Hypothalamic-Pituitary Dysfunction
Laura
from the The Chronic Pain and Fatigue Research Center at Georgetown University
website.
Can anyone explain this in regular english for me?
I do have pituitary gland disfunction. I am understanding parts but not all.
Laura, Keeper of the Hounds
Servant to 4 Cats, Shadow, Terra, Storm, Shotzie.
AKA
Lady's and Boomer's Mom. Slave to the Cats.
DDRitch
Laura,
I sure cannot explain this, but will be looking for responsess to your post.
The part about adrenal is one of the reasons I am having the CT scan next week.
I have done 2 24 hour urine collection tests (wow was that fun) and each one
read different.
I think I have had every blood test the endocrinologist can do and each time
the readings are diffferent. FM related - -me thinks so.
D
Dana
Remove stopewe to directly e-mail me
DGSABA
I read it twice and will re read it in the morning again. It seems to tell me
that these stages we call flares where as best I can explain it, is like the
stage I have been in non stop for over a year now.
If you go to an excercise class and over do the first few times your muscles
tell you the next day these muscles were used and you feel that after excercise
soreness. In normals this soreness goes away.
In my case I don't go to excercise classes but I remain in a constant stage of
that after use feeling of burning and aching in my muscles with hard swollen
painful masses present within certain muscles.
PT the past two weeks has stirred it up even more so and new medications are
slow to reveal any real change in comfort.
Iam sure when I am not so tired out and can re read it I will learn even more
from the article. Do you feel like your muscles are stuck in fright or flight
mode ???
Soft hugs,
Soft hugs,
Diana ~ Owfw
Private Membership Only
New Memberships Closed
http://hometown.aol.com/dgsaba/myhomepage/index.html
Rosemarie Shiver
Cortisol comes from the adrenal cortex.( the outside of lil' glands
perched atop yer kidneys) It is 'sposed to rise in the early AM and
fluctuate thru the day, lowering at bedtime. Not in many FM'ers, it don't.
When faced with a stressor, the hypothalamus ( a squiggly gland deep in
the brain) increases output of CRH to which the pituitary ( a bean shaped
gland smack in the middle of the brain, oft referred to as the Master gland)
responds by releasing ACTH aka corticotropin. An axis is a term for two
glands working in sync. The ACTH directs the adrenal cortex to output more
cortisol. Cortisol is also bound up in the blood by some glucoid molecules,
but this paper doesn't address whether too much cortisol may be stored and
unavailable.
Cortisol energizes and helps the body use fuel. It works with
insulin to insure enuff 'turbo charge' is ready if a saber-toothed tiger is
about to chase us up a tree. <g> I plan to stay outta the way of a city bus,
'cuz this sez I won't have the boost needed to get meself outta the way.
In many FM'ers, the CRH increase causing corticotropin increase does
NOT increase cortisol. In these FM'ers, cortisol stays low all the
time....not low enuff to be Addison's disease, but low enuff to cause muscle
weakness and pain, dizziness, low BP and fainting.
This is also true for many FMers/CFSers when it comes to exercise.
Physical exertion ought to cause an increase in CRH---->ACTH----->cortisol,
but nope, nada. If exercise actually lowers already low cortisol in FM or
CFS, that's why exercise intolerance feels so awful..it's almost induced
Addison's.(!!!)
This page also discusses a Growth Hormone activating enzyme
produced in the liver which isn't getting used in FM/CFS, because the
pituitary is low in output of the Growth Hormone for it to work with.
The pituitary has three lobes, m'dear..it depends on where your
tumor affected your pituitary as to which hormones are low for you. Bet it's
no surprise that one that modifies intensity of pain is produced in the
pituitary; as is another hormone that offsets depression.
I have webpages I found that will 'splain this summary I've written
in more detail, if ya want 'em, Lady of the Hounds. :-)
I'll be reviewing the other pages of Laura's site over the next few
days..some really GOOD stuff...but again, the psycho-social stuffs is 'oh,
geez.' LOL They were doing so well, too! :-)
I'll be back...you've been warned. <g>
Huggings,
Rosie S.
Demented Dame
--
"If you wanna get it done, you gotta fight for yourself."
-- Meat Loaf, Bat Outta Hell II
"Laura" <ada14...@aol.com> wrote in message
news:20010503173713...@ng-fx1.aol.com...
Deirdre
<< Okey doke, Laura, Cortisol comes from the adrenal cortex.( the
outside of lil' glands perched atop yer kidneys) It is 'sposed to rise
in the early AM
Yeah. Tell me about it. Lazy ol' good-fer-nuthing adrenals...
<< ...and fluctuate thru the day, lowering at bedtime. >>
By the time I want to get to bed I'm just getting some adrenaline - and
a good thing too because I *need it to sleep* - it's just a tiny bit
anyway.
<< ...Not in many FM'ers, it don't. >>
You can say that again, Lady Rosie.
<< When faced with a stressor, the hypothalamus ( a squiggly gland deep
in the brain) ...
A gland, remember. It's just *located* in the brain for convenience.
<< ...increases output of CRH ...>>
A likely story. That's in health people.
<< ...to which the pituitary ( a bean shaped gland smack in the middle
of the brain...>>
But STILL a *gland*.
<< ... oft referred to as the Master gland) responds by releasing ACTH
aka corticotropin. >>
Yeah. I 'spose. *Occasionally*.
<< ...An axis is a term for two glands working in sync. The ACTH directs
the adrenal cortex to output more cortisol. Cortisol is also bound up in
the blood by some glucoid molecules ...>>
Nummies. AKA food.
<< ...but this paper doesn't address whether too much cortisol may be
stored and unavailable.>>
OR not even synthesized or not even secreted... due to lack of NAD. I
find it's difficult keeping things simple because you have to leave
important stuff out.
<< Cortisol energizes and helps the body use fuel. >>
Otherwise the fuel is stored.
<< It works with insulin to insure enuff 'turbo charge' is ready if a
saber-toothed tiger is about to chase us up a tree. <g> >>
It could still happen...
<< I plan to stay outta the way of a city bus, 'cuz this sez I won't
have the boost needed to get meself outta the way. >>
You got *that* right... also you have to take into account the unhappy
fact that sometimes the brakes aren't all that good.... ;-(
....shocking but true.
<< In many FM'ers, the CRH increase causing corticotropin increase does
NOT increase cortisol. In these FM'ers, cortisol stays low all the
time....not low enuff to be Addison's disease, but low enuff to cause
muscle weakness and pain, dizziness, low BP and fainting. >>
Lovely. So I 'spose I'm right in thinking a minor case of Addison's is
sorta like a minor case of diabetes. They sorta fixed the lower limits
thing for diabetes, couldln't they do the same for Addison's? this has
been a major element in my problems all these years.
<< This is also true for many FMers/CFSers when it comes to exercise.
Physical exertion ought to cause an increase in
CRH---->ACTH----->cortisol, but nope, nada.>>
If exercise actually lowers already low cortisol in FM or CFS, that's
why exercise intolerance feels so awful...
I just came across some stuff that will bolster and flesh out this
argument.
<< it's almost induced Addison's.(!!!)
Tell me about it. I got more relief (questionable, though) from
*arsenic* than from anything else. Ever. I could be put on Warferin to
my *benefit*. For awhile, anyway.
<< This page also discusses a Growth Hormone activating enzyme produced
in the liver which isn't getting used in FM/CFS, because the pituitary
is low in output of the Growth Hormone for it to work with. >>
And this means you can't selectively up other things because if that
enzyme isn't being used the actual secretoary organ may conceivably have
atrophied in the meantime (ya know, while everyone's been dilly-dallying
around doing nothing about our DD. Grrrr.
<< The pituitary has three lobes, m'dear..it depends on where your tumor
affected your pituitary as to which hormones are low for you. >>
Gee. That makes it easy to figure out.
<< Bet it's no surprise that one that modifies intensity of pain is
produced in the
pituitary; >>
You mean an *endorphin*? what a *rip*...
<< as is another hormone that offsets depression. >>
Now I'm really getting po'd. Now they tell us. And all this stuff has
been kicking around in library basements for decades...
<< I have webpages I found that will 'splain this summary I've written
in more detail, if ya want 'em, Lady of the Hounds. :-) >>
Oh, Rosie... pleeeeeeez may I have 'em too? Pleeze...
Gee. I sure like the way you "rest", Rosie. Heh heh...
<< I'll be reviewing the other pages of Laura's site over the next few
days..some really GOOD stuff...>>
Bring it on, Rosie!
<< ...but again, the psycho-social stuffs is 'oh, geez.' LOL
LOL?
<< ...They were doing so well, too! :-) >>
Okay. Somehow I think we've arrived at a Moment of Clarity.
How about this? Read and learn biology and biochemistry or else be
treated like mud. I think we're beginning to get somewhere. I just found
an interesting website where the formula for an all-around mental
pick-me-up was all laid out there.
It's pretty well the same as my formula for my eyes - which just happens
to fix practically everything else too... maybe I'll post *again* - for
the umpteenth time - what works for my eyes and make the simple but
pointed observation that if these things aid *eye function*
(neurologically *and* structurally (to the complete disgust of my opthie
who couldn't do the catarectomy because the cataracts were then *too
thin*...) maybe someone will twig. Ya think?
<< I'll be back...you've been warned. <g> >>
Oh, goody. I'll just wait patiently ... heh heh... this *is* good stuff,
Rosie. Huggings to you!
All in re:
http://www.georgetown.edu/research/fmscfs/f-7.htm
from the The Chronic Pain and Fatigue Research Center at Georgetown
University website.
Thanks to Laura and
Love from Mrs Magoo ;-))
--
Attempt the end, and never stand to doubt;
Nothing's so hard but search will find it out.
"Seek and Find"
- Robert Herrick, 1591-1674
Laura
I had the pitutary gland problem long, long before I came down with fibro.
Maybe this is what pre disposed me to fibo and the injury I suffered just tiped
the scale.
its another piece of the puzzle
DGSABA
Mine was a neck injury ~ mva.
Soft hugs
Diana
Glo
time I have any energy. Don't get me wrong, I don't *like* that hyper
feeling. When I was on 60 mg/daily, there was a certain time of the day
when I would just shake like a leaf.
Just curious.
Luv,
Glo
----<----<<@
--
"Snowflakes are one of nature's most fragile things, but just look what they
can do when they stick together."
"Rosemarie Shiver" <pos...@strato.net> wrote in message
news:22BI6.193$2B6....@e420r-chi2.usenetserver.com...
johnie
Pred can definitely make you hyper and just like so many meds it varies
among individuals what specific reaction you will have to high dosages.
I have been on Pred for 10 years for my RA and try to keep it around
5mg. but right now am at 10mg. because of a recent flare. Ive had as
much as 100mg.IV before surgeries and Im fortunate that I dont have the
wild mood swings many have nor do I suffer from some of the devastating
long-term side effects. It has been the only thing Ive been able to take
to help control my RA. The shaking from 60mg. a day sounds like a
reaction many have on that high a dose. Many people with RA will get
60mg.or so IV before a vacation or extended business trip. As long as
you dont do this more than twice a year its fairly safe. Best Wishes.
johnie
Rosemarie Shiver
johnie's right of course, as usual. :-) Glad to see ya outta lurk mode, j!
But also, Glo...Pred makes yer muscles have tremors. It's a side effect
easily noticed in me, and I'm on a very low dose.
I hafta get my doc to insist that I get a mammogram from my wheelchair 'cuz
the involuntary tremors have made the last three sets of pics all blurry. I
can't stand up if I take the muscle relaxant to stop the tremors...so I
wonder if I'll wind up in the hosp. Radiology Dept.? <big grin>
Nuttin' johnie hasta worry about..so toddle along, dear j. LOL!
Affectionately Teasing Hugs,
Rosie S.
Demented Dame
--
"If you wanna get it done, you gotta fight for yourself."
-- Meat Loaf, Bat Outta Hell II
"johnie" <j...@theriver.com> wrote in message
news:3AF3466A...@theriver.com...
Laura
>Mine was a neck injury ~ mva.
>
>Soft hugs
>Diana
A back injury L-4 and L5 and c something
Glo
(hives caused by the inflammation of vasculitis) for the last three days
across my collarbones, but this morning I awoke with them up both sides of
my neck. Don't like that stuff inchin' up toward my peabrain. My
dermatologist (or is it dermy?) put me back on 50 mg. Prednisone for 2 days,
then 40 for 2 days, yadayadayada -- taper off, again. If I'm lucky enough
to sleep tonight, I'm sure I won't by tomorrow night. Insomnia, big time.
Yeah, and sometimes my wonderful, sweet personality <g> takes a ride on a
pretty big swing when I'm on 80, 60, and 50 mgs. Watch out hubby!
Hugs,
Glo
----<----<<@
--
"Snowflakes are one of nature's most fragile things, but just look what they
can do when they stick together."
"Rosemarie Shiver" <pos...@strato.net> wrote in message
news:8XHI6.1163$g61....@e420r-chi1.usenetserver.com...
DDRitch
>(hives caused by the inflammation of vasculitis) for the last three days
Glo
Can you explain what urticarial vascultis actually is?
I have hives all over the trunk of my body and cannot figure out if it is
caused by the contrast solution they used on me in my CT scan yesterday, or the
Aleeve that I just took. Yet another think I am allergic to????
I cannot sit still I itch so. Have started on the Benedryl...and that is
helping.
Glo
I'll try to explain what I know. I had hives before and while I was at Mayo
in '98. My primary doc there (who was an allergist I was sent to to rule
out mastocytosis), sent me to a dermatologist there. Mine were appr. 1-2"
across and would last for 2 or 3 days. So the dermy biopsied one of them.
The result showed inflammation, so his dx was "urticarial vasculitis". I
have systemic vasculitis. Really, that's about all I know about it. I'll
go Google, and if I find out anything interesting I'll post it.
The hives I have right now are much smaller and more numerous. They're too
small to be biopsied. (The dermy at Mayo told me he was glad the hives were
large because they have to take two "plugs" out of any one hive to biopsy.
Just had a couple of stitches.) Anyway, my dermy here in K.C. has a copy of
the biopsy results, and when I get hives we assume they're related to my
systemic vasculitic. And, yeah, they itch like heck! I use Sarna Anti-Itch
Lotion (non-steroidal). Doesn't smell real good, but it sure does the job.
I also had hives across my abdomen (when I was still healthy in the early
'70's) after I had been given IVP dye. The doc immediately gave me Benadryl
IV. The dye has changed a lot, for the better, since then. But, for
instance, when I had my angiogram 3/21, I was given Benadryl in my IV prior
to the test as a precaution. So, IMHO, I think Benadryl's a safe bet for
you. You might want to talk to your doc who gave you the contrast, though,
and let him know. If he thinks it's an allergic reaction you'll need to
know that for future tests with contrast.
Hugs,
Glo
----<----<<@
--
"Snowflakes are one of nature's most fragile things, but just look what they
can do when they stick together."
"DDRitch" <ddr...@aol.comstopewe> wrote in message
news:20010510001045...@ng-cf1.aol.com...
Glo
Okay, I Googled. Here are a couple of sites. When you read them, remember
I have Sjogren's Syndrome, and I'm on Azathioprine (Imuran) and back on
Prednisone for a week. Hope these help clarify it :-)
www.manbir-online.com/diseases/urticaria-1.htm
www.emedicine.com/DERM/topic449.htm
Hugs,
Glo
----<----<<@
--
"Snowflakes are one of nature's most fragile things, but just look what they
can do when they stick together."
"Glo" <gloria...@hotmail.com> wrote in message
news:tflfu5a...@corp.supernews.com...
Sampatron
>I *hate* itching, don't you?
>his dx was "urticarial vasculitis".
I don't have any diagosed autoimmune disorder and the vasculitis I have is
intermittent, but when I was working for pathologists, it was sort of
informally diagnosed by the chief. I never went to a doc for it, though.
Anyway, I used to get it pretty regularly, then when the FMS came into my life
it seemed to go away until just in the last couple of weeks it returned on my
hands. It is a nuisance and actually leaves teeny tiny little scars on my
fingers that you'd never notice if you weren't aware what had been there
before. Even the docs, when I show them after the fact, aren't real sure
they're seeing anything. At this moment, as we speak, I have some resolving
bumps on my left thumb and my right first finger third knuckle. Have never
figgered out what sets it off.
Sam in Texas §(ô¿ô)§
Minds are like parachutes; they function best when open.
A closed mind is a good thing to lose.
"Minds are like parachutes; most people use them only as a last resort."
~Ben Ostrowsky
Glo
had dx'd it then. I don't usually get mine on my hands (never say never:-),
but on my forearms and legs. I'm usually various shades of red, dark blue,
light blue, and what I *really* like is when I have a little green mixed in.
And I know exactly what you're talking about those little scars. Mine turn
kinda' light brown. My dermy looks at them with his headlight on! Last
time I saw him I asked if I was going to turn into leather. <g> He then
gave me some Lac-Hydrin (Rx) to try on my arms. I put a thin layer on after
I shower, and I think it's helping. At least, more than the Eucerin I
usually use on my skin.
Let me know if you learn anything else interesting about vasculitis.
Thanks.
Hugs,
Glo
----<----<<@
--
"Snowflakes are one of nature's most fragile things, but just look what they
can do when they stick together."
"Sampatron" <samp...@aol.com> wrote in message
news:20010510144239...@ng-cu1.aol.com...
Sampatron
> I don't usually get mine on my hands (never say never:-),
>but on my forearms and legs. I'm usually various shades of red, dark blue,
>light blue, and what I *really* like is when I have a little green mixed in.
Hmm. I don't know if I'm disappointed or pleased that there's no color
involved with mine. :>() LOL My scars are only visible as little slightly
smoother spots and if you weren't looking for them, and sometimes, even if you
are, they don't seem anything out of the ordinary. But whether I scratch or
not, they still leave scars when they resolve. When they're active they're
just little skin colored pinpoint bumps and they only get red if I scratch.
And sometimes they *do* itch! Whew! But so far I've only had them on my
fingers and hands, and maybe my toes, 'cause the itching is familiar, but I
can't get down there to look! LOL
Sampatron
while we both seem to have vasculitis they're two different entities. But it
was interesting to notice that one description of one type of vasculitis
sounded quite similar to FMS. But then again, what disease doesn't?! LOL
Here are some websites if anyone is interested.
http://www.hamline.edu/lupus/articles/vasculitis.html
http://www.users.globalnet.co.uk/~aair/urticaria.htm
http://www.emedicine.com/DERM/topic449.htm
Glo
bruises (even if I don't scratch). They're just part of the deal, for me.
I have a question about one thing I saw on the last site. It's the adult
dose for Azathioprine (Imuran). It says "adult dose not to exceed 2
mg/kg/d". Does that mean "not to exceed 2 mg/daily"? I take 50 mg. x 2
daily (100 mg.), as prescribed by my dermy, and my rheumy knows about it.
Don't know what to think about that. I may go Google some more! :-)
Hugs,
Glo
----<----<<@
--
"Snowflakes are one of nature's most fragile things, but just look what they
can do when they stick together."
"Sampatron" <samp...@aol.com> wrote in message
news:20010510163027...@ng-fp1.aol.com...
DDRitch
Thanks for the infomation and sites.
I will be mentioning the hives to my doctor when I see him to get results of CT
scan next Thursday.
GOSH I HATE THIS STUFF!!!!!
Sampatron
>I have a question about one thing I saw on the last site. It's the adult
>dose for Azathioprine (Imuran). It says "adult dose not to exceed 2
>mg/kg/d". Does that mean "not to exceed 2 mg/daily"?
Hi Glo,
It means the dosage is based on your weight. A kg equals 2.2 pounds, so you
take your weight in pounds, divide by 2.2 and that will tell you how many kg
you weigh. Then you should multiply the kg by 2 and that will tell you the
maximum dosage you should not exceed in a day.
For example, let's say you weigh 140 pounds. That's 63.6 kg. The maximum
dosage should not exceed 127 mg per day according to that statement.
HTH