I'm having trouble in understanding in which unit the pathways abundances are measured and if it is normal to have such a big variance in some pathways (e.g. from tenths in some subjects to thousands in other subjects). Thanks in advance.
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Pathway abundance is measured in the same units as gene abundance: i.e. reads per kilobase (RPK), which is itself a measure of sequencing coverage depth. In the case of pathways, you can think of the measurement as being the coverage of the least-abundant reaction in the pathway or (speaking relative to other pathways in the same sample) the number of complete copies of the pathway in a sample.Thanks,Eric
On Sun, Dec 1, 2019 at 9:35 AM cecilia silvestri <ceciliasi...@gmail.com> wrote:
I'm having trouble in understanding in which unit the pathways abundances are measured and if it is normal to have such a big variance in some pathways (e.g. from tenths in some subjects to thousands in other subjects). Thanks in advance.--
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