Biotech’s First Musical Instrument

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Juman Isstaif

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Sep 7, 2013, 4:56:26 AM9/7/13
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Hello everybody  :)
Hope you are fine

I was thinking about learning together and discovering about this :
http://www.scientificamerican.com/slideshow.cfm?id=biotechs-first-musical-instrument-plays-proteins-like-piano-keys-slideshow

I haven't found any "open source recipe" to do it,
so, it might be nice to explore it , or maybe just do it in a simple way

I have some friends that work on Arduino, so it would be nice to try it in our hackespace in Damascus

Do you think it's possible to be done in the  "DIY " way :) ?

Nathan McCorkle

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Sep 7, 2013, 6:16:41 PM9/7/13
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You can ask Josiah himself, he's the creator and hangs out on this list!

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Juman Isstaif

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Sep 8, 2013, 12:01:31 PM9/8/13
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Josiah Zayner

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Sep 9, 2013, 7:54:14 PM9/9/13
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If you want plasmid DNA to express the protein I can send it your way. Just give me an address. 

I can also send you code. Protocols for protein expression and schematics. The hard part is the protein expression and purification but by hard I just mean requires a centrifuge.

I built it all Open and Free.

Nathan McCorkle

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Sep 12, 2013, 3:52:34 PM9/12/13
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Do you have an oscilloscope trace of an input waveform and the output
of the protein sensor? If you use a range of frequencies, I think we
could develop a frequency response curve, then use this to compare to
wah wah and other effects pedals.
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Josiah Zayner

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Sep 15, 2013, 10:40:47 AM9/15/13
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I have done something similar though not exactly like this. The problem is that the output depends on things like concentration and "active" protein molecules. i.e. the ones that have not unfolded/degraded/&c. The proteins response can be modeled exponentially over the course of it being active so I do have an ok idea of what is going on at any specific time point. 

What are you thinking? Turn it into the first mass marketed protein wah pedal?


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