Turning my attention to prostacylcyn
cruiser
to my personal satisfaction, and am now turning my attention to the
overlooked prostacylcin vasodilation pathway.
To summarize again there are three vasorelaxation pathways.
Nitric Oxide
EDHF
Prostcyclin
I have learned that the nitic oxide pathway is interrupted by
arginase, which is expressed as a result of oxidative stress to the
zeta-chain.
The EDHF pathway may be inhibited by marijuana and/or vitamin D
deficiency.
Prostacyclin is the remaining endogenus vasodilator, which I have yet
to explore.
In the back of mind, I remain aware that vasoconstrictors may also be
a problem. Peroxinitrate caused by eNOS decoupling, is corrected by 10
mg of folic acid.
My attempts to correct the Nitric Oxide pathway have had inconsistent
results, using anitoxidants and other supplements.
The most effective of these supplements appears to be 10mg per day
folic acid, in combination with vitamin A and vitamin C.
I have been supplementing with Cod Liver oil, combined with calcium
and seeing some positive affects from that.
Foods that I have identified that show positive effects are Cod Liver
oil, trout, salmon, V8 Splash Tropical Blend, bacon and eggs with
toast and jam, milk, carrots, orange juice, and polish sausage with
sauerkraut.
I reiterate that vascular smooth muscle performs vaosrelaxation
normally when the endothelium is bypassed and the vascular smoothe
muscle is stimulated directly. For this reason I am fairly sure a that
the problem is with signaling from the endothelium.
There may be some opportunity to find something useful in the
reamining vaosrelaxation pathway, mediated by prostacyclin.
I was having some mixe results with Niacin flushing. This involves
histamine release, and there is soome information that this is related
to the prostacyclin vasorelaxation pathway.
The following link provides a good graphic of the chemicla pathway
that produces prostacylcin (PGI2), along with some discussion.
Figure 1. The three major pathways involved in arachidonic acid
metabolism. Arachidonic acid is derived directly from linolenic acid
or is ingested as a dietary constituent. Arachidonic acid is stored in
the cell membrane of virtually all cells and is released in response
to stimluli such as histamine and platelet-derived growth factor.
Arachidonic acid can be released by three pathways (not shown): (1)
conversion of phosphatidyl ethanolamine or phosphatidyl choline to
phosphatidic acid in a reaction catalysed by phospholipase D (PLD),
followed by formation of diglyceride and monoglyceride and the release
of arachidonic acid; (2) degradation of phosphatidylinositol via a
sequence of reactions beginning with PLC cleavage of the
phosphodiester bond of membrane lipids to yield diacylglycerol,
followed by the action of dilglyceride lipase and monoglyceride lipase
to release arachidonic acid and glycerol; and (3) direct action of
PLA2 on a phospholipid. (a) The cyclooxygenase (COX) pathway results
in the formation of prostaglandin G2 (PGG2) from arachidonic acid by a
cyclooxygenase reaction. In a subsequent peroxidase reaction, PGG2
undergoes a two-electron reduction to PGH2. Both of these reactions
are catalysed by COX (prostaglandin synthase H). PGG2 serves as a
substrate for cell-specific isomerases and synthases, producing other
eicosanoids such as prostacyclin (PGI2) and thromboxane A2 (TXA2). (b)
The lipoxygenase pathway forms hydroperoxyeicosatetraenoic acids
(HPETEs) and dihydroxyeicosatetraenoic acid (DEA) by lipoxygenase and
subsequently converts these to (1) hydroxyeicosatetraenoic acids
(HETEs) by peroxidases, (2) leukotrienes (e.g. LTC4) by hydrase and
glutathione S-transferase (GST), and (3) lipoxins by lipoxygenases.
(c) The epoxygenase pathway forms epoxyeicosatrienoic acid (EET) and
dihydroxyacids by cytochrome p450 epoxygenase (fig001dfd).
------------------------------------
Still digging...
cruiser
randall
> I feel that I have completed the vitamin D and calcium investigation,
Never... lol
>
> Still digging...
I'll find a link or two..<g>
>
> cruiser
Let's frame it with what's on taP.
And from a timely fashion:
And an abstract or two shall do:
http://www.ncbi.nlm.nih.gov/pubmed/18348729?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Can essential fatty acids reduce the burden of disease(s)?
Das UN.
UND Life Sciences, 13800 Fairhill Road, #321, Shaker Heights, OH
44120, USA. und...@hotmail.com
Coronary heart disease, stroke, diabetes mellitus, hypertension,
cancer, depression schizophrenia, Alzheimer's disease, and collagen
vascular diseases are low-grade systemic inflammatory conditions that
are a severe burden on health care resources. Essential fatty acids
(EFAs) and their metabolites: eicosapentaenoic acid (EPA),
docosahexaenoic acid (DHA), gamma-linolenic acid (GLA), dihomo-gamma-
linolenic acid (DGLA), and arachidonic acid (AA) and their products:
prostaglandin E1, prostacyclin, lipoxins, resolvins, and protectins
suppress inflammation, augment healing, and are of benefit in the
prevention and management of these conditions. Hence, supplementation
of EFAs could reduce burden of these disease(s).
PMID: 18348729
Is p JUST a *low-grade systemic inflammatory condition*? LOL
http://en.wikipedia.org/wiki/Eicosanoids
http://en.wikipedia.org/wiki/Prostacyclin
Can't seem to wonder how you missed the AA in the P equation?
Or the genes:
http://en.wikipedia.org/wiki/Phospholipase_A2
http://en.wikipedia.org/wiki/PLA2G4A
Is there a NEW pathway that's been missed?
Whats known:
VDR
http://en.wikipedia.org/wiki/Vitamin_D_receptor
Nuclear Receptors:
http://en.wikipedia.org/wiki/Nuclear_receptor
Next to the NOT so CLEAR areas?
ONe of the dirty dozen to the rescue. Or what's going on?
http://www.ncbi.nlm.nih.gov/pubmed/18388244?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Roles of Cytosolic Phospholipase A2 and Src Kinase in the Early Action
of TCDD through a Nongenomic Pathway in MCF10A Cells.
Dong B, Matsumura F.
University of California, Daivs.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) is known to
induce rapid inflammatory cellular responses through the mechanism
which has not been fully elucidated yet. In this report we show that
in MCF10A cells, an immortalized, normal mammary epithelial cell line,
TCDD rapidly activates the enzymatic activity of cytosolic
phospholipase A2 (cPLA2) as attested to by arachidonic acid release
within 15 min, followed by activation of Src kinase and induction of
several inflammation markers. Such an action of TCDD is clearly
blocked by MAFP, a specific inhibitor of cPLA2, siRNA against cPLA2,
and several calcium signaling blockers, indicating that this action of
TCDD is mediated by calcium-triggered activation of cPLA2. This action
of TCDD is quite different from the classic action of TCDD to induce
cytochrome P450 1A1 (CYP1A1) because blocking this newly identified
pathway did not affect the induction of CYP1A1. Moreover, this newly
identified pathway was found to depend only on aryl hydrocarbon
receptor (AhR), but not on aryl hydrocarbon receptor nuclear
translocator (ARNT). Together these findings support the model that
the early action of TCDD to induce rapid inflammatory responses is
carried out through a characteristic "nongenomic" pathway, which is
clearly different from the classical model of action of TCDD through
the "genomic" pathway.
PMID: 18388244
NONgenomic? Wouldn't that fit with Benjamin and your, *it's not a DNA*
thingy? LOL
http://en.wikipedia.org/wiki/Nuclear_receptor
http://en.wikipedia.org/wiki/P450-containing_systems
http://en.wikipedia.org/wiki/ALOX12
And what about hete's in this grail quest?
Was it 12r or 12s for weird hete's and P?
http://www.ncbi.nlm.nih.gov/pubmed/17963719?ordinalpos=18&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
12(S)-hydroperoxyeicosatetraenoic acid (12-HETE) increases
mitochondrial nitric oxide by increasing intramitochondrial calcium.
Nazarewicz RR, Zenebe WJ, Parihar A, Parihar MS, Vaccaro M, Rink C,
Sen CK, Ghafourifar P.
Department of Surgery, Davis Heart and Lung Research Institute,
Institute of Mitochondrial Biology, The Ohio State University, 460
West 12th Avenue, Columbus, OH 43210, USA.
12(S)-hydroxyeicosatetraenoic acid (12-HETE) is one of the metabolites
of arachidonic acid involved in pathological conditions associated
with mitochondria and oxidative stress. The present study tested
effects of 12-HETE on mitochondrial functions. In isolated rat heart
mitochondria, 12-HETE increases intramitochondrial ionized calcium
concentration that stimulates mitochondrial nitric oxide (NO) synthase
(mtNOS) activity. mtNOS-derived NO causes mitochondrial dysfunctions
by decreasing mitochondrial respiration and transmembrane potential.
mtNOS-derived NO also produces peroxynitrite that induces release of
cytochrome c and stimulates aggregation of mitochondria. Similarly, in
HL-1 cardiac myocytes, 12-HETE increases intramitochondrial calcium
and mitochondrial NO, and induces apoptosis. The present study
suggests a novel mechanism for 12-HETE toxicity.
PMID: 17963719
Or try
http://pmid.us/psoria*+prostacyclin
Whoops... 3 hits. What a gyP...LOL
http://pmid.us/prostacyclin+arachidonic
2695 hits is more like it.
Lets try my LPS link? I own LPS now... for p anyway.. NOPE.
http://pmid.us/prostacyclin+arachidonic+lps
Now we're getting somewhere.
Lets expand it.
http://pmid.us/lps+arachidonic
Calcium, nitric-oxide, hete's.. they all PoP uP....
What's not to get your attention?
How about some LL-37 and arachidonate?
http://www.ncbi.nlm.nih.gov/pubmed/17548641?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
&
http://www.ncbi.nlm.nih.gov/pubmed/11298331?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Evaluation of the effects of peptide antibiotics human beta-
defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2)
production from mast cells.
Niyonsaba F, Someya A, Hirata M, Ogawa H, Nagaoka I.
Department of Biochemistry, Juntendo University, School of Medicine,
Tokyo, Japan.
Antimicrobial peptides, human beta-defensins (hBD-1/-2), and LL-37 (a
peptide of human cathelicidin CAP18) are predominately expressed at
epithelial tissues, where they participate in the innate host defense
by killing invading microorganisms. In this study, to investigate the
interactions between epithelial cell-derived antimicrobial peptides
and mast cells, we evaluated the effects of hBD-1/-2 and LL-37 on mast
cell functions using rat peritoneal mast cells. hBD-2 and LL-37 but
not hBD-1 induced histamine release and intracellular Ca(2+)
mobilization, and hBD-2 was more potent than LL-37. Interestingly,
histamine release and intracellular Ca(2+) mobilization elicited by
hBD-2 and LL-37 were markedly suppressed by BAPTA-AM (an intracellular
Ca(2+) chelating agent), pertussis toxin and U-73122 (a phospholipase
C inhibitor). In addition, among the peptides examined, only hBD-2
significantly induced PGD(2) production, which was abolished by
indomethacin (cyclooxygenase-1/-2 inhibitor) but not NS-398
(cyclooxygenase-2 inhibitor), suggesting that hBD-2-induced PGD(2)
production is mediated by cyclooxygenase-1. Likewise, the PGD(2)
production was suppressed by pertussis toxin and U-73122. These
observations suggest that hBD-2 and LL-37 stimulate mast cells to
mobilize intracellular Ca(2+) and release histamine or generate PGD(2)
in a G protein-phospholipase C-dependent manner. Thus, hBD-2 and LL-37
may have modulatory effects on inflammatory reactions.
PMID: 11298331
Which begs the search.
Hey... that's a good one. Vitamin D and Stress and SKINny thing
poP right out at you...
randall...I require exercise to ponder the AA of P...
cruiser
> On Apr 6, 10:51 am, cruiser <tg.cruis...@northwindwireless.com> wrote:
>
> > I feel that I have completed the vitamin D and calcium investigation,
>
> Never... lol
>
What is that supposed to mean?
>
> http://www.ncbi.nlm.nih.gov/pubmed/18348729?ordinalpos=1&itool=Entrez...
> Can essential fatty acids reduce the burden of disease(s)?
> Das UN.
>
> UND Life Sciences, 13800 Fairhill Road, #321, Shaker Heights, OH
> 44120, USA. undu...@hotmail.com
>
> Coronary heart disease, stroke, diabetes mellitus, hypertension,
> cancer, depression schizophrenia, Alzheimer's disease, and collagen
> vascular diseases are low-grade systemic inflammatory conditions that
> are a severe burden on health care resources. Essential fatty acids
> (EFAs) and their metabolites: eicosapentaenoic acid (EPA),
> docosahexaenoic acid (DHA), gamma-linolenic acid (GLA), dihomo-gamma-
> linolenic acid (DGLA), and arachidonic acid (AA) and their products:
> prostaglandin E1, prostacyclin, lipoxins, resolvins, and protectins
> suppress inflammation, augment healing, and are of benefit in the
> prevention and management of these conditions. Hence, supplementation
> of EFAs could reduce burden of these disease(s).
>
So what?
There is no attempt to point out that PGE-1 is specifically of
interest here. PGE-1 is lost amongs all the other chemicals listed and
there is no indication that you even know that PGE-1 is of special
interest.
There is no explanation of how to increase PGE-1, or a way that
someone on this group can use this information for treatment.
So what good was accomplished by that post?
Why are you posting old discussions about arachidonic acid? It is not
of any interest. It is PGE-1 that is of interest, and there is no
indication of that.
It is no use dumping loads of research papers onto this group unless
you are going somewhere with it.
If you post every single research paper that you can find on
psoraisis, you will likely post something useful of real value
eventually, but what good is it if you don't recognize the value of
what you are posting, the kernel of useful information, and if you do
nothing about it?
What is the point of bringing up all these old posts all the time?
I mean really.
What are you trying to tell me?
So what if these things have come up before? No one did anything about
it. They just posted and ran away. Big deal. So, everybody is supposed
to figure it is a waste of time, because it was posted before, without
any attempt to actually use the information?
YOU just don't get it.
cruiser
randall
>
> YOU just don't get it.
>
> cruiser
OK, I'm willing to give up. What are friends for if not
to let each other make stupid decisions. LOL
After all i'm only the one who can easily clear his skin with
his protocols and i'm not talking barney formula
or banana's now. <w>
You want to get together any time for a CLEAR OFF?
Let me know, i'm ready and willing to GO for it.
We'll post pictures on flickr and let the group be the
judge after 30 days...winner take all.
And your still talking about GLA and EPO since 2002 or
was that another cruiser in those links? LOL
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/548fdc65e72b2d02
Right, right, toss some extra D3 and calcium in to that one. Why not
increase
aspirin as well? Take mega dosage's of all of it for all I care now.
I'm figuring if your so willing to take EPO (a w6 ratio enhancer) and
think your some how working to increase PGE1 while
avoiding all the other pathways I've tried to point out, then
what the heck have at it. Clearly all my help should be
suspect in your mind. To bad your skin can't change your
mind.... <g>
And why go back to one thing from six years ago that didn't
work then?
Here's some more advice your most likely gonna shine on,
GIVE UP the FOLIC acid mega dosages before you hurt
yourself.
Why should I care anyway? You never respond to requests
for demographic information and anything you say is
nearly worthless as a result. You offer up fallacious
and screw ball trials of mega dosages of folic acid and
when I try to point it out to you, you either don't notice
or have a closed mind to pertinent scientific evidence.
I hope you don't mind when I point out the futility of
your so called folic acid trials. I only hope I can help someone else
from
making a huge mistake while I know your gonna do
exactly what you deem a miracle verging on uwe
proportions. LOL
Have you cleared one iota yet from any of your trials?
You most likely gave uwe the $200 and was gypped?
No, you'd be crowing till the chickens came home
if he'd actually gave you good advice. Sure believe
a con man and don't believe the one person whose
taken the time to try to help. Fine thing huh?
Are you not gypping yourself when you avoid GOOD
advice and believe in uwe's SECRET nonsense?
Oh I get it now. I should be charging you for my advice?
Maybe not, huh?
I've got a good idea, Don't tell anyone till you have positive
results?
That would be nice. At least that way you can't hurt anyone
but yourself. :)
randall..
cruiser
> > YOU just don't get it.
>
> > cruiser
>
> OK, I'm willing to give up. What are friends for if not
> to let each other make stupid decisions. LOL
> After all i'm only the one who can easily clear his skin with
> his protocols and i'm not talking barney formula
> or banana's now. <w>
> You want to get together any time for a CLEAR OFF?
> Let me know, i'm ready and willing to GO for it.
>
> We'll post pictures on flickr and let the group be the
> judge after 30 days...winner take all.
>
What!?
This isn't a contest.
Is that why you are being such an a$$?
You think this is some sort of competition?
I would like to be clear of psoriasis, but that is not what this is
about.
This is about curing all disease. Psoriasis is just one of them.
Are you going to cure my mother's arthritis too?
Are you going to cure my sister's keltoids?
Are you going to cure my friend and neighbours cancer?
Are you going to cure the guy with AS who asked me to join his
discussion group?
Are you going to cure all those people on the CFS discussion group,
that Uwe abandonned?
If you can, then I will stop and pay attention.
I really don't care that you can clear your little case of psoriasis
for a few days, until you stop taking a mountain of things. watching
your diet, and shoving things up your rectum. Then it all comes back.
That's no cure.
cruiser
randall
> On Apr 8, 3:46 am, randall <ranhu...@aol.com> wrote:
>
> > > YOU just don't get it.
>
> > > cruiser
>
> > OK, I'm willing to give up. What are friends for if not
> > to let each other make stupid decisions. LOL
> > After all i'm only the one who can easily clear his skin with
> > his protocols and i'm not talking barney formula
> > or banana's now. <w>
> > You want to get together any time for a CLEAR OFF?
> > Let me know, i'm ready and willing to GO for it.
>
> > We'll post pictures on flickr and let the group be the
> > judge after 30 days...winner take all.
>
> What!?
>
> This isn't a contest.
Hey! I was in the spirit of the NCAA yesterday. You northern
brethren should know about these important things.
In the cream of the toP 64.
I was rooting for Saint Mary Gaels and Gonzaga. Then USD Toreros
and Davidson and Xavier. Lastly UCLA... And it got down
to Kansas Jayhawaks and Memphis Tiger's.
All the tigers needed to do was foul a Jayhawk and they'd
be the chamPs today...
That would have been a huge UWE moment. LOL
The wind was out of my main sail by the BIG
game. But The look on that kids face on the front
page of my newspaper brought what it's all about
home again..
Try this:
http://www.signonsandiego.com/uniontrib/20080408/
or
http://www.signonsandiego.com/uniontrib/20080408/images/sports220.jpg
>
> Is that why you are being such an a$$?
Good one. :)
>
> You think this is some sort of competition?
Sorry. That old spirit moves me still. I went to
the playoffs between Gonzaga, USD, St Mary's and
Santa Clara and GOT in the MOOD.
The WCC then sent three teams to march madness.
>
> I would like to be clear of psoriasis, but that is not what this is
> about.
OH? OK.. sorry. I should have realized you had a NEW set of rules
right after you followed the uwe hayek pied piper.
http://en.wikipedia.org/wiki/The_Pied_Piper_of_Hamelin
>
> This is about curing all disease. Psoriasis is just one of them.
How about strictly genetic conditions?
Like Tay-Sachs?
http://en.wikipedia.org/wiki/Tay-Sachs_disease
And if psoriasis is a multifactorial condition, what then?
http://pmid.us/psoria*+multifactorial
http://pmid.us/psoriasis+gene
http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=177900
Not to mention the hundreds of other likely candidates in
this rube goldberg like disease.
>
> Are you going to cure my mother's arthritis too?
Sure if her son loves her enough to lead her to ultimate health.
Try this book:::
Achieve Maximum Health: Colon Flora the Missing Link in Immunity,
Health & Longevity
by David Webster
http://www.amazon.com/Achieve-Maximum-Health-Immunity-Longevity/dp/0964753715
>
> Are you going to cure my sister's keltoids?
Is that a problem with her deltoids? <g>
>
> Are you going to cure my friend and neighbours cancer?
I've helped a few of those with the wit kit and diet. It's
amazing when the stress is taken off the body and the
garden within is A OK. Like back when your a baby
and you've got a full gut load, provided you were
breast fed etc, of GOOD FLORA.
Things just clear up in the process. If anything is
uPstream of inflammation it's tending to the garden
of NOT US that lives in US.
Get it? LOL
Candide:
"il faut cultiver notre jardin" Voltaire
http://en.wikipedia.org/wiki/Candide
>
> Are you going to cure the guy with AS who asked me to join his
> discussion group?
I know this. YOUR NOT and I stand a nearly 99% chance should
he be willing to stick a tube uP his yin yang. LOL
Sorry that I borrowed your parlance.
http://en.wikipedia.org/wiki/Parlance#Parlance
Good GOD... How much clearer can one GET and still NOT
be GOTTEN. LOL
>
> Are you going to cure all those people on the CFS discussion group,
> that Uwe abandonned?
He did? That's news to me.
One more log for the fire to burn him at the stake? LOL
He's one snake I choose to not have a thing to do with.
It was fun making it a competition to figure him out nevertheless. :)
Snake comes to mind. LOL
>
> If you can, then I will stop and pay attention.
If you haven't in the past, why would I expect you to now?
Your to anal retentive to get it. LOL
http://en.wikipedia.org/wiki/Anal_retentive
Most engineers are, you know?
Still i'd rather work with one of those then most attorneys. <w>
>
> I really don't care that you can clear your little case of psoriasis
> for a few days, until you stop taking a mountain of things. watching
> your diet, and shoving things up your rectum. Then it all comes back.
Well ok. I guess the fact that I did the wit kit over eight years ago
and i've been 70-90% clearer during the next eight years isn't
good enough for you....
And i've worked on dozens and dozens of things to try and
further the state of art of being even a little bit CLEARER.
I didn't come out of the chute with 2% like you. I clouded
over like a massive storm front settled in and then simmered
down to a cloudy day till the teen years stirred up a squall.
Then the dark days ruled for decades....till I came to the
light of clearness.
And I had decaying banana skin stuff smushed on to plaques
in the quest for the GRAIL....
And you don't think this is a GAME?
It's the GRAIL man...wake uP:::
Its the island with no P...
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?group=alt.support.skin-diseases.psoriasis&q=island+randall&qt_g=Search+this+group
The island in the STREAM (a state of consciousness)
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?group=alt.support.skin-diseases.psoriasis&q=islands+stream&qt_g=Search+this+group
It's the philosophers stone
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?group=alt.support.skin-diseases.psoriasis&q=philosophers+stone&qt_g=Search+this+group
Or just plain P stone:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?group=alt.support.skin-diseases.psoriasis&q=p+stone+randall&qt_g=Search+this+group
>
> That's no cure.
And how would you know?
You've invested to much in the mythical bullshitting uwe hayek gorgon
a dork.
http://en.wikipedia.org/wiki/Gorgon
And since he admits that isn't his real name he must
be gender neutral as well. LOL
I wonder if he's a fat ugly stuPid XXX
http://www.youtube.com/watch?v=Y22bCqGuH-o
Sure. UWE is as honest as an American Prez:
http://www.youtube.com/watch?v=nP5FunbZvJ8
randall... boy got GAME... Score...for the ncaa..& XXX-P :)
>
> cruiser