cBioPortal Newsletter April 2026

[Tali Mazor]

                               

        April 2026

Welcome to the April 2026 edition of the cBioPortal Newsletter!

With spring just around the corner, we’re looking forward to getting back out there, meeting many of you in person, and engaging more closely with the community. This month brings a mix of updates, new data, and opportunities to connect.

Connect with Us

Meet Us at AACR 2026  cBioPortal will be at the AACR Annual Meeting 2026, taking place in San Diego, California, from April 17–22, 2026. You can find us at Booth 2939, located near Poster Section 28–37. Whether you’re a long-time user or just getting started, we’d love to connect. Stop by to: See what’s new in cBioPortal Share feedback or feature requests Ask questions about your workflows Or simply say hello Poster Presentation: cBioPortal for Cancer Genomics Tuesday, April 21, 9a-12p Section: AACR Project GENIE: Genomic Characterization Poster Section 1, Board 2, Number 4097 View poster details here. Related Poster Presentations: Genome Nexus & reVUE Sunday, April 19, 2-5p Section: AACR Project GENIE: Predictive Models and AI Poster Section 1, Board 2, Number 2 Website: https://cancerrevue.org/ / https://genomenexus.org/ OncoKB Monday, April 20, 9a-12p Section: Data-Driven Approaches to Precision Oncology Poster Section 43, Board 5, Number 2498 Website: https://oncokb.org/

cBioPortal Community Call (New & Improved)

The cBioPortal Community Call is being revamped this year.

This monthly forum will bring together users and developers to share updates, discuss, and provide feedback on cBioPortal. Everyone is welcome to join.

The first call will be on Tuesday, April 28 at 11am EDT to share the results of our recent user survey.

If you’re interested in participating, sign up here to be added to the invite list.

Get Involved with the cBioPortal Community

Google Summer of Code (GSoC) 2026

We’re excited to share that cBioPortal has been accepted as a mentoring organization for Google Summer of Code 2026.

GSoC is a global program by Google that supports contributors in working on impactful open-source projects. This year, participants will have the opportunity to contribute to tools used by cancer researchers worldwide.

Explore the proposed projects: https://github.com/cBioPortal/GSoC

Help Us Test New AI Features

We are developing new AI-powered tools for cBioPortal and are looking for early users.

• DB Agent
  Query cBioPortal data using natural language. No coding required.
  Example: “What is the frequency of BRAF mutations across TCGA cohorts?”
  
  

• NAV Agent
  Navigate the platform more easily using guided prompts.
  Example: “Show KRAS mutations in TCGA lung cancer”

These tools are in active development, and your feedback will help shape their future.
Sign up to become an alpha tester. We are onboarding new users in groups, so we appreciate your patience until we get in touch.

Data Updates

Added data from 58,007 samples from 18 studies, including:

• Pan-cancer 50K MSK-IMPACT cohort with matched normals, offering comprehensive genomic profiling including mutations, copy number alterations, structural variants, mutational signatures, and HLA genotypes - 54,331 samples.

• Nine new iAtlas immunogenomic datasets that include neoantigen predictions, immune signatures, and cell-type abundance estimates - 1,020 samples

See the full list of studies here

Data Improvements

• Cancer Cell Line Encyclopedia (DepMap 2025 Q3): Added segmented copy number data, log2 CNA values, and RNA expression profiles to enhance molecular characterization. Explore the study here.
  
  
  

• Gene Table Updates: Gene tables (main and alias) have been updated based on the October 2025 HGNC release. Oct 7, 2025 HGNC release. See seedDB release notes here for details.
  
  

Feature Highlight

Feature Highlight: Patient Timelines in Patient View A longitudinal view of cancer progression at the patient level. Understanding cancer progression requires looking beyond static snapshots. The Patient View in cBioPortal includes an interactive timeline visualization that brings together clinical events, treatments, and molecular data across a patient’s journey. This is especially powerful in longitudinal datasets such as MSK-CHORD (MSK, Nature 2024), which includes sequencing data from over 25,000 tumors across nearly 25,000 patients, along with matched normals and rich clinical annotations. How to explore From the Study View, select a patient of interest and navigate to the Patient View. The Summary tab provides a timeline-based overview of: Sample acquisition and sequencing events Treatments (chemotherapy, immunotherapy, radiation) Diagnosis and disease progression Longitudinal lab measurements This enables rapid, intuitive understanding of how clinical events and molecular sampling evolve over time. Figure 1. Patient-level timeline view showing clinical events, treatments, and longitudinal measurements across the disease course. By combining clinical timelines with longitudinal genomic data, cBioPortal enables exploration of tumor evolution and treatment response at the individual patient level, complementing traditional cohort-level analyses.

Learn More

To learn more about cBioPortal, review our documentation, which includes FAQs, webinars, and tutorials. If you have questions, please do not hesitate to reach out to us at cbiop...@googlegroups.com.

Stay tuned for more updates, and thank you for your continued support in advancing cancer genomics research with cBioPortal.

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