Details? Are you using widgets? An RPC? Some sort of design pattern?
Are you using innerHTML placement or are you trying to build your
entire layout using javascript generated DOM objects? Are you building
new DOM structures inside or outside the body of the document? Do you
have a massive table of data and a event listener on every cell? Do
you have a one pixel wide background image you are repeating across
the entire page? How are you styling your CSS? Are you using a lot of
inheritance to try and style nodes (like .style b)? Are using the DOM
to try and find the position or dimensions of elements much? Have you
used a profiling application such as Speed Tracer (Yes it's not a IE
thing, but it can help) to try and narrow it down?
As you can see from that dense list of questions above, there are a
lot of things to consider in Javascript-GWT development. If you'd like
a prompt response, I would suggest you attempt to answer at least some
of them for yourself and posting your reflections back within this
thread. Try watching some of the videos from Google IO 2009/2010.
Hope that helps!