Hi Cy,
I have had the same experience for years. Have never determined a better, let alone best, combination of settings. The controls that exist are no better than placebos - they're just buttons to push and settings to try.
It would be nice to have a diagnostic tool that scans the wireless environment and suggests that a particular tag frequency channel is the quietest, or that a particular bandwidth works well for the current sensor distribution, etc. Not sure whether anything like this is even possible with the current tag manager - it might be too dumb. If anyone has ideas for such a tool, I'd be happy to help develop it/test it/whatever.
Some sensors are simply unreliable. They can be unreliable from day one, or they can degrade with age. Others keep working for years without any issues. Once they get unreliable, you might as well toss them and try replacements.
Cheers,
Fred