Maltol Attenuates Diabetic Peripheral Neuropathy

[ironjustice]

Maltol, a food flavor enhancer, attenuates diabetic peripheral neuropathy in streptozotocin-induced diabetic rats
Nan Guo 1, Caina Li, Quan Liu, Shuainan Liu, Yi Huan, Xing Wang, Guoliang Bai, Miaomiao Yang, Sujuan Sun, Caimin Xu, Zhufang Shen
PMID: 30411095 DOI: 10.1039/c8fo01964a
Free article
Abstract
Scope: Maltol (3-hydroxy-2-methy-4-pyrone), a potent antioxidative agent, typically is used to enhance flavor and preserve food. This study evaluated its effects on preventing diabetic peripheral neuropathy (DPN) in streptozotocin (STZ)-induced diabetic rats and explored its mechanisms.

Methods and results: We intraperitoneally injected Sprague-Dawley (SD) rats with STZ (65 mg kg-1, ip) and treated the rats with different doses of maltol after 4 weeks of injection. During treatment, we evaluated motor nerve conduction velocity (MNCV) and thermal and mechanical hyperalgesia and assayed the oxidative stress, Na+-K+-ATPase activity, and apoptosis. Repeated treatment with maltol for 12 weeks significantly improved thermal and mechanical hyperalgesia, increased the MNCV, elevated the Na+-K+-ATPase activity, and ameliorated oxidative stress and apoptosis in STZ-induced diabetic rats. We coincubated RSC96 cells, a Schwann cell line, with maltol and hydrogen peroxide (H2O2, 0.6 mM). Evidently, maltol increased cell viability and inhibited apoptosis after injury by H2O2.

Conclusions: Maltol was demonstrated to prevent DPN development and may provide a new alternative for the treatment of DPN.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING

[HeartDoc Andrew]

In the interim, I am simply wonderfully hungry (
http://tinyurl.com/StatCOVID19Test ) and hope you, Tom, also have a
healthy appetite too.

So how are you ?








...because we mindfully choose to openly care with our heart,

HeartDoc Andrew <><
--
Andrew B. Chung, MD/PhD
Cardiologist with an http://HeartMDPhD.com/EternalMedicalLicense
2024 & upwards non-partisan candidate for U.S. President:
http://HeartMDPhD.com/WonderfullyHungryPresident
and author of the 2PD-OMER Approach:
http://HeartMDPhD.com/HeartDocAndrewCare
which is the only **healthy** cure for the U.S. healthcare crisis

[HeartDoc Andrew]

Tom wrote:
> HeartDoc Andrew, in the Holy Spirit, boldly wrote:
>> Tom wrote:
>>> HeartDoc Andrew, in the Holy Spirit, boldly wrote:
>>>> Tom wrote:
>>>>> HeartDoc Andrew, in the Holy Spirit, boldly wrote:
>>>>>> Tom wrote in the subject line:
>>>>>>
>>>>>> > "Iron enrichment in fatness"
>>>>>>
>>>>>> Eating less down to the right amount, which is 32 oz per day, allows
>>>>>> us to avoid over-enrichment of all minerals including iron.
>>>>>>
>>>>>> In the interim, I am indeed wonderfully hungry (
>>>>>> http://bit.ly/Philippians4_12 ) and hope you, Tom, also have a healthy

>>>>>> appetite too.
>>>>>>
>>>>>> So how are you ?
>>>>>

>>>>> Can't say I'm wonderfully hungry ...
>>>>
>>>> The question was not whether you're able to "say" that you're
>>>> wonderfully hungry.
>>>>
>>>> Nonetheless, you did "say" that you're wonderfully hungry though also
>>>> falsely "saying" that you can't.
>>>>
>>>> We, who are alive, are either living (wonderfully hungry) or dying
>>>> (terribly not hungry).
>>>>
>>>> Those who are living (i.e. not dying) and yet really can't "say" they
>>>> are "wonderfully hungry" are those who are hangry (i.e. they have a
>>>> terrible attitude towards being wonderfully hungry).
>>>>
>>>> While wonderfully hungry ( http://bit.ly/Philippians4_12 ), I advise
>>>> that you, Tom, try to write more clearly and unequivocally that you're
>>>> "wonderfully hungry" since we've established here that you are:
>>>>
>>>> So now how are you ?
>>
>> Source:
>> https://groups.google.com/d/msg/alt.support.diabetes/85ZqCYZ3RjI/NUl2QHogAQAJ
>>
>>> (Those who are living (i.e. not dying) and yet really can't "say")
>>> they are "wonderfully hungry" are those who are hangry"
>>>
>>> Doctor Chung, you do know / have been told, you are confusing?
>>
>> Not by those who are saying they're wonderfully hungry.
>>
>>> In your interview for presidential consideration you seem to forget, being hungry actually makes you .. angry ..
>>
>> Not for those who are saying they're wonderfully hungry.
>>
>>> another Science based bit of evidence which you don't seem to believe.
>>
>> It remain my choice to focus on facts (i.e. what we can prove) instead
>> of beliefs.
>>
>>> You believe taking the food away from already angry folk, terrorists, and they will 'fall into line' ...
>>
>> No.
>>
>> I know that if hangry folks, including terrorists, started saying
>> they're wonderfully hungry, they'd stop terrorizing both themselves and
>> others.
>>
>> Therefore, while wonderfully hungry ( http://bit.ly/Philippians4_12 ),
>> I again advise that you, Tom, really try to write more clearly and
>> unequivocally that you're "wonderfully hungry" since we've established
>> here that you are:
>>
>> So now again, how are you ?
>
> I am wonderfully hungry.

Source:
https://groups.google.com/d/msg/alt.support.diabetes/85ZqCYZ3RjI/75m-tK6dAQAJ

While wonderfully hungry in the Holy Spirit, Who causes (Deuteronomy
8:3) us to hunger right now (Luke 6:21a), I note that you, Tom, are
rapture (Luke 17:37) ready and I pray (2 Chronicles 7:14) that GOD
continues to give us "much more" (Luke 11:13) Holy Spirit (Galatians
5:22-23) so that we'd have much more of His Help to always say/write
that we're "wonderfully hungry" in **all** ways including especially
caring to http://bit.ly/convince_it_forward (per John 15:12) in the
name
of Jesus Christ of Nazareth. Amen.

Laus DEO !

Be hungrier, which really is wonderfully healthier especially for
diabetics and other heart disease patients:

http://HeartMDPhD.com/HeartDocAndrewToutsHunger (Luke 6:21a) with all
glory ( http://HeartMDPhD.com/Psalm117_ ) to GOD, Who causes us to
hunger (Deuteronomy 8:3) when He blesses us right now (Luke 6:21a)
thereby removing the http://HeartMDPhD.com/VAT from around the heart