Serum New Version

[Azalee Rowling]

HiSteve, I have downloaded the demo of Serum a few days ago, must say I really impressed! I make music for 7 months, until now I had all the basic things I needed and I just got a new sound card couple of days ago. so after that, I decided its time for me to have better sources for my DAW sounds since I have used only built in plugins all that time, I just want to ask a few questions because I seriously considering buying Serum.

2.I have read a lot about CPU issues, now I know that you are not a wizard but I would like to write down my specs so maybe you can tell if it can handle Serum well or not.

I have Windows 8 64 bit, Intel Core I7 - 4790 @ 3,6 GHz and 8 GB RAM, to be honest for my small uses with the demo version I didn't noticed any problem.

However I wanted to check my CPU at an extreme situation, I had 50 channels of Serum playing at the same time (I didn't touched the Unison by the way), my computer didn't crash but the CPU usage was really high and the Peak was at maximum (at Cubase 8.5), I must say this situation probably never going to happen but since its a demo version it is hard for me to determine if it clashes with my CPU or not, so far I had a really few drop outs all over the past 7 months (but that happened with built in plugins only. although rarely) so that's the reason that I'm a little bit concerned.

3.As a beginner producer that knows basic synthesis and not more I managed to handle Serum and other "complicated" synths I have tried really good, does the description for every parameter available also at the full version?

I make effort to have CPU use go down, not up, with updates. But in terms of evaluation I would suggest the demo. 50 tracks is really a lot, freezing is customary with that much playing. You can try the full version free for three days with the Splice rent to own plan if you want an exact test.

re: 2, well, 50 tracks is a lot, that could strain any of my machines in CPU load. Serum is competitive to other high-quality WT synths in terms of per-voice CPU, it's easy to load it high with the per-voice unison. Most CPU complaints I have found first and foremost come from heavy voice count compounded by not watching poly limits sensibly (lower-right fraction in Serum). Some synths won't let that number exceed 64, so it's good to keep an eye on it yourself and be sensible with unison (16 can sound great, but isn't always better sounding!) My general rule is to freeze chord parts.

Thanks for the quick reply :), I understand that the full version is exactly like the demo in terms of functions (and its great!), I guess there are more presets than the demo? About the CPU usage, I don't think its necessary to go so wild with the voices per unison, ane the 50 tracks test was just about trying to found out whay happens at an extreme situation, I wrote my specs to know if I can get Serum run at the hjghest quality (honestly, I dont believe I will go that far with the unison), of course I have no problem with freezing, the main reason I was a little bit concerned is that I had few CPU overloads with my built in plugins (altough its super rare as I mentioned). Anyway, I think I am going to get Serum today and thats it, thank you very much :).

I was just looking at the weapons of choice and serum tool kit and opened them on new tabs at chrome. I was about to buy Serum only and continued the purchase with the first tab that only had serum in it.

I guess should have known that since I added those on new tabs it been added to my cart and I had to refresh the first tab to get the real result,

but too bad there wasn't confirmation option and info about the total amount of money after I fulfilled my credit card information, there is something to do about it? because I didn't want to buy those presets, the truth is that Serum alone isn't cheap although I'm sure worth every dollar.

It has made a hard distinction between the VSTs versions of the same app. Notwithstanding that may be reasonable, it still though means I have near half of my presets that cannot fully work with the extract sound from preset feature/browser.

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T cell infiltration into tumors is a favorable prognostic feature, but most solid tumors lack productive T cell responses. Mechanisms that coordinate T cell exclusion are incompletely understood. Here we identify hepatocyte activation via interleukin-6/STAT3 and secretion of serum amyloid A (SAA) proteins 1 and 2 as important regulators of T cell surveillance of extrahepatic tumors. Loss of STAT3 in hepatocytes or SAA remodeled the tumor microenvironment with infiltration by CD8+ T cells, while interleukin-6 overexpression in hepatocytes and SAA signaling via Toll-like receptor 2 reduced the number of intratumoral dendritic cells and, in doing so, inhibited T cell tumor infiltration. Genetic ablation of SAA enhanced survival after tumor resection in a T cell-dependent manner. Likewise, in individuals with pancreatic ductal adenocarcinoma, long-term survivors after surgery demonstrated lower serum SAA levels than short-term survivors. Taken together, these data define a fundamental link between liver and tumor immunobiology wherein hepatocytes govern productive T cell surveillance in cancer.

Bulk RNA-seq data and scRNA-seq data have been deposited at the Gene Expression Omnibus (GEO) under the accession code GSE232701. All other data are present in the article and Supplementary Information or from the corresponding author upon reasonable request. Source data are provided with this paper.

Experiments and data analysis were performed by M.L.S., J.L., J.W.L, H. Coho., M.T., M.M.W., V.M.H., H. Choi and S.C.-B.; design and preparation of AAVs by J.L.; RNA-seq analysis by M.L.S. and J.L.; scRNA-seq analysis by M.T.; immunohistochemistry by M.L.S., Y.X., S.K.Z., D.P. and K.M.; RNA in situ hybridization by M.L.S.; tumor cell culture by M.L.S.; animal studies by M.L.S., J.W.L. and H. Coho; flow cytometry by M.L.S.; real-time qPCR by J.W.L.; cytokine bead array by M.L.S.; ELISAs by H. Choi and V.M.H.; CyTOF by M.L.S. and M.W.; V.P.B. provided patient serum samples; G.L.B. and D.D. provided experimental advice; M.L.S. and G.L.B. designed the study; M.L.S., J.L. and G.L.B. prepared and wrote the paper.

J.L. has received compensation for prior consulting work from Anchor Molecular and Prescient Medicine unrelated to this work. G.L.B. reports prior or active roles as a consultant/advisory board member for Adicet Bio, Aduro Biotech, Alligator Biosciences, AstraZeneca, BiolineRx, BioMarin Pharmaceuticals, Boehinger Ingelheim, Bristol-Myers Squibb, Cantargia, Cour Pharmaceuticals, Genmab, HotSpot Therapeutics, Incyte, Janssen, Legend Biotech, Merck, Molecular Partners, Monopteros, Nano Ghosts, Opsona, Pancreatic Cancer Action Network, Seagen, Shattuck Laboratories and Verastem; reports receiving commercial research grants from Alligator Biosciences, Gilead Sciences, Incyte, Bristol-Myers Squibb, Verastem, Halozyme, Biothera, Hibercell, Newlink, Novartis, Arcus and Janssen. G.L.B. is an inventor of intellectual property (US patent numbers 10,640,569 and 10,577,417) and recipient of royalties related to CAR T cells that is licensed by the University of Pennsylvania to Novartis and Tmunity Therapeutics. M.M.W. reports prior or active roles as a consultant for Nanology. The other authors declare no competing interests.

Nature Immunology thanks Venu Pillarisetty and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Primary Handling Editor: N. Bernard, in collaboration with the Nature Immunology team.

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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