Take care everyone - will speak with you in a couple of days' time.
Meryl
On 27/09/2011, at 11:58 AM, JC wrote:
> Meryl,
>
> On an individual basis it's easy to make an emotive claim like "Surely
> a child's life is worth more?", and it's difficult to disagree. But I
> will. It's ugly, it's not desired, but a necessary evil is for people
> to make cost / benefit analysis, on a very large scale. When funds
> are limited, WHO needs to provide the most bang for the buck, in order
> to cover the highest number of people they can with what they have.
> As I pointed out before, OPV has probably caused about 200 cases of
> polio, compared to the many many thousands of cases from the wild
> type. The cases, both cVDPV and wild type, occur in communities with
> low coverage. Increase the coverage, and both rates decrease anyway.
> Please have a read of http://www.who.int/features/qa/64/en/index.html.
> That way you will be able to make more informed comments in the
> future.
> <snip>
Not to put words into Greg's mouth and I'm not sure if his reasoning is the same as mine, but prior to the polio vaccine being introduced, polio was almost always diagnosed by clinical symptoms - not laboratory testing. Once the vaccine was in use, the clinical diagnosis was changed and laboratory testing became the 'gold standard'. What I am concerned about then is that -- say 10,000 cases of polio were reported in one year in the US prior to vaccination (I have no idea what the number of reports were - this is just to make the maths easier) - say in 1952. Then, in 1956, the diagnostic criteria changed and most cases were laboratory tested and there were only 1,000 cases of polio but 9,000 cases of asceptic meningitis and acute flaccid paralysis. Was there actually a decline in polio of 9,000 cases or were the cases which would have normally been diagnosed as polio in 1952 now diagnosed as something else?
We all know that acute flaccid paralysis is caused or found in concert with a host of different viruses and bacteria - but the question is - was there a decline in actual cases of polio (AFP prior to the introduction of the vaccine) or was there simply a redistribution of the reports into various 'categories' of polio, asceptic meningitis, GBS, etc?
I don't know if I made that clear - please let me know if you want anything explained further.
All the best,
Meryl
Sent from my iPad
> --
> You received this message because you are subscribed to the Google Groups "Vaccination-Respectful Debate" group.
> To post to this group, send an email to vaccination-re...@googlegroups.com.
> To unsubscribe from this group, send email to vaccination-respectf...@googlegroups.com.
> For more options, visit this group at http://groups.google.com/group/vaccination-respectful-debate?hl=en-GB.
>
I'm Jess. Personally I am neither pro nor anti vax.
Firstly I would like to thank those willing to give their time to talk
about this issue, it is very much appreciated. I hope this groups works
well because the current polorization of this issue is not good for anyone.
My question is with regards to auto-immune disease and the research done
on whether vaccinations can 'trigger' them.
Thanks
Jess
I haven't gotten a chance to read this entire article yet, but from the
little I have read I think it might be useful in this discussion:
http://epirev.oxfordjournals.org/content/22/2/298.full.pdf
I'm also including a page from "Pediatric Infectious Diseases" by Hugh
Moffet on polio
(http://www.vaccinationnews.com/sites/default/files/Scandals/MoffetQuotePoli
o.pdf).
All the best,
Sandy
-----Original Message-----
From: vaccination-re...@googlegroups.com
[mailto:vaccination-re...@googlegroups.com] On Behalf Of JC
Sent: Tuesday, September 27, 2011 8:10 PM
To: Vaccination-Respectful Debate
Subject: Re: Polio in China
Hi Greg,
I honestly didn't realise that you were so sensitive. In medicine, we
learn to take criticism in a constructive manner, which is how we
learn to improve. If you can't achieve that level of maturity, then
perhaps a place such as this - a place of mature, respectful and
polite debate - is not for you.
You made a fairly basic error in definitions, and I'm not surprised
that you are a little confused. AFP is not recorded by WHO as a
single entity, because it is not a single entity. It is has many
different causes, and polio is one of them, depending on your
definition. If, as Meryl suggests, you think that doctors have simply
swapped polio diagnoses for AFP is also fairly without basis, in my
opinion. If you have other evidence, please provide it. I asked
around at RMH today, and the neurology department can only recall two
cases of it this year, both of which were Guillian Barre, and it's
accepted rate is about 1-2 per 10,000. GBS is the most common cause
of AFP. Polio, in areas where it is still prevalent, is much more
common, and has deadly consequences. GBS patients recover
comparatively well, albeit after a while. Polio patients, if they
survive, are often left with severe musculoskeletal sequelae which we
still see in areas where polio is prevalent. GBS patients don't
display the same features, apart from paralysis. AFP is not polio,
but polio may cause AFP.
Paralysis has many causes. Polio causes paralysis. That doesn't mean
that all cases of paralysis are polio.
I hope I've made that as clear as I can in a polite, mature and
respectful fashion.
Once again, I think you are misunderstanding what Greg wrote. It seemed very clear to me so perhaps, go back and read his post again.
AFP is an umbrella term for paralysis. Polio is ONE of the diseases which are put under that umbrella. There are others such as GBS, aseptic meningitis, coxsackie virus, etc.
What Greg was saying was that prior to the introduction of the polio vaccine, ALL of these diseases would have been put under the polio umbrella. It was only AFTER the introduction of the vaccine that we started to differentiate amongst these different causes. In addition, the diagnostic criteria for polio was changed concurrently with the introduction of the vaccine.
These events led to an immediate decline in the diagnosis of polio but did they lead to a decline in paralysis labelled as AFP? That is the question that Greg was asking and that I ask as well.
Since you are obviously au fait with medical research, perhaps you can find the answer to this question.
If this isn't clear, please let me know and either myself or Greg will be happy to explain it again.
All the best,
Meryl
On 28/09/2011, at 10:36 PM, JC wrote:
> <snip>
-----Original Message-----
From: vaccination-re...@googlegroups.com
[mailto:vaccination-re...@googlegroups.com] On Behalf Of JC
Sent: Tuesday, September 27, 2011 10:33 PM
To: Vaccination-Respectful Debate
Subject: Re: Polio in China
--
Hi everybody,
Here's my initial take after reading the article "Differential Diagnosis of Acute Flaccid Paralysis": diagnosing polio requires very specific testing which may or may not be occurring routinely, including of stool specimens. In the absence of such testing, there are quite a few conditions that can be confused with polio. Clinical presentation, which I believe has often been relied upon, both historically and currently, is inadequate for making a diagnosis.
Making the situation even more complex in my opinion is the fact that only between 0.1% and 1.0% of "infected individuals develop paralytic disease" (pg.303). This begs at least a few questions: 1) Why does the very small minority of polio infected people develop serious disease? 2) Is vaccinating everyone for a disease that so few, even if infected, have a problem with good policy? 3) How might those who are infected but have no, or mild, symptoms affect measurements of disease incidence, if at all? (e.g., might stool specimens, if being taken of “everyone” in a “polio-endemic area”, result in a higher assessment of polio incidence than is actually meaningful, if the concern is with paralytic polio, for instance?)
All the best,
Sandy
Here's my initial take after reading the article "Differential Diagnosis of
Acute Flaccid Paralysis"
(http://epirev.oxfordjournals.org/content/22/2/298.full.pdf): diagnosing
All the best,
Sandy
PS I tried sending this directly to the group and not as a reply, so that I
could hyperlink the article, but it never arrived. How do we initiate
emails?
-----Original Message-----
From: vaccination-re...@googlegroups.com
[mailto:vaccination-re...@googlegroups.com] On Behalf Of Sandy
Gottstein
Sent: Wednesday, September 28, 2011 2:34 PM
To: vaccination-re...@googlegroups.com
Subject: RE: Polio in China
Hi everybody,
All the best,
Sandy
-----Original Message-----
From: vaccination-re...@googlegroups.com
[mailto:vaccination-re...@googlegroups.com] On Behalf Of Greg
Beattie
Sent: Wednesday, September 28, 2011 4:39 PM
To: Vaccination-Respectful Debate
Subject: Re: Polio in China
Thank you - very respectful. I hope I have done the same. My
comments/questions are below.
-----Original Message-----
From: vaccination-re...@googlegroups.com
[mailto:vaccination-re...@googlegroups.com] On Behalf Of JC
Sent: Wednesday, September 28, 2011 11:45 PM
To: Vaccination-Respectful Debate
Subject: Re: Polio in China
Hi Sandy,
May I address your questions?
1) Why does the very small minority of polio infected people develop
serious disease? We probably don't know, but over the entire spectrum
of medicine, you'll find the same disease affect people with different
intensity. It could be a dose effect, genetic, pre-morbid status or a
combination of all and many more factors. Take influenza for example
- it kills some people, whilst others are left with just a few
myalgias. In my field, people can have very significant spinal
stenosis, but be asymptomatic whilst others are cripples.
Sandy's reply: I believe we should be trying to better understand what those
reasons are. For instance, was it injections (including antibiotics),
administered when polio was circulating
(http://www.vaccinationnews.com/Scandals/April_5_02/april_5_02/polio_injecti
ons_tonsillectomies.htm? Is one of the reasons polio has declined due to a
decrease in antibiotic injections now that antibiotics are normally given
orally? What about the decline in routine tonsillectomies
(http://www.vaccinationnews.com/Scandals/feb_8_02/polio%2526tonsillectomies.
htm)?
Sandy's reply: That cost benefit analysis assumes there are no meaningful
short or long-term consequences of polio vaccination. I would submit that
we don't really know the cost/benefit analysis having never compared the
polio-vaccinated to those unvaccinated against polio or anything else.
3) How might those who are infected but have no, or mild, symptoms
affect measurements of disease incidence, if at all? (e.g., might
stool specimens, if being taken of "everyone" in a "polio-endemic
area", result in a higher assessment of polio incidence than is
actually meaningful, if the concern is with paralytic polio, for
instance?)
One of the things that WHO does is do environmental surveillance.
They actually take samples of sewerage (ewwww!) to monitor the
prevalence of polio amongst populations, and to act as an extra method
of capturing the spread of the virus. Take a look at
http://www.polioeradication.org/Dataandmonitoring/Surveillance.aspx
and
http://www.who.int/vaccines-documents/DocsPDF03/www737.pdf
for more information on the comprehensive nature of the WHO programme.
Sandy's reply: Do you know if these measurements ever result in estimates
of polio incidence within a population? (Sorry, but I haven't looked at
those links yet, so if the answer is there, please let me know.)
I hope this has addressed sufficiently some of your questions in a
respectful and mature fashion.
John
--
I would like to expand on the point I made about cost/benefit analysis.
Let's say 2% (just as an example - I'm not trying to suggest this is the
case) of those who are vaccinated against polio develop chronic asthma.
That means 2-20 times the number who got serious polio have a life-long,
chronic disease that may or may not kill them prematurely, may or may not
subject them to repeated hospitalizations, probably will required life-long
medication, etc. besides seriously affecting their quality of life.
In that case the polio vaccine may or may not be cost effective.
All the best,
Sandy
-----Original Message-----
From: vaccination-re...@googlegroups.com
[mailto:vaccination-re...@googlegroups.com] On Behalf Of JC
Sent: Thursday, September 29, 2011 2:34 PM
To: Vaccination-Respectful Debate
Subject: Re: Polio in China
Hi Sandy,
John
--
Thanks for the references and I will get back to you when I have had a
chance to read them.
All the best,
Sandy
-----Original Message-----
From: vaccination-re...@googlegroups.com
[mailto:vaccination-re...@googlegroups.com] On Behalf Of JC
Sent: Thursday, September 29, 2011 5:44 PM
To: Vaccination-Respectful Debate
Subject: Re: Polio in China
Hi Sandy,
All the best,
John
--
My apologies for not responding to your question about the AFP 'umbrella' statement. There is a table out of Neil Miller's first book on vaccination where he took the reports of polio, aseptic meningitis and one other polio-like disease (can't remember which one) prior to the introduction of the vaccine and then - a year later. These figures are just made up as a demonstration - I don't have the information here:
Before vaccine:
Polio - 300
Aseptic Meningitis - 50
X Disease - 25
Total - 375
After vaccine:
Polio - 12
Aseptic meningitis - 240
X Disease - 120
Total 372
The correlation was just that obvious. I will have to ask if anyone else has this book or reference to this information because to me at least, it was very telling that there had been a shift in where the diagnoses were assigned more than an actual change in disease patterns.
Also, you have said that:
> Clinically, you may be interested in
> learning, is that polio would often affect just one limb, which is
> very unusual. Most other cases of AFP cause a symmetrical weakness,
> and this was one of the hallmarks of polio when it was diagnosed.
Prior to the mid-1950s however, that was not part of the definition of polio. I will see if I can find some of my journal articles in my online storage (getting on to my server is proving to be impossible from here!) and if I find them I will forward them to the list. If not, it will have to wait until I'm back in Oz unless someone else has that information, sorry..
Polio had a very broad and inclusive diagnostic criteria before the vaccine was introduced which is exactly the point I was making - that what we called polio in the days before the vaccine is now called something else. it's been redefined - not necessarily eradicated.
I am really enjoying this discussion and will try to get more information for you on this issue as quickly as I can.
All the best,
Meryl
Sent from my iPad
On 29/09/2011, at 9:25 PM, JC <jc_bi...@yahoo.com.au> wrote:
> Hi Greg,
>
> I appreciate your thoughts on Dave's reply, and your own ideas about
> what has happened in the past. However, I also wrote you a reply
> which you haven't replied to yet. I also sent a shorter one to Meryl
> who hasn't replied, so maybe you could take your time with this. This
> is, after all, based on the figures that you presented to me, so I'm
> sure you've thought through the implications of them. If not, then I
> hope this presents to you an opportunity to consider the epidemiology
> of these numbers.
>
> <snip>
>
> Peter Bowditch
>
> Hi. I thought we might have heard from you here after what you said on
> the "Introduction" thread. You used the term 'nonsense' to describe
> the argument that I have subsequently put here. I asked you to read
> this thread and consider participating. Is there anything here that
> you disagree with?
I don't know what more I can say. I listed five lies that are regularly
told by people opposing vaccines. You repeated four of them as if
repetition somehow made them less false.
--
Peter Bowditch
The Millenium Project - http://www.ratbags.com/rsoles
I'm @RatbagsDotCom on Twitter
Is it necessary to say things like "I met better adversaries in secondary
school"? BTW, I think both sides are guilty of using subtle and not so
subtle put-downs to make their points.
Thanks,
Sandy
-----Original Message-----
From: vaccination-re...@googlegroups.com
[mailto:vaccination-re...@googlegroups.com] On Behalf Of JC
Sent: Sunday, October 09, 2011 8:21 PM
To: Vaccination-Respectful Debate
Subject: Re: Polio in China
Greg,
John
--
You received this message because you are subscribed to the Google Groups
"Vaccination-Respectful Debate" group.
To post to this group, send an email to
vaccination-re...@googlegroups.com.
To unsubscribe from this group, send email to
vaccination-respectf...@googlegroups.com.
-----Original Message-----
From: vaccination-re...@googlegroups.com
[mailto:vaccination-re...@googlegroups.com] On Behalf Of JC
Sent: Monday, October 10, 2011 5:45 PM
To: Vaccination-Respectful Debate
Subject: Re: Polio in China
Hi Sandy,
John
--