Magnesium deficiency in type-2 diabetics.
Andrew B. Chung, MD/PhD
>
> http://groups.google.com/group/sci.med.cardiology/msg/6d728ff9844134d2?
"Magnesium is a cofactor in more than 300 enzyme regulated reactions.
Most importantly forming and using ATP, i.e. kinase. There is a
direct
effect on sodium- (Na), potassium- (K) and calcium (Ca)channels. It
has several effects:
**Potassium channels are inhibited by magnesium. Hypomagnesemia
results in increased efflux of intracellular Mg. The cell loses
potassium which then is excreted by the kidneys, resulting in
hypokalemia. **
Release of calcium from the sarcoplasmic reticulum is inhibited by
magnesium. Low levels of magnesium stimulate the release of calcium
and thereby an intracellular level of calcium. This effect similar to
calcium inhibitors makes it "nature's calcium inhibitor." Lack of
magnesium inhibits the release of parathyroid hormone, which can also
result in hypocalcemia. Furthermore, it makes skeletal and muscle
receptors less sensitive to parathyroid hormone.
Through relaxation of bronchial smooth muscle it causes
bronchodilation.
The neurological effects are:
reducing electrical excitation
blocking release of acetylcholine
blocking N-methyl-D-aspartate, an excitatory neurotransmitter of the
central nervous system
http://en.wikipedia.org/wiki/Hypomagnesemia "
"Hypomagnesemia can also cause hypokalemia, as magnesium is required
for the adequate processing of potassium. This may come to light when
hypokalemia persists despite potassium supplementation. Other
electrolyte abnormalities may also be present. "
Magnesium is typically plentiful in the foods we eat. There is no
deficiency of magnesium in type-2 diabetic folks who are overeating.
Andrew <><
--
Andrew B. Chung, MD/PhD
http://EmoryCardiology.com
Kumar
Decreased Intake
Protein calorie malnutrition
Starvation
Alcoholism
Prolonged IV Therapy
Inadequate parenteral supplementation
Decreased Absorption
Malabsorption (e.g. Celiac Sprue)
Small intestine absorption
Neonatal gut immaturity
Excessive GI loss
Prolonged gastric suction
Laxatives
Intestinal or biliary fistula
Severe Diarrhea
Excessive Renal Losses
Diuretics
Acute Tubular Necrosis (Diuretic phase)
Acute Renal Failure diuresis
Primary Aldosteronism
**Hypercalcemia
Renal Tubular Acidosis (RTA)
Idiopathic renal wasting
Chronic Renal Failure with wasting
Miscellaneous Causes
Idiopathic
Acute Pancreatitis
Porphyria with SIADH
Multiple transfusions with citrated blood
Endocrine
Hyperthyroidism
Hyperparathyroidism
**Diabetes Mellitus and Diabetic Ketoacidosis
**Hyperaldosteronism
Symptoms
Weakness
Vertigo
Dysphagia
http://www.fpnotebook.com/REN93.htm "
"Calcium Parenteral Administration:Indications
Hypocalcemia
Often occurs after blood transfusion
*Hyperkalemia
*Hypermagnesemia
Calcium Channel Blocker overdose or toxicity
May also prevent hypotensive effect of IV agent
Not indicated in:
Asystole
Pulseless Electrical Activity
http://www.fpnotebook.com/REN101.htm "
"
Hyperkalemia Causes
"Redistribution (ICF to ECF)
**Acidosis (more likely with mineral acids NH4, HCl)
Hyperkalemic periodic paralysis
**Insulin deficiency (Diabetes Mellitus)
*Rapid ECF rise
**Hypertonic glucose or mannitol infused
Dialysis
Coronary bypass
Medications
Succinylcholine (if concurrent tissue damage)
Beta Blockers
Digitalis intoxication (Digoxin Toxicity)
Arginine
Tissue necrosis or Burn Injury
http://www.fpnotebook.com/REN115.htm
Hypokalemia due to Transcellular Potassium Shift: Cause
Medications
Beta-agonist
*Insulin excess
*Acute glucose load
Vitamin B12 Supplementation
Delirium Tremens
*Alkalosis
Hypokalemic Periodic Paralysis
Anabolic states
http://www.fpnotebook.com/REN120.htm "
It can be important to understand glucose/salt/sodium/dehydration/
chloride and acidosis oriented Redistribution (ICF to ECF) of ICF
contents AND their excesses in ECF, blood and in urine to maintain
normal blood levels till body/kidney is able/not degenerated ALSO
their intake for compensting such abnormal urine loss. Altertions in
Hyper/hypo conditions in ECF/blood and in ICF may be there due to
Redistribution (ICF to ECF), compesatory abnormalities in intakes,
impaired/degenarative digestive activities, excessive loss in urine,
impaired/altered kidney functions etc.?
Pls link all Synergists and Antagonists/Inhibitors to such K, Mg, P,
Ca, Na, Cl, acidosis, alkalosis, hyperglycemia, tonic abnormilities,
ICF/ECF?
Kumar
More to add;
"Other Notable Effects of Insulin
In addition to insulin's effect on entry of glucose into cells, it
also stimulates the uptake of amino acids, again contributing to its
overall anabolic effect. When insulin levels are low, as in the
fasting state, the balance is pushed toward intracellular protein
degradation.
**Insulin also increases the permiability of many cells to potassium,
magnesium and phosphate ions. The effect on potassium is clinically
important. Insulin activates sodium-potassium ATPases in many cells,
causing a flux of potassium into cells. Under certain circumstances,
injection of insulin can kill patients because of its ability to
acutely suppress plasma potassium concentrations.
http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/pancreas/insulin_phys.html
"
Whether lack of insulin causes the reverse of above in persisting
hyperglycemic folks?
Andrew B. Chung, MD/PhD
> convicted neighbor Kumar wrote:
Wiser to overcome the brainwashing that "hunger is bad" in order to
befriend it so as to stop overeating:
http://HeartMDPhD.com/HolySpirit/overweight.asp
Kumar
> > "
> > Whether lack of insulin causes the reverse of above in persisting
> > hyperglycemic folks?
>
> Wiser to overcome the brainwashing that "hunger is bad" in order to
> befriend it so as to stop overeating:
expose myself to lesser insulin. Though initially, I feel that glucose
levels are increased periodically may be due to more breakdown of
energy stores resulted from decreased insulin's action but many other
things even persisting hyperglycemia, VAT start reversing. How?
> http://HeartMDPhD.com/HolySpirit/overweight.asp
>
> Andrew <><
> --
> Andrew B. Chung, MD/PhDhttp://EmoryCardiology.com- Hide quoted text -
>
> - Show quoted text -
Andrew B. Chung, MD/PhD
Until you believe that "hunger is good" in the heart of your soul, it
will continue to be a struggle where you feel that you are suffering.
> Though initially, I feel that glucose
> levels are increased periodically may be due to more breakdown of
> energy stores resulted from decreased insulin's action but many other
> things even persisting hyperglycemia, VAT start reversing.
VAT is lost while we are eating less and being hungrier.
> How?
By GOD's design:
Kumar
energy stores initiate persisting inflammatory responses or oxidative
stress or systemic inflammatory cytokines?
Andrew B. Chung, MD/PhD
> Andrew, in the Holy Spirit, boldly wrote:
> > convicted neighbor Kumar wrote:
> >
> > > > > http://groups.google.com/group/sci.med.cardiology/msg/6d728ff9844134d2?
<snip>
> > Until you believe that "hunger is good" in the heart of your soul, it
> > will continue to be a struggle where you feel that you are suffering.
> >
> > > Though initially, I feel that glucose
> > > levels are increased periodically may be due to more breakdown of
> > > energy stores resulted from decreased insulin's action but many other
> > > things even persisting hyperglycemia, VAT start reversing.
> >
> > VAT is lost while we are eating less and being hungrier.
>
> Naturally. However, can decreased or resisted/restricted breakdown of
> energy stores initiate persisting inflammatory responses or oxidative
> stress or systemic inflammatory cytokines?
No. The source of the pro-inflammatory cytokines that are the
proximal cause of insulin resistance for type-2 diabetics is VAT.
Kumar
Andrew B. Chung, MD/PhD wrote:
> convicted neighbor Kumar wrote:
> > Andrew, in the Holy Spirit, boldly wrote:
> > > convicted neighbor Kumar wrote:
> > >
> > > > > > http://groups.google.com/group/sci.med.cardiology/msg/6d728ff9844134d2?
>
> <snip>
>
> > > Until you believe that "hunger is good" in the heart of your soul, it
> > > will continue to be a struggle where you feel that you are suffering.
> > >
> > > > Though initially, I feel that glucose
> > > > levels are increased periodically may be due to more breakdown of
> > > > energy stores resulted from decreased insulin's action but many other
> > > > things even persisting hyperglycemia, VAT start reversing.
> > >
> > > VAT is lost while we are eating less and being hungrier.
> >
> > Naturally. However, can decreased or resisted/restricted breakdown of
> > energy stores initiate persisting inflammatory responses or oxidative
> > stress or systemic inflammatory cytokines?
>
> No. The source of the pro-inflammatory cytokines that are the
> proximal cause of insulin resistance for type-2 diabetics is VAT.
Andrew B. Chung, MD/PhD
It would be GOD's purpose:
To chasten us for the sin of gluttony (overeating).
"The wages of sin is death." -- Holy Spirit.
Amen.
Kumar
Andrew B. Chung, MD/PhD wrote:
> convicted neighbor Kumar wrote:
> > Andrew, in the Holy Spirit, boldly wrote:
> > > convicted neighbor Kumar wrote:
> > > > Andrew, in the Holy Spirit, boldly wrote:
> > > > > convicted neighbor Kumar wrote:
> > > > >
> > > > > > http://groups.google.com/group/sci.med.cardiology/msg/6d728ff9844134d2?
> > >
> > > <snip>
> > >
> > > > > Until you believe that "hunger is good" in the heart of your soul, it
> > > > > will continue to be a struggle where you feel that you are suffering.
> > > > >
> > > > > > Though initially, I feel that glucose
> > > > > > levels are increased periodically may be due to more breakdown of
> > > > > > energy stores resulted from decreased insulin's action but many other
> > > > > > things even persisting hyperglycemia, VAT start reversing.
> > > > >
> > > > > VAT is lost while we are eating less and being hungrier.
> > > >
> > > > Naturally. However, can decreased or resisted/restricted breakdown of
> > > > energy stores initiate persisting inflammatory responses or oxidative
> > > > stress or systemic inflammatory cytokines?
> > >
> > > No. The source of the pro-inflammatory cytokines that are the
> > > proximal cause of insulin resistance for type-2 diabetics is VAT.
> >
> > What can be the purpose of VAT releasing inflammatory cytokines?
>
> It would be GOD's purpose:
>
> To chasten us for the sin of gluttony (overeating).
Andrew B. Chung, MD/PhD
To discipline us, steering us away from sin.
HE is the Good Shepherd.
Andrew B. Chung, MD/PhD
To discipline us, steering us away from sin.
HE is the Good Shepherd.
> > "The wages of sin is death." -- Holy Spirit.
Kumar
> HE is the Good Shepherd.
>
> > > "The wages of sin is death." -- Holy Spirit.
>
> > > Amen.
>
> Andrew <><
> --
Andrew B. Chung, MD/PhD
GOD is omnipresent so that there is no chasing.
When we stray from HIS perfect will (by overeating and accumulating
VAT for example), we become less hungry:
> > http://groups.google.com/group/sci.med.cardiology/msg/73b1a2ff323f1a23?
Kumar
anything?
Kumar
Andrew B. Chung, MD/PhD
>
> > > > HE is the Good Shepherd.
> > > >
> > > > > > "The wages of sin is death." -- Holy Spirit.
> > > >
> > > > > > Amen.
>
> When HE is omnipresent and omniscient, how can we wrong in doing
> anything?
By not being perfect because our LORD Almighty GOD is perfect.
Kumar
> Andrew <><
> --
Andrew B. Chung, MD/PhD
It remains GOD infinite and perfect will that all souls retain HIS
generous gift of free will.
Kumar
To gain inner strength and pure consititution is good, but to maintain
that, one may also to get such envoronment as existed during time when
so indicated adam or eve type of constitutions were existed. Everyone
may like to go to heaven but no one may like to die. Maintainable
constitution/body with many mutations/tolerances/resistances may be
needed and valid for survival here under current changed environment.
So current theories/tellings may be more valid and maintainable than
older eventhough those may be leading to ultimate/some adversities.
Best wishes.
> Andrew <><
> --
Andrew B. Chung, MD/PhD
It is not. It remains a generous gift from LORD Almighty GOD, Creator
of heaven and earth, Giver of life, Author of all reality (including
the alternate ones).
> To gain inner strength and pure consititution is good, but to maintain
> that, one may also to get such envoronment as existed during time when
> so indicated adam or eve type of constitutions were existed. Everyone
> may like to go to heaven but no one may like to die. Maintainable
> constitution/body with many mutations/tolerances/resistances may be
> needed and valid for survival here under current changed environment.
> So current theories/tellings may be more valid and maintainable than
> older eventhough those may be leading to ultimate/some adversities.
> Best wishes.
http://abchung.livejournal.com/986.html?thread=6618#t6618