors, producers. That is doable, but we found it a lot easier using incoming timecode and much simpler.
We can find a way to make the new way work, it is just really different than how we have been doing it for the last 6+ years or so that we have been using qlab.
Hope that helps clarify our setup. Let mw know if you have any other questions about it.