I don't know anything of mod passenger (looks ruby-centric to me), but there
is plenty of documentation around how to set up TG2 using mod_wsgi. And if
wsgi is your entry-point, that should be good.
For example:
http://getmediacore.com/blog/turbogears-2-tg2-with-mod_wsgi-and-virtual-
environments/
Diez