PDE4 Inhibitor-->In Vino Veritas (Red Wine) --- cAMP versus cGMP (GEE! no G as in Guano -->CRAP of Psor LIFE?) --> Polyamines -- Et tu, Brute?

[randall]

hi


Will J get what he pays for in this LIFE from TJ's resveratrol?

Will he figure this one out?

http://www.ncbi.nlm.nih.gov/pubmed/22304913
[...] pmid: 22304913

Did he get the import of iron and L. Plantarum or any old
lactobaccillus to
make a nice home of biofilm in you thus---ly insuring Good GUT flora?

In FUN STUFF:
http://www.ncbi.nlm.nih.gov/pubmed/22039501
Identification and characterisation of an iron-responsive candidate
probiotic.
[...] PMID: 22039501

In the top of this thread:

Fri, Feb 10 2012 11:38 am
Subject: Re: FUN stuff --> Longevinex - (10) Mercola - Byron -Ai->
Diabetes - JBS look back -->JW (The Duke) --Charles Murray-->Imprimis
--Jobs down the Whirlpool? --Hire Chinese? -- Mucin & Cancer --VSL#3 -
Cogan -INQ -> Pagano -TIME -Higgs Boson
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/974724fdfbeace4d

Will randall and Jxr avoid cancer even though sunshine is so good to
hide their plaque, i mean pride of having a plaque
that makes one take back... their pride? LOL

Hide the Pride!

Cover that plaque... or drink some red wine?

I know this...

Time flies when you DIE..

so drink a nice glass of in vino veritas (red wine) each day?

Yes id squid...

Or take www.longevinex.com

Jeanne Calment might have lived longer then 122 1/2?

LOL... no clue on that amazing human BEAN.

But besides red wine Jeanne consumed bitter? chocolate
one kilo a week iirc and evoo (extra virgin olive oil) and
... well the red wine is this post...so moving on.

But will do a thread on Bernando Lapallo (111 years old now?) next...
or soon.. or i'm a goon. <G>

And there are some RED WINE-ish story's below to suPPort that TRUTH...

What?

In vino veritas?

Drinking Wine - G. Love and Special Sauce
http://www.youtube.com/watch?v=-8IrvCmjQSA
<time:5:58> <views: 36>

36 views... low production values but i'm
going for the lyric.... LOL

He be drinking that wine wine wine all the time.

No cocaine in his brain...

Only red wine Truths:
http://en.wikipedia.org/wiki/In_vino_veritas
In vino veritas is a Latin phrase that translates, “in wine [there is
the] truth". It is also known as a Greek phrase “Ἐν οἴνῳ ἀλήθεια” En
oino álétheia, which has the same meaning. The author of the Latin
phrase is Pliny the Elder;[1] the Greek phrase is attributed to the
Greek poet Alcaeus.

The Greek poet Alcaeus is the oldest known source for the phrase. The
Roman historian Tacitus described how the Germanic peoples always
drank wine while holding councils, as they believed nobody could lie
effectively when drunk.

[...] 1770s, Benjamin Cooke wrote a glee by the title of In Vino
Veritas. His lyrics [with modern punctuation, etc.] are as follows:

Round, round with the glass, boys, as fast as you can,
Since he who don't drink cannot be a true man.
For if truth is in wine, then 'tis all but a whim
To think a man's true when the wine's not in him.
Drink, drink, then, and hold it a maxim divine
That there's virtue in truth, and there's truth in good wine
<snip>



Pde4 is inhibited by RED wine...

so now we KNOW....

But id squid wants to KNOW....

what?

WELL...

PDE4 what PORE?


OK...

57 hits in google news for: pde4 + resveratrol
Use : http://news.google.com/nwshp?hl=en&tab=wn

Here's my #1 of 57

http://www.myhealthnewsdaily.com/2189-resveratrol-works-alzheimers-drugs.html
Hold Your Glass! Benefits of 1,000 Bottles of Red Wine Could Come from
Drug
<snip>

So.... let's look at these players in terms of being PSOR...

nothing more... but cAMP vs. cGMP moves to the fore via pde4.

PDE
http://en.wikipedia.org/wiki/Phosphodiesterase

Viagra is a PDE5 inhibitor BTW.


http://en.wikipedia.org/wiki/Phosphodiesterase-4_inhibitor
A phosphodiesterase type 4 inhibitor, commonly referred to as a PDE4
inhibitor, is a drug used to block the degradative action of
phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP).
It is a member of the larger family of PDE inhibitors. The PDE4 family
of enzymes are the most prevalent PDE in immune cells. They are
predominantly responsible for hydrolyzing cAMP within both immune
cells and cells in the central nervous system.

[...] Mode of action

PDE4 hydrolyzes cyclic adenosine monophosphate (cAMP) to inactive
adenosine monophosphate (AMP). Inhibition of PDE4 blocks hydrolysis of
cAMP, thereby increasing levels of cAMP within cells.
<snip>

How many times have i said we NEED more cAMP and less gAMP?


A zillion?

No id squid... but at least a 100 iirc.

So let's see just for my id and i?

OK...


h'mm...

ONLY 30 hits for: cyclic adenosine monophosphate

http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=cyclic+adenosine+monophosphate+&start=0&

But we pick up 478 hits for c-AMP - p ng:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=c-amp&start=0&scoring=d&

But those have like camp fires in them... LOL

And we want:

http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate

We want optimum levels of cAMP and less cGMP.

But crap (guano as in guanosine) builds up in Th1 skewed people due to
something.

Like we eat to much crap?

Or crap has a tendency to build up so starvation lowers inflammations?

We've talked about this for a decaDE... DUH.

So

Cyclic guanosine monophosphate (cGMP)
http://en.wikipedia.org/wiki/Cyclic_guanosine_monophosphate

105 hits -keyword: c-gmp- p ng:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=c-gmp&start=0&
by time backwards:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=c-gmp&start=0&scoring=d&


What are the crap guys? What does this crap look like?

5 results for c-gmp putrescine spermine spermidine-- p ng
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=c-gmp+putrescine+spermine+spermidine&start=0&scoring=d&


We get 3 times more crap taking c-gmp outa that search:

14 results for putrescine spermine spermidine-- p ng
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=+putrescine+spermine+spermidine&start=0&

The crap boys are polyamines:

http://en.wikipedia.org/wiki/Polyamine

While they have a function i suppose one can have to MUCH:

http://en.wikipedia.org/wiki/Polyamine#Functions

And we've gone over polyamines -- 50 times in the P NG
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=+polyamines&start=0&


So now we get to have a RED GLASS of WINE or take some

Aprmilast.... LOL

resveratrol + pde4 move towards the front of the LINE today:


33 hits: resveratrol pde4 - P NG
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=pde4&start=0&
by date: (most recent backwards)
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=pde4&start=0&scoring=d&

One third of these has pde4 inhibitor Apremilast.
pde4 Apremilast-- 11 hits - P NG
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=pde4+Apremilast&start=0&scoring=d&


In the p ng we've got 23 hits for Apremilast:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=Apremilast+&start=0&
by time:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=Apremilast+&start=0&scoring=d&

NPF forum memebers talk about Apremilast:
https://www.inspire.com/groups/talk-psoriasis/discussion/apremilast/


================================

http://www.resveratrolnews.com/initial-gene-target-of-resveratrol-finally-identified/487/

image:
http://www.resveratrolnews.com/wp-content/uploads/2012/02/resveratrol-action-pathway.gif

Initial Gene Target Of Resveratrol Finally Identified.
Lifts Cloud Of Uncertainty From This Super Molecule, But Researchers
Want To Supplant It With A Drug

By Bill Sardi

Over eight years after a Harvard University researcher mistakenly
identified the primary gene target of resveratrol (rez-vair-ah-troll)
as a survival gene (Sirtuin1) that is also variably activated by
calorie restricted diets, National Institutes of Health (NIH)
researchers say they have now identified an enzyme (phosphodiesterase4
or PDE4) as the first gene target of resveratrol. Specifically, this
enzyme is inhibited by resveratrol, known as a red wine molecule. All
of the antioxidant molecules in red wine are enzyme inhibitors.
http://www.ncbi.nlm.nih.gov/pubmed/22304913
pmid: 22304913

The Sirtuin1 gene is not totally out of the picture, it is activated
indirectly in the gene pathway along with other important metabolic
gene targets such as NAD, PGC1a and AMPK. The study, which was
conducted in mice, needs to be replicated in humans.
http://www.ncbi.nlm.nih.gov/pubmed/22304906
pmid: 22304906

Will resveratrol be supplanted by a drug?

Dr. Jay H. Chung, chief of the Laboratory of Obesity and Aging
Research at the National Heart, Lung & Blood Institute, said that a
PDE4-inhibiting drug, Rolipram, reproduces all of the metabolic
benefits of resveratrol, including diet-induced obesity and an
increase in cellular energy, physical stamina and blood sugar
tolerance in laboratory mice. NIH researchers posed Rolipram as
possibly “less toxic than resveratrol itself and said by targeting
PDE4 potential side effects would be minimized.”

In a health care system that financially rewards patentable synthetic
drugs over natural unpatentable remedies, the fact NIH researchers
prefer PDE4-inhibiting drugs over resveratrol should be expected.
However, in this instance, resveratrol may be far safer and certainly
more economical.
<snip as this is copy RIGHTed by bill....Sardi... thanks for a great
a product bill!>

read full story here:
http://www.resveratrolnews.com/initial-gene-target-of-resveratrol-finally-identified/487/

And a nice site that puts FACTs first and cuts the BULL...


zzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzzz

pde4 inhibitors - 2035 hits:
http://www.ncbi.nlm.nih.gov/pubmed?term=pde4%20inhibitors

Only one of these 2035 has resveratrol... and in vino veritas is out
of the BAG


http://www.ncbi.nlm.nih.gov/pubmed/22304913
Cell. 2012 Feb 3;148(3):421-33.
Resveratrol ameliorates aging-related metabolic phenotypes by
inhibiting cAMP phosphodiesterases.

Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H,
Taussig R, Brown AL, Kim MK, Beaven MA, Burgin AB, Manganiello V,
Chung JH.

Source
Laboratory of Obesity and Aging Research, Genetics and Developmental
Biology Center, National Heart Lung and Blood Institute, National
Institutes of Health, Bethesda, MD 20892, USA.

Abstract
Resveratrol, a polyphenol in red wine, has been reported as a calorie
restriction mimetic with potential antiaging and antidiabetogenic
properties. It is widely consumed as a nutritional supplement, but its
mechanism of action remains a mystery. Here, we report that the
metabolic effects of resveratrol result from competitive inhibition of
cAMP-degrading phosphodiesterases, leading to elevated cAMP levels.
The resulting activation of Epac1, a cAMP effector protein, increases
intracellular Ca(2+) levels and activates the CamKKβ-AMPK pathway via
phospholipase C and the ryanodine receptor Ca(2+)-release channel. As
a consequence, resveratrol increases NAD(+) and the activity of Sirt1.
Inhibiting PDE4 with rolipram reproduces all of the metabolic benefits
of resveratrol, including prevention of diet-induced obesity and an
increase in mitochondrial function, physical stamina, and glucose
tolerance in mice. Therefore, administration of PDE4 inhibitors may
also protect against and ameliorate the symptoms of metabolic diseases
associated with aging.

PMID: 22304913

1027 hits - "Chung JH"[Author]
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Chung%20JH%22%5BAuthor%5D

Chung is a hit machine... twice as many almost as Dipak Das... LOL




OK K2?

k why?

no KY... lol


randall -- i've GOt bigger Pigger FISH to fry.... or try... or DIE?
Time to DIE...? but, but, but,,,,--------> why?