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Psoriasis as CRAPPY Dis-EASE : Polyamines - Putrescine -Guno things - > cGMP vs cAMP --Spermidine Spermine --Lactobacillus Plantarum --OrWellian Dystopianism - Animal Farm - DrD4 Politics -SELF Realization via Mother EARTHism - Peyote -LSD- Ergot
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randall
May 17, 2012, 11:19:35 PM5/17/12
to
hi
OK so this one takes a slightly different tack..
The last five today... are cool... but this takes another tack...
Room at the mark...
port to star dork? Don't get bored... randall tar baby...
OK id squid... what have you got?
Doing Abstracts today:
Pig skin for psor human SKIN:
http://www.ncbi.nlm.nih.gov/pubmed/22590584
PLoS One. 2012;7(5):e36658. Epub 2012 May 10.
Development of Transgenic Cloned Pig Models of Skin Inflammation by
DNA Transposon-Directed Ectopic Expression of Human β1 and α2
Integrin.
Staunstrup NH, Madsen J, Primo MN, Li J, Liu Y, Kragh PM, Li R,
Schmidt M, Purup S, Dagnæs-Hansen F, Svensson L, Petersen TK, Callesen
H, Bolund L, Mikkelsen JG.
Source
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Abstract
Integrins constitute a superfamily of transmembrane signaling
receptors that play pivotal roles in cutaneous homeostasis by
modulating cell growth and differentiation as well as inflammatory
responses in the skin. Subrabasal expression of integrins α2 and/or β1
entails hyperproliferation and aberrant differentiation of
keratinocytes and leads to dermal and epidermal influx of activated T-
cells. The anatomical and physiological similarities between porcine
and human skin make the pig a suitable model for human skin diseases.
In efforts to generate a porcine model of cutaneous inflammation, we
employed the Sleeping Beauty DNA transposon system for production of
transgenic cloned Göttingen minipigs expressing human β1 or α2
integrin under the control of a promoter specific for subrabasal
keratinocytes. Using pools of transgenic donor fibroblasts, cloning by
somatic cell nuclear transfer was utilized to produce reconstructed
embryos that were subsequently transferred to surrogate sows. The
resulting pigs were all transgenic and harbored from one to six
transgene integrants. Molecular analyses on skin biopsies and cultured
keratinocytes showed ectopic expression of the human integrins and
localization within the keratinocyte plasma membrane. Markers of
perturbed skin homeostasis, including activation of the MAPK pathway,
increased expression of the pro-inflammatory cytokine IL-1α, and
enhanced expression of the transcription factor c-Fos, were identified
in keratinocytes from β1 and α2 integrin-transgenic minipigs,
suggesting the induction of a chronic inflammatory phenotype in the
skin. Notably, cellular dysregulation obtained by overexpression of
either β1 or α2 integrin occurred through different cellular signaling
pathways. Our findings mark the creation of the first cloned pig
models with molecular markers of skin inflammation. Despite the
absence of an overt psoriatic phenotype, these animals may possess
increased susceptibility to severe skin damage-induced inflammation
and should be of great potential in studies aiming at the development
and refinement of topical therapies for cutaneous inflammation
including psoriasis.
PMID: 22590584
147 hits for INTEGRIN - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=integrin&start=0&
Eight hits for Beta - 1 integrins...
Cd55 and PsA
http://www.ncbi.nlm.nih.gov/pubmed/22590509
PLoS One. 2012;7(5):e35606. Epub 2012 May 10.
Triggering of the dsRNA Sensors TLR3, MDA5, and RIG-I Induces CD55
Expression in Synovial Fibroblasts.
Karpus ON, Heutinck KM, Wijnker PJ, Tak PP, Hamann J.
Source
Department of Experimental Immunology, Academic Medical Center,
University of Amsterdam, Amsterdam, The Netherlands.
Abstract
BACKGROUND:
CD55 (decay-accelerating factor) is a complement-regulatory protein
highly expressed on fibroblast-like synoviocytes (FLS). CD55 is also a
ligand for CD97, an adhesion-type G protein-coupled receptor
abundantly present on leukocytes. Little is known regarding the
regulation of CD55 expression in FLS.
METHODS:
FLS isolated from arthritis patients were stimulated with pro-
inflammatory cytokines and Toll-like receptor (TLR) ligands.
Transfection with polyinosinic-polycytidylic acid (poly(I:C)) and 5'-
triphosphate RNA were used to activate the cytoplasmic double-stranded
(ds)RNA sensors melanoma differentiation-associated gene 5 (MDA5) and
retinoic acid-inducible gene-I (RIG-I). CD55 expression, cell
viability, and binding of CD97-loaded beads were quantified by flow
cytometry.
RESULTS:
CD55 was expressed at equal levels on FLS isolated from patients with
rheumatoid arthritis (RA), osteoarthritis, psoriatic arthritis and
spondyloarthritis. CD55 expression in RA FLS was significantly induced
by IL-1β and especially by the TLR3 ligand poly(I:C). Activation of
MDA5 and RIG-I also enhanced CD55 expression. Notably, activation of
MDA5 dose-dependently induced cell death, while triggering of TLR3 or
RIG-I had a minor effect on viability. Upregulation of CD55 enhanced
the binding capacity of FLS to CD97-loaded beads, which could be
blocked by antibodies against CD55.
CONCLUSIONS:
Activation of dsRNA sensors enhances the expression of CD55 in
cultured FLS, which increases the binding to CD97. Our findings
suggest that dsRNA promotes the interaction between FLS and CD97-
expressing leukocytes.
PMID: 22590509
Cd55 and psoria* - 6 hits -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=psoria*%20cd55
Should i run a CD55 and Integrin search?
Yes please.
48 hits : integrin + CD55 - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=cd55%20integrin
Only 1 of 48 is autoimmun*
http://www.ncbi.nlm.nih.gov/pubmed?term=cd55%20integrin%20autoimmun*
*********************
What is the crap of psoriasis? iz it really craP?
Like putrescine?
http://en.wikipedia.org/wiki/Putrescine
Putrescine (sometimes spelled putrescin) is a foul-smelling[1] organic
chemical compound NH2(CH2)4NH2 (1,4-diaminobutane or butanediamine)
that is related to cadaverine; both are produced by the breakdown of
amino acids in living and dead organisms and both are toxic in large
doses.[2][3] The two compounds are largely responsible for the foul
odor of putrefying flesh, but also contribute to the odor of such
processes as bad breath and bacterial vaginosis. They are also found
in semen and some microalgae, together with related molecules like
spermine and spermidine.
<snip>
Or does tar baby randall like to say the crap word?
crap... crap... crap...and erap1... LOL
Or is it guano crap? I like to say that... but the reason is guanine
and it ain't guano.
Guanine is G (goes with C, A, T = gattaca & DNA fame) and cGMP is not
cAMP:
http://en.wikipedia.org/wiki/Gattaca
http://en.wikipedia.org/wiki/Transhumanism#Genetic_divide_.28Gattaca_argument.29
Doesn't moooooooochele and obama want a dystopian craPPY society? LoL
Let's drop the imPolitic and stick with C-geee and c-ampppp...
http://en.wikipedia.org/wiki/Cyclic_guanosine_monophosphate
But more cAMP is more energy and less craPPy cGMP:
http://en.wikipedia.org/wiki/Cyclic_AMP
But guano crap (bird dung) does make gunpowder and is good fertilizer
for the garden:
http://en.wikipedia.org/wiki/Guano
But crap slows down your liver from living more... and that equals
less energy.
Or less glutathione or less SOD and GpX and all the other things if
it's
putting up with polyamines....
Sheesh..
http://en.wikipedia.org/wiki/Polyamines#Putrescine
http://en.wikipedia.org/wiki/Polyamines#Cadaverine
http://en.wikipedia.org/wiki/Polyamines#Spermidine_and_spermine
http://www.ncbi.nlm.nih.gov/pubmed/22584898
Acta Dermatovenerol Alp Panonica Adriat. 2012 Mar;21(1):3-5.
Comparative analysis of polyamine metabolism in benign and neoplastic
keratinocytic proliferations.
Broshtilova V, Lozanov V, Miteva L.
Source
Faculty of Medicine, Department of Dermatology and Venereology, 1,
Georgi Sofiisky st., 1431 Sofia, Bulgaria. brosh...@mail.bg.
Abstract
INTRODUCTION:
Polyamines (putrescine, spermidine, and spermine) are polycationic
compounds that play a central role in keratinocytic proliferation,
differentiation, and regulation. The objective was to elucidate the
polyamine metabolic changes that occur in various benign and
neoplastic skin proliferations.
METHODS:
The study included 58 patients: 31 with the plaque form of psoriasis
vulgaris and 27 with non-melanoma skin tumors. The levels of
putrescine, spermidine, and spermine were detected in lesional and non-
lesional skin samples.
RESULTS:
Findings were representative (p < 0.05). Psoriatic lesions showed a
twofold elevation of all polyamines in lesional skin compared to non-
lesional skin. Spermine had the highest concentration, which suggested
a leading position of propylamine synthesis in psoriatic pathogenesis.
Results on the polyamine metabolism of basal cell carcinoma
represented basic characteristics similar to those of psoriasis.
Conversely, squamous-cell carcinoma lesions showed the highest
concentration of putrescine, suggesting a crucial role of spermidine-
spermine acetyltransferase in their pathogenesis.
DISCUSSION:
Our findings showed different polyamine metabolic changes in lesions
from benign and neoplastic keratinocytic proliferations. Basal-cell
carcinoma polyamine metabolism revealed a closer relationship to
psoriasis than to squamous-cell carcinoma, which might explain its
long-term benign course and non-metastatic nature.
PMID: 22584898
23 hits: putrescine spermidine spermine psoria* -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=putrescine%20spermidine%20spermine%20psoria*
95 hits: polyamines + psoria* -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=polyamines%20psoria*
expanding this search:
267 hits: polyamines + LPS
http://www.ncbi.nlm.nih.gov/pubmed?term=polyamines%20LPS
So call in the L. Plantarum?
yes..#4 of 267
http://www.ncbi.nlm.nih.gov/pubmed/21958471
Life Sci. 2011 Dec 5;89(23-24):847-53. Epub 2011 Sep 19.
Effect of Lactobacillus plantarum and L-arginine against endotoxin-
induced liver injury in a rat model.
Rishi P, Bharrhan S, Singh G, Kaur IP.
Source
Department of Microbiology, Panjab University, Chandigarh-160014,
India. riship...@yahoo.com
Abstract
AIMS:
Use of probiotics, alone or as adjunct to other established therapies,
has been reported to have potential benefits. Recently, we have
reported protective potential of probiotic against Salmonella-induced
liver injury. However, co-supplementation with prebiotics did not
result in meaningful synergism at systemic level. Owing to the action
of probiotics at the mucosal level and of arginine at systemic level,
the present study was designed to evaluate the effect of Lactobacillus
plantarum alone or in conjunction with arginine to combat endotoxin-
mediated liver injury in rats.
MAIN METHODS:
Bacterial endotoxin/lipopolysaccharide (LPS) was injected
intraperitoneally and animals were sacrificed 8h post-challenge.
Efficacy of L. plantarum alone or in conjunction with l-arginine was
determined on the basis of enzyme markers, histology, levels of nitric
oxide (NO) and tumor necrosis factor-alpha (TNF-α) in addition to
identification of amino acids by paper chromatography.
KEY FINDINGS:
Prior supplementation of LPS-challenged rats with L. plantarum
(10(10)CFU per rat given orally for 10 days) demonstrated decreased
levels of liver enzymes, NO and TNF-α. Interestingly, complementing
Lactobacillus with arginine revealed a synergistic decrease not only
in the liver markers but also in NO and TNF-α along with increased
intensity of ornithine and methionine. Histological evidence also
confirmed the protective efficacy of probiotic in conjunction with l-
arginine.
SIGNIFICANCE:
Presence of ornithine and methionine in the probiotic-arginine co-
supplemented group suggests involvement of arginase-induced synthesis
of polyamines. This study highlights that L. plantarum may direct l-
arginine metabolism towards polyamine synthesis thereby exhibiting
synergistic effect against liver injury.
PMID: 21958471
55 hits - polyamines - p ng
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=polyamines&start=0&
121 hits : polyamines - lactobacillus -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=Lactobacillus%20polyamines
#1 of 121
Finding the nemo of gut flora?
sorta
http://www.ncbi.nlm.nih.gov/pubmed/22402370
J Nutr Biochem. 2012 Mar 6.
Infant formula supplemented with polyamines alters the intestinal
microbiota in neonatal BALB/cOlaHsd mice.
Gómez-Gallego C, Collado MC, Ilo T, Jaakkola UM, Bernal MJ, Periago
MJ, Salminen S, Ros G, Frias R.
Source
Department of Food Science and Nutrition, Faculty of Veterinary
Sciences, University of Murcia, Campus de Espinardo, Espinardo
(Murcia), Spain.
Abstract
Polyamines play a critical role in the development of intestinal and
immune systems during the infant breastfeeding period, but the effect
of polyamines on the microbiota has not been reported. The aim of our
study was to characterize the impact on the colonization pattern in
neonatal BALB/cOlaHsd mice after supplementing an infant formula (IF)
with a mixture of putrescine (PUT), spermidine (SPD) and spermine
(SPM). A total of 48 pups (14 days old) were randomly assigned to 4-
day intervention groups as follows: breast-fed (unweaned) pups (n=12);
weaned pups (n=12) fed an infant formula (IF); weaned pups (n=12) fed
an IF enriched with a low concentration of PUT, SPD and SPM (2.10,
22.05 and 38.00 μg/day, respectively); and weaned pups (n=12) fed with
IF enriched with a high concentration of PUT, SPD and SPM (8.40, 88.20
and 152.00 μg/day, respectively) of polyamines in accordance with
normal proportions found in human milk. Microbiota composition was
analyzed by fluorescent in situ hybridization (FISH) with flow
cytometry detection. Microbiota changes in formula-fed mice were
significantly greater following supplementation with polyamines (P<.
01). Bifidobacterium group bacteria, Akkermansia-like bacteria and
Lactobacillus-Enterococcus group levels were higher in the groups fed
infant formula supplemented with polyamines, resulting in even higher
numbers of bacteria than in the breastfed pups. Our findings indicate
that infant formulas enriched with polyamines may interact with gut
microbiota, suggesting that further studies in human infants are
required to assess the impact of polyamines on both growth and
microbiota levels.
PMID: 22402370
OTOH society smells like crap under stalin and marxism...
Even George (who could help it) Orwell knew that score:
http://en.wikipedia.org/wiki/Animal_farm
Animal Farm is an allegorical novella by George Orwell published in
England on 17 August 1945. According to Orwell, the book reflects
events leading up to and during the Stalin era before the Second World
War. Orwell, a democratic socialist,[1] was a critic of Joseph Stalin
and hostile to Moscow-directed Stalinism, especially after his
experiences with the NKVD, and what he saw of the results of the
influence of Communist policy ("ceaseless arrests, censored
newspapers, prowling hordes of armed police" – "Communism is now a
counter-revolutionary force"),[2] during the Spanish Civil War. In a
letter to Yvonne Davet, Orwell described Animal Farm as his novel
"contre Stalin"
<snip>
Orwell being a kewl socialist: : ?
http://en.wikipedia.org/wiki/George_Orwell#Political_views
So George couldn't help it?
Yet what if? I dig him uP and scan his gene's?
And...
He's got at LEAST one copy of the 7R DRD4 gene.. or maybe 2 copies and
full on libby pooh?
Who?
YOU?
Yes id squid... i'm at least one copy of that gene... LOL
Maybe even 2... but i can still THINK with gray cells and actively
suppress the Heart emotions.. (<w><G>)
So maybe some of my marxian friends have a point up to a point?
Is that pointed enough?
Full of crap and some crap in balance is OK?
The yin yang of crapism?
Sounds craPPY but true ... if it's homeOstatic craP?
So i like mine on rye go easy on the mayo....
You know?
http://en.wikipedia.org/wiki/Why_Orwell_Matters
I bet hitchens had 2 copies:
http://en.wikipedia.org/wiki/Christopher_Hitchens
And 2nd Wife Sonia Brownell Orwell must of had one or two copies of
the
libby pooh gene...
Sonia was in to phenomenology literally :
http://en.wikipedia.org/wiki/Phenomenology_(philosophy)
Or, as in the love of her life:
http://en.wikipedia.org/wiki/Sonia_Brownell
[...] She also had an affair with the French phenomenological
philosopher Maurice Merleau-Ponty, whom she described as her true love;
[citation needed] she hoped he would leave his wife for her.
<snip>
How else does one explain her marxian lover, Maurice Merleau-Ponty?
http://en.wikipedia.org/wiki/Maurice_Merleau-Ponty
Maurice Merleau-Ponty (French pronunciation: [mɔʁis mɛʁlopɔ̃ti]) (14
March 1908 – 3 May 1961) was a French phenomenological philosopher,
strongly influenced by Karl Marx,[1] Edmund Husserl and Martin
Heidegger in addition to being closely associated with Jean-Paul
Sartre (who later stated he had been "converted" to Marxism by Merleau-
Ponty[2]) and Simone de Beauvoir.
<snip>
I bet birds and turds of a feather, weather the drd4 7R alleles two-
gether. LOL
These marxian nit wits need FLOWER power...
http://en.wikipedia.org/wiki/File:Flowering_peyote_cactus.jpg
And the living bible of truth... <w>
http://en.wikipedia.org/wiki/Peyote#Uses
But marxian euro type nit wits being closer to africa might use rye
ergot or epoptes?
Or ibogaine ---> 8 hits - p ng
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=ibogaine+&start=0&
Even the Ancients used this stuff... like oregano oil for skin
farts... and..
let's do it?
Ok id squid... i haven't done this trip in a coon's age..
So... getting initiated in to ancient brain trips....
YiPPPPeee..
Hold on id squid... i know how you want to do the gala festival and
FEAST trip..
But this is... well...ok it is... LOL
Can we Fix the marxian quest to be smarty pooh and classless?
Yes... i can... LOL
Show the CLASS LESS via the mirror of their MIND their so Classy and
sassy and stuPidly... LOL
http://en.wikipedia.org/wiki/Quintus_Valerius_Soranus#Literary_works
[...] (epoptes, "initiate," feminine epoptis and plural epoptides),"
the highest grade of initiate at the Eleusinian mysteries.
<snip>
8 hits: epoptes - p ng
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=epoptes&start=0&
http://en.wikipedia.org/wiki/Eleusinian_mysteries
http://en.wikipedia.org/wiki/Eleusinian_mysteries#Secrets
[...] Upon reaching Eleusis, there was a day of fasting in
commemoration of Demeter's fasting while searching for Persephone. The
fast was broken while drinking a special drink of barley and
pennyroyal, called kykeon.
<snip>
Did they FAST on Friday, Saturday or Sunday? LOL
Sice they didn't have LENT yet... still a FAST isn't so FAST?
Most people do it for their religion:
http://en.wikipedia.org/wiki/Fasting
Some people have mental or physical health as their RELIGION... like
transhumanist timothy leary?
http://en.wikipedia.org/wiki/Timothy_Leary
Can you imagine some pennyroyal laden kykeon with peyote or just
peyote or JUST a hit of LSD?.. LOL
http://en.wikipedia.org/wiki/Kykeon
Kykeon (Gr. κυκεών, from κυκάω, "to stir, to mix") was an Ancient
Greek drink made mainly of water, barley and naturally occurring
substances. It was used at the climax of the Eleusinian Mysteries to
break a sacred fast, but it was also a favourite drink of Greek
peasants.
Kykeon is mentioned in Homeric texts: the Iliad describes it as
consisting of barley, water, herbs, and ground goat cheese (XI, 638–
641). In the Odyssey, Circe adds some honey and pours her magic potion
into it (X, 234). In The Homeric Hymn to Demeter, the goddess refuses
red wine but accepts kykeon made from water, barley and pennyroyal.
It was supposed to have digestive properties. Hermes recommends it in
Aristophanes' Peace (v. 712) to the hero who ate too much dry fruit
and nuts. Aristocrats shunned it as a peasant drink. Theophrastus
depicts in his Characters (IV, 2–3) a peasant whose thyme breath
inconveniences his neighbours at the Ecclesia.
In an attempt to solve the mystery of how so many people over the span
of two millennia could have consistently experienced revelatory states
during the culminating ceremony of the Eleusinian Mysteries, it has
been posited that the barley used in the Eleusinian kykeon was
parasitized by ergot, and that the psychoactive properties of that
fungus triggered the intense experiences alluded to by the
participants at Eleusis.[1]
For more on the possibilities of the Kykeon's psychoactive properties,
see entheogenic theories of the mysteries.
<snip>
Ergot fungi that old time religion:
The evil rich richie rich's didn't like that low caste stuff... LOL
http://en.wikipedia.org/wiki/Ergot
Some bad triPs...
http://en.wikipedia.org/wiki/Ergotism
Witch ones?
These:
http://en.wikipedia.org/wiki/Ergotism#Salem_witchcraft_accusations
Why rye when you've got LSD or peyote or african bark?
Bark, bark, bark:
Rye is not to die for:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/4ab1e4dd5237b2ff
Maybe they used the pennyroyal to protect themselves from unwanted
products of unconsciousness and sexual meschiveousness during those
wild weekends?
http://en.wikipedia.org/wiki/Pennyroyal
is an abortifacient
http://en.wikipedia.org/wiki/Abortifacient
So the higher class didn't need it as their mind over physical
weakness prevailed?
Did not females have to overcome coming in to HEAT while hubby pooh
was being a big time hunter?
http://en.wikipedia.org/wiki/Estrous_cycle#Differences_from_the_menstrual_cycle
[...] In species with estrous cycles, females are generally only
sexually active during the estrus phase of their cycle (see below for
an explanation of the different phases in an estrous cycle). This is
also referred to as being "in heat". In contrast, females of species
with menstrual cycles can be sexually active at any time in their
cycle,
<snip>
OK and teach your daughters to use the google thingy pooh instead of
going in to heat
on those celebrations in college after football games...
http://www.technewsworld.com/story/75136.html
or
http://googleblog.blogspot.com/2012/05/introducing-knowledge-graph-things-not.html
Introducing the Knowledge Graph: things, not strings
May 16, 2012
Search is a lot about discovery—the basic human need to learn and
broaden your horizons. But searching still requires a lot of hard work
by you, the user. So today I’m really excited to launch the Knowledge
Graph, which will help you discover new information quickly and
easily.
Take a query like [taj mahal]. For more than four decades, search has
essentially been about matching keywords to queries. To a search
engine the words [taj mahal] have been just that—two words.
But we all know that [taj mahal] has a much richer meaning. You might
think of one of the world’s most beautiful monuments, or a Grammy
Award-winning musician, or possibly even a casino in Atlantic City,
NJ. Or, depending on when you last ate, the nearest Indian restaurant.
It’s why we’ve been working on an intelligent model—in geek-speak, a
“graph”—that understands real-world entities and their relationships
to one another: things, not strings.
The Knowledge Graph enables you to search for things, people or places
that Google knows about—landmarks, celebrities, cities, sports teams,
buildings, geographical features, movies, celestial objects, works of
art and more—and instantly get information that’s relevant to your
query. This is a critical first step towards building the next
generation of search, which taps into the collective intelligence of
the web and understands the world a bit more like people do.
Google’s Knowledge Graph isn’t just rooted in public sources such as
Freebase, Wikipedia and the CIA World Factbook. It’s also augmented at
a much larger scale—because we’re focused on comprehensive breadth and
depth. It currently contains more than 500 million objects, as well as
more than 3.5 billion facts about and relationships between these
different objects. And it’s tuned based on what people search for, and
what we find out on the web.
The Knowledge Graph enhances Google Search in three main ways to
start:
1. Find the right thing
Language can be ambiguous—do you mean Taj Mahal the monument, or Taj
Mahal the musician? Now Google understands the difference, and can
narrow your search results just to the one you mean—just click on one
of the links to see that particular slice of results:
<snip>
Introducing the Knowledge Graph
http://www.youtube.com/watch?feature=player_embedded&v=mmQl6VGvX-c
<time: 2:45>
So every age has a counterculture... like beatniks and hippies
http://en.wikipedia.org/wiki/Counterculture_of_the_1960s
And ancient triPPies...
So... snort some tax crack and become obama and spend $1.5 trillion on
the national credit card
is a power trip...
And the same thing as taking LSD.
http://en.wikipedia.org/wiki/Lsd
Huxley and the minds antipodes:
one hit: minds huxley antipodes - p ng
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=huxley+minds+antipodes&start=0&
Same search ALL groups: 8,660 hits
http://groups.google.com/groups/search?q=huxley+minds+antipodes
http://en.wikipedia.org/wiki/Heaven_and_Hell_(essay)
Heaven and Hell is a philosophical essay by Aldous Huxley published in
1956. Huxley derived the title from William Blake's book The Marriage
of Heaven and Hell. The essay discusses the relationship between
bright, colorful objects, geometric designs, psychoactives, art, and
profound experience. Heaven and Hell metaphorically refer to what
Huxley conceives to be two contrary mystical experiences that
potentially await when one opens the "doors of perception"—not only in
a mystical experience, but in prosaic life.
Huxley uses the term antipodes to describe the "regions of the mind"
that one can reach via meditation, vitamin deficiencies, self-
flagellation, fasting, or (most effectively, he says) with the aide of
certain chemical substances like LSD or mescaline. Essentially, Huxley
defines these "antipodes" of the mind as mental states that one may
reach when one's brain is disabled (from a biological point of view)
and can then be conscious of certain "regions of the mind" that one
would otherwise never be able to pay attention to, due to the lack of
biological/utilitarian usefulness. Huxley states that while these
states of mind are biologically useless, they are nonetheless
spiritually significant, and furthermore, are the singular 'regions'
of the mind from which all religions are derived. For example, he says
that the Medieval Christians frequently experienced "visions" of
Heaven and Hell during the winter, when their diets were severely
hampered by lack of critical nutrients in their food supplies (vitamin
B, vitamin C)--these people frequently contracted Scurvy and other
deficiencies, causing them to hallucinate. He also said that
Christians and other religions fast in order to make themselves
delirious, thus inducing visions and views of these "antipodes of the
mind". Today, Huxley says people can reach these states of mind
without harm to their bodies with the aid of certain drugs.
Essentially, Huxley says this state of mind allows a person to be
conscious of things that would not normally concern him because they
have nothing to do with the typical concerns of the world.
In his earlier narrative The Doors of Perception (1954), Huxley
recounted in detail his first experience of mescaline.
<snip>
Here and nOW boys author:
http://en.wikipedia.org/wiki/Aldous_Huxley
Fixing the dystopian Orwellian society of marxian numb nutz... LOL
http://en.wikipedia.org/wiki/Island_(novel)
Pass the peyote:
http://en.wikipedia.org/wiki/Entheogen
Is Moksha the reason why they pop some LSD before dying?
http://en.wikipedia.org/wiki/Moksha
In Indian religions moksha (Sanskrit: मोक्ष mokṣa; liberation) or
mukti (Sanskrit: मुक्ति; release —both from the root muc "to let
loose, let go") is the final extrication of the soul or consciousness
(purusha) from samsara and the bringing to an end of all the suffering
involved in being subject to the cycle of repeated death and rebirth
(reincarnation).
Origins
It is highly probable that the concept of moksha was first developed
by Indian people whose spiritual ideas greatly influenced later
religious thought. Buddhism and Jainism are continuations of this
tradition, and the early Upanishadic movement was influenced by it.
Reincarnation was likely adopted from this religious culture by
Brahmin orthodoxy. Brahmins wrote the earliest recorded scriptures
containing these ideas in the early Upanishads
But aren't those the rich dudes?
http://en.wikipedia.org/wiki/Vedic_Brahmanism
http://en.wikipedia.org/wiki/Brahmanism
I wonder if re-incarnated souls from India have zero problems with
cremation?
http://en.wikipedia.org/wiki/Cremation
I wonder if Ramana Maharshi did the cremation?
He didn't buy the Brahmin trip, though born one.
OK let's look:
http://en.wikipedia.org/wiki/Ramana_Maharshi
http://en.wikipedia.org/wiki/Ramana_Maharshi#Final_Years
Cremation and a shooting star? LOL
http://en.wikipedia.org/wiki/Sri_Ramana_Ashram
http://en.wikipedia.org/wiki/File:Arunachala.JPG
Arunachala.JPG
[...] British writer Paul Brunton in 1931, who is credited with
introducing Ramana Maharshi to the West through his books "A Search in
Secret India" (1934) and "The Secret Path". In fact in his first book,
he mentioned, Ramana discouraging villagers from calling him Bhagwan,
as he found the title excessive and inflated[2]. Writer W. Somerset
Maugham who visited the ashram in 1938, and later used Maharishi as
the model for the holy man, Shri Ganesha in his novel, The Razor’s
Edge (1944)[3][4]. Other visitors include, Swami Sivananda,
Paramahansa Yogananda[5], Alfred Sorensen (Sunyata) and Wei Wu Wei
amongst others.[6].
Arthur Osborne stayed here for twenty years, and edited Ashram's
journal, The Mountain Path, besides writing several book on Maharishi
and his teachings, Mouni Sadhu spent several months here in 1949[7].
David Godman came to the ashram in 1976, and has since written or
edited fourteen books on topics related to Sri Ramana Maharshi and
continues to live near the ashram.
Niranjananda Swami, brother of Ramana Maharshi, who had moved to the
ashram along his mother in 1916, stayed at the ashram for the rest of
his life and handling its management, and after him his son and
grandson looked after the ashram[8].
<snip>
http://en.wikipedia.org/wiki/Advaita_Vedanta
[...] Necessity of a Guru
See also: Guru-shishya tradition
According to Śankara and others, anyone seeking to follow the
philosophy of Advaita Vedānta must do so under the guidance of a Guru
(teacher).[7] The Guru must have the following qualities (see Mundaka
Upanishad 1.2.12):
Śrotriya — must be learned in the Vedic scriptures and Sampradaya
Brahmaniṣṭhā — literally meaning 'established in Brahman'; must have
realised the oneness of Brahman in everything, and in himself/herself.
The seeker must serve the Guru, and submit questions with all humility
in order to remove all doubts (see Bhagavad Gita 4.34). By doing so,
Advaita says, the seeker will attain Moksha ('liberation from the
cycle of births and deaths').
According to Adi Śankara, knowledge of Brahman springs from inquiry
into the words of the Upanişads, and the knowledge of Brahman that
Sruti provides cannot be obtained in any other way. It is the teacher
who through exegesis of Sruti and skillful handling of words generates
a hitherto unknown knowledge in the disciple. The teacher does not
merely provide stimulus or suggestion
<snip>
Should i do my TIME equations with this as a theme?
http://en.wikipedia.org/wiki/Advaita_Vedanta#Theory_of_creation.3B_causality
http://en.wikipedia.org/wiki/Samkhya
We've got Duality but i like yin/yang more, i'm wondering.
http://en.wikipedia.org/wiki/Samkhya#Nature_of_Duality
[...] Theory of Existence
The Samkhya system is based on Sat-kārya-vāda. According to
Satkāryavāda, the effect pre-exists in the cause. Cause and effect are
seen as different temporal aspects of the same thing – the effect lies
latent in the cause which in turn seeds the next effect.
<snip>
http://en.wikipedia.org/wiki/Causality
OTOH i still tend to love those kogi Mama's and their GREAT MOTHER
creator:
http://en.wikipedia.org/wiki/Kogi_Indians
And those parrots on Island said what again?
Be here now goys? LOL
Let's see:
http://en.wikipedia.org/wiki/Island_(novel)#Quotations
Hey i don't see the parrots.... sayings?
OK..
I'll find them..
http://www.huxley.net/island/aldoushuxley-island.html
[...] "here and now, boys," Changed the bird: "here and now boys"
Are those parrots, actually mynah birds?
Is a true Utopia being HERE now?
And what about Georgism?
George can't helP it... he was born with a silver foot in his mut?
http://en.wikipedia.org/wiki/Georgism
Georgism (also called Geoism or Geonomics) is an economic philosophy
and ideology that holds that people own what they create, but that
things found in nature, most importantly land, belong equally to all.
[1] The Georgist philosophy is based on the writings of the economist
Henry George (1839–1897), and is usually associated with the idea of a
single tax on the value of land. Georgists argue that a tax on land
value is economically efficient, fair and equitable; and that it can
generate sufficient revenue so that other taxes (e.g. taxes on
profits, sales or income), which are less fair and efficient, can be
reduced or eliminated. A tax on land value has been described by many
as a progressive tax, since it would be paid primarily by the wealthy,
and would reduce income inequality.[2]
<snip>
Wow check out the people influenced by Georgism
http://en.wikipedia.org/wiki/Georgism#Notable_people_influenced_by_Georgism
Some of these had to negatively influenced, i'm guessing.. LOL
And what about the divine mushroom?
I almost forgot about it.
used to make the monks in tillable poor lands high in the himalya's
have good spiritual progress
and thereby keep the poopulation DOWN.
They should have exported it to INDIA? LOL
http://en.wikipedia.org/wiki/R._Gordon_Wasson#Work
Wasson's studies in ethnomycology began during his 1927 honeymoon trip
to the Catskill Mountains when his bride, Valentina Pavlovna Guercken
(1901–1958), a paediatrician, chanced upon some edible wild mushrooms.
Fascinated by the marked difference in cultural attitudes towards the
fungus in Russia compared to the United States, the couple began field
research that led to the publication of Mushrooms, Russia and History
in 1957. In the course of their investigations they mounted
expeditions to Mexico to study the religious use of mushrooms by the
native population, and became the first Westerners to participate in a
Mazatec mushroom ritual. In May 1957 they published a Life magazine
article titled Seeking the Magic Mushroom, which brought knowledge of
the existence of psychoactive mushrooms to a wide audience for the
first time. Together, Wasson and botanist Roger Heim collected and
identified various species of family Strophariaceae and genus
Psilocybe, while Albert Hofmann,[4] using material grown by Heim from
specimens collected by the Wassons, identified the chemical structure
of the active compounds, psilocybin and psilocin. Hofmann and Wasson
were also among the first Westerners to collect specimens of the
Mazatec hallucinogen Salvia divinorum, though these specimens were
later deemed not suitable for rigorous scientific study or taxonomic
classification.[5] Two species of mushroom, Psilocybe wassonii heim
and Psilocybe wassonorum guzman, were named in honor of Wasson along
with Heim and Gastón Guzmán, the latter of whom Wasson met during an
expedition to Huautla de Jiménez in 1957.
Wasson's next major contribution was a study of the ancient Vedic
intoxicant soma, which he proposed was based on the psychoactive fly
agaric (Amanita muscaria) mushroom. This hypothesis was published in
1967 under the title Soma: Divine Mushroom of Immortality. His
attention then turned to the Eleusinian Mysteries, the initiation
ceremony of the ancient Greek cult of Demeter and Persephone. In The
Road to Eleusis: Unveiling the Secret of the Mysteries (1978), co-
authored with Albert Hofmann and Carl A. P. Ruck, it was proposed that
the special potion "kykeon", a pivotal component of the ceremony,
contained psychoactive ergoline alkaloids from the fungus Ergot
(Claviceps spp.).
<snip>
Wow... NOW i know why i FLAKE...
so i can know who the REAL flakes are?
r they?
randall... YOU TELL me!...
OK so this one takes a slightly different tack..
The last five today... are cool... but this takes another tack...
Room at the mark...
port to star dork? Don't get bored... randall tar baby...
OK id squid... what have you got?
Doing Abstracts today:
Pig skin for psor human SKIN:
http://www.ncbi.nlm.nih.gov/pubmed/22590584
PLoS One. 2012;7(5):e36658. Epub 2012 May 10.
Development of Transgenic Cloned Pig Models of Skin Inflammation by
DNA Transposon-Directed Ectopic Expression of Human β1 and α2
Integrin.
Staunstrup NH, Madsen J, Primo MN, Li J, Liu Y, Kragh PM, Li R,
Schmidt M, Purup S, Dagnæs-Hansen F, Svensson L, Petersen TK, Callesen
H, Bolund L, Mikkelsen JG.
Source
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Abstract
Integrins constitute a superfamily of transmembrane signaling
receptors that play pivotal roles in cutaneous homeostasis by
modulating cell growth and differentiation as well as inflammatory
responses in the skin. Subrabasal expression of integrins α2 and/or β1
entails hyperproliferation and aberrant differentiation of
keratinocytes and leads to dermal and epidermal influx of activated T-
cells. The anatomical and physiological similarities between porcine
and human skin make the pig a suitable model for human skin diseases.
In efforts to generate a porcine model of cutaneous inflammation, we
employed the Sleeping Beauty DNA transposon system for production of
transgenic cloned Göttingen minipigs expressing human β1 or α2
integrin under the control of a promoter specific for subrabasal
keratinocytes. Using pools of transgenic donor fibroblasts, cloning by
somatic cell nuclear transfer was utilized to produce reconstructed
embryos that were subsequently transferred to surrogate sows. The
resulting pigs were all transgenic and harbored from one to six
transgene integrants. Molecular analyses on skin biopsies and cultured
keratinocytes showed ectopic expression of the human integrins and
localization within the keratinocyte plasma membrane. Markers of
perturbed skin homeostasis, including activation of the MAPK pathway,
increased expression of the pro-inflammatory cytokine IL-1α, and
enhanced expression of the transcription factor c-Fos, were identified
in keratinocytes from β1 and α2 integrin-transgenic minipigs,
suggesting the induction of a chronic inflammatory phenotype in the
skin. Notably, cellular dysregulation obtained by overexpression of
either β1 or α2 integrin occurred through different cellular signaling
pathways. Our findings mark the creation of the first cloned pig
models with molecular markers of skin inflammation. Despite the
absence of an overt psoriatic phenotype, these animals may possess
increased susceptibility to severe skin damage-induced inflammation
and should be of great potential in studies aiming at the development
and refinement of topical therapies for cutaneous inflammation
including psoriasis.
PMID: 22590584
147 hits for INTEGRIN - p ng
https://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=integrin&start=0&
Eight hits for Beta - 1 integrins...
Cd55 and PsA
http://www.ncbi.nlm.nih.gov/pubmed/22590509
PLoS One. 2012;7(5):e35606. Epub 2012 May 10.
Triggering of the dsRNA Sensors TLR3, MDA5, and RIG-I Induces CD55
Expression in Synovial Fibroblasts.
Karpus ON, Heutinck KM, Wijnker PJ, Tak PP, Hamann J.
Source
Department of Experimental Immunology, Academic Medical Center,
University of Amsterdam, Amsterdam, The Netherlands.
Abstract
BACKGROUND:
CD55 (decay-accelerating factor) is a complement-regulatory protein
highly expressed on fibroblast-like synoviocytes (FLS). CD55 is also a
ligand for CD97, an adhesion-type G protein-coupled receptor
abundantly present on leukocytes. Little is known regarding the
regulation of CD55 expression in FLS.
METHODS:
FLS isolated from arthritis patients were stimulated with pro-
inflammatory cytokines and Toll-like receptor (TLR) ligands.
Transfection with polyinosinic-polycytidylic acid (poly(I:C)) and 5'-
triphosphate RNA were used to activate the cytoplasmic double-stranded
(ds)RNA sensors melanoma differentiation-associated gene 5 (MDA5) and
retinoic acid-inducible gene-I (RIG-I). CD55 expression, cell
viability, and binding of CD97-loaded beads were quantified by flow
cytometry.
RESULTS:
CD55 was expressed at equal levels on FLS isolated from patients with
rheumatoid arthritis (RA), osteoarthritis, psoriatic arthritis and
spondyloarthritis. CD55 expression in RA FLS was significantly induced
by IL-1β and especially by the TLR3 ligand poly(I:C). Activation of
MDA5 and RIG-I also enhanced CD55 expression. Notably, activation of
MDA5 dose-dependently induced cell death, while triggering of TLR3 or
RIG-I had a minor effect on viability. Upregulation of CD55 enhanced
the binding capacity of FLS to CD97-loaded beads, which could be
blocked by antibodies against CD55.
CONCLUSIONS:
Activation of dsRNA sensors enhances the expression of CD55 in
cultured FLS, which increases the binding to CD97. Our findings
suggest that dsRNA promotes the interaction between FLS and CD97-
expressing leukocytes.
PMID: 22590509
Cd55 and psoria* - 6 hits -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=psoria*%20cd55
Should i run a CD55 and Integrin search?
Yes please.
48 hits : integrin + CD55 - pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=cd55%20integrin
Only 1 of 48 is autoimmun*
http://www.ncbi.nlm.nih.gov/pubmed?term=cd55%20integrin%20autoimmun*
*********************
What is the crap of psoriasis? iz it really craP?
Like putrescine?
http://en.wikipedia.org/wiki/Putrescine
Putrescine (sometimes spelled putrescin) is a foul-smelling[1] organic
chemical compound NH2(CH2)4NH2 (1,4-diaminobutane or butanediamine)
that is related to cadaverine; both are produced by the breakdown of
amino acids in living and dead organisms and both are toxic in large
doses.[2][3] The two compounds are largely responsible for the foul
odor of putrefying flesh, but also contribute to the odor of such
processes as bad breath and bacterial vaginosis. They are also found
in semen and some microalgae, together with related molecules like
spermine and spermidine.
<snip>
Or does tar baby randall like to say the crap word?
crap... crap... crap...and erap1... LOL
Or is it guano crap? I like to say that... but the reason is guanine
and it ain't guano.
Guanine is G (goes with C, A, T = gattaca & DNA fame) and cGMP is not
cAMP:
http://en.wikipedia.org/wiki/Gattaca
http://en.wikipedia.org/wiki/Transhumanism#Genetic_divide_.28Gattaca_argument.29
Doesn't moooooooochele and obama want a dystopian craPPY society? LoL
Let's drop the imPolitic and stick with C-geee and c-ampppp...
http://en.wikipedia.org/wiki/Cyclic_guanosine_monophosphate
But more cAMP is more energy and less craPPy cGMP:
http://en.wikipedia.org/wiki/Cyclic_AMP
But guano crap (bird dung) does make gunpowder and is good fertilizer
for the garden:
http://en.wikipedia.org/wiki/Guano
But crap slows down your liver from living more... and that equals
less energy.
Or less glutathione or less SOD and GpX and all the other things if
it's
putting up with polyamines....
Sheesh..
http://en.wikipedia.org/wiki/Polyamines#Putrescine
http://en.wikipedia.org/wiki/Polyamines#Cadaverine
http://en.wikipedia.org/wiki/Polyamines#Spermidine_and_spermine
http://www.ncbi.nlm.nih.gov/pubmed/22584898
Acta Dermatovenerol Alp Panonica Adriat. 2012 Mar;21(1):3-5.
Comparative analysis of polyamine metabolism in benign and neoplastic
keratinocytic proliferations.
Broshtilova V, Lozanov V, Miteva L.
Source
Faculty of Medicine, Department of Dermatology and Venereology, 1,
Georgi Sofiisky st., 1431 Sofia, Bulgaria. brosh...@mail.bg.
Abstract
INTRODUCTION:
Polyamines (putrescine, spermidine, and spermine) are polycationic
compounds that play a central role in keratinocytic proliferation,
differentiation, and regulation. The objective was to elucidate the
polyamine metabolic changes that occur in various benign and
neoplastic skin proliferations.
METHODS:
The study included 58 patients: 31 with the plaque form of psoriasis
vulgaris and 27 with non-melanoma skin tumors. The levels of
putrescine, spermidine, and spermine were detected in lesional and non-
lesional skin samples.
RESULTS:
Findings were representative (p < 0.05). Psoriatic lesions showed a
twofold elevation of all polyamines in lesional skin compared to non-
lesional skin. Spermine had the highest concentration, which suggested
a leading position of propylamine synthesis in psoriatic pathogenesis.
Results on the polyamine metabolism of basal cell carcinoma
represented basic characteristics similar to those of psoriasis.
Conversely, squamous-cell carcinoma lesions showed the highest
concentration of putrescine, suggesting a crucial role of spermidine-
spermine acetyltransferase in their pathogenesis.
DISCUSSION:
Our findings showed different polyamine metabolic changes in lesions
from benign and neoplastic keratinocytic proliferations. Basal-cell
carcinoma polyamine metabolism revealed a closer relationship to
psoriasis than to squamous-cell carcinoma, which might explain its
long-term benign course and non-metastatic nature.
PMID: 22584898
23 hits: putrescine spermidine spermine psoria* -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=putrescine%20spermidine%20spermine%20psoria*
95 hits: polyamines + psoria* -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=polyamines%20psoria*
expanding this search:
267 hits: polyamines + LPS
http://www.ncbi.nlm.nih.gov/pubmed?term=polyamines%20LPS
So call in the L. Plantarum?
yes..#4 of 267
http://www.ncbi.nlm.nih.gov/pubmed/21958471
Life Sci. 2011 Dec 5;89(23-24):847-53. Epub 2011 Sep 19.
Effect of Lactobacillus plantarum and L-arginine against endotoxin-
induced liver injury in a rat model.
Rishi P, Bharrhan S, Singh G, Kaur IP.
Source
Department of Microbiology, Panjab University, Chandigarh-160014,
India. riship...@yahoo.com
Abstract
AIMS:
Use of probiotics, alone or as adjunct to other established therapies,
has been reported to have potential benefits. Recently, we have
reported protective potential of probiotic against Salmonella-induced
liver injury. However, co-supplementation with prebiotics did not
result in meaningful synergism at systemic level. Owing to the action
of probiotics at the mucosal level and of arginine at systemic level,
the present study was designed to evaluate the effect of Lactobacillus
plantarum alone or in conjunction with arginine to combat endotoxin-
mediated liver injury in rats.
MAIN METHODS:
Bacterial endotoxin/lipopolysaccharide (LPS) was injected
intraperitoneally and animals were sacrificed 8h post-challenge.
Efficacy of L. plantarum alone or in conjunction with l-arginine was
determined on the basis of enzyme markers, histology, levels of nitric
oxide (NO) and tumor necrosis factor-alpha (TNF-α) in addition to
identification of amino acids by paper chromatography.
KEY FINDINGS:
Prior supplementation of LPS-challenged rats with L. plantarum
(10(10)CFU per rat given orally for 10 days) demonstrated decreased
levels of liver enzymes, NO and TNF-α. Interestingly, complementing
Lactobacillus with arginine revealed a synergistic decrease not only
in the liver markers but also in NO and TNF-α along with increased
intensity of ornithine and methionine. Histological evidence also
confirmed the protective efficacy of probiotic in conjunction with l-
arginine.
SIGNIFICANCE:
Presence of ornithine and methionine in the probiotic-arginine co-
supplemented group suggests involvement of arginase-induced synthesis
of polyamines. This study highlights that L. plantarum may direct l-
arginine metabolism towards polyamine synthesis thereby exhibiting
synergistic effect against liver injury.
PMID: 21958471
55 hits - polyamines - p ng
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=polyamines&start=0&
121 hits : polyamines - lactobacillus -pubmed
http://www.ncbi.nlm.nih.gov/pubmed?term=Lactobacillus%20polyamines
#1 of 121
Finding the nemo of gut flora?
sorta
http://www.ncbi.nlm.nih.gov/pubmed/22402370
J Nutr Biochem. 2012 Mar 6.
Infant formula supplemented with polyamines alters the intestinal
microbiota in neonatal BALB/cOlaHsd mice.
Gómez-Gallego C, Collado MC, Ilo T, Jaakkola UM, Bernal MJ, Periago
MJ, Salminen S, Ros G, Frias R.
Source
Department of Food Science and Nutrition, Faculty of Veterinary
Sciences, University of Murcia, Campus de Espinardo, Espinardo
(Murcia), Spain.
Abstract
Polyamines play a critical role in the development of intestinal and
immune systems during the infant breastfeeding period, but the effect
of polyamines on the microbiota has not been reported. The aim of our
study was to characterize the impact on the colonization pattern in
neonatal BALB/cOlaHsd mice after supplementing an infant formula (IF)
with a mixture of putrescine (PUT), spermidine (SPD) and spermine
(SPM). A total of 48 pups (14 days old) were randomly assigned to 4-
day intervention groups as follows: breast-fed (unweaned) pups (n=12);
weaned pups (n=12) fed an infant formula (IF); weaned pups (n=12) fed
an IF enriched with a low concentration of PUT, SPD and SPM (2.10,
22.05 and 38.00 μg/day, respectively); and weaned pups (n=12) fed with
IF enriched with a high concentration of PUT, SPD and SPM (8.40, 88.20
and 152.00 μg/day, respectively) of polyamines in accordance with
normal proportions found in human milk. Microbiota composition was
analyzed by fluorescent in situ hybridization (FISH) with flow
cytometry detection. Microbiota changes in formula-fed mice were
significantly greater following supplementation with polyamines (P<.
01). Bifidobacterium group bacteria, Akkermansia-like bacteria and
Lactobacillus-Enterococcus group levels were higher in the groups fed
infant formula supplemented with polyamines, resulting in even higher
numbers of bacteria than in the breastfed pups. Our findings indicate
that infant formulas enriched with polyamines may interact with gut
microbiota, suggesting that further studies in human infants are
required to assess the impact of polyamines on both growth and
microbiota levels.
PMID: 22402370
OTOH society smells like crap under stalin and marxism...
Even George (who could help it) Orwell knew that score:
http://en.wikipedia.org/wiki/Animal_farm
Animal Farm is an allegorical novella by George Orwell published in
England on 17 August 1945. According to Orwell, the book reflects
events leading up to and during the Stalin era before the Second World
War. Orwell, a democratic socialist,[1] was a critic of Joseph Stalin
and hostile to Moscow-directed Stalinism, especially after his
experiences with the NKVD, and what he saw of the results of the
influence of Communist policy ("ceaseless arrests, censored
newspapers, prowling hordes of armed police" – "Communism is now a
counter-revolutionary force"),[2] during the Spanish Civil War. In a
letter to Yvonne Davet, Orwell described Animal Farm as his novel
"contre Stalin"
<snip>
Orwell being a kewl socialist: : ?
http://en.wikipedia.org/wiki/George_Orwell#Political_views
So George couldn't help it?
Yet what if? I dig him uP and scan his gene's?
And...
He's got at LEAST one copy of the 7R DRD4 gene.. or maybe 2 copies and
full on libby pooh?
Who?
YOU?
Yes id squid... i'm at least one copy of that gene... LOL
Maybe even 2... but i can still THINK with gray cells and actively
suppress the Heart emotions.. (<w><G>)
So maybe some of my marxian friends have a point up to a point?
Is that pointed enough?
Full of crap and some crap in balance is OK?
The yin yang of crapism?
Sounds craPPY but true ... if it's homeOstatic craP?
So i like mine on rye go easy on the mayo....
You know?
http://en.wikipedia.org/wiki/Why_Orwell_Matters
I bet hitchens had 2 copies:
http://en.wikipedia.org/wiki/Christopher_Hitchens
And 2nd Wife Sonia Brownell Orwell must of had one or two copies of
the
libby pooh gene...
Sonia was in to phenomenology literally :
http://en.wikipedia.org/wiki/Phenomenology_(philosophy)
Or, as in the love of her life:
http://en.wikipedia.org/wiki/Sonia_Brownell
[...] She also had an affair with the French phenomenological
philosopher Maurice Merleau-Ponty, whom she described as her true love;
[citation needed] she hoped he would leave his wife for her.
<snip>
How else does one explain her marxian lover, Maurice Merleau-Ponty?
http://en.wikipedia.org/wiki/Maurice_Merleau-Ponty
Maurice Merleau-Ponty (French pronunciation: [mɔʁis mɛʁlopɔ̃ti]) (14
March 1908 – 3 May 1961) was a French phenomenological philosopher,
strongly influenced by Karl Marx,[1] Edmund Husserl and Martin
Heidegger in addition to being closely associated with Jean-Paul
Sartre (who later stated he had been "converted" to Marxism by Merleau-
Ponty[2]) and Simone de Beauvoir.
<snip>
I bet birds and turds of a feather, weather the drd4 7R alleles two-
gether. LOL
These marxian nit wits need FLOWER power...
http://en.wikipedia.org/wiki/File:Flowering_peyote_cactus.jpg
And the living bible of truth... <w>
http://en.wikipedia.org/wiki/Peyote#Uses
But marxian euro type nit wits being closer to africa might use rye
ergot or epoptes?
Or ibogaine ---> 8 hits - p ng
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=ibogaine+&start=0&
Even the Ancients used this stuff... like oregano oil for skin
farts... and..
let's do it?
Ok id squid... i haven't done this trip in a coon's age..
So... getting initiated in to ancient brain trips....
YiPPPPeee..
Hold on id squid... i know how you want to do the gala festival and
FEAST trip..
But this is... well...ok it is... LOL
Can we Fix the marxian quest to be smarty pooh and classless?
Yes... i can... LOL
Show the CLASS LESS via the mirror of their MIND their so Classy and
sassy and stuPidly... LOL
http://en.wikipedia.org/wiki/Quintus_Valerius_Soranus#Literary_works
[...] (epoptes, "initiate," feminine epoptis and plural epoptides),"
the highest grade of initiate at the Eleusinian mysteries.
<snip>
8 hits: epoptes - p ng
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=epoptes&start=0&
http://en.wikipedia.org/wiki/Eleusinian_mysteries
http://en.wikipedia.org/wiki/Eleusinian_mysteries#Secrets
[...] Upon reaching Eleusis, there was a day of fasting in
commemoration of Demeter's fasting while searching for Persephone. The
fast was broken while drinking a special drink of barley and
pennyroyal, called kykeon.
<snip>
Did they FAST on Friday, Saturday or Sunday? LOL
Sice they didn't have LENT yet... still a FAST isn't so FAST?
Most people do it for their religion:
http://en.wikipedia.org/wiki/Fasting
Some people have mental or physical health as their RELIGION... like
transhumanist timothy leary?
http://en.wikipedia.org/wiki/Timothy_Leary
Can you imagine some pennyroyal laden kykeon with peyote or just
peyote or JUST a hit of LSD?.. LOL
http://en.wikipedia.org/wiki/Kykeon
Kykeon (Gr. κυκεών, from κυκάω, "to stir, to mix") was an Ancient
Greek drink made mainly of water, barley and naturally occurring
substances. It was used at the climax of the Eleusinian Mysteries to
break a sacred fast, but it was also a favourite drink of Greek
peasants.
Kykeon is mentioned in Homeric texts: the Iliad describes it as
consisting of barley, water, herbs, and ground goat cheese (XI, 638–
641). In the Odyssey, Circe adds some honey and pours her magic potion
into it (X, 234). In The Homeric Hymn to Demeter, the goddess refuses
red wine but accepts kykeon made from water, barley and pennyroyal.
It was supposed to have digestive properties. Hermes recommends it in
Aristophanes' Peace (v. 712) to the hero who ate too much dry fruit
and nuts. Aristocrats shunned it as a peasant drink. Theophrastus
depicts in his Characters (IV, 2–3) a peasant whose thyme breath
inconveniences his neighbours at the Ecclesia.
In an attempt to solve the mystery of how so many people over the span
of two millennia could have consistently experienced revelatory states
during the culminating ceremony of the Eleusinian Mysteries, it has
been posited that the barley used in the Eleusinian kykeon was
parasitized by ergot, and that the psychoactive properties of that
fungus triggered the intense experiences alluded to by the
participants at Eleusis.[1]
For more on the possibilities of the Kykeon's psychoactive properties,
see entheogenic theories of the mysteries.
<snip>
Ergot fungi that old time religion:
The evil rich richie rich's didn't like that low caste stuff... LOL
http://en.wikipedia.org/wiki/Ergot
Some bad triPs...
http://en.wikipedia.org/wiki/Ergotism
Witch ones?
These:
http://en.wikipedia.org/wiki/Ergotism#Salem_witchcraft_accusations
Why rye when you've got LSD or peyote or african bark?
Bark, bark, bark:
Rye is not to die for:
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/msg/4ab1e4dd5237b2ff
Maybe they used the pennyroyal to protect themselves from unwanted
products of unconsciousness and sexual meschiveousness during those
wild weekends?
http://en.wikipedia.org/wiki/Pennyroyal
is an abortifacient
http://en.wikipedia.org/wiki/Abortifacient
So the higher class didn't need it as their mind over physical
weakness prevailed?
Did not females have to overcome coming in to HEAT while hubby pooh
was being a big time hunter?
http://en.wikipedia.org/wiki/Estrous_cycle#Differences_from_the_menstrual_cycle
[...] In species with estrous cycles, females are generally only
sexually active during the estrus phase of their cycle (see below for
an explanation of the different phases in an estrous cycle). This is
also referred to as being "in heat". In contrast, females of species
with menstrual cycles can be sexually active at any time in their
cycle,
<snip>
OK and teach your daughters to use the google thingy pooh instead of
going in to heat
on those celebrations in college after football games...
http://www.technewsworld.com/story/75136.html
or
http://googleblog.blogspot.com/2012/05/introducing-knowledge-graph-things-not.html
Introducing the Knowledge Graph: things, not strings
May 16, 2012
Search is a lot about discovery—the basic human need to learn and
broaden your horizons. But searching still requires a lot of hard work
by you, the user. So today I’m really excited to launch the Knowledge
Graph, which will help you discover new information quickly and
easily.
Take a query like [taj mahal]. For more than four decades, search has
essentially been about matching keywords to queries. To a search
engine the words [taj mahal] have been just that—two words.
But we all know that [taj mahal] has a much richer meaning. You might
think of one of the world’s most beautiful monuments, or a Grammy
Award-winning musician, or possibly even a casino in Atlantic City,
NJ. Or, depending on when you last ate, the nearest Indian restaurant.
It’s why we’ve been working on an intelligent model—in geek-speak, a
“graph”—that understands real-world entities and their relationships
to one another: things, not strings.
The Knowledge Graph enables you to search for things, people or places
that Google knows about—landmarks, celebrities, cities, sports teams,
buildings, geographical features, movies, celestial objects, works of
art and more—and instantly get information that’s relevant to your
query. This is a critical first step towards building the next
generation of search, which taps into the collective intelligence of
the web and understands the world a bit more like people do.
Google’s Knowledge Graph isn’t just rooted in public sources such as
Freebase, Wikipedia and the CIA World Factbook. It’s also augmented at
a much larger scale—because we’re focused on comprehensive breadth and
depth. It currently contains more than 500 million objects, as well as
more than 3.5 billion facts about and relationships between these
different objects. And it’s tuned based on what people search for, and
what we find out on the web.
The Knowledge Graph enhances Google Search in three main ways to
start:
1. Find the right thing
Language can be ambiguous—do you mean Taj Mahal the monument, or Taj
Mahal the musician? Now Google understands the difference, and can
narrow your search results just to the one you mean—just click on one
of the links to see that particular slice of results:
<snip>
Introducing the Knowledge Graph
http://www.youtube.com/watch?feature=player_embedded&v=mmQl6VGvX-c
<time: 2:45>
So every age has a counterculture... like beatniks and hippies
http://en.wikipedia.org/wiki/Counterculture_of_the_1960s
And ancient triPPies...
So... snort some tax crack and become obama and spend $1.5 trillion on
the national credit card
is a power trip...
And the same thing as taking LSD.
http://en.wikipedia.org/wiki/Lsd
Huxley and the minds antipodes:
one hit: minds huxley antipodes - p ng
http://groups.google.com/group/alt.support.skin-diseases.psoriasis/search?q=huxley+minds+antipodes&start=0&
Same search ALL groups: 8,660 hits
http://groups.google.com/groups/search?q=huxley+minds+antipodes
http://en.wikipedia.org/wiki/Heaven_and_Hell_(essay)
Heaven and Hell is a philosophical essay by Aldous Huxley published in
1956. Huxley derived the title from William Blake's book The Marriage
of Heaven and Hell. The essay discusses the relationship between
bright, colorful objects, geometric designs, psychoactives, art, and
profound experience. Heaven and Hell metaphorically refer to what
Huxley conceives to be two contrary mystical experiences that
potentially await when one opens the "doors of perception"—not only in
a mystical experience, but in prosaic life.
Huxley uses the term antipodes to describe the "regions of the mind"
that one can reach via meditation, vitamin deficiencies, self-
flagellation, fasting, or (most effectively, he says) with the aide of
certain chemical substances like LSD or mescaline. Essentially, Huxley
defines these "antipodes" of the mind as mental states that one may
reach when one's brain is disabled (from a biological point of view)
and can then be conscious of certain "regions of the mind" that one
would otherwise never be able to pay attention to, due to the lack of
biological/utilitarian usefulness. Huxley states that while these
states of mind are biologically useless, they are nonetheless
spiritually significant, and furthermore, are the singular 'regions'
of the mind from which all religions are derived. For example, he says
that the Medieval Christians frequently experienced "visions" of
Heaven and Hell during the winter, when their diets were severely
hampered by lack of critical nutrients in their food supplies (vitamin
B, vitamin C)--these people frequently contracted Scurvy and other
deficiencies, causing them to hallucinate. He also said that
Christians and other religions fast in order to make themselves
delirious, thus inducing visions and views of these "antipodes of the
mind". Today, Huxley says people can reach these states of mind
without harm to their bodies with the aid of certain drugs.
Essentially, Huxley says this state of mind allows a person to be
conscious of things that would not normally concern him because they
have nothing to do with the typical concerns of the world.
In his earlier narrative The Doors of Perception (1954), Huxley
recounted in detail his first experience of mescaline.
<snip>
Here and nOW boys author:
http://en.wikipedia.org/wiki/Aldous_Huxley
Fixing the dystopian Orwellian society of marxian numb nutz... LOL
http://en.wikipedia.org/wiki/Island_(novel)
Pass the peyote:
http://en.wikipedia.org/wiki/Entheogen
Is Moksha the reason why they pop some LSD before dying?
http://en.wikipedia.org/wiki/Moksha
In Indian religions moksha (Sanskrit: मोक्ष mokṣa; liberation) or
mukti (Sanskrit: मुक्ति; release —both from the root muc "to let
loose, let go") is the final extrication of the soul or consciousness
(purusha) from samsara and the bringing to an end of all the suffering
involved in being subject to the cycle of repeated death and rebirth
(reincarnation).
Origins
It is highly probable that the concept of moksha was first developed
by Indian people whose spiritual ideas greatly influenced later
religious thought. Buddhism and Jainism are continuations of this
tradition, and the early Upanishadic movement was influenced by it.
Reincarnation was likely adopted from this religious culture by
Brahmin orthodoxy. Brahmins wrote the earliest recorded scriptures
containing these ideas in the early Upanishads
But aren't those the rich dudes?
http://en.wikipedia.org/wiki/Vedic_Brahmanism
http://en.wikipedia.org/wiki/Brahmanism
I wonder if re-incarnated souls from India have zero problems with
cremation?
http://en.wikipedia.org/wiki/Cremation
I wonder if Ramana Maharshi did the cremation?
He didn't buy the Brahmin trip, though born one.
OK let's look:
http://en.wikipedia.org/wiki/Ramana_Maharshi
http://en.wikipedia.org/wiki/Ramana_Maharshi#Final_Years
Cremation and a shooting star? LOL
http://en.wikipedia.org/wiki/Sri_Ramana_Ashram
http://en.wikipedia.org/wiki/File:Arunachala.JPG
Arunachala.JPG
[...] British writer Paul Brunton in 1931, who is credited with
introducing Ramana Maharshi to the West through his books "A Search in
Secret India" (1934) and "The Secret Path". In fact in his first book,
he mentioned, Ramana discouraging villagers from calling him Bhagwan,
as he found the title excessive and inflated[2]. Writer W. Somerset
Maugham who visited the ashram in 1938, and later used Maharishi as
the model for the holy man, Shri Ganesha in his novel, The Razor’s
Edge (1944)[3][4]. Other visitors include, Swami Sivananda,
Paramahansa Yogananda[5], Alfred Sorensen (Sunyata) and Wei Wu Wei
amongst others.[6].
Arthur Osborne stayed here for twenty years, and edited Ashram's
journal, The Mountain Path, besides writing several book on Maharishi
and his teachings, Mouni Sadhu spent several months here in 1949[7].
David Godman came to the ashram in 1976, and has since written or
edited fourteen books on topics related to Sri Ramana Maharshi and
continues to live near the ashram.
Niranjananda Swami, brother of Ramana Maharshi, who had moved to the
ashram along his mother in 1916, stayed at the ashram for the rest of
his life and handling its management, and after him his son and
grandson looked after the ashram[8].
<snip>
http://en.wikipedia.org/wiki/Advaita_Vedanta
[...] Necessity of a Guru
See also: Guru-shishya tradition
According to Śankara and others, anyone seeking to follow the
philosophy of Advaita Vedānta must do so under the guidance of a Guru
(teacher).[7] The Guru must have the following qualities (see Mundaka
Upanishad 1.2.12):
Śrotriya — must be learned in the Vedic scriptures and Sampradaya
Brahmaniṣṭhā — literally meaning 'established in Brahman'; must have
realised the oneness of Brahman in everything, and in himself/herself.
The seeker must serve the Guru, and submit questions with all humility
in order to remove all doubts (see Bhagavad Gita 4.34). By doing so,
Advaita says, the seeker will attain Moksha ('liberation from the
cycle of births and deaths').
According to Adi Śankara, knowledge of Brahman springs from inquiry
into the words of the Upanişads, and the knowledge of Brahman that
Sruti provides cannot be obtained in any other way. It is the teacher
who through exegesis of Sruti and skillful handling of words generates
a hitherto unknown knowledge in the disciple. The teacher does not
merely provide stimulus or suggestion
<snip>
Should i do my TIME equations with this as a theme?
http://en.wikipedia.org/wiki/Advaita_Vedanta#Theory_of_creation.3B_causality
http://en.wikipedia.org/wiki/Samkhya
We've got Duality but i like yin/yang more, i'm wondering.
http://en.wikipedia.org/wiki/Samkhya#Nature_of_Duality
[...] Theory of Existence
The Samkhya system is based on Sat-kārya-vāda. According to
Satkāryavāda, the effect pre-exists in the cause. Cause and effect are
seen as different temporal aspects of the same thing – the effect lies
latent in the cause which in turn seeds the next effect.
<snip>
http://en.wikipedia.org/wiki/Causality
OTOH i still tend to love those kogi Mama's and their GREAT MOTHER
creator:
http://en.wikipedia.org/wiki/Kogi_Indians
And those parrots on Island said what again?
Be here now goys? LOL
Let's see:
http://en.wikipedia.org/wiki/Island_(novel)#Quotations
Hey i don't see the parrots.... sayings?
OK..
I'll find them..
http://www.huxley.net/island/aldoushuxley-island.html
[...] "here and now, boys," Changed the bird: "here and now boys"
Are those parrots, actually mynah birds?
Is a true Utopia being HERE now?
And what about Georgism?
George can't helP it... he was born with a silver foot in his mut?
http://en.wikipedia.org/wiki/Georgism
Georgism (also called Geoism or Geonomics) is an economic philosophy
and ideology that holds that people own what they create, but that
things found in nature, most importantly land, belong equally to all.
[1] The Georgist philosophy is based on the writings of the economist
Henry George (1839–1897), and is usually associated with the idea of a
single tax on the value of land. Georgists argue that a tax on land
value is economically efficient, fair and equitable; and that it can
generate sufficient revenue so that other taxes (e.g. taxes on
profits, sales or income), which are less fair and efficient, can be
reduced or eliminated. A tax on land value has been described by many
as a progressive tax, since it would be paid primarily by the wealthy,
and would reduce income inequality.[2]
<snip>
Wow check out the people influenced by Georgism
http://en.wikipedia.org/wiki/Georgism#Notable_people_influenced_by_Georgism
Some of these had to negatively influenced, i'm guessing.. LOL
And what about the divine mushroom?
I almost forgot about it.
used to make the monks in tillable poor lands high in the himalya's
have good spiritual progress
and thereby keep the poopulation DOWN.
They should have exported it to INDIA? LOL
http://en.wikipedia.org/wiki/R._Gordon_Wasson#Work
Wasson's studies in ethnomycology began during his 1927 honeymoon trip
to the Catskill Mountains when his bride, Valentina Pavlovna Guercken
(1901–1958), a paediatrician, chanced upon some edible wild mushrooms.
Fascinated by the marked difference in cultural attitudes towards the
fungus in Russia compared to the United States, the couple began field
research that led to the publication of Mushrooms, Russia and History
in 1957. In the course of their investigations they mounted
expeditions to Mexico to study the religious use of mushrooms by the
native population, and became the first Westerners to participate in a
Mazatec mushroom ritual. In May 1957 they published a Life magazine
article titled Seeking the Magic Mushroom, which brought knowledge of
the existence of psychoactive mushrooms to a wide audience for the
first time. Together, Wasson and botanist Roger Heim collected and
identified various species of family Strophariaceae and genus
Psilocybe, while Albert Hofmann,[4] using material grown by Heim from
specimens collected by the Wassons, identified the chemical structure
of the active compounds, psilocybin and psilocin. Hofmann and Wasson
were also among the first Westerners to collect specimens of the
Mazatec hallucinogen Salvia divinorum, though these specimens were
later deemed not suitable for rigorous scientific study or taxonomic
classification.[5] Two species of mushroom, Psilocybe wassonii heim
and Psilocybe wassonorum guzman, were named in honor of Wasson along
with Heim and Gastón Guzmán, the latter of whom Wasson met during an
expedition to Huautla de Jiménez in 1957.
Wasson's next major contribution was a study of the ancient Vedic
intoxicant soma, which he proposed was based on the psychoactive fly
agaric (Amanita muscaria) mushroom. This hypothesis was published in
1967 under the title Soma: Divine Mushroom of Immortality. His
attention then turned to the Eleusinian Mysteries, the initiation
ceremony of the ancient Greek cult of Demeter and Persephone. In The
Road to Eleusis: Unveiling the Secret of the Mysteries (1978), co-
authored with Albert Hofmann and Carl A. P. Ruck, it was proposed that
the special potion "kykeon", a pivotal component of the ceremony,
contained psychoactive ergoline alkaloids from the fungus Ergot
(Claviceps spp.).
<snip>
Wow... NOW i know why i FLAKE...
so i can know who the REAL flakes are?
r they?
randall... YOU TELL me!...
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