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Hi Jack,You should look into dopamine blocking therapies. They esstientially have people continue to do the action that they are addicted to, while on a drug that stops the release of dopamine and other feel good chemicals. It's proven very effective and with some tweaking like adding in a negative stimulus while on the dopamine blocking drug everytime they perform the action I think it could be a promiaing avenue for attacking addiction.Best Wishes,Louis J Anderson
On Thu, Sep 19, 2019, 14:40 jackson parks <jacksonpar...@gmail.com> wrote:
--Hello,Thank you for letting me in. I'm Jack. A friend of mine named Jonathyn recently quit the idea of engaging in CRISPR CAS9 technology because he found out that it can't do anything for adult humans. We've been trying to find a way to help people with drug addiction, and we got introduced to biohacking. We're interested in being able to change people's nervous systems either through microwave radiation (https://www.ncbi.nlm.nih.gov/pubmed/1312845), CRISPR (if it can do anything at all), or whatever other means that don't technically need surgical procedures.Thank you all, Jack.
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Why not try working to biosynthesize an opioid blocker, like naloxone
or similar, which is synthesized by gut bacteria? Then this
"probiotic" could last quite a while in the gut, until the person
takes too much antibiotic materials. Alternatively you could try using
gene insertion to push this synthesis pathway into whatever cells you
can manage to get it into. Of course getting the biosynthesized dosage
to be correct would require feedback to a gene promoter, etc... which
seems like a pretty tricky part (requiring a lot of testing and
debugging).
On Thu, Sep 19, 2019 at 2:40 PM jackson parks
<jacksonpar...@gmail.com> wrote:
Hello,
Thank you for letting me in. I'm Jack. A friend of mine named Jonathyn recently quit the idea of engaging in CRISPR CAS9 technology because he found out that it can't do anything for adult humans. We've been trying to find a way to help people with drug addiction, and we got introduced to biohacking. We're interested in being able to change people's nervous systems either through microwave radiation (https://www.ncbi.nlm.nih.gov/pubmed/1312845), CRISPR (if it can do anything at all), or whatever other means that don't technically need surgical procedures.
Thank you all, Jack.
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Why not try working to biosynthesize an opioid blocker, like naloxone
or similar, which is synthesized by gut bacteria? Then this
"probiotic" could last quite a while in the gut, until the person
takes too much antibiotic materials. Alternatively you could try using
gene insertion to push this synthesis pathway into whatever cells you
can manage to get it into. Of course getting the biosynthesized dosage
to be correct would require feedback to a gene promoter, etc... which
seems like a pretty tricky part (requiring a lot of testing and
debugging).
On Thu, Sep 19, 2019 at 2:40 PM jackson parks
<jacksonpar...@gmail.com> wrote:
>
> Hello,
>
> Thank you for letting me in. I'm Jack. A friend of mine named Jonathyn recently quit the idea of engaging in CRISPR CAS9 technology because he found out that it can't do anything for adult humans. We've been trying to find a way to help people with drug addiction, and we got introduced to biohacking. We're interested in being able to change people's nervous systems either through microwave radiation (https://www.ncbi.nlm.nih.gov/pubmed/1312845), CRISPR (if it can do anything at all), or whatever other means that don't technically need surgical procedures.
>
> Thank you all, Jack.
>
> --
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> Learn more at www.diybio.org
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I am worried that applying biology to drug addiction is like applying nuclear fission to warfare. Drug addiction and war are social problems, not biological or physical problems, so bringing in biology and physics really just escalates the arsenal.How's about applying science to analyze and correct the social problem?Best Wishes,Chris Santos-Lang
On Mon, Sep 23, 2019 at 3:27 AM Darlene Aldente <darlene...@gmail.com> wrote:
--Check out D-Cycloserine. a search of "d-cycloserine and addiction" in pub med or google scholar will give you a ton of recent peer reviewed articles. This is an old tuberculosis antibiotic that has been discovered to act on the glutamate receptor int the brain which is central to the neuroplasticity disruption associated with addition. It has shown real results when combined with CBT and the CBT sessions are times with ingestion of the drug. Same method has shown great results for war related PTSD. because the drug increases neuroplasticity, and for other reasons, it has a measurable positive effect on learning (if only I had this drug in college). You Do NOT need to take the full tuberculosis dose, just half. Also, I'm not sure about the duration of treatment.There is one BIG problem however: the cost. This drug has recently fallen prey to opportunistic "investors." in 2015 the price of cycloserine increased from $500 for 30 pills to $10,800 Rodelis Therapeutics purchased it. Purdue University, the previous owner, which retained "oversight of the manufacturing operation" intervened and Rodelis returned the drug to an NGO of Purdue University foundation whi8ch now charges $1,050 for 30 capsules. If you discover a way to use the NGO system through wich governments and non-profits obtain the drug for a fraction of the price please let us know!!
On Thursday, September 19, 2019 at 5:40:44 PM UTC-4, jackson parks wrote:Hello,Thank you for letting me in. I'm Jack. A friend of mine named Jonathyn recently quit the idea of engaging in CRISPR CAS9 technology because he found out that it can't do anything for adult humans. We've been trying to find a way to help people with drug addiction, and we got introduced to biohacking. We're interested in being able to change people's nervous systems either through microwave radiation (https://www.ncbi.nlm.nih.gov/pubmed/1312845), CRISPR (if it can do anything at all), or whatever other means that don't technically need surgical procedures.Thank you all, Jack.
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...on top of the fact that if you do this via genetic egineering than only the new nerve cells will exhibit the traits you are looking for
The "new cells" are the cells that have been altered via CRISPR to have whatever the new material you inserted. Existing neurons won't be affected. So while adult neurogenesis does happen, the maximum effect (assuming it even worked) is going to be restricted to newly grown cells.
Check out D-Cycloserine. a search of "d-cycloserine and addiction" in pub med or google scholar will give you a ton of recent peer reviewed articles. This is an old tuberculosis antibiotic that has been discovered to act on the glutamate receptor int the brain which is central to the neuroplasticity disruption associated with addition. It has shown real results when combined with CBT and the CBT sessions are times with ingestion of the drug. Same method has shown great results for war related PTSD. because the drug increases neuroplasticity, and for other reasons, it has a measurable positive effect on learning (if only I had this drug in college). You Do NOT need to take the full tuberculosis dose, just half. Also, I'm not sure about the duration of treatment.There is one BIG problem however: the cost. This drug has recently fallen prey to opportunistic "investors." in 2015 the price of cycloserine increased from $500 for 30 pills to $10,800 Rodelis Therapeutics purchased it. Purdue University, the previous owner, which retained "oversight of the manufacturing operation" intervened and Rodelis returned the drug to an NGO of Purdue University foundation whi8ch now charges $1,050 for 30 capsules. If you discover a way to use the NGO system through wich governments and non-profits obtain the drug for a fraction of the price please let us know!!