You cannot rename the file.
You cannot change the machine name.
You cannot modify certain a parts of the start. Gcode.
MW uses a G92 command to overwrite the values recalled from homing offsets. If you change the build area, you may have to adjust this to center the print.
The changes take effect when you restart the service.
You must the recreate any x3g files to see the changes.
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Makerbot made this hard on purpose to prevent cloners or other companies from using Makerware easily.
You can make it work but it does take a lot of previous knowledge and a sound understanding of gcode, x3g, and all interactions in between.
For a rev e based build and 17t pulleys use replicator single or dual.
You do not have to do it that way but you don't have to change as many parameters. For me, I have to edit a profile I don't use. For example, I don't own a 2 or 2x but I do own a regular replicator dual. So I made my single small core xy machine mapped to replicator single. I can't change the name of the profile so I just have to remember replicator single = small core xy. Replicator dual is a normal profile because I own one. Replicator 2x is the 4foot cubed beast of a printer.
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Dan
Just trying to point out ones that got me early on.