That depends. If you're running Safari on a Mac it's somewhat trivial.
The autoreload functionality is in django.util.autoreload. Adding
something along the lines of:
os.system("""osascript -e 'tell application "Safari" to do JavaScript
"document.location = document.location;" in document 1'""")
to restart_with_reloader() to send a reload event to Safari would
achieve the goal. The only real problem would be tweaking the timing
somehow so that Safari actually gives Django enough time to finish
reloading.
Of course, that's not much use on Windows or Linux.
scott.