Membraneless compartment

[Cécilia Brancheriau]

Hello,

I would like to represent two compartments which are not separated with a membrane. Is it possible?

Thanks!

[les...@gmail.com]

Hi,

I assume you mean in a spatial model. There are some good examples of this in a recent paper by myself and Ann Cowan where we define spherical regions within the cytosol to represent condensates. Those regions contain fixed (D=0) binding partners for molecules that can diffuse in and out. See the results starting near the end of page 3730 in:

 

Cowan, A. E., and L. M. Loew. 2023. Beyond analytic solution: Analysis of FRAP experiments by spatial simulation of the forward problem. Biophysical Journal. 122:3722-3737, doi: https://doi.org/10.1016/j.bpj.2023.06.013, https://www.sciencedirect.com/science/article/pii/S0006349523004010.

You can look at the published VCell model ‘‘FRAP Condensate Droplet”. I’d be happy to explain further if needed.

Best,

Les

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[Cécilia Brancheriau]

Thank you, it helps a lot!

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