first report or new disease

[hayman awla]

how can I know my Actinomycete its first report? any way to check in? 

[Dakota Hamill]

What is the question?  I might be able to help

On Feb 20, 2015 2:12 PM, "hayman awla" <hayma...@gmail.com> wrote:

how can I know my Actinomycete its first report? any way to check in? 

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[Tom Hodder]

On Wednesday, 18 February 2015 14:54:11 UTC, hayman awla wrote:

how can I know my Actinomycete its first report? any way to check in? 

You'd have to give more details re what your finding is, in order to determine which databases and literature to search for previous reports. 

But the "traditional" protocol for establishing the link between an organism and a disease are Koch's postulates;

(from http://en.wikipedia.org/wiki/Koch%27s_postulates)

1. The microorganism must be found in abundance in all organisms suffering from the disease, but should not be found in healthy organisms.
2. The microorganism must be isolated from a diseased organism and grown in pure culture.
3. The cultured microorganism should cause disease when introduced into a healthy organism.
4. The microorganism must be reisolated from the inoculated, diseased experimental host and identified as being identical to the original specific causative agent.

Or the revised versions of Koch’s postulates: By Fredricks and Relman:

1. A nucleic acid sequence belonging to a putative pathogen should be present in most cases of an infectious disease. Microbial nucleic acids should be found preferentially in those organs or gross anatomic sites known to be diseased, and not in those organs that lack pathology.
2. Fewer, or no, copies of pathogen-associated nucleic acid sequences should occur in hosts or tissues without disease.
3. With resolution of disease, the copy number of pathogen-associated nucleic acid sequences should decrease or become undetectable. With clinical relapse, the opposite should occur.
4. When sequence detection predates disease, or sequence copy number correlates with severity of disease or pathology, the sequence-disease association is more likely to be a causal relationship.
5. The nature of the microorganism inferred from the available sequence should be consistent with the known biological characteristics of that group of organisms.
6. Tissue-sequence correlates should be sought at the cellular level: efforts should be made to demonstrate specific in situ hybridization of microbial sequence to areas of tissue pathology and to visible microorganisms or to areas where microorganisms are presumed to be located.
7. These sequence-based forms of evidence for microbial causation should be reproducible.

[Cathal Garvey]

We need more detail on what you mean.

But, assuming you're asking something like "I found an actinomycete, how
do I know if it's already discovered or a new species?", then:

Categorising bacteria into species is a bit tricky. That's because,
basically, species are a human idea to try and make sense of the world,
but really there is no such thing.

So, what defines one bacteria as being distinct from another? Whether or
not most scientists agree that it's meaningfully different and merits a
new name.

These days, DNA sequencing tends to be the accepted standard; if you can
show that the genomes of two bacteria differ significantly, then you
have grounds to declare a new species. You then try to assert that this
species belongs somewhere in a phylogenetic tree by analysing accepted
"standard" genes that are believed to mutate at fairly predictable rates
and comparing their sequences to suspected close relatives.

That's pretty much it. It's arbitrary voodoo. :)

On 18/02/15 14:54, hayman awla wrote:
> how can I know my Actinomycete its first report? any way to check in?
>

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