Bohgosity Challenge -- Biotical or PLC (Carnitines) or Lavender (caveats & suspect) or xyz (Katy Wilson) --> Chester Reed, Jack LaLanne, Paul Bragg or Jeanne Calment --> GOLD medal Longevity - Brown Rice (ERF) - Butyrate --IL12p70 & hiv

[randall]

hi




The PLC + Bohgosity BumaskiL , challenge has been MADE: (sorta more
or LESS)


Less would be if BB isn't reading this. LOL

We had flower POWER (lavender) and a will block PLC to quell IBD 2
days ago.

Flower power is so kewl... i'm going to DO part II on it.... sometime
soon!


OK & what is PLC? Just so i KNOW right NOW.


Propionyl L-Carnitine - 4 hits on August 7, 2012 - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=Propionyl+L-Carnitine+&start=0&


Will Bohgosity BumaskiL take the PLC gut trip or use lavender or
whatever Katy Wilson (alternative medical practitioner) uses in her
psor CURE:


see:
Tues, Aug 7 2012 9:17 am
Subject: Re: Vitamin U
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/7209d102b4e6179f
from the BB thread:
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_frm/thread/72f7333437b53e3e#


Propionyl L-Carnitine
http://www.webmd.com/vitamins-supplements/ingredientmono-803-PROPIONYL-L-CARNITINE.aspx

Dr. Sinatra: Broad Spectrum Carnitine Benefits
http://www.youtube.com/watch?v=-D19oPjMEIg
<time: 2:17> <views: 2,729>
Dr. Sinatra speaks about the benefits of Carnitine and the 3 forms
that make-up Broad Spectrum Carnitine.
<snip>


Mentions NO (nitric oxide) for YOU KNOW WHO?


who?


You know... YOU... LOL


http://en.wikipedia.org/wiki/Prebiotic_(nutrition)
Prebiotics are non-digestible food ingredients that stimulate the
growth and/or activity of bacteria in the digestive system in ways
claimed to be beneficial to health. They were first identified and
named by Marcel Roberfroid in 1995.[1] As a functional food component,
prebiotics, like probiotics, are conceptually intermediate between
foods and drugs. Depending on the jurisdiction, they typically receive
an intermediate level of regulatory scrutiny, in particular of the
health claims made concerning them.

Roberfroid offered a refined definition in the 2007 Journal of
Nutrition[2] stating:
A prebiotic is a selectively fermented ingredient that allows specific
changes, both in the composition and/or activity in the
gastrointestinal microflora that confers benefits upon host well-being
and health"

Additionally, in his 2007 revisit of Prebiotics, Roberfroid stated
that only two particular fructooligosaccharides fully meet this
definition: oligofructose and inulin.[3] Other authorities also
classify galactooligosaccharides (GOS) and lactulose as prebiotics.
Mannan Oligosaccharides (MOS) have been termed as prebiotics but would
more correctly be termed immunosaccharides

Researchers now also focus on the distinction between short-chain,
long-chain, and full-spectrum prebiotics. "Short-chain" prebiotics,
e.g. oligofructose, contain 2-8 links per saccharide molecule and are
typically fermented more quickly in the right-side of the colon
providing nourishment to the bacteria in that area. Longer-chain
prebiotics, e.g. inulin, contain 9-64 links per saccharide molecule,
and tend to be fermented more slowly, nourishing bacteria
predominantly in the left-side colon. Full-spectrum prebiotics provide
the full range of molecular link-lengths from 2-64 links per molecule,
and nourish bacteria throughout the colon, e.g. Oligofructose-Enriched
Inulin (OEI). The majority of research done on prebiotics is based on
full-spectrum prebiotics, typically using OEI as the research
substance

FOOD Prebiotic Fiber:
Raw Chicory Root 64.6%
Raw Jerusalem Artichoke 31.5%
Raw Dandelion Greens 24.3%
Raw Garlic 17.5%
Raw Leek 11.7%
Raw Onion 8.6%
Cooked Onion 5%
Raw Asparagus 5%
Raw Wheat bran 5%
Whole Wheat flour, Cooked 4.8%
Raw Banana 1%

<didn't that 96 year old guy who retired RECENTLY from the postal
service eat a slice of RAW ONION each day? ans: YES>

And here he is: one hit: raw onion + postal worker - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/browse_frm/thread/f7c23401483b22e9/69b0edf76c396c74?lnk=gst&q=raw+onion+postal+worker#69b0edf76c396c74

And HIS name is Chester REED and Jack LaLanne is prominent in this
thread and so is Paul BRAGG who might still be alive had he not cardio
evented OUT ("Ventricular Tachycardia and Fibrillation due to Coronary
Occlussion") at the age of 81 in 1976.

So Paul would be: 2012 - 1976 = 36 (36 + 81 = 119 years old) or
three and a half years younger then Jeanne Calment at 122 1/2 years
old.

Dang it Paul Bragg... we could have bragged over you beating Jeanne to
123 or more? If you only had more PLC (carnitine) to keep your ticker
ticking!

duh....

http://en.wikipedia.org/wiki/Paul_Bragg
http://en.wikipedia.org/wiki/Jack_lalanne (96 years old)

and the GOLD goes to FRANCE and Jeanne C for LONGEVITY!

http://en.wikipedia.org/wiki/Jeanne_calment (122 1/2 y/o)


So how do you DO IT?


Pre or PRO BACTERIA and/or biotic!

http://www.sbwire.com/press-releases/uk-health-expert-takes-a-good-look-at-good-bacteria-157707.htm
UK Health Expert Takes a Good Look at Good Bacteria

Leeds, West Yorkshire -- (SBWIRE) -- 08/08/2012 -- Dr Sarah Jarvis has
given her views on the benefits of taking prebiotics and probiotics in
an article on UK health information website Patient.co.uk. Widely sold
in the UK as a method for maintaining the levels of good bacteria in
an individual’s body, such supplements have been steadily gaining in
popularity in recent years and a number of supermarkets now stock own
brand products alongside well known names such as Actimel, Yakult and
Bimuno.

Also known as ‘friendly bacteria’, good bacteria (such as
lactobacillus) are present in everybody’s guts and are important in
the process of digestion. While such bacteria are usually maintained
naturally at their own healthy levels, occasionally there may be a
need for supplements and this is where products such as Actimel are
sometimes recommended.

In an article on Patient.co.uk, Sarah wrote: “There’s a constant
battle between ‘good’ and ‘bad’ bacteria, and sometimes the unhealthy
bacteria get the upper hand. That’s where probiotics and prebiotics
come in.”

That said, Sarah is keen to point out that it’s certainly not the case
that everyone needs to supplement their diet with probiotics. Indeed,
lactobacillus is present in a number of dairy products, most commonly
yoghurt, and prebiotic rich food stuffs include such vegetables as
Jerusalem Artichokes, leek and asparagus.

Nevertheless, while Sarah suggests that such supplements are not
always essential if an individual has a balanced diet, she does write
that “there are lots of times when they can be useful.”

Examples offered by Sarah as to when probiotics are beneficial include
those times when suffering from IBS, when afflicted by diarrhoea and
when experiencing a severe stomach bug. While probiotics and
prebiotics will not totally alleviate such conditions, they will
potentially relieve some of the symptoms.

Sarah goes on to say that there are also other occasions in life when
good bacteria supplements may prove to be invaluable such as during
the first trimester of pregnancy, when you’re likely to be low on
vitamin D and calcium, and when you’re struggling to keep food down or
have a diminished appetite.

For more information on prebiotics and probiotics, visit http://www.Patient.co.uk
and the full article from Dr Sarah Jarvis can be found on her blog at
the same website.

About Patient.co.uk [http://www.Patient.co.uk]:
<snip>


Or you can eat your BROwN Rice? YOU want the eRF one!


What's an ERF?


ERF if i KNOW!


Enzyme-treated rice fiber (ERF) - erf erf!


http://www.ncbi.nlm.nih.gov/pubmed/20735154
Scand J Gastroenterol. 2011 Jan;46(1):40-52. Epub 2010 Aug 24.
New prebiotics from rice bran ameliorate inflammation in murine
colitis models through the modulation of intestinal homeostasis and
the mucosal immune system.

Komiyama Y, Andoh A, Fujiwara D, Ohmae H, Araki Y, Fujiyama Y,
Mitsuyama K, Kanauchi O.

Source
Kirin Holdings Co., Central Labs for Frontier Technology, 1-13-5
Fukuura Kanazawa-ku, Yokohama, Japan.

Abstract
BACKGROUND:
Enzyme-treated rice fiber (ERF) is a recently developed prebiotic
product made from rice bran by heat-resistant amylase, protease and
hemicellulase treatment. Although the detailed mechanism of
inflammatory bowel disease (IBD) is still unclear, the role of the
resident luminal bacteria and its interaction on the mucosal barrier
seem to be an important factor in the development of IBD and its
chronicity. With the objective of manipulating the intestinal
microbiota in IBD, this study was carried out to evaluate the effects
of ERF on IBD with using experimental colitis models.

METHODS:
Three colitis models were used and they were induced by the oral
administration of dextran sodium sulfate in male Sprague-Dawley rats
or BALB/c mice and transferring CD4+ CD45RB(high) T cells to female
SCID mice, sequentially their CD4+ T cells were retransferred to new
SCID mice. The evaluation included the measurement of body weight,
spleen weight, colon length, histological examination, serum and
mucosal cytokine (tumor necrosis factor-alpha (TNF-α), an interferon-
gamma (IFN-γ), interleukin-12 p70 (IL-12p70), IL-1β, IL-6, IL-4)
analysis, mucosal serotonin (5HT), and organic acid production and a
microbiota analysis of the cecal contents. The characteristics of T
cell surface markers including CD4, CD69, CD45RB of spleen and
mesenteric lymph nodes (MLN) were also analyzed. In addition, the
effects of ERF on the change in the induction of dendritic cells (DCs)
were evaluated.

RESULTS:
The preventive effect of ERF on colitis was significantly superior to
that of raw material rice bran or control group. An overexpression of
inflammatory cytokine production was attenuated by ERF treatment,
which was accompanied with a decrease in both the colonic mucosal
damage and 5HT production. Furthermore, ERF significantly attenuated
the T cell activation (CD4+CD69+) of spleen and MLN, and this
characteristic was inherited by the retransferred mice. ERF
significantly suppressed the growth of Clostiridium, and increased
short-chain fatty acids (acetate, propionate and butyrate) content in
colitis. The relatively hydrophilic fraction of ERF (ethanol-methanol
soluble fraction) is therefore considered to have a potent ability to
attenuate the induction of DCs.

CONCLUSION:
A new prebiotic, ERF, reduced inflammation by modulating the colonic
environment and regulating immune cell differentiation. Although a
more detailed study is required, this study showed the promising anti-
inflammatory effects of an adjunctive prebiotic treatment for IBD.

PMID: 20735154

But is it good stress or BAD stress?

http://www.ncbi.nlm.nih.gov/pubmed/22294825
pmid: 22294825

To raise butyrate and good stuff or what?


http://www.ncbi.nlm.nih.gov/pubmed/20198303
Int J Mol Med. 2010 Apr;25(4):547-55.
Preventive effects of enzyme-treated rice fiber in a restraint stress-
induced irritable bowel syndrome model.

Kanauchi O, Mitsuyama K, Komiyama Y, Yagi M, Andoh A, Sata M.

Source
Central Laboratories for Frontier Technology, Kirin Holdings Co. Ltd.,
Kanazawa-ku, Yokohama, 236-0004, Japan. kana...@kirin.co.jp

Abstract
Irritable bowel syndrome (IBS) is a common health issue that is
characterized by abdominal pain, abnormal bowel movements, altered
visceral perception, and abnormal metabolism of 5-hydroxy triptamine
(serotonin; 5HT). The use of prebiotics or probiotics treatment for
IBS has become increasingly important as an adjunct to pharmaceutical
options. The aim of this study was to determine the efficacy of enzyme-
treated rice fiber (ERF) on an IBS model. We obtained a new prebiotic
from defatted rice bran that was developed as an insoluble dietary
fiber through amylase and hemicellulase treatment followed by removal
of the soluble fraction. Containing approximately 70% hemicellulose,
ERF is utilized by lactobacilli and subsequently converted to butyrate
using Eubacterium limosum. We employed a restraint stress IBS model
which involved the continuous application of stress for 4 h per day
for 3 days. Polycarbophil Ca (PC) (500 mg/kg body weight) was used as
a positive control and ERF was added to the diet at 4% in diet. During
restraint stress, ERF significantly attenuated urgent fecal excretion,
colonic mucosal 5HT secretion, and hyperalgesthesia compared with the
control. ERF also significantly increased cecal butyrate production as
well as total organic acid content. PC was only effective in regard to
preventing increases in 5HT levels. Furthermore, there were no
significant levels of pro-inflammatory markers CINC-1 and TNF-alpha
among the groups. Although more detailed studies are needed, the ERF
prebiotic demonstrated potency in attenuating major symptoms of IBS.

PMID: 20198303


And don't forget to KEEP your MyD88 on it's TOES!



Biosci Biotechnol Biochem. 2007 Dec;71(12):3026-32. Epub 2007 Dec 7.
MyD88 but not TLR2, 4 or 9 is essential for IL-12 induction by lactic
acid bacteria.

Ichikawa S, Fujii R, Fujiwara D, Komiyama Y, Kaisho T, Sakaguchi M,
Konishi Y.

Source
Central Laboratories for Frontier Technology, Kirin Holdings Company
Ltd., Yokohama, Japan. Shintaro...@kirin.co.jp

Abstract
Although lactic acid bacteria (LAB) affect the immune system, for
example, having an anti-allergic effect, little is known about the
actual mechanisms of immune modulation. Toll-like receptors (TLRs)
recognize conserved microbial molecular patterns, and are presumed to
be involved in the recognition of LAB. However, there are few detailed
reports examining the relationships between TLR and LAB. We measured
here production of IL-12, a cytokine considered to play an important
role in anti-allergic effects, induced by Lactobacillus paracasei
strain KW3110 and other typical LAB by cells from TLR2-, TLR4-, TLR9-
and myeloid differentiation factor 88 (MyD88)-deficient mice.
Unexpectedly, similar cytokine production from wild-type and TLR2-, 4-
and 9-deficient mice was observed. In contrast, cells from MyD88-
deficient mice failed to respond to stimulation with LAB. It is
therefore concluded that although LAB, including strain KW3110, are
not likely to be recognized by TLR2, 4 or 9, MyD88 is essential for
the response to these bacteria.

PMID: 18071261
Free full text
http://joi.jlc.jst.go.jp/JST.JSTAGE/bbb/70414?lang=en&from=PubMed


I eat prunes and don't notice much more then the generally expected BM
the next day.


But, would these prunes or essence of them help HIV/Aids and cancer
folks?


By raising IL-12p70 ?


Is lack of IL12 p70 due to mutations?

http://en.wikipedia.org/wiki/IL-12_and_IL-12_Receptor_%CE%B21_Mutations

http://www.wikigenes.org/e/ref/e/16751389.html

to

http://www.ncbi.nlm.nih.gov/pubmed/16751389
J Immunol. 2006 Jun 15;176(12):7438-46.
T cell-independent, TLR-induced IL-12p70 production in primary human
monocytes.

Bekeredjian-Ding I, Roth SI, Gilles S, Giese T, Ablasser A, Hornung V,
Endres S, Hartmann G.

Source
Department of Internal Medicine, Division of Clinical Pharmacology,
University of Munich, Germany.

Abstract
IL-12p70 is a key cytokine for the induction of Th1 immune responses.
IL-12p70 production in myeloid cells is thought to be strictly
controlled by T cell help. In this work we demonstrate that primary
human monocytes can produce IL-12p70 in the absence of T cell help. We
show that human monocytes express TLR4 and TLR8 but lack TLR3 and TLR7
even after preincubation with type I IFN. Simultaneous stimulation of
TLR4 and TLR8 induced IL-12p70 in primary human monocytes. IL-12p70
production in peripheral blood myeloid dendritic cells required
combined stimulation of TLR7/8 ligands together with TLR4 or with TLR3
ligands. In the presence of T cell-derived IL-4, but not IFN-gamma,
stimulation with TLR7/8 ligands was sufficient to stimulate IL-12p70
production. In monocytes, type I IFN was required but not sufficient
to costimulate IL-12p70 induction by TLR8 ligation. Furthermore, TLR8
ligation inhibited LPS-induced IL-10 in monocytes, and LPS alone
gained the ability to stimulate IL-12p70 in monocytes when the IL-10
receptor was blocked. Together, these results demonstrate that
monocytes are licensed to synthesize IL-12p70 through type I IFN
provided via the Toll/IL-1R domain-containing adaptor inducing IFN-
beta pathway and the inhibition of IL-10, both provided by combined
stimulation with TLR4 and TLR8 ligands, triggering a potent Th1
response before T cell help is established.

PMID: 16751389
Free full text
http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=16751389

54 hits: IL-12p70 + Th17 - pubmed:
http://www.ncbi.nlm.nih.gov/pubmed?term=IL-12p70%20%20Th17


ONE of 54 has HIV:

http://www.ncbi.nlm.nih.gov/pubmed?term=IL-12p70%20Th17%20hiv
J Leukoc Biol. 2010 Apr;87(4):645-53. Epub 2010 Jan 22.
IL-23 and IL-12p70 production by monocytes and dendritic cells in
primary HIV-1 infection.

Louis S, Dutertre CA, Vimeux L, Fery L, Henno L, Diocou S, Kahi S,
Deveau C, Meyer L, Goujard C, Hosmalin A.

Source
Institut Cochin, Universite Paris Descartes, CNRS (UMR 8104), Paris,
France.

Abstract
IL-12 enhances protective responses against HIV replication. Its
production after in vitro stimulation is defective in chronic HIV
infection, but higher responses can be found. IL-23 shares the p40
chain and some properties with IL-12 and enhances Th17 responses, but
its role in HIV infection is unknown. The production of IL-12 and
IL-23 and the respective contribution of monocytes and myeloid
conventional DC (cDCs) during primary HIV infection were determined.
Sixteen patients included in the French PRIMO-ANRS Cohort without
antiretroviral treatment were followed prospectively and compared with
uninfected donors. Intracellular p40 expression by monocytes and cDCs,
analyzed by flow cytometry, was transiently increased in monocytes and
cDCs in response to LPS and more consistently, in monocytes in
response to LPS + IFN-gamma. IL-23 production, measured by ELISA after
PBMC stimulation, was induced by LPS in strong correlation with VLs.
IL-12p70 production required the addition of IFN-gamma and was
transiently increased in patients compared with controls in
correlation with VLs, whereas IL-23 was increased sustainedly.
Therefore, an apparent domination of IL-23 over IL-12 responses
occurred throughout primary HIV infection, and a potential restoration
of IL-12 responses might be expected from a treatment mimicking
activated T cell signals.

PMID: 20097848
Free full text
http://www.jleukbio.org/cgi/pmidlookup?view=long&pmid=20097848


And we get 25 hits if we take out Th17:

25 hits - IL-12p70 + hiv -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=IL-12p70%20%20hiv

And same thing with cancer and

210 hits: IL-12p70 + cancer
http://www.ncbi.nlm.nih.gov/pubmed?term=IL-12p70%20cancer

And six of 210 has: Th17
http://www.ncbi.nlm.nih.gov/pubmed?term=IL-12p70%20cancer%20%20Th17

-----------

129 hits: IL-12p70 hiv - all groups
https://groups.google.com/groups/search?q=IL-12p70+hiv&btnG=Search&sitesearch=

with cancer:
https://groups.google.com/groups/search?q=IL-12p70+cancer&btnG=Search&sitesearch=

http://en.wikipedia.org/wiki/Interleukin_12


==========================


OK the PLANT thread is calling me... so bye bye for NOW....


I can smell night blooming cereus?


Seriously?


Yes... and i see them hanging limPly after their blooms the next
morning. LoL


Gosh..


Talk about lack of staying POWER..

If only they had ROsE power for ... hanging around?



randall.. on plant II and less stress.... next!