Sepsis in Children: New National Data

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Centers for Disease Control and Prevention

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Mar 25, 2026, 12:13:57 PM (7 days ago) Mar 25
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Nearly 1 in 5 pediatric hospital deaths involved sepsis

Data Update: CDC-Funded Study Provides National Burden of Sepsis in Children

“Sepsis is a medical emergency. Each year, more than 18,000 children in the U.S. develop sepsis. More than 1,800 children who develop sepsis die during their hospitalization or are discharged to hospice. Learn more at cdc.gov/sepsis.” Get Ahead of Sepsis and CDC logos on bottom.

A new CDC-funded study published in the Journal of the American Medical Association (JAMA) shows the impact of pediatric sepsis in U.S. hospitals. Using a robust, validated Pediatric Sepsis Event definition based on electronic health record data, the authors estimate that:

  • More than 18,000 hospitalized children in the United States have sepsis each year, including more than 1,800 who do not survive to discharge. 

  • Sepsis occurs in about 1 in every 75 pediatric hospitalizations. 

  • Most cases of sepsis in children (73%) started in the community

  • About 1 in 10 children with sepsis died during hospitalization. 

  • Nearly 1 in 5 pediatric hospital deaths involved sepsis.

Sepsis is a major public health threat for children. With the new validated measurement approach, we can better identify trends, improve patient safety, and guide strategies to get ahead of sepsis. CDC remains committed to strengthening national surveillance of sepsis, working with healthcare partners to turn this data into action, and improving patient care for children nationwide. 


Healthcare Professionals: 

  • Encourage implementation of the Hospital Sepsis Program Core Elements at your facility. CDC developed this tool to help clinicians, hospitals, and healthcare systems improve programs that support the care of patients with sepsis. 

  • Explore and share materials for healthcare providers and patients to educate and protect people from sepsis. Educate your colleagues, patients, and their parents and guardians about actions they can take to prevent infections that can lead to sepsis

  • Know sepsis signs and symptoms to identify and treat patients early. Remember: this study shows 73% of pediatric sepsis cases started in the community. Know your facility’s guidance for diagnosing and managing sepsis in children. 

“Sepsis signs and symptoms: high heart rate or weak pulse; Boxes showing figures of a person beside six signs and symptoms of sepsis: high heart rate or low blood pressure; fever, shivering, or feeling very cold; confusion or disorientation; shortness of breath; extreme pain or discomfort; clammy or sweaty skin." Get Ahead of Sepsis and CDC logos on bottom.

Parents, Caregivers, and Volunteers: 

  • Be aware that infections can put children at risk for sepsis, the body's extreme response to an infection. Sepsis is a life-threatening medical emergency and major cause of death in children worldwide. 

  • Recognize sepsis and act fast if you suspect it—based on the study, most sepsis cases started in the community (73%)

  • Use our Protect Your Child from Sepsis fact sheet for parents and caregivers and Protect Children from Sepsis fact sheet for youth counselors, coaches, and other volunteers to learn how to stop an infection before it leads to sepsis. 
Partners:

  • Use our public health partner toolkit to customize social media messages, graphics, and drop-in articles to reach parents and caregivers and childcare organizations. 
Help protect children from preventable deaths. Use CDC’s free resources to spread the word about how to get ahead of sepsis: https://www.cdc.gov/sepsis/index.html.


New national data from a @CDCgov-funded study show the high impact of #sepsis in children. This study advances monitoring for pediatric sepsis, which can improve prevention efforts. #GetAheadOfSepsis and read here: https://jamanetwork.com/journals/jama/fullarticle/2846848.


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