Anti Deep Ze 7.22.0203453
Rubie Mccloughan
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Advances in deep learning technology have enabled complex task solutions. The accuracy of image classification tasks has improved owing to the establishment of convolutional neural networks (CNN). Cellular senescence is a hallmark of ageing and is important for the pathogenesis of ageing-related diseases. Furthermore, it is a potential therapeutic target. Specific molecular markers are used to identify senescent cells. Moreover senescent cells show unique morphology, which can be identified. We develop a successful morphology-based CNN system to identify senescent cells and a quantitative scoring system to evaluate the state of endothelial cells by senescence probability output from pre-trained CNN optimised for the classification of cellular senescence, Deep Learning-Based Senescence Scoring System by Morphology (Deep-SeSMo). Deep-SeSMo correctly evaluates the effects of well-known anti-senescent reagents. We screen for drugs that control cellular senescence using a kinase inhibitor library by Deep-SeSMo-based drug screening and identify four anti-senescent drugs. RNA sequence analysis reveals that these compounds commonly suppress senescent phenotypes through inhibition of the inflammatory response pathway. Thus, morphology-based CNN system can be a powerful tool for anti-senescent drug screening.
How to use:
As a shampoo, apply evenly on wet scalp and hair. Gently lather with the softest part of the tip of your fingers and without over-massaging (to not excessively activate the sebum glands). As a clay mask, apply and leave on for 3-5 min. Rinse thoroughly. In case of contact with eyes, rinse them immediately and thoroughly.
Pro tips:
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Results & benefits:
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The rigorous evaluation of anti-poverty programs is key to the fight against global poverty. Traditional approaches rely heavily on repeated in-person field surveys to measure program effects. However, this is costly, time-consuming, and often logistically challenging. Here we provide the first evidence that we can conduct such program evaluations based solely on high-resolution satellite imagery and deep learning methods. Our application estimates changes in household welfare in a recent anti-poverty program in rural Kenya. Leveraging a large literature documenting a reliable relationship between housing quality and household wealth, we infer changes in household wealth based on satellite-derived changes in housing quality and obtain consistent results with the traditional field-survey based approach. Our approach generates inexpensive and timely insights on program effectiveness in international development programs.
We thank Edward Miguel, Jeremy Magruder, Ben Faber, Marshall Burke, Joshua Blumenstock, Supreet Kaur, Ethan Ligon, Elisabeth Sadoulet, Alain De Janvry, Aprajit Mahajan, the participants in the AGU Fall Meeting 2019 (Session GC34C), the UC Berkeley Trade Lunch, Development Workshop, Development Lunch, Good Data Seminar, and the FAO Technical Network on Poverty Analysis for feedback. We thank Edward Miguel, Michael Walker, Dennis Egger, Johannes Haushofer, Paul Niehaus, and the rest of the GiveDirectly team, for generously sharing the dataset with us and responding to our inquiries. The views expressed herein are those of the authors and do not necessarily reflect the views of the National Bureau of Economic Research.
Criminalizing consensual same-sex relationships and gender expression not only violates fundamental human rights but also undermines efforts to end AIDS by driving marginalized populations underground and away from essential health services, including life-saving HIV prevention, treatment and care services.
Globally, the movement for human rights has made progress in the past 40 years. At the start of the AIDS pandemic in the early 1980s, most countries criminalized same-sex sexual activity between men, now two thirds do not. An increasing number of countries have also recognized the rights of trans and other gender diverse people. However, this new legislation in Iraq represents a significant setback and is part of a wave of punitive and restrictive laws being passed that undermine the rights of LGBTQ+ people.
The legislation passed in parliament is an amendment to an existing 1988 anti-sex work law which continues to criminalize both the selling and buying of sexual services. The amendments passed on Saturday 27 April 2024 increase the penalties in relation to sex work. These laws, which countries committed to removing under the 2021 United Nations General Assembly Political Declaration on HIV and AIDS, likewise undermine the human rights and public health of sex workers.
Long distance travel is a risk factor in the development of blood clots. The risk is not confined to air travel; it increases with the duration of travel and is more common in those with pre-existing risk factors.
Prolonged periods of immobility can lead to slow blood flow in the veins which increases the risk of developing a blood clot within a deep vein in the body; this is called deep vein thrombosis (DVT). Blood clots most commonly form in the legs. If parts of the clot break off and travel to the lungs, this can block blood vessels and is called pulmonary embolism (PE) which is a potentially life threatening condition.
If you are at an increased risk of DVT or PE, anti-embolism stockings (AES) might be recommended to reduce your risk. You should discuss this with your travel health advisor or GP. AES are sometimes called graduated compression stockings (GCS):
Low molecular weight heparin can be considered for those at higher risk of developing DVT (see above). This treatment is administered by injection and must be prescribed by your GP or hospital specialist and used under their direction.
Transformation from the four corruption syndromes described above towards building social foundations for reform involve long-term, indirect ways of empowering and supporting political opposition to corruption. Johnston (2014) suggests that, in the long run, one of the most important anti-corruption approaches is "deep democratization", which enables people to defend their interests by political means. This overarching approach has the potential to revive long-term conflicts and political developments in societies where corruption has been brought within workable limits. In contrast to other reform strategies, deep democratization conceives better government in terms of justice and fairness and not as more efficient administration. Reaching that goal involves the improvement of the quality of institutions, laws, and enforcement measures which, in turn, require sustained political, economic and social demand that reforms and controls be implemented effectively.
Yet, the relationship between anti-corruption efforts and democratization must always be considered and understood within localized contexts - both in understanding how corruption is fostered and in developing ways to eradicate it. It also calls for embracing the complexity of cultural and political diversity, despite broad agreement with respect to universal values (for more information about universal values and political diversity see Module 2 and Module 5 of the E4J University Module Series on Integrity and Ethics). Thus, the association of democracy with honest and clean governments depends very much on a country's broader political environment and other local circumstances (Kramer, 2018). For example, in Oligarch and Clan situations, reform priorities should revolve around creating a safe and valued political and economic space within which citizens and businesses can articulate, discuss and defend their interests and needs. Basic law enforcement and security of legal rights should be of high priority; so, too, should be sound currency and banking, and building an independent and accessible justice system. Here, too, corruption is most likely to be only one of many issues to drive contention and debate, but underlying most such issues will be questions of accountability and fairness (Johnston, 2014; 2017).
In Official Moguls situations that are characterized by an authoritarian inner circle, anti-corruption strategies might start with attempts to secure even modest civil liberties. This could, for example, contribute to better implementation of development aid projects even in undemocratic environments; reducing police and military oppression of citizen groups; increasing interest in political life; and raising corruption as an issue in an indirect way. That is not to say that such attempts will necessarily have such positive influences, rather the idea is that they could.
Curbing corruption is complex and requires a multi-pronged approach that continues over a long period of time - irrespective of whether the regime is democratic, hybrid or authoritarian. In the end, "the key is gradual and indirect change making way for such contention to emerge within society, driven by issues and grievances people care about" (Johnston, 2017, p. 7). The idea here is that curbing corruption is a dynamic process that takes place over time and involves a suite of administrative and procedural interventions and reforms to improve transparency, accountability, fairness and equality. As noted in Kubbe (2017):
This kind of vertical accountability, which is also referred to as social accountably, is associated with democracies. In hybrid and authoritarian regimes, civil society movements and individual citizens must be empowered to demand better government and effective corruption control in the long term. In this context, Collier (2002, p. 27) argues that "an empowered civil society playing a vital role in elite accountability emerges as the foundation for building commitment rules". Thus, the deep democratization approach is linked to both social accountability and social empowerment, two factors that are essential for the fight against corruption. These and related issues are discussed further in Module 10 of the E4J University Module Series on Anti-Corruption.
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