As of 2015, 1P-LSD is unscheduled in the United States, but may be considered illegal if sold or used for human consumption as a structural analog of LSD under the Federal Analogue Act.[9] 1P-LSD is a controlled substance in France,[13] Finland,[14]

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1P-LSD (1-propanoyl-lysergic acid diethylamide)

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2024 1P-LSD (1-propanoyl-lysergic acid diethylamide)

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 is a psychedelic drug of the lysergamide class that is a derivative and functional analogue of LSD and a homologue of ALD-52. It originated in 2015 when it appeared a designer drug sold online.[1][2][3][4][5][6] It modifies the LSD molecule by adding a propionyl group to the nitrogen molecule of LSD's indole group.[7][8]

Pharmacology[edit]

Like ALD-52, 1P-LSD is believed to act as prodrug for LSD via hydrolysis of the propionyl group. When 1P-LSD is incubated in human serum,[9] administered intravenously to rats,[10] or administered either orally or intravenously to human subjects,[11] high levels of LSD and relatively low levels of 1P-LSD are quickly detected, demonstrating that 1P-LSD is rapidly hydrolyzed into LSD in vivo following ingestion. Indeed, following intravenous administration in humans 1P-LSD is detectable in serum for no longer than 4 hours, after which it is completely converted to LSD.[11] These findings are supported by the similar duration and behavioral effects of 1P-LSD and LSD in both animal and human experiments.[9][11]

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The subjective effects of 1P-LSD are not well defined in the scientific literature, although they are generally thought to be comparable to that of LSD.[12] In a 2020 study, the qualitative effects of 1P-LSD and LSD were similar when measured using visual analog scales.

Legal status[edit]

As of 2015, 1P-LSD is unscheduled in the United States, but may be considered illegal if sold or used for human consumption as a structural analog of LSD under the Federal Analogue Act.[9] 1P-LSD is a controlled substance in France,[13] Finland,[14] Denmark,[15] Germany,[16] Estonia,[17] Japan,[18] Latvia,[19] Norway,[20] Romania,[21] Sweden,[22] Switzerland,[23] United Kingdom,[24] Italy,[citation needed] Singapore,[25] the Czech Republic,[26] and Croatia.[27] 1P-LSD has been illegal in Russia since 2017 as an LSD derivative.[28]

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