I love Smalltalk and have a killer framework using an object database, all server-side. Seaside and AidaWeb are great, but not what I need for numerous reasons.
Server-side Smalltalk has many integration issues with existing systems, but is great for highly complex systems.
Client-side Smalltalk, such as Amber running on a ubiquitous Javascript virtual-machine provides much more flexibility. For example, I might want to embed a client-side app in a CMS system or deploy on mobile devices... I am seeking other like-minded Smalltalk developers that can envision a complete development/deployment stack for building enterprise quality web apps. Far more can be done in an open-source and/or team environment.