Hello,
This is a discussion that follows up
this question. I don't have a specific problem with Rqtl but it is more about how to proceed with bimodal phenotypes and discuss a recent paper using 2p for bimodal data.
So it seems that if the residuals are normally distributed or close to that, no matter if the phenotype itself is bimodal, the normal model can be used, right ? But what they didn't say is : if the residuals are not normal, do we have to use "np" model instead ?
Because if I understood well, Karl said that bimodal data shouldn't be transformed to maybe not loose the major loci effect, right?
I saw in
this paper that they used "2p" model for their bimodal phenotypes (
supplementary figure S2). It is very confusing because I thought that "2p" model was developed for spike-like distribution. What are your thoughts ?
Thank you so much for such a wonderful work !
Best regards,
Diana