I wouldn't suggest Apache / mod_proxy. Our experience wasn't really nice. (https, long polling, web socket) issues and more.. We implemented a node.js extension for Parallel's Plesk. So Parallel Plesk users can host node applications.
Check it here That simply works on top of JXcore and proxy the things over nginx. If you have a chance to install this extension on plesk, you can simply focus on your node application instead all the tricky parts.
However, soon we might open source this extension and you might even make it a standalone solution. There are many articles on node.js & nginx ,
for example