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Sildenafil Dosage For Men Health “ED Treatment in Worldwide”

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An erection is the result of increased blood flow into the penis. Sexual stimulation increases blood flow into the penis, temporarily trapping it in spaces called the corpus cavernosum. These spaces make up most of the penis and surround the urethra, the tube shared by both the urinary and the reproductive systems.

Smooth muscle lines the small blood vessels called capillaries that enter the penis, contracting and relaxing to decrease or increase blood flow through them. Damage to these blood vessels from diabetes, high blood pressure, or lipid deposits can reduce blood flow.




When blood enters the penis and fills the corpus cavernosum, the swollen tissue presses on blood vessels draining the penis. This process results in vasocongestion or holding blood in the penis. The pressure within the penis increases, and it becomes rigid.







Nitric oxide is a small molecule found throughout the body. It is released from nerve endings near the blood vessels in the corpus cavernosum of the penis after sexual stimulation. Nitric oxide triggers a chemical cascade that dilates blood vessels and increases blood flow into the penis, resulting in an erection. cGMP (another chemical in the cascade) levels must remain high to maintain the erection. Phosphodiesterase inactivates cGMP. When cGMP is deactivated, the smooth muscles in the walls of small blood vessels contract, reducing blood flow and ending the erection.

Oral ED medications, such as sildenafil, are phosphodiesterase inhibitors. By inhibiting phosphodiesterase, nitric oxide continues to trigger the cascade, and blood flow into the penis is maintained, meaning a firm erection. Understanding this cascade led to the development and subsequent FDA approval of sildenafil in 1998.

How to take sildenafil
Typically sildenafil is taken about an hour before sex. Because it’s taken as-needed, you don’t have to worry about remembering to take a pill every day—just when the moment is right. It’s often suggested that you take it on an empty stomach, but follow your provider’s recommendation for best results.



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This medicine is only for men & should not be used by women or children below 18. It can be potentially risky if used by women during pregnancy or breastfeeding. Talk to your doctor if your medical history has heart disease, kidney or liver disease, diabetes, glaucoma, blood pressure issues, etc.

You can discontinue this medicine under medical guidance only. Don’t stop it suddenly otherwise, you can experience measurable side effects

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