Reactive carbonyls and oxidative stress: Potential for therapeutic intervention
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Reactive carbonyls and oxidative stress: Potential for therapeutic
intervention.Ellis EM.
Strathclyde Institute of Pharmacy and Biomedical Sciences, University
of Strathclyde, 204 George Street, Glasgow, G1 1XW, United Kingdom.
Reactive aldehydes and ketones are produced as a result of oxidative
stress in several disease processes. Considerable evidence is now
accumulating that these reactive carbonyl products are also involved
in the progression of diseases, including neurodegenerative disorders,
diabetes, atherosclerosis, diabetic complications, reperfusion after
ischemic injury, hypertension, and inflammation. To counter carbonyl
stress, cells possess enzymes that can decrease aldehyde load. These
enzymes include aldehyde dehydrogenases (ALDH), aldo-keto reductases
(AKR), carbonyl reductase (CBR), and glutathione S-transferases (GST).
Some of these enzymes are inducible by chemoprotective compounds via
Nrf2/ARE- or AhR/XRE-dependent mechanisms. This review describes the
metabolism of reactive carbonyls and discusses the potential for
manipulating levels of carbonyl-metabolizing enzymes through chemical
intervention.
PMID: 17570531 [PubMed - in process]
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