Once a patient/study/series is created in Orthanc, an excerpt of its so-called "main DICOM tags" is extracted and stored into the database (SQLite/PostgreSQL/MySQL). This is this set of tags that is displayed by Orthanc Explorer.
To ensure consistency and performance, this information is never automatically changed, as long as the patient/study/series is not deleted.
You can ask Orthanc to refresh its index by calling the "/{patients|studies|series|instances}/.../reconstruct" route in the REST API (it is a POST without a body).
For instance, in your case, after modifying some instance with Orthanc identifier "{id}" and uploading it back, you could POST to "/instances/{id}/reconstruct" in order to update the main DICOM tags.
HTH