TMB measurements variation

[Alessandro Di Federico]

Hi,

I'm an oncology research fellow and I'm learning to use the cbioportal for my studies. I would like to thank you so much for your incredible work.

I had just one question about the tumor mutation burden. I guess measurements methods vary between studies, and we know that TMB values can vary across assays. How do you address these variations? May they represent an important limit at the time of examining the TMB of patients from different studies in cbioportal?

Thank you, I'm looking forward to hearing from you.

Alessandro

[David Higgins]

Hi Alessandro,

 

Tumor mutational burden (TMB) is a value that cBioPortal calculates on our own for each study based on the genetic data we receive. Because we are calculating this value and not receiving it from the study investigators, the calculations will be consistent across study.

 

cBioPortal calculates TMB as mutations per megabase of sequenced DNA.

 

If you have any follow-up questions, please Reply All so that our continued conversation is captured on the cBioPortal Google Group.

 

Best,

 

David M. Higgins, Ph.D. | (he/him)
Informatics Program Manager
Center for Data-Driven Discovery in Biomedicine (D3b)
Children’s Hospital of Philadelphia, USA

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[Alessandro Di Federico]

Great to hear that! Thank you very much for your prompt answer.

Best,

Alessandro Di Federico