Hotkeys are hotkeys: They Work in the whole application, in my experience at least If the Key Event that Gets informed about the journey press issues a event.Skip().
What you can do, though, is to catch the wxKeyEvent in your book and handle the hotkey by hand.
Be aware,though, if you are working on a multilingual application that the excellent hotkey in one keyboard might be the way to enter a backslash or a unit mu on the other => hotkeys need to be translated along with the rest of the application which is why the "\t hotkey" mechanism is this great.
Kind regards,
Gunter.