The need to develop centers for environmental oncology
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To: atzmonh
Sent: 3/12/2009 11:00:32 A.M. Central Daylight Time
Subj: Re: Devra Davis paper
Subject: Devra Davis, et al, Biomedicine & Pharmacotherapy xx (2007)
1-9 - Need for Environmental Oncology Centers
Thank, Iris! This is an important paper for sure! Also applies to
Alzheimers and other diseases. I almost get nauseous reading all the
posts on Alzheimers forum with one person after another "following
along" in belief that since Grandpa, or some other relative had
Alzheimers, he or she also "has the gene...!!!" As you know,
Alzheimers is linked to Leukemia by the fact Gleevec (a Leukemia
treatment) was also considered for use in Alzheimers' patients. Both
diseases are related to chronic inflammation and immune deficiency as
are most other health problems.
While I am able to review at least this once (I often can not open
certain items again), I am not able to print same. I get a little
window saying "need CD Rom...."
Thanks anyway and I sure hope Dr. Davis can make major headway toward
informing public we must "focus" on environment! While I did not see
any reference to the vital need to move electric appls, telephone
equipment and any item w/speaker (magnet) away from close proximity to
beds, in this paper, the public "needs to know" and needs to know
now!. That will be a "major beginning" of what must be accomplished
toward resolving issues re cellular antennae, high voltage lines, WiFi,
etc. Lacking fast action on that front, society will no longer have
anyone who doesn't suffer from cognitive dissonance..
Sorry, I know you are "very aware" of the critical situation! Thanks
much tho for this important paper! Take care - Joanne
Joanne C. Mueller
Guinea Pigs "R" Us
731 - 123rd Avenue N.W.
Minneapolis, Minnesota 55448-2127 USA
Phone: 763-755-6114
Email: jcmpe...@aol.com <mailto:jcmpe...@aol.com> (3-12-09)
WEBSITE: http://guineapigsrus.org <http://guineapigsrus.org/>
ARE YOU AND YOUR CHILDREN GUINEA PIGS? Letter 7-22-04 by Joanne Mueller
http://omega.twoday.net/stories/282050/
In a message dated 3/12/2009 10:23:22 A.M. Central Daylight Time, atzmonh:
Dr. Devra Davis will be in Israel on the 26.3 , this is her
article on the need for environemental oncology centers
Iris.
In a message dated 3/12/2009 10:54:29 A.M. Central Daylight Time, KSEWW
writes:
Is this what you want? Tessa
Re: Devra Davis paper
Point of view
The need to develop centers for environmental oncology
Devra Lee Davis a,*, Maryann Donovan g, Ronald Herberman b, Mitchell
Gaynor c,
Deborah Axelrod d, Nik van Larebeke e, Annie J. Sasco f
a University of Pittsburgh Cancer Institute and Graduate School of
Public Health, University of Pittsburgh, Pittsburgh, PA, USA
b University of Pittsburgh Cancer Institute, University of
Pittsburgh Medical Center, Pittsburgh, PA, USA
c Cornell Medical College, Strang Cancer Prevention Center, Cornell,
NY, USA
d New York University Medical Center, Director Breast Services and
Community Outreach, New York, USA
e Study Centre for Carcinogenesis and Primary Prevention of Cancer,
Ghent University, University Hospital 3K3
f Epidemiology for Cancer Prevention, Inserm, U 593 Universite´
Victor Segalen Bordeaux 2, Bordeaux, France
g University of Pittsburgh Cancer Institute and Department of
Pathology, University of Pittsburgh, Pittsburgh, PA, USA
Received 22 May 2007; accepted 7 June 2007
Abstract
The scale and scope of the cancer problem in the United States today
is much greater than four decades ago when the formal war against the
disease was first announced. Patterns of the disease are not fully
explained by known risk factors. Much progress has been made in
understanding
the molecular basis of carcinogenesis, particularly the near
consensus (realization) that virtually all cancers arise from an
accumulation of
genetic mutations and the more recent recognition of the role of
inflammation and the tissue microenvironment, in particular for
hormonedependant
cancers. However, most genetic mutations that contribute to cancer
are not inherited, and thus must be attributable to accumulation
of somatic mutations and epigenetic changes, from as yet poorly
understood environmental factors, that certainly cannot be explained
entirely by
tobacco, use and arise over the course of a lifetime. Much of the
national effort to control cancer has focused on detecting and
treating the
diseasednot on seeking approaches to prevent cases from arising.
Given this reality, we present a cross-disciplinary framework for
establishing
comprehensive research and policy centers focused on environmental
oncology to be based at selected academic cancer centers across the
country.
The principal goal of such centers is to improve the ability to
prevent cancer, by developing effective interventions based on
insights obtained
from epidemiology, including molecular epidemiology and basic
scientific research on genomic, metabolomic, and other biomarkers of
exposure,
susceptibility, and disease. As the needed scientific evidence for
environmental factors contributing to cancer is revealed, these academic
centers will develop specific interventions and/or policy
recommendations regarding ways to lower the burden of cancer, based
on existing
information about cancer hazards in the personal, occupational, and
general environment. Ultimately the centers will improve the ability
to identify
and control the underlying causes of the occurrence of cancer and
its progression.
2007 Elsevier Masson SAS. All rights reserved.
Keywords: Cancer; Epidemiology; Toxicology; Environmental;
Carcinogenesis; Oncology; Risk
1. Scope of the cancer problem
Within the next decade, cancer is likely to replace heart disease
as the leading cause of death [1]. One in three Americans
will be diagnosed with cancer during their lifetimes, and more
than one in four will die of the disease [2]. This growth in importance
of cancer is not simply a consequence of the expanding
and aging of the population. For persons aged 45e64,
cancer is responsible for more deaths than the next three
causes (heart disease, accidents, and stroke) combined. After
accidents, cancer is also the leading cause of death in children
and young white men and women under the age of 30 [3]. Public
policy efforts to lower the risk of developing cancer by
addressing multiple causes that are associated with the ambient
environment remain limited.
* Corresponding author at: 5150 Centre Ave, Suite 432, Pittsburgh, PA
15232, USA. Tel.: þ1 412 623 1172; fax: þ1 412 623 1382.
E-mail address: dav...@upmc.edu <mailto:dav...@upmc.edu> (D. L.
Davis).
0753-3322/$ - see front matter 2007 Elsevier Masson SAS. All
rights reserved.
doi:10.1016/j.biopha.2007.06.006
ARTICLE IN PRESS
Please cite this article in press as: Davis D.L. et al., The need to
develop centers for environmental oncology, Biomed Pharmacother
(2007), doi:10.1016/
j.biopha.2007.06.006
Biomedicine & Pharmacotherapy xx (2007) 1e9
www.elsevier.com/locate/biopha <http://www.elsevier.com/locate/biopha>
+ MODEL