iRefScape plugin for Cytoscape
Ian Donaldson
Dear iRefIndex users:
We are pleased to announce the most recent versions of the iRefScape plugin for Cytoscape.
iRefScape allows users to search protein interaction data that has been consolidated from multiple databases including BIND, BioGrid, IntAct, MINT, MPPI and OPHID (MPACT, CORUM, and Imex records from DIP will be made available in the next iRefIndex release. HPRD records are also available on request – see http://irefindex.uio.no/wiki/iRefIndex#License).
Cytoscape
2.7 users:
Install iRefScape 0.90 beta from the Plugins menu.
This version is not backwards compatible with Cytoscape 2.6.3.
Linux users with Java 1.6 (not 1.5) will not be able to install the plugin
using the Plugin manager (instead, install manually – see link below)
Details on plugin installation and use are available at
http://irefindex.uio.no/wiki/README_Cytoscape_plugin_0.9x
Cytoscape
2.6.3 users:
Install iRefScape 0.89 beta from the Plugins menu
This will be the last iRefScape that supports Cytoscape 2.6.3
Details on plugin installation and use are available at
http://irefindex.uio.no/wiki/README_Cytoscape_plugin_0.8x
iRefScape is based on version 7.0 of the iRefIndex (see http://irefindex.uio.no for
details).
Best regards,
SabryRazick
Paul Boddie
Ian Donaldson
Details
about the plugin
1) Each node
in the iRefScape view represents a distinct protein sequence from a distinct
taxon.
2) Each node
is also assigned a canonical group identifier which groups together related
proteins.
3) Each edge represents evidence from some source database that
supports this interaction. Multiple edges between nodes are possible.
This multi-edge view can be toggled on and
off under the iRefScape/View Tools/Toggle selected multi-edges.
4) Complex
data are represented separately from binary data using a bi-partite graph representation
(hexagonal nodes represent complexes).
5) The
iRefScape plugin downloads all data locally when first installed (about 300
Mb). Searching thereafter is independent of a network connection.
6) An
extensive set of node and edge attributes are loaded with search results.
Google
group for announcements and feedback: http://groups.google.com/group/irefindex
Source data for build 7.0: http://irefindex.uio.no/wiki/Sources_iRefIndex_7.0
Statistics for build 7.0: http://irefindex.uio.no/wiki/Statistics_iRefIndex_7.0
iRefWeb interface to release 6.0 of the data: http://wodaklab.org/iRefWeb/
(will be updated to 7.0 once the paper is reviewed).
Brian Turner
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