Fwd: Roche NimbleGen Webinar Series
Jaysen Knezovich
From: Shaun Aron <shaun...@gmail.com>
Date: 29 January 2010 08:24
Subject: Fwd: Roche NimbleGen Webinar Series
To: Jaysen Knezovich <jaysen.k...@gmail.com>
May be of interest.
From: Roche NimbleGen <Roche_N...@mail.vresp.com>
Date: Fri, Jan 29, 2010 at 8:22 AM
Subject: Roche NimbleGen Webinar Series
To: shaun...@gmail.com
| Introducing the NimbleGen ChIP-chip and DNA Methylation Multiplex Arrays |
Thursday, February 18, 2010 |
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| Speaker | Abstract | |
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Senior Scientist, Epigenetics Roche NimbleGen |
Introducing the NimbleGen ChIP-chip and DNA Methylation Multiplex Arrays Epigenetic changes in DNA methylation patterns and chromatin structure play key roles in the development of disease. Examples include Angelman and Prader-Willi syndromes, where epigenetic silencing is one factor in the development of these diseases. Therefore, understanding epigenetics is critical to our future understanding of many important diseases. Methods exist to analyze DNA methylation patterns in higher eukaryotes including methylated DNA immunoprecipitation-on-chip (MeDIP-chip), an affinity based approach to enrich methylated DNA regions from genomic DNA followed by microarray analysis. Similarly, chromatin structure and DNA-binding proteins can be mapped using chromatin immunoprecipitation-on-chip (ChIP-chip) using target protein specific antibodies and microarrays. Here we introduce our new Human, Mouse and Rat 3x720K ChIP-chip and DNA Methylation Arrays which offer comprehensive coverage of gene promoters and CpG islands in a multiplex platform. These arrays offer high resolution, 100bp probe spacing through all covered regions for highly sensitive and reproducible detection of DNA methylation and target protein DNA binding. In addition, the DNA methylation arrays also include probes covering positive, negative and nonCpG control regions to aid in assessment of the overall array performance. In this presentation, we will (1) describe the array designs and content in more detail, (2) demonstrate the sensitive and reproducible detection capabilities of these new arrays, and (3) compare the performance of these multiplex arrays with the single-plex 2.1M Deluxe Promoter arrays. |
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| For life science research only. Not for use in diagnostic procedures. NIMBLEGEN is a trademark of Roche. |
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Shaun Aron
Bioinformatics Node
University of the Witwatersrand
011 717 6174
083 478 2890
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Regards,
Jaysen Knezovich.
PhD Candidate
Division of Human Genetics
National Health Laboratory Service (NHLS)
University of the Witwatersrand
Johannesburg
South Africa
Tel: +2711 489 9225
Cell: +2784 900 1515