Lipinski rule of five

[Saravanan Rajamanikam]

i need details about "rule of Five " Lipinski. basically i am from Physics background.

according to Rule of Five.

first rule is the molecular weight is greater than 500 but for paracetamol the molecular weight is 151.69. then how it is satisfies the rule of five.

 

Regards

Saravanan Rajamanikam,
Research Scholar (Part time)

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[Rama Rams]

Hi,

As per the Lipinski's rule, Molecular weight should be less than 500...

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Thanks and Regards,
M.Rama

Research scholar

Department of chemistry,

Manipal Institute of Technology,

Manipal.

[nachi ..]

Hi Saravanan Rajamanikam,

       The Lipinski's rule of five states the following,

5 hydrogen bond donors and not more

10 hydrogen bond acceptors and not more

log P value not more than 5 and finally 

molecular mass not greater than 500 daltons (it should be lesser than 500)

so i hope now you would be clear and the attachment would help you in some way .

Thank you 

with regards

On Fri, Dec 20, 2013 at 9:55 AM, Saravanan Rajamanikam <sara...@yahoo.co.in> wrote:

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***************************************
Nachiappan.M
Research Scholar,
Department of Bioinformatics,
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Alagappa University,
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[ADARSH V. K.]

Dear Saravanan Rajamanikam,

Kindly see this website.

http://preadmet.bmdrc.org/index.php?option=com_content&view=frontpage&Itemid=1

http://preadmet.bmdrc.org/index.php?option=com_user&view=login&Itemid=88

You can also use Schrödinger software -> quick prop.
-----------------------------------------

These are only prediction based on drugs that are already in market. If you look details of individual drugs, some time you may notice one or two exception to this rule.

Just run 'Quick prop'  on your molecule (paracetamol) / any from TTD and see the result page. You can lean about it or simply try online with ' pre-ADMT ' website.

Try Google :- A number of simple topics you can read.

Regards,

Adarsh V. K.

Lecturer in Chem-informatics

On Fri, Dec 20, 2013 at 9:55 AM, Saravanan Rajamanikam <sara...@yahoo.co.in> wrote:

[Devi Priyanka]

Hi saravanan
The molecular weight should less than 500 Daltons... see the below link for more details

http://www.pharmainformatic.com/html/rule_of_5.html


Regards
Priyanka

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