A comparative simulation between NGSPICE and Xyce (Serial build on Debian Linux) has been done on a non trivial Power Amplifier design drawn with
XSCHEM.
Some small changes were needed to port the original for-Ngspice design to Xyce; For example Xyce does not accept expressions for .tran Tstep and Tmax.
Since Xyce has adaptive time step calculation some tuning has been done on the .tran parameters to force the 2 simulators generating the same size output result raw file. Results were extremely good, both simulators giving the exact same results. However Xyce performed the simulation in half time:
schippes@mazinga:~/.xschem/simulations$ time ngspice -b -r poweramp.raw -o poweramp.out poweramp.spice >log
real 0m18.738s
user 0m18.345s
sys 0m0.113s
schippes@mazinga:~/.xschem/simulations$ time Xyce -r poweramp_xyce.raw poweramp_xyce.spice > log
real 0m9.429s
user 0m8.904s
sys 0m0.380s

XSCHEM is a schematic editor for digital / analog / mixed-mode VLSI / ASIC designs and supports SPICE, Verilog and VHDL netlist generations.
Stefan.