A Question about Extended Mutation Data and MSKCC Mutation Data

[Tianying Zhao]

Hi,

I downloaded the data for Lung Adenocarcinoma (Broad, Cell 2012). Would you please tell me the difference between data_mutations_extended.txt and data_mutations_mskcc.txt? I found that those files have almost the same size and same content.

Thank you so much for your help!

Tianying

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Tianying Zhao

Ph.D. Student

University of Hawaii, John A. Burns School of Medicine, Bioinformatics Core

[Angelica Ochoa]

Hi Tianying,

The difference between the two MAFs is the isoform with which they were annotated with using Genome Nexus. data_mutations_extended.txt is annotated with UniProt isoforms and data_mutations_mskcc.txt is annotated with MSKCC isoforms.

I hope this answers your questions.

Best,

Angelica

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[Tianying Zhao]

Hi Angelica,

Thank you so much for your reply!

May I ask another question? I used "lung" as a key word and obtained 16 datasets (please see the screenshot below). Are these mutation data sets somatic mutation or germline mutation?

I appreciate your help!

Tianying 

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Tianying Zhao

Ph.D. Student

University of Hawaii, John A. Burns School of Medicine, Bioinformatics Core