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111 Year Old Bernando LaPallo --(diet + more tips) -- Epstein-Barr Virus & Psor? - ERAP1 (ARTS-1) --> EBV &Vitamin D3 ->RecePtors --CFS -> mAbs and Apremilast ++++
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randall
Feb 10, 2012, 5:07:33 PM2/10/12
to
hi
when will we cut out the cRAP of LIFE?
Not easy, when half the people see yin yang one way and the udder
the oPPosite whey?
Are they looking at night?
No id squid their brains are inverse and reverse wired i'm thinking
this TIME.
And take time to think about this..
Jeanne Calment never sweat the small or LARGE stuff come to think
about it?
How much time should i think about that?
All the time?
OK... as it's a big world... spin me..
What is happening in the Middle east?
Not much that wasn't predicted years ago:
When Obama told them he was a Muslim? LOL
Did he lie to them or us? <G>
ABSOLUTELY SHOCKING! What Was Predicted 3 Years Ago is NOW HERE! BHO
EXPOSED! (Avi Lipkin)
http://www.youtube.com/watch?v=zSAW4YTZAwY
<time: 4:26> <views: 87,676>
Hear Carl Gallups (Narrator of this video) on Live talk radio on NW
FL's TALK RADIO - 1330 WEBY AM - broadcasting to a 4 state area on the
Gulf Coast - every Friday afternoon - 4-6 pm CT.
http://www.hickoryhammockbaptist.org/radio
Maybe the truth will come out in another 50 years?
Yeah, like this one poPPing out of JFK's closet.
The virgin stutter that made JFK's putter Flutter?
what? what, what,, wha wa wa?
See;
below....xxx rated... and makes me blush if John-john was still alive
for this jive:
http://en.wikipedia.org/wiki/John_F._Kennedy,_Jr.
Yikes...!
Sins of the FATHER....Coming uP below.... LOL
I know, i know....
BUT,
First:
I like old-ster Jeanne calment...i think and BELIEVE she's the
GREATEST or one of the GREATEST
humans who EVER LIVED.
Even Better then Muhammad Ali?
Yes...
<<<<she lived the longest on RECOrD for the record books>>>
While Ali might be a little punch drunk Jeanne stay'd sober...
she's my IDOL...
But now we've got a NEW guy who LIKEs to blog...and ... and about 11
years jeanne calments junior..
and going strong:
Bernando LaPallo
Rhymes with Frenando?
ok
ABBA - Fernando
http://www.youtube.com/watch?v=4ohr4P8E_io
<time: 4:20> <views: 12,464,642 >
Great production values...12 million views...>
There was something there in the stars in the night?
But no lyrics in their wiki page... LOL
http://en.wikipedia.org/wiki/Fernando_(song)
But this is for BERNANDO....
http://en.wikipedia.org/wiki/Bernando_LaPallo
Bernando LaPallo (born 17 August 1901) is an American supercentenarian
and author of “Age Less/Live More: Achieving Health and Vitality at
107 and Beyond.” At age 110, LaPallo is the world's oldest blogger.[1]
If his birthdate is correct, LaPallo is the first supercentenarian
blogger.
Bernando Lapallo was born in Brazil on August 17, 1901, and moved with
his family to the United states at age five. He grew up in New York,
were he has lived most of his life. In later years he has lived in
Mesa, Arizona. At age 110, he is currently working on a second book.[2]
[3][4]
Bernardo LaPallo attributes his health and longevity to a vegetarian
and raw food diet and various other natural and alternative health
habits
<snip>
2 hits: for : Bernando LaPallo -- in the p ng
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=Bernando+LaPallo+&start=0&
And only 43 hits for HIM in ALL GROUPs:
http://groups.google.com/groups/search?qt_s=1&q=Bernando+LaPallo+
Only one hit on a google news search to his blog:
http://agelesslivemorestore.com/
And here's another site for extendlife
http://www.xtend-life.com/Blog/12-02-09/How_To_Age_Less_Live_More.aspx
How To Age Less & Live More
09 FEBRUARY 2012
How about this for inspiration. Author, blogger and Super Centenarian
Bernando LaPallo will be 111 this year, and feels on top of the world:
"As I move into my 111th year of life, I still feel great and am
grateful for my good health which allows me to stay active both
physically and mentally. I have never been sick in my life."
Bernando walks briskly or runs at least a mile daily, reads and writes
voraciously, looks half his age, and is called daily by people
worldwide eager to hear how he's done it.
How Has He ‘Done It’?
Simplicity, humility and natural living: “You don't need a recipe book
or health guide to age less and live more” he says.
http://agelesslivemorestore.com/
According to Bernando what you do need is to "Eat properly and get
your rest as stress is a killer."
Specifically, eat: raw fresh veggies, super-foods, raw nuts and
berries, extra virgin olive oil, raw honey, cinnamon, fresh garlic,
dark chocolate , barley soup, fresh coconut and plentiful alkaline
water.
He especially stresses the value of the following fresh foods since:
“Cooking your foods kills the nutrients...”
Fresh organic fruit and veggies: for low calorie, high fibre and
nutrient rich vitamins, minerals, enzymes, phyto-nutrients and
antioxidants boosting vitality and balanced health. He’s a big fan of
juiced fruits and veggies.
http://www.xtend-life.com/Blog/10-12-21/Smoothie_Anyone.aspx
High quality, organic, cold-pressed extra virgin olive oil: use on the
skin as lotion, in foods and salad dressing to lessen the risk of
colon cancer and heart disease.
Dark, organic chocolate: to lower blood pressure, cholesterol, stress
and depression.
Organic garlic considered nature's antibiotic which helps to fight
coughs and colds, and aids digestion and intestinal health.
http://www.xtend-life.com/Blog/11-04-23/The_Remarkable_Health_Benefits_of_the_Stinking_Rose.aspxnan
Organic cinnamon: antibacterial and antifungal; reduces leukemia and
lymphoma cancer cells.
Organic honey: has antioxidant and antibacterial properties and boosts
energy and weight loss.
...all "to be eaten in moderation, slowly, and only at certain times
of the day. Ensure you sit down to eat and relax afterwards, as
opposed to eat on the go like fastfood drive thru’s".
Bernando credits his health and longevity to his father, a doctor, who
lived to be 98. "I can remember things my father told me when I was 8
years old....He told me not to eat processed red meat...He said lamb
is OK but red meat, stay away from it. Hot dogs, French fries and all
those things don't eat it."
His father also encouraged his culinary interest resulting in Bernando
studying cooking at the Sorbonne School of Culinary Arts in the
1920’s. “We had to learn about the origins of food like barley,
coconut and the like and their uses which is something that is not
taught in America today.”
Indeed!
Another healthy habit gleaned from his dad is, he says: "treating his
body as a temple. It’s important to clean out the colon on a regular
basis and to look after your feet and clean them regularly. If our
inner vital organs can do the jobs as they were designed, then we
should stay healthy and live a long life. Use olive oil rubbed into
the skin of the feet and also on your body and face... Then you'll
never rust."
Clearly, despite Bernando’s simple life and attitude, his father
inspired him to have a rich life worth living.
"He taught me how to live, how to eat and to have faith in God and he
would take care of me," smiled LaPallo. "And so far it has happened.
Amen."
<snip>
See bernando on this abc link:
http://www.abc15.com/dpp/news/region_southeast_valley/mesa/valley-man-turns-110-years-old-and-said-5-foods-helped-him-live-long-life
He eats: cinnamon, chocolate, olive oil, garlic and honey ....
Eat lamb but no other red meats... he says.
His dad lived to 98 and had faith in GOD.
on youtube:
Amazing 108 Years Old and Healthy! Part 1 of 3
http://www.youtube.com/watch?v=mj7knA3-YUs
<time: 9:46>
Amazing 108 Years Old and Healthy! Part 2 of 3
http://www.youtube.com/watch?v=F7XbuyokaWY&feature=relmfu
<time: 10:01>
=======================
Bernando must not have problems with Epstein-Barr Virus ?
Well... NO, as he's never been sick...so it's asymptomatic or not a
problem.
So what does it mean then if YOUR psor and have psor genes?
My take.
but i can use microbiota to change the genetics via epigenetics....
LOL
or i can starve myself and turn on sirt! LOL
Or i can turn on sirt1 via resveratrol...DUH...
or you could get a virus and change it ALL (for the worse)
yourself>>>> duh..
hiv certainly changes the playing field...
epstein barr EBV on this one.
http://www.ncbi.nlm.nih.gov/pubmed/22286212
J Natl Cancer Inst. 2012 Jan 27.
Genome-Wide Association Study of Classical Hodgkin Lymphoma and
Epstein-Barr Virus Status-Defined Subgroups.
<authors deleted>
Abstract
Background
Accumulating evidence suggests that risk factors for classical Hodgkin
lymphoma (cHL) differ by tumor Epstein-Barr virus (EBV) status. This
potential etiological heterogeneity is not recognized in current
disease classification.
Methods
We conducted a genome-wide association study of 1200 cHL patients and
6417 control subjects, with validation in an independent replication
series, to identify common genetic variants associated with total cHL
and subtypes defined by tumor EBV status. Multiple logistic regression
was used to calculate odds ratios (ORs) and 95% confidence intervals
(CIs) assuming a log-additive genetic model for the variants. All
statistical tests were two-sided.
Results
Two novel loci associated with total cHL irrespective of EBV status
were identified in the major histocompatibility complex region; one
resides adjacent to MICB (rs2248462: OR = 0.61, 95% CI = 0.53 to 0.69,
P = 1.3 × 10(-13)) and the other at HLA-DRA (rs2395185: OR = 0.56, 95%
CI = 0.50 to 0.62, P = 8.3 × 10(-25)) with both results confirmed in
an independent replication series. Consistent with previous reports,
associations were found between EBV-positive cHL and genetic variants
within the class I region (rs2734986, HLA-A: OR = 2.45, 95% CI = 2.00
to 3.00, P = 1.2 × 10(-15); rs6904029, HCG9: OR = 0.46, 95% CI = 0.36
to 0.59, P = 5.5 × 10(-10)) and between EBV-negative cHL and rs6903608
within the class II region (rs6903608, HLA-DRA: OR = 2.08, 95% CI =
1.84 to 2.35, P = 6.1 × 10(-31)). The association between rs6903608
and EBV-negative cHL was confined to the nodular sclerosis
histological subtype. Evidence for an association between EBV-negative
cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4
x 10(-9)), a variant previously linked to psoriasis and asthma, was
observed; however, the evidence for replication was less clear.
Notably, one additional psoriasis-associated variant, rs27524 (5q15,
ERAP1), showed evidence of an association with cHL in the genome-wide
association study (OR = 1.21, 95% CI = 1.10 to 1.33, P = 1.5 × 10(-4))
and replication series (P = .03).
Conclusion
Overall, these results provide strong evidence that EBV status is an
etiologically important classification of cHL and also suggest that
some components of the pathological process are common to both EBV-
positive and EBV-negative patients.
PMID: 22286212
Are you getting the reasons why i spend so much time on STAT to the
ER? LOL
erap1
http://en.wikipedia.org/wiki/ARTS-1
<see below for erap1 info>
to much CRAP in the ER...... duh..
it's now wonder i'm not psorer... due to the c rap...
but i rap it out via resveratrol.....
longevinex.com.... WORKs.... i've proven that to myself for how many
YEARs?
So, what does it mean?
It means your Th1 skewed and not Th2 skewed:
http://www.ncbi.nlm.nih.gov/pubmed/22312480
Autoimmune Dis. 2012;2012:189096. Epub 2012 Jan 24.
CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D
Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis.
Pender MP.
Source
School of Medicine, The University of Queensland, Brisbane, QLD 4072,
Australia.
Abstract
CD8+ T-cell deficiency is a feature of many chronic autoimmune
diseases, including multiple sclerosis, rheumatoid arthritis, systemic
lupus erythematosus, Sjögren's syndrome, systemic sclerosis,
dermatomyositis, primary biliary cirrhosis, primary sclerosing
cholangitis, ulcerative colitis, Crohn's disease, psoriasis, vitiligo,
bullous pemphigoid, alopecia areata, idiopathic dilated
cardiomyopathy, type 1 diabetes mellitus, Graves' disease, Hashimoto's
thyroiditis, myasthenia gravis, IgA nephropathy, membranous
nephropathy, and pernicious anaemia. It also occurs in healthy blood
relatives of patients with autoimmune diseases, suggesting it is
genetically determined. Here it is proposed that this CD8+ T-cell
deficiency underlies the development of chronic autoimmune diseases by
impairing CD8+ T-cell control of Epstein-Barr virus (EBV) infection,
with the result that EBV-infected autoreactive B cells accumulate in
the target organ where they produce pathogenic autoantibodies and
provide costimulatory survival signals to autoreactive T cells which
would otherwise die in the target organ by activation-induced
apoptosis. Autoimmunity is postulated to evolve in the following
steps: (1) CD8+ T-cell deficiency, (2) primary EBV infection, (3)
decreased CD8+ T-cell control of EBV, (4) increased EBV load and
increased anti-EBV antibodies, (5) EBV infection in the target organ,
(6) clonal expansion of EBV-infected autoreactive B cells in the
target organ, (7) infiltration of autoreactive T cells into the target
organ, and (8) development of ectopic lymphoid follicles in the target
organ. It is also proposed that deprivation of sunlight and vitamin D
at higher latitudes facilitates the development of autoimmune diseases
by aggravating the CD8+ T-cell deficiency and thereby further
impairing control of EBV. The hypothesis makes predictions which can
be tested, including the prevention and successful treatment of
chronic autoimmune diseases by controlling EBV infection.
PMID: 22312480
EBV + psoria* - 19 hits:
http://www.ncbi.nlm.nih.gov/pubmed?term=psoria*%20ebv
#1 and #2 of 19 are above btw.
So have have next to zero hits over decades and in two days TWO hits
for ebv and P.... LOL
Why, why, why, (<w><G>)
Easy... peezy... know how they harp on Vitamin D3 and autoimmunity?
Yes..
WELL check it out.
http://www.ncbi.nlm.nih.gov/pubmed/20593215
Cell Mol Life Sci. 2010 Dec;67(24):4249-56. Epub 2010 Jul 1.
Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and
blocks activation of its target genes.
Yenamandra SP, Hellman U, Kempkes B, Darekar SD, Petermann S, Sculley
T, Klein G, Kashuba E.
Source
Department of Microbiology, Tumor, and Cell Biology (MTC), Karolinska
Institute, 171 77, Stockholm, Sweden.
Abstract
Epstein-Barr virus (EBV) is a human gamma herpes virus that infects B
cells and induces their transformation into immortalized lymphoblasts
that can grow as cell lines (LCLs) in vitro. EBNA-3 is a member of the
EBNA-3-protein family that can regulate transcription of cellular and
viral genes. The identification of EBNA-3 cellular partners and a
study of its influence on cellular pathways are important for
understanding the transforming action of the virus. In this work, we
have identified the vitamin D receptor (VDR) protein as a binding
partner of EBNA-3. We found that EBNA3 blocks the activation of VDR-
dependent genes and protects LCLs against vitamin-D3-induced growth
arrest and/or apoptosis. The presented data shed some light on the
anti-apoptotic EBV program and the role of the EBNA-3-VDR interaction
in the viral strategy.
PMID: 20593215
http://en.wikipedia.org/wiki/EBNA-3
EBV nuclear antigen 3 is a family of viral proteins associated with
Epstein-Barr virus.
EBNA-3A
EBNA-3B
EBNA-3C
These genes also bind the host RBP-Jκ protein.
EBNA-3C can recruit a ubiquitin-ligase and has been shown to target
cell cycle regulators like pRb
<snip>
http://en.wikipedia.org/wiki/PRb
The retinoblastoma protein (abbreviated pRb, RB or RB1) is a tumor
suppressor protein that is dysfunctional in several major cancers.[1]
One function of pRb is to prevent excessive cell growth by inhibiting
cell cycle progression until a cell is ready to divide. It is also a
recruiter of several chromatin remodeling enzymes such as methylases
and acetylases.
pRb belongs to the pocket protein family, whose members have a pocket
for the functional binding of other proteins.[2][3] Should an
oncogenic protein, such as those produced by cells infected by high-
risk types of human papillomaviruses, bind and inactivate pRb, this
can lead to cancer.
<snip>
http://en.wikipedia.org/wiki/PRb#Activation_and_inactivation
We've got 59 hits for EBV in out grouP:
Epstein Barr Virus - 59 hits - P NG
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=Epstein+Barr+Virus+&start=0&
While EBV might not be a big deal for psor folks it's big for other
autoimmune conditions.
LOOK
http://en.wikipedia.org/wiki/Epstein%E2%80%93Barr_virus
The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4),
is a virus of the herpes family and is one of the most common viruses
in humans. It is best known as the cause of infectious mononucleosis.
It is also associated with particular forms of cancer, particularly
Hodgkin's lymphoma, Burkitt's lymphoma, nasopharyngeal carcinoma, and
central nervous system lymphomas associated with HIV.[1] Finally,
there is evidence that infection with the virus is associated with a
higher risk of certain autoimmune diseases, especially
dermatomyositis[citation needed], systemic lupus erythematosus,[2][3]
rheumatoid arthritis,[3] Sjögren's syndrome,[3] and multiple sclerosis.
[4]
Most people become infected with EBV and gain adaptive immunity. In
the United States, about half of all five-year-old children and 90 to
95 percent of adults have evidence of previous infection.[5] Infants
become susceptible to EBV as soon as maternal antibody protection
disappears. Many children become infected with EBV, and these
infections usually cause no symptoms or are indistinguishable from the
other mild, brief illnesses of childhood. In the United States, and in
other developed countries, many people are not infected with EBV in
their childhood years. When infection with EBV occurs during
adolescence or teenage years, it causes infectious mononucleosis 35
percent to 50 percent of the time.
<snip>
So all these folks with CFS and allied conditions due to herpes or
eBV?
No...
OK what if?
What if what?
LOL we LOOK again:
http://en.wikipedia.org/wiki/Alternative_names_for_chronic_fatigue_syndrome
Chronic fatigue syndrome (CFS) is the name currently used by the
majority of the medical and scientific community to describe a
condition or set of conditions characterized by fatigue and other
symptoms. The term is contested, mostly by patients and patient
advocacy groups, but also by some doctors. Several of the more common
alternative names used to describe what most believe to be the same
condition or subtypes include myalgic encephalomyelitis (ME), chronic
fatigue immune dysfunction syndrome (CFIDS), and post-viral fatigue
syndrome (PVFS).[1]
In 1959, E.D. Acheson an early investigator of benign myalgic
encephalomyelitis, wrote: "The wisdom of naming a disorder, the nature
of which cannot at present be proved, and which may be due to more
than one agent, is debatable."[2] The name used to label the condition
(or set of conditions) is one of several controversies related to CFS.
http://en.wikipedia.org/wiki/Chronic_fatigue_syndrome
http://en.wikipedia.org/wiki/Chronic_fatigue_syndrome#Onset
OK... what if cancer is due to a virus that MAKES a Th2 skew inside of
YOU?
And CFS symptoms are the ONLY clues to having the virus?
And it's EBV and shuts down vitamin D3 receptors?
Yikes... sounds good BUT WRONG... mister randall wong dong... LOL
OK i'm not being perfect but pluperfect you ain't?
OK what if? And is?
As is, isn't when it comes to is-ness for BILL Clinton.
And JFK nails...virgin...intern Marion B. Alford in the pluperfection
of the White house
and in wife's (Jacqueline) boudoir no LESS.... LoL
http://www.dailymail.co.uk/indiahome/indianews/article-2097897/Mimi-Alford-How-did-JFK-seduce-virgin-intern-White-House.html
How did JFK seduce a virgin intern at the White House?
By ANGSHUKANTA CHAKRABORTY
Last updated at 9:13 AM on 8th February 2012
<snip>
Will ~ 50 years hence obama secrets arise of a similar nature?
Or is he a GOOD muslim? With 50 virgins hiding in the pair of dice?
I wouldn't be surprised.
If he's hidding those cig's from mooooooooooochele then he's smoking
them now and then
with xyz and loving it.... <W>
Will obama get sick like JFK?
No... not the same but it's still insane in the membrane.
Is it plu perfect?
http://en.wikipedia.org/wiki/Pluperfect
The pluperfect (from Latin plus quam perfectum more than perfect),
also called past perfect in English, is a grammatical combination of
past tense with the perfect, itself a combination of tense and aspect,
that exists in most Indo-European languages though there is not one in
Irish. It is used to refer to an event that had continuing relevance
to a past time.[dubious – discuss] Comrie[1]:p.64 classifies the
pluperfect as an absolute-relative tense because it absolutely (not by
context) establishes a deixis (the past event) and places the action
relative to the deixis (before it).
In the sentence "A man who for years had thought he had reached the
absolute limit of all possible suffering now found that suffering had
no limits, and that he could suffer still more, and more
intensely" (from Victor Frankl's Man's Search for Meaning), "had
thought" and "had reached" are examples of the pluperfect. They refer
to an event (a man thinking he has reached the limit of his capacity
to suffer), which takes place before another event (the man
discovering that his capacity to suffer has no limit), that are still
relevant at the time of the later event. Because that second,
subsequent event is itself a past event and the past tense is used to
refer to it ("a man...now found"), the pluperfect is needed to make it
clear that the first event (reaching the limit) has taken place even
earlier in the past.
<snip>
see notes below: for whole hog on this virgin expose.
and here they are:
imagine that....<W>
===========
notes:
http://www.dailymail.co.uk/indiahome/indianews/article-2097897/Mimi-Alford-How-did-JFK-seduce-virgin-intern-White-House.html
How did JFK seduce a virgin intern at the White House?
By ANGSHUKANTA CHAKRABORTY
White House, that enormous reservoir of secrets - of both the open and
closely guarded varieties - is once again drawing attention.
This time for the exploits of its 35th President, John F. Kennedy, who
was as famous for his string of sexual peccadilloes as for his liberal
policies that defined the Camelot-era American polity.
In a tell-all memoir, a former intern, Marion 'Mimi' Beardsley Alford,
now a retired church administrator with a Manhattan Presbyterian
church, reveals the seamy side of JFK who 'seduced' the 19-year-old
and claimed her 'virginity' at an exclusive White House 'pool party',
which the President was having with some 'close aides'.
Alford's Once Upon a Secret: My Affair with President John F. Kennedy
and Its Aftermath is published by Random House and will be released in
New York on Tuesday.
intern Marion B. Alford (pictured) reveals in her book how President
John F. Kennedy seduced the 19-year-old virgin at an exclusive pool
party
The advance figures are reportedly touching Rs 5 crore, though Susan
Mercandett, the executive editor of Random House says 'an
extraordinary heart and soul exists in the book' and that it is as
much about a 'loss of innocence' as it is a 'woman's coming-of-age
story.'
Alford breaks a silence of over four decades when she had a torrid
affair with JFK, who seduced her for the first time in his wife's
(Jacqueline) boudoir. Ironically, not only does the young Alford
resemble the First Lady in her looks, but also received edification at
the same exclusive private academy that Jacqueline had attended.
Alford first acknowledged the 18-month-long 'sexual relationship,'
that lasted from June 1962 up to the President's assassination in
November 1963, in 2003.
This was following a biography of JFK by Robert Dallek publishing
portions of a 1964 oral history that detailed the liaison.
The Time had also published a piece by former White House journalist
Hugh Sidney who had written that "there was a Mimi" on JFK's list of
conquests.
In her memoir Alford (pictured) describes the sexual sadomasochism
that JFK was infamous for
Alford, now 69, recounts how the President maintained a sexual
relationship with her and his exploits were fuelled by narcotics.
Her memoir also describes the sexual sadomasochism that JFK was
infamous for, especially in a telling episode when he had asked her to
perform oral sex on his close aide David Powers.
'I don't think the President thought I'd do it, but I'm ashamed to say
that I did,' she says in her book that is already available in a
Manhattan store.
http://i.dailymail.co.uk/i/pix/2012/02/07/article-2097897-11A134D9000005DC-499_233x423.jpg
http://i.dailymail.co.uk/i/pix/2012/02/07/article-2097897-11A134CA000005DC-841_233x338.jpg
http://i.dailymail.co.uk/i/pix/2012/02/07/article-2097897-11A134DE000005DC-504_468x286.jpg
<snip>
I kissed a goy and i like it!
Geee, no GE and not G but B?
I see.
But got CFS and aids/hiv and a host of other conditions like mono and
autoimmunity. LOL
Hey! So do it.... imagine that... LOL
And in the PAST he/she was PERFECT.....flu perfect?
Is or was john Sculley a genius or blow HARD job or nit wit?
Yes, no, yes, no = zero....
http://en.wikipedia.org/wiki/John_Sculley
What is is... and isness and beingness ARE.
What are YOU doing to BE?
You ain't john or me.... just BE... you (?)
And john wasn't steve JOBs as he took an acid trip
That was HIS trip...
Yours is BEING autoimmune and you need a DRUG called a mAB from big
pig pharma?
Or some apremilast?
I do?
Yes... you do... dim wit.
OK which juan?
That apremilast in the last thread today sounds cool:
Found here:
Fri, Feb 10 2012 12:01 pm
Subject: PDE4 Inhibitor-->In Vino Veritas (Red Wine) --- cAMP versus
cGMP (GEE! no G as in Guano -->CRAP of Psor LIFE?) --> Polyamines --
Et tu, Brute?
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/c51500c40ca0ca4e
pde4 inhibitor:
This brilliant btw:
http://www.ncbi.nlm.nih.gov/pubmed/22304913
Resveratrol ameliorates aging-related metabolic phenotypes by
inhibiting cAMP phosphodiesterases.
[...] pmid: 22304913
This wand.
Chronic fatigue syndrome cfs- 5550 hits: pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20fatigue%20syndrome%20cfs
are we short on mAbs?
I'm sure big PHARMA will take care of that juan?
LOL
4 hits: Chronic fatigue syndrome cfs mab
http://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20fatigue%20syndrome%20cfs%20mab
<randall note: no mAbs due to it being viral?>
#2 of 4
It's a GUT triP?
Who would have KNOWN? <w>
http://www.ncbi.nlm.nih.gov/pubmed/17872383
J Clin Pathol. 2008 Jan;61(1):43-8. Epub 2007 Sep 13.
Chronic fatigue syndrome is associated with chronic enterovirus
infection of the stomach.
Chia JK, Chia AY.
Source
EV Med Research, Lomita, California 90717, USA. ev...@sbcglobal.net
Abstract
BACKGROUND AND AIMS:
The aetiology for chronic fatigue syndrome (CFS) remains elusive
although enteroviruses have been implicated as one of the causes by a
number of studies. Since most CFS patients have persistent or
intermittent gastrointestinal (GI) symptoms, the presence of viral
capsid protein 1 (VP1), enterovirus (EV) RNA and culturable virus in
the stomach biopsy specimens of patients with CFS was evaluated.
METHODS:
165 consecutive patients with CFS underwent upper GI endoscopies and
antrum biopsies. Immunoperoxidase staining was performed using EV-
specific monoclonal antibody (mAb) or a control mAb specific for
cytomegalovirus (CMV). RT-PCR ELISA was performed on RNA extracted
from paraffin sections or samples preserved in RNA later. Biopsies
from normal stomach and other gastric diseases served as controls. 75
samples were cultured for EV.
RESULTS:
135/165 (82%) biopsies stained positive for VP1 within parietal cells,
whereas 7/34 (20%) of the controls stained positive (p< or =0.001).
CMV mAb failed to stain any of the biopsy specimens. Biopsies taken
from six patients at the onset of the CFS/abdominal symptoms, and 2-8
years later showed positive staining in the paired specimens. EV RNA
was detected in 9/24 (37%) paraffin-embedded biopsy samples; 1/21
controls had detectable EV RNA (p<0.01); 1/3 patients had detectable
EV RNA from two samples taken 4 years apart; 5 patient samples showed
transient growth of non-cytopathic enteroviruses.
CONCLUSION:
Enterovirus VP1, RNA and non-cytopathic viruses were detected in the
stomach biopsy specimens of CFS patients with chronic abdominal
complaints. A significant subset of CFS patients may have a chronic,
disseminated, non-cytolytic form of enteroviral infection, which could
be diagnosed by stomach biopsy.
Comment in
J Clin Pathol. 2008 Jan;61(1):1-2.
http://www.ncbi.nlm.nih.gov/pubmed/17873115
PMID: 17872383 [
Shall we go down the rabbit hole , alice?
Sure... steve jobs had HIS BEST trip on LSD.
And randall dork goy finds a dearth of Th17and CFS?
I expected it with mAbs... but not with th17
4 hits: Chronic fatigue syndrome Th17 -pubmed:
http://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20fatigue%20syndrome%20Th17
http://www.ncbi.nlm.nih.gov/pubmed/21950132
Vestn Ross Akad Med Nauk. 2011;(8):24-33.
[Regulatory T-cells: modern approaches to optimization of their
numbers].
[Article in Russian]
Pukhal'skiĭ AL, Shmarina GV, Aleshkin VA.
Abstract
Regulatory T-cells (Tregs) are important components of the complex
adaptive system of the body responsive to environmental challenges.
Tregs ensure peripheral tolerance and play an important role in
control of inflammatory reactions. Several subsets of Tregs have been
described. Naturally occurring CD4+CD25+ Tregs are recognized as a
major subset of immune cells responsible for peripheral immune self-
tolerance. Another subtype of Tregs is inducible. Such Tregs are
generated in the periphery and realize their suppressive potential
largely in the form of anti-inflammatory activity. The latter plays an
important role in cooperation of three principal anti-inflammatory
mechanisms that developed in the course of evolution: macrophages
possessed of suppressive activity, Tregs, and stress hormones.
Normally, all the three mechanisms of inflammation control are in
equilibrium. However, the balance may be disturbed with ageing due to
repeated episodes of stress and HPA axis activation. As a result,
secretion of stress hormones coupled to antigen overload leads to Treg
accumulation. In the course of time activation of the HPA axis is
replaced by its inhibition manifested both as a decrease of the
baseline cortisol level and a reduction of stress-induced cortisol
response. Cortisol present in blood at low concentrations is no longer
capable of controlling inflammation and Tregs become a principal
mechanism of anti-inflammatory machinery. Superfluous Treg
accumulation results in the development of functional somatic
syndromes, such as chronic fatigue syndrome, and (in some patients) in
the growth of tumours resulting from the suppression of anticancer
immunity. On the other hand, the lack of adequate antigen loading in
the childhood may delay Treg maturation. Allergy and asthma
manifestations may be a consequence of such Treg insufficiency. Thus,
both excess and deficiency of Tregs may be at the bottom of morbid
conditions. The advances in modern pharmacology open up opportunities
for developing new methods to control the Treg level.
PMID: 21950132
Without even LOOKing it looks Th2 skewish...<G>
http://www.ncbi.nlm.nih.gov/pubmed/20447453
Brain Behav Immun. 2010 Oct;24(7):1209-17. Epub 2010 May 4.
A formal analysis of cytokine networks in chronic fatigue syndrome.
Broderick G, Fuite J, Kreitz A, Vernon SD, Klimas N, Fletcher MA.
Source
Division of Pulmonary Medicine, Department of Medicine, University of
Alberta, College Plaza, 8215 112 Street NW, Edmonton, Alberta, Canada.
gordon.b...@ualberta.ca
Abstract
Chronic Fatigue Syndrome (CFS) is a complex illness affecting 4
million Americans for which no characteristic lesion has been
identified. Instead of searching for a deficiency in any single
marker, we propose that CFS is associated with a profound imbalance in
the regulation of immune function forcing a departure from standard
pre-programmed responses. To identify these imbalances we apply
network analysis to the co-expression of 16 cytokines in CFS subjects
and healthy controls. Concentrations of IL-1a, 1b, 2, 4, 5, 6, 8, 10,
12, 13, 15, 17 and 23, IFN-γ, lymphotoxin-α (LT-α) and TNF-α were
measured in the plasma of 40 female CFS and 59 case-matched controls.
Cytokine co-expression networks were constructed from the pair-wise
mutual information (MI) patterns found within each subject group.
These networks differed in topology significantly more than expected
by chance with the CFS network being more hub-like in design. Analysis
of local modularity isolated statistically distinct cytokine
communities recognizable as pre-programmed immune functional
components. These showed highly attenuated Th1 and Th17 immune
responses in CFS. High Th2 marker expression but weak interaction
patterns pointed to an established Th2 inflammatory milieu. Similarly,
altered associations in CFS provided indirect evidence of diminished
NK cell responsiveness to IL-12 and LT-α stimulus. These observations
are consistent with several processes active in latent viral infection
and would not have been uncovered by assessing marker expression
alone. Furthermore this analysis identifies key sub-networks such as
IL-2:IFN-γ:TNF-α that might be targeted in restoring normal immune
function.
Comment in
Brain Behav Immun. 2010 Oct;24(7):1218; author reply 1219.
http://www.ncbi.nlm.nih.gov/pubmed/20561580
PMID: 20447453
Free PMC Article
Or women with CFS and cytokines:
http://www.ncbi.nlm.nih.gov/pubmed/19909538
------------
Moving up or wider so to speak:
17 hits: Chronic fatigue syndrome Th1- pubmed:
http://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20fatigue%20syndrome%20Th1
19 hits: Chronic fatigue syndrome Th2- pubmed:
http://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20fatigue%20syndrome%20Th2
12 have both Th1 and Th2:
Chronic fatigue syndrome Th2 Th1
http://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20fatigue%20syndrome%20Th2%20Th1
WELL #1 of 12 looks like a Th2 skew with foxp3, IL-10 etc is d
http://www.ncbi.nlm.nih.gov/pubmed/21619669
J Transl Med. 2011 May 28;9:81.
Immunological abnormalities as potential biomarkers in Chronic Fatigue
Syndrome/Myalgic Encephalomyelitis.
Brenu EW, van Driel ML, Staines DR, Ashton KJ, Ramos SB, Keane J,
Klimas NG, Marshall-Gradisnik SM.
Source
Population Health and Neuroimmunology Unit, Faculty of Health Science
and Medicine, Bond University, Robina, Queensland, Australia.
Abstract
BACKGROUND:
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is
characterised by severe prolonged fatigue, and decreases in cognition
and other physiological functions, resulting in severe loss of quality
of life, difficult clinical management and high costs to the health
care system. To date there is no proven pathomechanism to
satisfactorily explain this disorder. Studies have identified
abnormalities in immune function but these data are inconsistent. We
investigated the profile of markers of immune function (including
novel markers) in CFS/ME patients.
METHODS:
We included 95 CFS/ME patients and 50 healthy controls. All
participants were assessed on natural killer (NK) and CD8(+) T cell
cytotoxic activities, Th1 and Th2 cytokine profile of CD4(+) T cells,
expression of vasoactive intestinal peptide receptor 2 (VPACR2),
levels of NK phenotypes (CD56(bright) and CD56(dim)) and regulatory T
cells expressing FoxP3 transcription factor.
RESULTS:
Compared to healthy individuals, CFS/ME patients displayed significant
increases in IL-10, IFN-γ, TNF-α, CD4(+)CD25(+) T cells, FoxP3 and
VPACR2 expression. Cytotoxic activity of NK and CD8(+) T cells and NK
phenotypes, in particular the CD56(bright) NK cells were significantly
decreased in CFS/ME patients. Additionally granzyme A and granzyme K
expression were reduced while expression levels of perforin were
significantly increased in the CFS/ME population relative to the
control population. These data suggest significant dysregulation of
the immune system in CFS/ME patients.
CONCLUSIONS:
Our study found immunological abnormalities which may serve as
biomarkers in CFS/ME patients with potential for an application as a
diagnostic tool.
PMID: 21619669
Free PMC Article
OK does that mean people with sebopsoriasis being both Th1 and Th2
could have CFS?
I wonder?
I Gotta Feeling - Black Eyed Peas ~ HQ ~ with Lyrics
http://www.youtube.com/watch?v=lmvAVX8_szs
maybe not?
OK this science THING is not hitting all cylinders... maybe 7 of 8 or
10 of 12?
Whatever... it takes.. and you live to 111 like Bernando LaPallo or
122 like Jeanne calment.
And you see LIFE for a little BIT longer then the rest of us?
No way...
My TIME equations will take us out of that box..
So what is it to be truly conscious of time and beingness in this BOX
called the universe?
randall... not enough time? To much? But if you die you don't CARE
as MUCH?
when will we cut out the cRAP of LIFE?
Not easy, when half the people see yin yang one way and the udder
the oPPosite whey?
Are they looking at night?
No id squid their brains are inverse and reverse wired i'm thinking
this TIME.
And take time to think about this..
Jeanne Calment never sweat the small or LARGE stuff come to think
about it?
How much time should i think about that?
All the time?
OK... as it's a big world... spin me..
What is happening in the Middle east?
Not much that wasn't predicted years ago:
When Obama told them he was a Muslim? LOL
Did he lie to them or us? <G>
ABSOLUTELY SHOCKING! What Was Predicted 3 Years Ago is NOW HERE! BHO
EXPOSED! (Avi Lipkin)
http://www.youtube.com/watch?v=zSAW4YTZAwY
<time: 4:26> <views: 87,676>
Hear Carl Gallups (Narrator of this video) on Live talk radio on NW
FL's TALK RADIO - 1330 WEBY AM - broadcasting to a 4 state area on the
Gulf Coast - every Friday afternoon - 4-6 pm CT.
http://www.hickoryhammockbaptist.org/radio
Maybe the truth will come out in another 50 years?
Yeah, like this one poPPing out of JFK's closet.
The virgin stutter that made JFK's putter Flutter?
what? what, what,, wha wa wa?
See;
below....xxx rated... and makes me blush if John-john was still alive
for this jive:
http://en.wikipedia.org/wiki/John_F._Kennedy,_Jr.
Yikes...!
Sins of the FATHER....Coming uP below.... LOL
I know, i know....
BUT,
First:
I like old-ster Jeanne calment...i think and BELIEVE she's the
GREATEST or one of the GREATEST
humans who EVER LIVED.
Even Better then Muhammad Ali?
Yes...
<<<<she lived the longest on RECOrD for the record books>>>
While Ali might be a little punch drunk Jeanne stay'd sober...
she's my IDOL...
But now we've got a NEW guy who LIKEs to blog...and ... and about 11
years jeanne calments junior..
and going strong:
Bernando LaPallo
Rhymes with Frenando?
ok
ABBA - Fernando
http://www.youtube.com/watch?v=4ohr4P8E_io
<time: 4:20> <views: 12,464,642 >
Great production values...12 million views...>
There was something there in the stars in the night?
But no lyrics in their wiki page... LOL
http://en.wikipedia.org/wiki/Fernando_(song)
But this is for BERNANDO....
http://en.wikipedia.org/wiki/Bernando_LaPallo
Bernando LaPallo (born 17 August 1901) is an American supercentenarian
and author of “Age Less/Live More: Achieving Health and Vitality at
107 and Beyond.” At age 110, LaPallo is the world's oldest blogger.[1]
If his birthdate is correct, LaPallo is the first supercentenarian
blogger.
Bernando Lapallo was born in Brazil on August 17, 1901, and moved with
his family to the United states at age five. He grew up in New York,
were he has lived most of his life. In later years he has lived in
Mesa, Arizona. At age 110, he is currently working on a second book.[2]
[3][4]
Bernardo LaPallo attributes his health and longevity to a vegetarian
and raw food diet and various other natural and alternative health
habits
<snip>
2 hits: for : Bernando LaPallo -- in the p ng
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=Bernando+LaPallo+&start=0&
And only 43 hits for HIM in ALL GROUPs:
http://groups.google.com/groups/search?qt_s=1&q=Bernando+LaPallo+
Only one hit on a google news search to his blog:
http://agelesslivemorestore.com/
And here's another site for extendlife
http://www.xtend-life.com/Blog/12-02-09/How_To_Age_Less_Live_More.aspx
How To Age Less & Live More
09 FEBRUARY 2012
How about this for inspiration. Author, blogger and Super Centenarian
Bernando LaPallo will be 111 this year, and feels on top of the world:
"As I move into my 111th year of life, I still feel great and am
grateful for my good health which allows me to stay active both
physically and mentally. I have never been sick in my life."
Bernando walks briskly or runs at least a mile daily, reads and writes
voraciously, looks half his age, and is called daily by people
worldwide eager to hear how he's done it.
How Has He ‘Done It’?
Simplicity, humility and natural living: “You don't need a recipe book
or health guide to age less and live more” he says.
http://agelesslivemorestore.com/
According to Bernando what you do need is to "Eat properly and get
your rest as stress is a killer."
Specifically, eat: raw fresh veggies, super-foods, raw nuts and
berries, extra virgin olive oil, raw honey, cinnamon, fresh garlic,
dark chocolate , barley soup, fresh coconut and plentiful alkaline
water.
He especially stresses the value of the following fresh foods since:
“Cooking your foods kills the nutrients...”
Fresh organic fruit and veggies: for low calorie, high fibre and
nutrient rich vitamins, minerals, enzymes, phyto-nutrients and
antioxidants boosting vitality and balanced health. He’s a big fan of
juiced fruits and veggies.
http://www.xtend-life.com/Blog/10-12-21/Smoothie_Anyone.aspx
High quality, organic, cold-pressed extra virgin olive oil: use on the
skin as lotion, in foods and salad dressing to lessen the risk of
colon cancer and heart disease.
Dark, organic chocolate: to lower blood pressure, cholesterol, stress
and depression.
Organic garlic considered nature's antibiotic which helps to fight
coughs and colds, and aids digestion and intestinal health.
http://www.xtend-life.com/Blog/11-04-23/The_Remarkable_Health_Benefits_of_the_Stinking_Rose.aspxnan
Organic cinnamon: antibacterial and antifungal; reduces leukemia and
lymphoma cancer cells.
Organic honey: has antioxidant and antibacterial properties and boosts
energy and weight loss.
...all "to be eaten in moderation, slowly, and only at certain times
of the day. Ensure you sit down to eat and relax afterwards, as
opposed to eat on the go like fastfood drive thru’s".
Bernando credits his health and longevity to his father, a doctor, who
lived to be 98. "I can remember things my father told me when I was 8
years old....He told me not to eat processed red meat...He said lamb
is OK but red meat, stay away from it. Hot dogs, French fries and all
those things don't eat it."
His father also encouraged his culinary interest resulting in Bernando
studying cooking at the Sorbonne School of Culinary Arts in the
1920’s. “We had to learn about the origins of food like barley,
coconut and the like and their uses which is something that is not
taught in America today.”
Indeed!
Another healthy habit gleaned from his dad is, he says: "treating his
body as a temple. It’s important to clean out the colon on a regular
basis and to look after your feet and clean them regularly. If our
inner vital organs can do the jobs as they were designed, then we
should stay healthy and live a long life. Use olive oil rubbed into
the skin of the feet and also on your body and face... Then you'll
never rust."
Clearly, despite Bernando’s simple life and attitude, his father
inspired him to have a rich life worth living.
"He taught me how to live, how to eat and to have faith in God and he
would take care of me," smiled LaPallo. "And so far it has happened.
Amen."
<snip>
See bernando on this abc link:
http://www.abc15.com/dpp/news/region_southeast_valley/mesa/valley-man-turns-110-years-old-and-said-5-foods-helped-him-live-long-life
He eats: cinnamon, chocolate, olive oil, garlic and honey ....
Eat lamb but no other red meats... he says.
His dad lived to 98 and had faith in GOD.
on youtube:
Amazing 108 Years Old and Healthy! Part 1 of 3
http://www.youtube.com/watch?v=mj7knA3-YUs
<time: 9:46>
Amazing 108 Years Old and Healthy! Part 2 of 3
http://www.youtube.com/watch?v=F7XbuyokaWY&feature=relmfu
<time: 10:01>
=======================
Bernando must not have problems with Epstein-Barr Virus ?
Well... NO, as he's never been sick...so it's asymptomatic or not a
problem.
So what does it mean then if YOUR psor and have psor genes?
My take.
but i can use microbiota to change the genetics via epigenetics....
LOL
or i can starve myself and turn on sirt! LOL
Or i can turn on sirt1 via resveratrol...DUH...
or you could get a virus and change it ALL (for the worse)
yourself>>>> duh..
hiv certainly changes the playing field...
epstein barr EBV on this one.
http://www.ncbi.nlm.nih.gov/pubmed/22286212
J Natl Cancer Inst. 2012 Jan 27.
Genome-Wide Association Study of Classical Hodgkin Lymphoma and
Epstein-Barr Virus Status-Defined Subgroups.
<authors deleted>
Abstract
Background
Accumulating evidence suggests that risk factors for classical Hodgkin
lymphoma (cHL) differ by tumor Epstein-Barr virus (EBV) status. This
potential etiological heterogeneity is not recognized in current
disease classification.
Methods
We conducted a genome-wide association study of 1200 cHL patients and
6417 control subjects, with validation in an independent replication
series, to identify common genetic variants associated with total cHL
and subtypes defined by tumor EBV status. Multiple logistic regression
was used to calculate odds ratios (ORs) and 95% confidence intervals
(CIs) assuming a log-additive genetic model for the variants. All
statistical tests were two-sided.
Results
Two novel loci associated with total cHL irrespective of EBV status
were identified in the major histocompatibility complex region; one
resides adjacent to MICB (rs2248462: OR = 0.61, 95% CI = 0.53 to 0.69,
P = 1.3 × 10(-13)) and the other at HLA-DRA (rs2395185: OR = 0.56, 95%
CI = 0.50 to 0.62, P = 8.3 × 10(-25)) with both results confirmed in
an independent replication series. Consistent with previous reports,
associations were found between EBV-positive cHL and genetic variants
within the class I region (rs2734986, HLA-A: OR = 2.45, 95% CI = 2.00
to 3.00, P = 1.2 × 10(-15); rs6904029, HCG9: OR = 0.46, 95% CI = 0.36
to 0.59, P = 5.5 × 10(-10)) and between EBV-negative cHL and rs6903608
within the class II region (rs6903608, HLA-DRA: OR = 2.08, 95% CI =
1.84 to 2.35, P = 6.1 × 10(-31)). The association between rs6903608
and EBV-negative cHL was confined to the nodular sclerosis
histological subtype. Evidence for an association between EBV-negative
cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4
x 10(-9)), a variant previously linked to psoriasis and asthma, was
observed; however, the evidence for replication was less clear.
Notably, one additional psoriasis-associated variant, rs27524 (5q15,
ERAP1), showed evidence of an association with cHL in the genome-wide
association study (OR = 1.21, 95% CI = 1.10 to 1.33, P = 1.5 × 10(-4))
and replication series (P = .03).
Conclusion
Overall, these results provide strong evidence that EBV status is an
etiologically important classification of cHL and also suggest that
some components of the pathological process are common to both EBV-
positive and EBV-negative patients.
PMID: 22286212
Are you getting the reasons why i spend so much time on STAT to the
ER? LOL
erap1
http://en.wikipedia.org/wiki/ARTS-1
<see below for erap1 info>
to much CRAP in the ER...... duh..
it's now wonder i'm not psorer... due to the c rap...
but i rap it out via resveratrol.....
longevinex.com.... WORKs.... i've proven that to myself for how many
YEARs?
So, what does it mean?
It means your Th1 skewed and not Th2 skewed:
http://www.ncbi.nlm.nih.gov/pubmed/22312480
Autoimmune Dis. 2012;2012:189096. Epub 2012 Jan 24.
CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D
Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis.
Pender MP.
Source
School of Medicine, The University of Queensland, Brisbane, QLD 4072,
Australia.
Abstract
CD8+ T-cell deficiency is a feature of many chronic autoimmune
diseases, including multiple sclerosis, rheumatoid arthritis, systemic
lupus erythematosus, Sjögren's syndrome, systemic sclerosis,
dermatomyositis, primary biliary cirrhosis, primary sclerosing
cholangitis, ulcerative colitis, Crohn's disease, psoriasis, vitiligo,
bullous pemphigoid, alopecia areata, idiopathic dilated
cardiomyopathy, type 1 diabetes mellitus, Graves' disease, Hashimoto's
thyroiditis, myasthenia gravis, IgA nephropathy, membranous
nephropathy, and pernicious anaemia. It also occurs in healthy blood
relatives of patients with autoimmune diseases, suggesting it is
genetically determined. Here it is proposed that this CD8+ T-cell
deficiency underlies the development of chronic autoimmune diseases by
impairing CD8+ T-cell control of Epstein-Barr virus (EBV) infection,
with the result that EBV-infected autoreactive B cells accumulate in
the target organ where they produce pathogenic autoantibodies and
provide costimulatory survival signals to autoreactive T cells which
would otherwise die in the target organ by activation-induced
apoptosis. Autoimmunity is postulated to evolve in the following
steps: (1) CD8+ T-cell deficiency, (2) primary EBV infection, (3)
decreased CD8+ T-cell control of EBV, (4) increased EBV load and
increased anti-EBV antibodies, (5) EBV infection in the target organ,
(6) clonal expansion of EBV-infected autoreactive B cells in the
target organ, (7) infiltration of autoreactive T cells into the target
organ, and (8) development of ectopic lymphoid follicles in the target
organ. It is also proposed that deprivation of sunlight and vitamin D
at higher latitudes facilitates the development of autoimmune diseases
by aggravating the CD8+ T-cell deficiency and thereby further
impairing control of EBV. The hypothesis makes predictions which can
be tested, including the prevention and successful treatment of
chronic autoimmune diseases by controlling EBV infection.
PMID: 22312480
EBV + psoria* - 19 hits:
http://www.ncbi.nlm.nih.gov/pubmed?term=psoria*%20ebv
#1 and #2 of 19 are above btw.
So have have next to zero hits over decades and in two days TWO hits
for ebv and P.... LOL
Why, why, why, (<w><G>)
Easy... peezy... know how they harp on Vitamin D3 and autoimmunity?
Yes..
WELL check it out.
http://www.ncbi.nlm.nih.gov/pubmed/20593215
Cell Mol Life Sci. 2010 Dec;67(24):4249-56. Epub 2010 Jul 1.
Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and
blocks activation of its target genes.
Yenamandra SP, Hellman U, Kempkes B, Darekar SD, Petermann S, Sculley
T, Klein G, Kashuba E.
Source
Department of Microbiology, Tumor, and Cell Biology (MTC), Karolinska
Institute, 171 77, Stockholm, Sweden.
Abstract
Epstein-Barr virus (EBV) is a human gamma herpes virus that infects B
cells and induces their transformation into immortalized lymphoblasts
that can grow as cell lines (LCLs) in vitro. EBNA-3 is a member of the
EBNA-3-protein family that can regulate transcription of cellular and
viral genes. The identification of EBNA-3 cellular partners and a
study of its influence on cellular pathways are important for
understanding the transforming action of the virus. In this work, we
have identified the vitamin D receptor (VDR) protein as a binding
partner of EBNA-3. We found that EBNA3 blocks the activation of VDR-
dependent genes and protects LCLs against vitamin-D3-induced growth
arrest and/or apoptosis. The presented data shed some light on the
anti-apoptotic EBV program and the role of the EBNA-3-VDR interaction
in the viral strategy.
PMID: 20593215
http://en.wikipedia.org/wiki/EBNA-3
EBV nuclear antigen 3 is a family of viral proteins associated with
Epstein-Barr virus.
EBNA-3A
EBNA-3B
EBNA-3C
These genes also bind the host RBP-Jκ protein.
EBNA-3C can recruit a ubiquitin-ligase and has been shown to target
cell cycle regulators like pRb
<snip>
http://en.wikipedia.org/wiki/PRb
The retinoblastoma protein (abbreviated pRb, RB or RB1) is a tumor
suppressor protein that is dysfunctional in several major cancers.[1]
One function of pRb is to prevent excessive cell growth by inhibiting
cell cycle progression until a cell is ready to divide. It is also a
recruiter of several chromatin remodeling enzymes such as methylases
and acetylases.
pRb belongs to the pocket protein family, whose members have a pocket
for the functional binding of other proteins.[2][3] Should an
oncogenic protein, such as those produced by cells infected by high-
risk types of human papillomaviruses, bind and inactivate pRb, this
can lead to cancer.
<snip>
http://en.wikipedia.org/wiki/PRb#Activation_and_inactivation
We've got 59 hits for EBV in out grouP:
Epstein Barr Virus - 59 hits - P NG
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=Epstein+Barr+Virus+&start=0&
While EBV might not be a big deal for psor folks it's big for other
autoimmune conditions.
LOOK
http://en.wikipedia.org/wiki/Epstein%E2%80%93Barr_virus
The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4),
is a virus of the herpes family and is one of the most common viruses
in humans. It is best known as the cause of infectious mononucleosis.
It is also associated with particular forms of cancer, particularly
Hodgkin's lymphoma, Burkitt's lymphoma, nasopharyngeal carcinoma, and
central nervous system lymphomas associated with HIV.[1] Finally,
there is evidence that infection with the virus is associated with a
higher risk of certain autoimmune diseases, especially
dermatomyositis[citation needed], systemic lupus erythematosus,[2][3]
rheumatoid arthritis,[3] Sjögren's syndrome,[3] and multiple sclerosis.
[4]
Most people become infected with EBV and gain adaptive immunity. In
the United States, about half of all five-year-old children and 90 to
95 percent of adults have evidence of previous infection.[5] Infants
become susceptible to EBV as soon as maternal antibody protection
disappears. Many children become infected with EBV, and these
infections usually cause no symptoms or are indistinguishable from the
other mild, brief illnesses of childhood. In the United States, and in
other developed countries, many people are not infected with EBV in
their childhood years. When infection with EBV occurs during
adolescence or teenage years, it causes infectious mononucleosis 35
percent to 50 percent of the time.
<snip>
So all these folks with CFS and allied conditions due to herpes or
eBV?
No...
OK what if?
What if what?
LOL we LOOK again:
http://en.wikipedia.org/wiki/Alternative_names_for_chronic_fatigue_syndrome
Chronic fatigue syndrome (CFS) is the name currently used by the
majority of the medical and scientific community to describe a
condition or set of conditions characterized by fatigue and other
symptoms. The term is contested, mostly by patients and patient
advocacy groups, but also by some doctors. Several of the more common
alternative names used to describe what most believe to be the same
condition or subtypes include myalgic encephalomyelitis (ME), chronic
fatigue immune dysfunction syndrome (CFIDS), and post-viral fatigue
syndrome (PVFS).[1]
In 1959, E.D. Acheson an early investigator of benign myalgic
encephalomyelitis, wrote: "The wisdom of naming a disorder, the nature
of which cannot at present be proved, and which may be due to more
than one agent, is debatable."[2] The name used to label the condition
(or set of conditions) is one of several controversies related to CFS.
http://en.wikipedia.org/wiki/Chronic_fatigue_syndrome
http://en.wikipedia.org/wiki/Chronic_fatigue_syndrome#Onset
OK... what if cancer is due to a virus that MAKES a Th2 skew inside of
YOU?
And CFS symptoms are the ONLY clues to having the virus?
And it's EBV and shuts down vitamin D3 receptors?
Yikes... sounds good BUT WRONG... mister randall wong dong... LOL
OK i'm not being perfect but pluperfect you ain't?
OK what if? And is?
As is, isn't when it comes to is-ness for BILL Clinton.
And JFK nails...virgin...intern Marion B. Alford in the pluperfection
of the White house
and in wife's (Jacqueline) boudoir no LESS.... LoL
http://www.dailymail.co.uk/indiahome/indianews/article-2097897/Mimi-Alford-How-did-JFK-seduce-virgin-intern-White-House.html
How did JFK seduce a virgin intern at the White House?
By ANGSHUKANTA CHAKRABORTY
Last updated at 9:13 AM on 8th February 2012
<snip>
Will ~ 50 years hence obama secrets arise of a similar nature?
Or is he a GOOD muslim? With 50 virgins hiding in the pair of dice?
I wouldn't be surprised.
If he's hidding those cig's from mooooooooooochele then he's smoking
them now and then
with xyz and loving it.... <W>
Will obama get sick like JFK?
No... not the same but it's still insane in the membrane.
Is it plu perfect?
http://en.wikipedia.org/wiki/Pluperfect
The pluperfect (from Latin plus quam perfectum more than perfect),
also called past perfect in English, is a grammatical combination of
past tense with the perfect, itself a combination of tense and aspect,
that exists in most Indo-European languages though there is not one in
Irish. It is used to refer to an event that had continuing relevance
to a past time.[dubious – discuss] Comrie[1]:p.64 classifies the
pluperfect as an absolute-relative tense because it absolutely (not by
context) establishes a deixis (the past event) and places the action
relative to the deixis (before it).
In the sentence "A man who for years had thought he had reached the
absolute limit of all possible suffering now found that suffering had
no limits, and that he could suffer still more, and more
intensely" (from Victor Frankl's Man's Search for Meaning), "had
thought" and "had reached" are examples of the pluperfect. They refer
to an event (a man thinking he has reached the limit of his capacity
to suffer), which takes place before another event (the man
discovering that his capacity to suffer has no limit), that are still
relevant at the time of the later event. Because that second,
subsequent event is itself a past event and the past tense is used to
refer to it ("a man...now found"), the pluperfect is needed to make it
clear that the first event (reaching the limit) has taken place even
earlier in the past.
<snip>
see notes below: for whole hog on this virgin expose.
and here they are:
imagine that....<W>
===========
notes:
http://www.dailymail.co.uk/indiahome/indianews/article-2097897/Mimi-Alford-How-did-JFK-seduce-virgin-intern-White-House.html
How did JFK seduce a virgin intern at the White House?
By ANGSHUKANTA CHAKRABORTY
White House, that enormous reservoir of secrets - of both the open and
closely guarded varieties - is once again drawing attention.
This time for the exploits of its 35th President, John F. Kennedy, who
was as famous for his string of sexual peccadilloes as for his liberal
policies that defined the Camelot-era American polity.
In a tell-all memoir, a former intern, Marion 'Mimi' Beardsley Alford,
now a retired church administrator with a Manhattan Presbyterian
church, reveals the seamy side of JFK who 'seduced' the 19-year-old
and claimed her 'virginity' at an exclusive White House 'pool party',
which the President was having with some 'close aides'.
Alford's Once Upon a Secret: My Affair with President John F. Kennedy
and Its Aftermath is published by Random House and will be released in
New York on Tuesday.
intern Marion B. Alford (pictured) reveals in her book how President
John F. Kennedy seduced the 19-year-old virgin at an exclusive pool
party
The advance figures are reportedly touching Rs 5 crore, though Susan
Mercandett, the executive editor of Random House says 'an
extraordinary heart and soul exists in the book' and that it is as
much about a 'loss of innocence' as it is a 'woman's coming-of-age
story.'
Alford breaks a silence of over four decades when she had a torrid
affair with JFK, who seduced her for the first time in his wife's
(Jacqueline) boudoir. Ironically, not only does the young Alford
resemble the First Lady in her looks, but also received edification at
the same exclusive private academy that Jacqueline had attended.
Alford first acknowledged the 18-month-long 'sexual relationship,'
that lasted from June 1962 up to the President's assassination in
November 1963, in 2003.
This was following a biography of JFK by Robert Dallek publishing
portions of a 1964 oral history that detailed the liaison.
The Time had also published a piece by former White House journalist
Hugh Sidney who had written that "there was a Mimi" on JFK's list of
conquests.
In her memoir Alford (pictured) describes the sexual sadomasochism
that JFK was infamous for
Alford, now 69, recounts how the President maintained a sexual
relationship with her and his exploits were fuelled by narcotics.
Her memoir also describes the sexual sadomasochism that JFK was
infamous for, especially in a telling episode when he had asked her to
perform oral sex on his close aide David Powers.
'I don't think the President thought I'd do it, but I'm ashamed to say
that I did,' she says in her book that is already available in a
Manhattan store.
http://i.dailymail.co.uk/i/pix/2012/02/07/article-2097897-11A134D9000005DC-499_233x423.jpg
http://i.dailymail.co.uk/i/pix/2012/02/07/article-2097897-11A134CA000005DC-841_233x338.jpg
http://i.dailymail.co.uk/i/pix/2012/02/07/article-2097897-11A134DE000005DC-504_468x286.jpg
<snip>
I kissed a goy and i like it!
Geee, no GE and not G but B?
I see.
But got CFS and aids/hiv and a host of other conditions like mono and
autoimmunity. LOL
Hey! So do it.... imagine that... LOL
And in the PAST he/she was PERFECT.....flu perfect?
Is or was john Sculley a genius or blow HARD job or nit wit?
Yes, no, yes, no = zero....
http://en.wikipedia.org/wiki/John_Sculley
What is is... and isness and beingness ARE.
What are YOU doing to BE?
You ain't john or me.... just BE... you (?)
And john wasn't steve JOBs as he took an acid trip
That was HIS trip...
Yours is BEING autoimmune and you need a DRUG called a mAB from big
pig pharma?
Or some apremilast?
I do?
Yes... you do... dim wit.
OK which juan?
That apremilast in the last thread today sounds cool:
Found here:
Fri, Feb 10 2012 12:01 pm
Subject: PDE4 Inhibitor-->In Vino Veritas (Red Wine) --- cAMP versus
cGMP (GEE! no G as in Guano -->CRAP of Psor LIFE?) --> Polyamines --
Et tu, Brute?
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/c51500c40ca0ca4e
pde4 inhibitor:
This brilliant btw:
http://www.ncbi.nlm.nih.gov/pubmed/22304913
Resveratrol ameliorates aging-related metabolic phenotypes by
inhibiting cAMP phosphodiesterases.
[...] pmid: 22304913
This wand.
Chronic fatigue syndrome cfs- 5550 hits: pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20fatigue%20syndrome%20cfs
are we short on mAbs?
I'm sure big PHARMA will take care of that juan?
LOL
4 hits: Chronic fatigue syndrome cfs mab
http://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20fatigue%20syndrome%20cfs%20mab
<randall note: no mAbs due to it being viral?>
#2 of 4
It's a GUT triP?
Who would have KNOWN? <w>
http://www.ncbi.nlm.nih.gov/pubmed/17872383
J Clin Pathol. 2008 Jan;61(1):43-8. Epub 2007 Sep 13.
Chronic fatigue syndrome is associated with chronic enterovirus
infection of the stomach.
Chia JK, Chia AY.
Source
EV Med Research, Lomita, California 90717, USA. ev...@sbcglobal.net
Abstract
BACKGROUND AND AIMS:
The aetiology for chronic fatigue syndrome (CFS) remains elusive
although enteroviruses have been implicated as one of the causes by a
number of studies. Since most CFS patients have persistent or
intermittent gastrointestinal (GI) symptoms, the presence of viral
capsid protein 1 (VP1), enterovirus (EV) RNA and culturable virus in
the stomach biopsy specimens of patients with CFS was evaluated.
METHODS:
165 consecutive patients with CFS underwent upper GI endoscopies and
antrum biopsies. Immunoperoxidase staining was performed using EV-
specific monoclonal antibody (mAb) or a control mAb specific for
cytomegalovirus (CMV). RT-PCR ELISA was performed on RNA extracted
from paraffin sections or samples preserved in RNA later. Biopsies
from normal stomach and other gastric diseases served as controls. 75
samples were cultured for EV.
RESULTS:
135/165 (82%) biopsies stained positive for VP1 within parietal cells,
whereas 7/34 (20%) of the controls stained positive (p< or =0.001).
CMV mAb failed to stain any of the biopsy specimens. Biopsies taken
from six patients at the onset of the CFS/abdominal symptoms, and 2-8
years later showed positive staining in the paired specimens. EV RNA
was detected in 9/24 (37%) paraffin-embedded biopsy samples; 1/21
controls had detectable EV RNA (p<0.01); 1/3 patients had detectable
EV RNA from two samples taken 4 years apart; 5 patient samples showed
transient growth of non-cytopathic enteroviruses.
CONCLUSION:
Enterovirus VP1, RNA and non-cytopathic viruses were detected in the
stomach biopsy specimens of CFS patients with chronic abdominal
complaints. A significant subset of CFS patients may have a chronic,
disseminated, non-cytolytic form of enteroviral infection, which could
be diagnosed by stomach biopsy.
Comment in
J Clin Pathol. 2008 Jan;61(1):1-2.
http://www.ncbi.nlm.nih.gov/pubmed/17873115
PMID: 17872383 [
Shall we go down the rabbit hole , alice?
Sure... steve jobs had HIS BEST trip on LSD.
And randall dork goy finds a dearth of Th17and CFS?
I expected it with mAbs... but not with th17
4 hits: Chronic fatigue syndrome Th17 -pubmed:
http://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20fatigue%20syndrome%20Th17
http://www.ncbi.nlm.nih.gov/pubmed/21950132
Vestn Ross Akad Med Nauk. 2011;(8):24-33.
[Regulatory T-cells: modern approaches to optimization of their
numbers].
[Article in Russian]
Pukhal'skiĭ AL, Shmarina GV, Aleshkin VA.
Abstract
Regulatory T-cells (Tregs) are important components of the complex
adaptive system of the body responsive to environmental challenges.
Tregs ensure peripheral tolerance and play an important role in
control of inflammatory reactions. Several subsets of Tregs have been
described. Naturally occurring CD4+CD25+ Tregs are recognized as a
major subset of immune cells responsible for peripheral immune self-
tolerance. Another subtype of Tregs is inducible. Such Tregs are
generated in the periphery and realize their suppressive potential
largely in the form of anti-inflammatory activity. The latter plays an
important role in cooperation of three principal anti-inflammatory
mechanisms that developed in the course of evolution: macrophages
possessed of suppressive activity, Tregs, and stress hormones.
Normally, all the three mechanisms of inflammation control are in
equilibrium. However, the balance may be disturbed with ageing due to
repeated episodes of stress and HPA axis activation. As a result,
secretion of stress hormones coupled to antigen overload leads to Treg
accumulation. In the course of time activation of the HPA axis is
replaced by its inhibition manifested both as a decrease of the
baseline cortisol level and a reduction of stress-induced cortisol
response. Cortisol present in blood at low concentrations is no longer
capable of controlling inflammation and Tregs become a principal
mechanism of anti-inflammatory machinery. Superfluous Treg
accumulation results in the development of functional somatic
syndromes, such as chronic fatigue syndrome, and (in some patients) in
the growth of tumours resulting from the suppression of anticancer
immunity. On the other hand, the lack of adequate antigen loading in
the childhood may delay Treg maturation. Allergy and asthma
manifestations may be a consequence of such Treg insufficiency. Thus,
both excess and deficiency of Tregs may be at the bottom of morbid
conditions. The advances in modern pharmacology open up opportunities
for developing new methods to control the Treg level.
PMID: 21950132
Without even LOOKing it looks Th2 skewish...<G>
http://www.ncbi.nlm.nih.gov/pubmed/20447453
Brain Behav Immun. 2010 Oct;24(7):1209-17. Epub 2010 May 4.
A formal analysis of cytokine networks in chronic fatigue syndrome.
Broderick G, Fuite J, Kreitz A, Vernon SD, Klimas N, Fletcher MA.
Source
Division of Pulmonary Medicine, Department of Medicine, University of
Alberta, College Plaza, 8215 112 Street NW, Edmonton, Alberta, Canada.
gordon.b...@ualberta.ca
Abstract
Chronic Fatigue Syndrome (CFS) is a complex illness affecting 4
million Americans for which no characteristic lesion has been
identified. Instead of searching for a deficiency in any single
marker, we propose that CFS is associated with a profound imbalance in
the regulation of immune function forcing a departure from standard
pre-programmed responses. To identify these imbalances we apply
network analysis to the co-expression of 16 cytokines in CFS subjects
and healthy controls. Concentrations of IL-1a, 1b, 2, 4, 5, 6, 8, 10,
12, 13, 15, 17 and 23, IFN-γ, lymphotoxin-α (LT-α) and TNF-α were
measured in the plasma of 40 female CFS and 59 case-matched controls.
Cytokine co-expression networks were constructed from the pair-wise
mutual information (MI) patterns found within each subject group.
These networks differed in topology significantly more than expected
by chance with the CFS network being more hub-like in design. Analysis
of local modularity isolated statistically distinct cytokine
communities recognizable as pre-programmed immune functional
components. These showed highly attenuated Th1 and Th17 immune
responses in CFS. High Th2 marker expression but weak interaction
patterns pointed to an established Th2 inflammatory milieu. Similarly,
altered associations in CFS provided indirect evidence of diminished
NK cell responsiveness to IL-12 and LT-α stimulus. These observations
are consistent with several processes active in latent viral infection
and would not have been uncovered by assessing marker expression
alone. Furthermore this analysis identifies key sub-networks such as
IL-2:IFN-γ:TNF-α that might be targeted in restoring normal immune
function.
Comment in
Brain Behav Immun. 2010 Oct;24(7):1218; author reply 1219.
http://www.ncbi.nlm.nih.gov/pubmed/20561580
PMID: 20447453
Free PMC Article
Or women with CFS and cytokines:
http://www.ncbi.nlm.nih.gov/pubmed/19909538
------------
Moving up or wider so to speak:
17 hits: Chronic fatigue syndrome Th1- pubmed:
http://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20fatigue%20syndrome%20Th1
19 hits: Chronic fatigue syndrome Th2- pubmed:
http://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20fatigue%20syndrome%20Th2
12 have both Th1 and Th2:
Chronic fatigue syndrome Th2 Th1
http://www.ncbi.nlm.nih.gov/pubmed?term=Chronic%20fatigue%20syndrome%20Th2%20Th1
WELL #1 of 12 looks like a Th2 skew with foxp3, IL-10 etc is d
http://www.ncbi.nlm.nih.gov/pubmed/21619669
J Transl Med. 2011 May 28;9:81.
Immunological abnormalities as potential biomarkers in Chronic Fatigue
Syndrome/Myalgic Encephalomyelitis.
Brenu EW, van Driel ML, Staines DR, Ashton KJ, Ramos SB, Keane J,
Klimas NG, Marshall-Gradisnik SM.
Source
Population Health and Neuroimmunology Unit, Faculty of Health Science
and Medicine, Bond University, Robina, Queensland, Australia.
Abstract
BACKGROUND:
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is
characterised by severe prolonged fatigue, and decreases in cognition
and other physiological functions, resulting in severe loss of quality
of life, difficult clinical management and high costs to the health
care system. To date there is no proven pathomechanism to
satisfactorily explain this disorder. Studies have identified
abnormalities in immune function but these data are inconsistent. We
investigated the profile of markers of immune function (including
novel markers) in CFS/ME patients.
METHODS:
We included 95 CFS/ME patients and 50 healthy controls. All
participants were assessed on natural killer (NK) and CD8(+) T cell
cytotoxic activities, Th1 and Th2 cytokine profile of CD4(+) T cells,
expression of vasoactive intestinal peptide receptor 2 (VPACR2),
levels of NK phenotypes (CD56(bright) and CD56(dim)) and regulatory T
cells expressing FoxP3 transcription factor.
RESULTS:
Compared to healthy individuals, CFS/ME patients displayed significant
increases in IL-10, IFN-γ, TNF-α, CD4(+)CD25(+) T cells, FoxP3 and
VPACR2 expression. Cytotoxic activity of NK and CD8(+) T cells and NK
phenotypes, in particular the CD56(bright) NK cells were significantly
decreased in CFS/ME patients. Additionally granzyme A and granzyme K
expression were reduced while expression levels of perforin were
significantly increased in the CFS/ME population relative to the
control population. These data suggest significant dysregulation of
the immune system in CFS/ME patients.
CONCLUSIONS:
Our study found immunological abnormalities which may serve as
biomarkers in CFS/ME patients with potential for an application as a
diagnostic tool.
PMID: 21619669
Free PMC Article
OK does that mean people with sebopsoriasis being both Th1 and Th2
could have CFS?
I wonder?
I Gotta Feeling - Black Eyed Peas ~ HQ ~ with Lyrics
http://www.youtube.com/watch?v=lmvAVX8_szs
maybe not?
OK this science THING is not hitting all cylinders... maybe 7 of 8 or
10 of 12?
Whatever... it takes.. and you live to 111 like Bernando LaPallo or
122 like Jeanne calment.
And you see LIFE for a little BIT longer then the rest of us?
No way...
My TIME equations will take us out of that box..
So what is it to be truly conscious of time and beingness in this BOX
called the universe?
randall... not enough time? To much? But if you die you don't CARE
as MUCH?
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