Which 5th gen?
This matters greatly. I've had very little (well really none at all) printing raftless on the Mini.
All of the 5th gens use the nozzle homing sequence which I have been less than impressed with as far as accurate and repeatable first layer height goes- hence the reason for using rafts in the first place as a compensating factor.
Now, they just announced new firmware and software for the 5th gens and specifically, homing is one area they supposedly fixed in the latest version. I cannot test until I get my Mini back.
So again, the bottom line best answer is update the firmware and try to print raftless. Otherwise- you are going to have to dig deep and edit the profile and pray you find the magic combination of settings.
Sorry if that's a non-answer but it's what I know
Update the firmware and MakerBot Desktop
Try and print raftless
If that doesn't work- well time to read up on editing profiles and a lot of experimentation.