ARV7 score for SU2C data

[Maryam Labaf]

Greetings,

For a part of my alanysis, I need to compare the patients with positive AR-V7 and negative. Currently there is score for AR gene but not for AR-V7. Can you please guide me how can I calculate the score for the AR-V7 SRPM for SU2C data?


Thank you,
Maryam labaf,
Graduate student,
University of Massachusetts Boston

[debr...@mskcc.org]

Hi Maryam,

Thanks for reaching out!

Unfortunately we don't support querying expression by specific isoforms of AR, but I noticed that for this study there is a chart related to AR-V7 spliced read counts:

https://www.cbioportal.org/study/summary?id=prad_su2c_2019

I haven't fully gone through the paper, but one option is to e.g. compare those samples that have AR-V7 SPRM > 0 vs those with AR-V7 == NA:

https://www.cbioportal.org/comparison/overlap?comparisonId=62157cfa04dc35387468a203


Note that the study has two data attributes related to this: polyA AR-V7 SPRM and Capture AR-V7 SPRM. Best to refer to the study to see exactly how to use each of these

For more information on how to make groups see:

https://www.cbioportal.org/tutorials#group-comparison

Hope that helps!

Best wishes,
Ino

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