Hi Brett,
I use Orange Seal in tubes (butyl and latex) with Compass 584x38 and 584x42 (regular, not EL casing).
I think it helps, but my frequency of flats was low before sealant. My rides are generally commutes, and getting a flat can be an expensive nuisance if I'm late for child pickup.
For set up, I install tube+tire and air it up (without sealant). If it looks good, then I deflate the tube and remove the valve core. (BTW: Park chain tool, probably others, can be used to remove the valve core; the "arms" are the right distance to engage the flats of the core.)
With valve ~4 o'clock position (and tire off the ground), I inject ~4 oz of Orange Seal. I could probably get away with less sealant, but... half of 8 is 4 and I figured that if I stored the bottle, the remaining sealant would probably dry out. (My LBS didn't have the 4oz size.)
Next, reinstall the core and air it up. I recently read someone advising adding Boeshield or similar to the core before installation (to prevent clogging). Maybe I'll try that next time. I can't say that it's been much of a problem for me, though.
Good luck!
shoji
Arlington MA