While I am not 100% sure of what you are asking, I believe you may want to check out accelerator tables. Using Mike Driscoll's blog as a guide wxPython Keyboard Shortcuts (accelerators) I was able to get around an annoying issue with one of my programs not properly using Ctrl+C to copy data to the pc clipboard.
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While this will work on Windows I do not believe it will work for Mac's due to the use of win32con to bind the keys. By using the accelerator tables and Mike Driscoll's suggestion of catching EVT_KEY_DOWN and EVT_CHAR it will be easier to support multiple OS platforms. Of course you could add more to the code of your program that would detect the running OS and switch how it will bind the keys, it may just take more time and coding to get it working.